Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS7873 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- BBOX1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human BBOX1.
- Description
- BBOX1 (butyrobetaine (ÎÛ), 2-oxoglutarate dioxygenase 1), also known as BBH, BBOX, G-BBH (ÎÛ-butyrobetaine hydroxylase) or ÎÛ-BBH, is a member of the ÎÛ-BBH/TMLD family of proteins. Localizing to the cytoplasm and predominantly expressed in kidney, BBOX1 plays a role in the biosynthesis of amines, polyamines and carnitines. More specifically, BBOX1 catalyzes the hydroxylation of ÎÛ-butyrobetaine to L-carnitine, a reaction that requires iron and ascorbate as cofactors. This is the last of five steps comprising the L-carnitine biosynthesis pathway and it is important for the proper transport of activated fatty acids across the mitochondrial membrane. Coupled to this reaction, BBOX1 simultaneously catalyzes the oxidative decarboxylation of Ï«-ketoglutarate to succinate.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- WesternBlot (WB) analysis of BBOX1 polyclonal antibody