16837-1-AP

antibody from Proteintech Group

Targeting: ALKBH5 FLJ20308, OFOXD1

Provider product page for 16837-1-AP

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Product number: 16837-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16837-1-AP, RRID:AB_2242665
Product name: ALKBH5 antibody
Antibody type: Polyclonal
Description: KD/KO validated ALKBH5 antibody (Cat. #16837-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ALKBH5 protein structure - 16837-1-AP shown in red.

Submitted references 3-Hydroxystearic acid promotes cholesterol efflux and attenuates atherosclerosis via the ALKBH5/PAX-8/ABCA1 pathway.

Zhou QY, Liu W, Zhao ZW, Gong D, Ma XF, Tang CK
Frontiers in immunology 2026;17:1750021

m(6)A-mediated CABLES1 translation potentiates tumor radioresistance via facilitating nonhomologous end-joining repair.

Li C, Tang X, Zeng Z, Yang L, Cao F, Zhu H, Zhu L, Shen J, Bian X, Wang L, Liu Y, Mao F, Chang D, Jiao P, Wang H, Li K
Cell death and differentiation 2026 May 9;

YTHDF2 promotes arsenic carcinogenesis through m(6)A-dependent SMAD7 decay and PRR5 escape from decay.

Zhang Q, Man J, Cai J, Zhao T, Zhang Z
International journal of biological macromolecules 2026 Mar;348:150816

Integrative Multi-Analysis Identifies METTL3-Regulated FGF19 and H6PD as Candidate Targets in Diabetic Cognitive Impairment.

Fu J, Wang H, Yan J, Chen W, Wang R, Gao H, Li C
Biomolecules 2026 Mar 20;16(3)

Regulatory mechanisms of ALKBH5/CIITA axis in the synergistic modulation of hepatocellular carcinoma radiotherapy and immunotherapy.

Wang F, Hou H, Yang H, Dou T, Wang Z, Fu H, Li H, Zhang W, Zhao H, Yang H
Genes and immunity 2026 Mar 10;

Down-regulation of M(6)A demethylase ALKBH5 facilitates morphine tolerance via SGK1 in mice.

Shi Y, Cao W, Xing M, Li Z, Peng J, Tian L, Zou W
British journal of pharmacology 2026 Jun;183(11):2739-2760

HucMSC-sEV-derived miR-320d alleviates IBD by inhibiting macrophage ferroptosis through m6A-mediated BCAT2 upregulation.

Wang N, Yuan J, Wang X, Yao D, Ocansey DKW, Mao F
Bioorganic chemistry 2026 Jul 5;175:109817

ALKBH5 deficiency suppresses hepatocarcinogenesis in mice via m(6)A-dependent STAT1 restoration.

Wang KT, Yang S, Zhao ZH, Rui CH, Shen SY, Cao D, Guo LN, Tang SH, Chen L, Wang HY, Qiu XY
Acta pharmacologica Sinica 2026 Jan;47(1):209-221

m(6)A modification in the 3'‑leader region of EBOV genome antagonizes ISG20 to facilitate viral replication.

Zhao B, Cao Z, Zhang K, Xiao S, Shen X, Li F, Wu Y, Zhang B, Wang Q, Zhang H, Chuai X, Chiu S
International journal of biological macromolecules 2026 Jan;339(Pt 2):149804

Periplocin and bufalin induce cardiotoxicity by regulating AMPK/SIRT1/PGC-1α pathway to inhibit energy metabolism and trigger autophagy.

Gao X, Zhang J, Lin Y, Tian K, Tu J, Wu Z, Lv X, Hu H, Liu X, Lin S, Zhu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157688

METTL3-mediated m6A modification of FDX1 confers resistance to cuproptosis and promotes hepatocellular carcinoma progression.

Jiang Q, Peng C, Mao W, Yu Z, Feng Y, Li Y, Zhu J, Zhao J, Liao D, Sun T
Communications biology 2026 Jan 8;9(1):222

ALKBH5 promotes gastric cancer angiogenesis by stabilizing LncRNA PVT1 and VEGFA RNAs via m6A demethylation.

Geng Q, Li D, Zhu W, Qi C, Wang T, Yang H, Shu Y, Jiang H
Molecular and cellular biochemistry 2026 Feb;481(2):1029-1044

RMzyme: regulations of RNA-modifying enzymes in humans.

Luo R, Xu H, Zhou Q, Ding S, Qiang M, Wen J, Kim P, Yang X, Cai Y, Xie K, Zhu J, Xu Y, Lan T, Zhou X, Wu H
Signal transduction and targeted therapy 2026 Feb 12;11(1):52

HIV-1 Vpr activates microglia by upregulating m6A modification through ubiquitin-proteasome pathway-mediated degradation of the demethylase ALKBH5.

Peng Q, Li W, Qian F, Zhu Y, Hu S, Shi Y, Xia Y, Liu W, Shu X, Wan P, Liu Y, Sun B
Virulence 2026 Dec;17(1):2645908

ALKBH5 Regulates Inflammation and Pyroptosis of Coronary Heart Disease by Targeting SPEN in a YTHDF1-Mediated Manner.

Huang S, Huang J, Lu Y, Hong Z, Lai G, Chen Y
Cardiovascular drugs and therapy 2026 Apr;40(2):475-491

M6A demethylase ALKBH5 mediated Igfbp4 mRNA m6A modification drives fibroblast activation and pathological upper airway fibrosis.

Wang J, Liao Z, Xu M, Zheng Y, Hu B, Xia Q, Xu H
Clinical and translational medicine 2026 Apr;16(4):e70656

m6A Modification of ATOX1 Inhibits Acute Myeloid Leukemia Progression by Promoting Cuproptosis.

Peng J, Fu X, Li S, Hu C, Zhao X, Peng J
Cancer research communications 2026 Apr 1;6(4):714-727

Ginsenoside Rh2-Pretreated Mesenchymal Stem Cell Exosomes Ameliorate Collagen-Induced Arthritis via N6-Methyladenosine Methylation.

Zhou Z, Wu S, Li Y, Shao P, Jiang J
Biomaterials research 2025;29:0220

N(6)-methyladenosine Reader IGF2BP2-modified HMMR Promotes Non-small Cell Lung Cancer Metastasis via Interaction with MAP4K4.

Zhang J, Zhang M, Qiu A, Li C, Chen Q, Li J, Zeng Y, Zhu J, Huang JA, Zhang X, Liu Z
International journal of biological sciences 2025;21(4):1391-1409

N6-methyladenosine RNA landscape in the aged mouse hearts.

Jing X, Li Y, Liao Z, Wu JY, Xu ZY, Yang ZP, Mo HL, Xu S, Liu X, Wu Z, Tao J, Xiong XD
Frontiers in cardiovascular medicine 2025;12:1563364

Changes of N6-methyladenosine and ferroptosis in cadmium-induced reproductive toxicity of male mice fed a high fat and high sugar diet.

Liu D, Zhao Y, Dai J, Li R, Yuan J, Shen K, He Z, Gu S
Toxicology 2025 Sep;516:154172

METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.

He Y, Pan X, Liu Z, Zuo P, Sheng Z, Hao C, Tao Z, Chen Z, Song J, Ma G, Ling S
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829

Inhibition of GRK4 reduces arrhythmia susceptibility and alleviates connexin43 dysregulation after myocardial infarction.

Yu J, Zhao X, Hao Y, Tao Y, Gao Z, Li W, Wang J, Li X, Wang J, Yang Y, Liang Z, Duan C, Liao W, Chen Z, Yuan Y, Du Z
Biochemical pharmacology 2025 Sep;239:117035

METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA.

Wang J, Yu Y, Xiong Z, Wang P, Wang Z, Du A, Han S, Wang X, Zhang L
Biochemical pharmacology 2025 Sep;239:117016

ALKBH5 reverses romidepsin-mediated anti-multiple myeloma activity via regulation of m6A modification of FOXM1.

Zhang Y, Cao X, Li W, Cui Z, Mao J, Yao R, Liu L
Biochemical pharmacology 2025 Sep;239:116998

ALKBH5-Mediated M(6)A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia-Reperfusion Injury.

Li W, Li W, Leng Y, Xu H, Xia Z, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e07254

RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.

Yan Z, Cao H, Zhang X, Wang Y, Chang Q
International immunopharmacology 2025 Sep 23;162:115141

ALKBH5-mediated m(6)A demethylation modification of RAD51 inhibits osteogenic differentiation via promoting DNA damage in osteoporosis.

Qiu M, Liao Z, Wu X, He P, Wen X, Xie Y, Qi J
Molecular immunology 2025 Oct;186:82-94

ADAP-METTL3 modulates the inflammatory responses of macrophages via m(6)A modification of Spry1.

Dong A, Zhang P, Yang F, Wang Y, Liu H
Cell death & disease 2025 Oct 7;16(1):708

Decreased ALKBH5 in neutrophil correlates with disease activity in rheumatoid arthritis and ALKBH5 modulates neutrophil autophagy.

Luo Q, Lan M, Wu Z, Wang S, Fu P, Xiao Q, Fu B, Guo Y, Qing C, Huang Z, Li J
Scientific reports 2025 Oct 29;15(1):37880

ZEB1 and ALKBH5 coregulate CRABP2 and FABP5 and jointly determine the sensitivity of anaplastic thyroid cancers to gemcitabine and retinoic acid.

Tian X, Peng K, Zhao T, Jia B, Ma Q, Miao Y, Yang S, Wu J, Ma L, Su D, Zhang X
NPJ precision oncology 2025 Oct 27;9(1):334

Changes of N(6)-methyladenosine modification and unfolded protein response in renal cell injury induced by cadmium.

Wang N, Dai J, Li R, Li W, Liu D, Liu X, Mei Z, Lu H, He Z, Gu S
Ecotoxicology and environmental safety 2025 Oct 15;305:119228

m(6)A deficiency impairs uterine spiral artery remodeling to induce preeclampsia-like symptoms via FGF2.

Liu S, Chen W, Chen J, Liu T, Deng M, Xia L, Li Z, Shi J, Li Y, Peng Y, Ren Q, Miao Z, Wu G, Cao X, Xiao S, Zhang J, Zhong M, Wang L, Xia L
Science China. Life sciences 2025 Nov;68(11):3138-3150

The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation.

Deng X, Xie S, Zhou M, Yuan Q, Wu S, Huang P, Chen M, Zeng J, Guo P, Qin J, Chen C, Liu J, Liu B, He X, Sun L, Zhang H, Li L, Pan T
PLoS biology 2025 Nov;23(11):e3003486

ALKBH5-mediated RNA N6-methyladenosine demethylation protects against myocardial I/R-induced injury via FSP1-dependent inhibition of ferroptosis.

Tian Z, Zhou J, Kuang L, Wang L, Hua H, Tan W, Hua Y, Yan H, Liu Z, Wen T
Journal of molecular histology 2025 Nov 24;57(1):5

ALKBH5-mediated m6A regulates the alternative splicing events of SRSF10 in ovarian cancer.

Li K, Pei Y, Dong X, Wu Y, Lou X, Li Y, Liang S, Wu Y, Xu D, Li B, Cui W
Cancer gene therapy 2025 May;32(5):584-594

YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response.

Li H, Yu K, Zhang X, Li J, Hu H, Deng X, Zeng S, Dong X, Zhao J, Zhang Y
Genes & diseases 2025 May;12(3):101327

An Investigation of the RNA Modification m(6)A and Its Regulatory Enzymes in Rat Brains Affected by Chronic Morphine Treatment and Withdrawal.

Hronova A, Pritulova E, Hejnova L, Novotny J
International journal of molecular sciences 2025 May 4;26(9)

Arg-Gly-Asp engineered mesenchymal stem cells as targeted nanotherapeutics against kidney fibrosis by modulating m6A.

Zhang X, Zhao J, Ge R, Zhang X, Sun H, Guo Y, Wang Y, Chen L, Li S, Yang J, Sun D
Acta biomaterialia 2025 May 15;198:85-101

TDP-43/ALKBH5-mediated m(6)A modification of CDC25A mRNA promotes glioblastoma growth by facilitating G1/S cell cycle transition.

Zhang Y, Xie S, Li W, Gu J, Zhang XA, Ni B, Wang Z, Yang R, Song H, Zhong Y, Huang P, Zhou J, Cao Y, Guo J, Liu Y, Qi S, Wang H
MedComm 2025 Mar;6(3):e70108

ALKBH5 promotes cardiac fibroblasts pyroptosis after myocardial infarction through Notch1/NLRP3 pathway.

Cui LG, Wang SH, Komal S, Yin JJ, Zhai MM, Zhou YJ, Yu QW, Wang C, Wang P, Wang ZM, Zafar AM, Shakeel M, Zhang LR, Han SN
Cellular signalling 2025 Mar;127:111574

The m6A modification regulates the composition of myofiber types in chicken skeletal muscle.

Shan Y, Liu Y, Zhang M, Pang L, Ji G, Ju X, Tu Y, Shu J
Poultry science 2025 Mar;104(3):104811

The Flip Side of the Coin: METTL3 Serves as a Novel Cellular Senescence Accelerator via Negative Regulation of ITGA9.

Li Y, Huang L, Fang M, Ye L, Yang H, Wu W, Yuan Y, Cao K, Zheng HL, Sun X, Wu Y, Xiong XD, Liu X, Xu S
Aging and disease 2025 Mar 18;17(2):1034-1051

Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation.

Guo D, Pang Y, Wang W, Feng Y, Wang L, Sun Y, Hao J, Li F, Zhao S
Cells 2025 Mar 1;14(5)

Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA.

Chen Z, Zhou Y, Xue C, Zeng L, Deng S, Xu Z, Li M, Zhao H, He X, Liu S, Liu J, Liu S, Zhao S, Zhang S, Peng X, Wu X, Bai R, Zhuang L, Wu S, Zhang J, Lin D, Huang X, Zheng J
Nature cell biology 2025 Jun;27(6):1035-1047

The dual mechanism of m(6)A demethylase ALKBH5 in regulating energy metabolism during exposure to MC-LR.

Sun X, Tan Q, Yang Y, Wei J, Zhou X, Gao S, Yang F
Cell death & disease 2025 Jul 3;16(1):489

ALKBH5-mediated NPC2 mRNA m(6)A demethylation promotes resistance to oxaliplatin in colorectal cancer.

Wan P, Ren Y, Li HT
Functional & integrative genomics 2025 Jul 19;25(1):158

AlkB Homolog 5 Regulates Hexokinase 2-Mediated Glycolysis and Participates in the Progression of Endometriosis.

Liu JJ, Fang YQ, Xiong WQ, Liu HW, Li JY, Wang XP, Wang HJ, Zhang L, Liu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70813

ALKBH5 regulates intrauterine adhesion progression through m6A dependent FABP4 mRNA stabilization and serum lipid metabolism.

Yang X, Feng Q
Communications biology 2025 Jul 1;8(1):973

ALKBH5 deletion ameliorates inflammation by regulating IRF3 signaling in an m(6)A-dependent manner after myocardial infarction.

Zhao X, Liang Z, Zhao W, Tao Y, Hao Y, Liu Y, Wang J, Yu J, Ji H, Jiang H, Xu S, Gu J, Yuan Y, Du Z
Biochemical and biophysical research communications 2025 Jan;742:151039

IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression.

Tian Q, Dan G, Wang X, Zhu J, Chen C, Tang D, Wang Z, Chen D, Lei S, Yang C, Wang H, Guo B, Jin B, Chen T, Tang L
Cell death discovery 2025 Jan 25;11(1):22

Comprehensive Analysis Reveals Midnolin as a Potential Prognostic, Therapeutic, and Immunological Cancer Biomarker.

Zhang XG, Li WT, Jin X, Fu C, Jiang W, Bai J, Shi ZZ
Biomedicines 2025 Jan 23;13(2)

Mechanism of hsa_circ_0069443 promoting early pregnancy loss through ALKBH5/FN1 axis in trophoblast cells.

Li BX, Wu MY, Wang ZH, Zhou DM, Li JQ, Lu BF, Lin XL, Zhao Y, Sheng XJ
iScience 2025 Jan 17;28(1):111608

ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization.

Guan Z, Wang X, Xu C, Lu R
Heliyon 2025 Jan 15;11(1):e41495

ALKBH5 controlled autophagy of peripheral blood mononuclear cells by regulating NRG1 mRNA stability in ankylosing spondylitis.

Xie X, Li H, Luo B, Fan X, Li Y, Zhang Y, Cui X, Yin W, Liu B, Xu H, Cheng H, Li W, Yu H, Wu F
International immunopharmacology 2025 Jan 10;144:113670

Overexpression of ALKBH5 alleviates LPS induced neuroinflammation via increasing NFKBIA.

Ye C, Huang X, Tong Y, Chen Y, Zhao X, Xie W, Wang Y, Wang J, Zhang A, Mo Y
International immunopharmacology 2025 Jan 10;144:113598

RNA m(6)A involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells.

Zhang N, Yang J, Zhao Y, Li W, Zhao B, Li R, He Z, Gu S
Cell death discovery 2025 Jan 10;11(1):4

N 6-Methyladenosine Demethylase FTO Controls Macrophage Homeostasis in Diabetic Vasculopathy.

Feng S, Zhang Q, Liu Q, Huang C, Zhang H, Wang F, Zhu Y, Jian Q, Chen X, Jiang Q, Yan B
Diabetes 2025 Jan 1;74(1):82-95

Organophosphate flame retardant triphenyl phosphate (TPhP) induced colonic fibrosis by bringing about epithelial-mesenchymal transition.

Peng C, Wang M, Zheng C, Zhang X, Chen Y, Wang L
Ecotoxicology and environmental safety 2025 Feb;291:117913

Cis-Regulation of an m(6)A Eraser by an Insertion Variant Associated with Survival of Patients With Non-Small Cell Lung Carcinoma.

Cheng L, Hu Q, Wang Y, Nie W, Lu H, Zhang B, Zhao G, Ding S, Pan F, Shen Y, Zhong R, Zhang R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2407652

Prognostic value of IFI27 in HNSCC and functional analysis under ALKBH5 regulation.

Wang C, Chen Z, Li T, Bao Y, Guo J, Zhang S
Scientific reports 2025 Feb 24;15(1):6606

Targeting the ALKBH5-NLRP3 positive feedback loop alleviates cardiomyocyte pyroptosis after myocardial infarction.

Cui LG, Zhai MM, Yin JJ, Wang ZM, Wang SH, Zhou YJ, Li PP, Wang Y, Xia L, Wang P, Cha XX, Zhang LR, Han SN
European journal of pharmacology 2025 Feb 15;989:177247

FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway.

Qian Y, Wu J, Yang W, Lyu R, You Q, Li J, He Q, Zhuang Y, Wang W, Wang Y, Zhu Y, Wu Z, Chen D
Nature communications 2025 Feb 11;16(1):1519

ALKBH5 promotes autophagy and progression by mediating m6A methylation of lncRNA UBOX5-AS1 in endometriosis.

Liu H, Liang J, Wang X, Xiong W, Zhang L, Dai X, Wang X, Wang X, Xu Y, Liu Y
American journal of physiology. Cell physiology 2025 Feb 1;328(2):C639-C656

Novel role of FTO in regulation of gut-brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure.

Chen R, Chai X, Zhang Y, Zhou T, Xia Y, Jiang X, Lv B, Zhang J, Zhou L, Tian X, Wang R, Mao L, Zhao F, Zhang H, Hu J, Qiu J, Zou Z, Chen C
Gut microbes 2025 Dec;17(1):2438471

Influenza NS1 drives N(6)-methyladenosine (m(6)A)-mediated autoregulation of viral mRNA splicing.

Liao Y, Liu J, Wang P, Mok BW, Chen H
Emerging microbes & infections 2025 Dec;14(1):2572761

ALKBH5-Mediated ITGB1 m6A Modification in Ovarian Cancer Progression and Immune Evasion.

He Z, Wang D, Zhao W, Ma M, Du C
NPJ precision oncology 2025 Dec 9;9(1):399

TRIM21 promotes K63-linked ubiquitination of ALKBH5 and suppresses cuproptosis via down-regulation of LIAS in esophageal squamous cell carcinoma.

Feng A, He L, Li Z, Wang Z, Sun M, Zhao Z, Zhang Z, Fang K, Wu H, Wang X, Zhang S, Chen Z, Zhang L, Chen T, Xu M
Communications biology 2025 Dec 18;8(1):1783

Expression pattern of RNA demethylase ALKBH5 in fetal and adult human testis.

Fang F, Ni K
Tissue & cell 2025 Aug;95:102901

PRMT5 K240lac confers ferroptosis resistance via ALKBH5/SLC7A11 axis in colorectal cancer.

Qu S, Feng B, Xing M, Qiu Y, Ma L, Yang Z, Ji Y, Huang F, Wang Y, Zhou J, Xu M, He J, Zhou Q, Zhou X, Xiong W, Yao B, Liu M, Dong Q, Yang L, Gu S
Oncogene 2025 Aug;44(32):2814-2830

METTL3 increases ferroptosis resistance to facilitate the tumor-like features of rheumatoid arthritis synovial fibroblasts through enhancing SLC7A11 mRNA stability in an m6A-IGF2BP2-dependent manner.

Xu Y, Liu W, Zai Z, Qian X, Hu W, Peng X, Chen F
International journal of biological macromolecules 2025 Aug;320(Pt 1):145698

Excessive ultra-processed foods exposure aggravates ulcerative colitis via macrophage ferroptosis.

Pang X, Yan J, Lv X, Wang J, Chen Q, Qi Y, Xu X, Wang B, Cao H
Environment international 2025 Aug;202:109706

MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2.

Gao X, Jia S, Gao L, Chen S, Zhang Y, Liang X, Zhang L, Zhang B, Meng C
Free radical biology & medicine 2025 Aug 1;235:213-230

Cell-Type-Specific mRNA N(6)-Methyladenosine Landscape and Regulatory Mechanisms Underlying Immune Dysregulation of Sleep-Deprived.

Liu Y, Wang Z, Liu S, Li X, Wang D, Wang D, Li Y, Liu C, Xu Y
Journal of pineal research 2025 Apr;77(3):e70046

RNA methylation of CD47 mediates tumor immunosuppression in EGFR-TKI resistant NSCLC.

Zhang W, Wang J, Liang J, He Z, Wang K, Lin H
British journal of cancer 2025 Apr;132(6):569-579

AP001885.4 promotes the proliferation of esophageal squamous cell carcinoma cells by histone lactylation- and NF-κB (p65)-dependent transcription activation and METTL3-mediated mRNA stability of c-myc.

Fu C, Jiang W, Wang C, Song SJ, Tao H, Zhang XG, Li WT, Jin X, Yu BB, Hao JJ, Sun WJ, Bai J, Shi ZZ
Animal cells and systems 2024;28(1):536-550

Evidence for the potential role of m6A modification in regulating autophagy in models of amyotrophic lateral sclerosis.

An D, Han J, Fang P, Bu Y, Ji G, Liu M, Deng J, Song X
CytoJournal 2024;21:33

Branch Chain Amino Acid Metabolism Promotes Brain Metastasis of NSCLC through EMT Occurrence by Regulating ALKBH5 activity.

Mao L, Wang L, Lyu Y, Zhuang Q, Li Z, Zhang J, Gu Z, Lu S, Wang X, Guan Y, Xiong J, Wang Y, Mao Y, Yang H, Liu Y
International journal of biological sciences 2024;20(9):3285-3301

m(6)A modification enhances the stability of CDC25A promotes tumorigenicity of esophagogastric junction adenocarcinoma via cell cycle.

Pan Y, Feng H, Zhou J, Zhang W, Liu Y, Zheng J, Wang J, Gao S, Li Y
International journal of biological sciences 2024;20(11):4209-4221

Characterization of the m(6)A regulators' landscape highlights the clinical significance of acute myocardial infarction.

Chao P, Zhang X, Zhang L, Wang Y, Wusiman M, Aimaijiang G, Chen X, Yang Y
Frontiers in immunology 2024;15:1308978

FSH induces EMT in ovarian cancer via ALKBH5-regulated Snail m6A demethylation.

Xu X, Zhuang X, Yu H, Li P, Li X, Lin H, Teoh JP, Chen Y, Yang Y, Cheng Y, Chen W, Fu X
Theranostics 2024;14(5):2151-2166

ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction.

Qin C, Wu J, Wei X, Liu X, Lin Y
PeerJ 2024;12:e18227

Changes of m(6)A Regulatory Proteins and Nrf2 Signaling Molecules in Liver Tissue of Type 2 Diabetes Mellitus Rats.

Wang N, Yang J, Liu X, Liu G, He Z, Gu S
Cell biochemistry and biophysics 2024 Sep;82(3):2217-2226

Characterization of ACTN4 as a novel antiviral target against SARS-CoV-2.

Zhu M, Huang F, Sun H, Liu K, Chen Z, Yu B, Hao H, Liu H, Ding S, Zhang X, Liu L, Zhang K, Ren J, Liu Y, Liu H, Shan C, Guan W
Signal transduction and targeted therapy 2024 Sep 18;9(1):243

The functional role of m6A demethylase ALKBH5 in cardiomyocyte hypertrophy.

Meng C, Su H, Shu M, Shen F, Lu Y, Wu S, Su Z, Yu M, Yang D
Cell death & disease 2024 Sep 18;15(9):683

N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication.

Zhao H, Gao Z, Sun J, Qiao H, Zhao Y, Cui Y, Zhao B, Wang W, Chiu S, Chuai X
Viruses 2024 Sep 11;16(9)

HSV-1-induced N6-methyladenosine reprogramming via ICP0-mediated suppression of METTL14 potentiates oncolytic activity in glioma.

Chen Y, Bian S, Zhang J, Luan Y, Yin B, Dai W, Wang H, Chen X, Dong Y, Cai Y, Dong R, Yu L, Shu M
Cell reports 2024 Oct 22;43(10):114756

Lactylation of RNA m(6)A demethylase ALKBH5 promotes innate immune response to DNA herpesviruses and mpox virus.

Li W, Zhou J, Gu Y, Chen Y, Huang Y, Yang J, Zhu X, Zhao K, Yan Q, Zhao Z, Li X, Chen G, Jia X, Gao SJ, Lu C
Proceedings of the National Academy of Sciences of the United States of America 2024 Oct 22;121(43):e2409132121

TGF-β Promotes Hepatocellular Carcinoma Metastasis Through Through m6A Modification of PCDHGA9.

Wang H, Guan W, Zhang X, Wu Y, Ou Y, Zhang Y, Zeng Z, Yao H
Cancer biotherapy & radiopharmaceuticals 2024 Nov;39(9):644-653

The methyltransferase METTL3 regulates endothelial cell proliferation and inflammation via m(6)A RNA methylation-mediated TRAF1 expression.

Chen D, Xu W, Zheng H, Zhang Y, Lin Y, Han Y, Yao F, Shen H
Biochemical and biophysical research communications 2024 Nov 5;732:150399

Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.

Zhu X, Wang J, Zhang H, Yue H, Zhu J, Li J, Wang K, Shen K, Yang K, Leng X, Xi Q, Shi T
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470

Exploring Potential Diagnostic Biomarkers for Mechanical Asphyxia in the Heart Based on Proteomics Technology.

Huang Y, Qiu H, Chen Q, Meng Z, Qiao D, Yue X
International journal of molecular sciences 2024 Nov 26;25(23)

TIMP1 regulates ferroptosis in osteoblasts by inhibiting TFRC ubiquitination: an in vitro and in vivo study.

Peng B, Feng Z, Yang A, Liu J, He J, Xu L, Tian C, Sheng X, Wang Y, Chen R, Wang X, Ren X, Geng B, Xia Y
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):226

Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels.

Liang Q, Jing J, He H, Huang X, Liu J, Wang M, Qi Z, Zhang L, Huang Z, Yan Y, Liu S, Gao M, Zou Y
Environment international 2024 May;187:108672

Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis.

Ji W, Huo Y, Zhang Y, Qian X, Ren Y, Hu C, Zhang J
International immunopharmacology 2024 May 10;132:111968

GDF11 mitigates high glucose-induced cardiomyocytes apoptosis by inhibiting the ALKBH5-FOXO3-CDR1as/Hippo signaling pathway.

Shao Y, Li M, Wang Y, Qu Y, Gong M, Yu Q, Yang X, Liu D, Li H, Wang Y, Sun H, Zhang Y, Zhang X, Liu T, Liu J, Gong T, Sun Y, Du Z, Jiao L, Zhang Y
Biochimica et biophysica acta. Molecular cell research 2024 Mar;1871(3):119656

METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.

Feng ZW, Peng B, Wang SH, Zhao DC, Wang YB, Yang A, Zhan HW, Sheng XY, Xu LH, Ren XJ, Yang F, Geng B, Xia YY
Cellular signalling 2024 Mar;115:111038

ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice.

Zhuang T, Chen MH, Wu RX, Wang J, Hu XD, Meng T, Wu AH, Li Y, Yang YF, Lei Y, Hu DH, Li YX, Zhang L, Sun AJ, Lu W, Zhang GN, Zuo JL, Ruan CC
Nature communications 2024 Mar 5;15(1):1995

FTO-mediated m6A mRNA demethylation aggravates renal fibrosis by targeting RUNX1 and further enhancing PI3K/AKT pathway.

Wang DX, Bao SY, Song NN, Chen WZ, Ding XQ, Walker RJ, Fang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23436

Changes of RNA m(6)A/m(5)C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas.

Liu X, Wang N, Gu S, He Z
Cell biochemistry and biophysics 2024 Jun;82(2):1279-1289

Long noncoding RNA TUG1 promotes malignant progression of osteosarcoma by enhancing ZBTB7C expression.

An X, Wu W, Wang P, Mahmut A, Guo J, Dong J, Gong W, Liu B, Yang L, Ma Y, Xu X, Chen J, Cao W, Jiang Q
Biomedical journal 2024 Jun;47(3):100651

Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.

Qiu T, Hou K, Zhang J, Wang N, Yao X, Yang G, Jiang L, Dong J, Miao M, Bai J, Sun X
Ecotoxicology and environmental safety 2024 Jun 15;278:116435

LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53-driven tumour progression through miR-5683/FGF2.

Liu N, Jiang X, Zhang G, Long S, Li J, Jiang M, Jia G, Sun R, Zhang L, Zhang Y
Clinical and translational medicine 2024 Jul;14(7):e1777

SUMOylation modification of FTO facilitates oxidative damage response of arsenic by IGF2BP3 in an m6A-dependent manner.

Zhang H, Chen Q, Han H, Guo C, Jiang X, Xia Y, Zhang Y, Zhou L, Zhang J, Tian X, Mao L, Qiu J, Zou Z, Chen C
Journal of hazardous materials 2024 Jul 5;472:134440

Hepatitis B Virus-Mediated m6A Demethylation Increases Hepatocellular Carcinoma Stemness and Immune Escape.

Meng Y, Shu Z, Wang X, Hong L, Wang B, Jiang J, He K, Cao Q, Shi F, Wang H, Gong L, Diao H
Molecular cancer research : MCR 2024 Jul 2;22(7):642-655

The demethylase ALKBH5 mediates ZKSCAN3 expression through the m(6)A modification to activate VEGFA transcription and thus participates in MNNG-induced gastric cancer progression.

Wang Q, Huang Y, Jiang M, Tang Y, Wang Q, Bai L, Yu C, Yang X, Ding K, Wang W, Bai J, Chen Y
Journal of hazardous materials 2024 Jul 15;473:134690

Characterization of m6A Modifiers and RNA Modifications in Uterine Fibroids.

George JW, Cancino RA, Griffin Miller JL, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
Endocrinology 2024 Jul 1;165(8)

Fat mass and obesity-related protein contributes to the development and maintenance of bone cancer pain in rats by abrogating m6A methylation of RNA.

Liu B, Meng D, Luo M, Xu L, Yao M
Molecular pain 2024 Jan-Dec;20:17448069241295987

Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis.

Fang X, Ao X, Xiao D, Wang Y, Jia Y, Wang P, Li M, Wang J
Cellular & molecular biology letters 2024 Jan 3;29(1):3

The m(6)A demethylases FTO and ALKBH5 aggravate the malignant progression of nasopharyngeal carcinoma by coregulating ARHGAP35.

Yang Z, Zhang S, Xiong J, Xia T, Zhu R, Miao M, Li K, Chen W, Zhang L, You Y, You B
Cell death discovery 2024 Jan 23;10(1):43

Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma.

Dai W, Tian R, Yu L, Bian S, Chen Y, Yin B, Luan Y, Chen S, Fan Z, Yan R, Pan X, Hou Y, Li R, Chen J, Shu M
Nature communications 2024 Jan 2;15(1):131

METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner.

Cao F, Chen G, Xu Y, Wang X, Tang X, Zhang W, Song X, Yang X, Zeng W, Xie J
Cell death & disease 2024 Jan 13;15(1):43

Demethylase FTO-Mediated m6A Modification of lncRNA MEG3 Activates Neuronal Pyroptosis via NLRP3 Signaling in Cerebral Ischemic Stroke.

Yan H, Huang W, Rao J, Yan D, Yuan J
Molecular neurobiology 2024 Feb;61(2):1023-1043

ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2α/CHOP signaling pathway in an m(6)A-YTHDF1-dependent manner.

Liu C, Chen H, Tao X, Li C, Li A, Wu W
Experimental neurology 2024 Feb;372:114629

METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.

Lu W, Yang X, Zhong W, Chen G, Guo X, Ye Q, Xu Y, Qi Z, Ye Y, Zhang J, Wang Y, Wang X, Wang S, Zhao Q, Zeng W, Huang J, Ma H, Xie J
The Journal of clinical investigation 2024 Feb 6;134(6)

ALKBH5 promotes the development of lung adenocarcinoma by regulating the polarization of M2 macrophages through CDCA4.

Tan J, Chen F, Wang J, Li J, Ouyang B, Li X, Li Y, Zhang W, Jiang Y
Gene 2024 Feb 15;895:147975

Severe fever with thrombocytopenia syndrome virus induces lactylation of m6A reader protein YTHDF1 to facilitate viral replication.

Liu B, Tian X, Li L, Zhang R, Wu J, Jiang N, Yuan M, Chen D, Su A, Xu S, Wu Z
EMBO reports 2024 Dec;25(12):5599-5619

N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1.

Xu L, Chen S, Fan Q, Zhu Y, Mei H, Wang J, Yu H, Chen Y, Liu F
BMC biology 2024 Dec 31;22(1):302

METTL3 mediates m6A modification of hsa_circ_0072380 to regulate the progression of gestational diabetes mellitus.

Zhang S, Cai S, Ye L, Shen L, Zhu C, Huang J, Wang Z, Chen H
Gene 2024 Dec 30;931:148894

Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14.

Zhang C, Scott RL, Tunes L, Hsieh MH, Wang P, Kumar A, Khadgi BB, Yang YY, Doxtader Lacy KA, Herrell E, Zhang X, Evers B, Wang Y, Xing C, Zhu H, Nam Y
Science advances 2024 Dec 20;10(51):eads4750

WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy.

Fu K, Jing C, Shi J, Mao S, Lu R, Yang M, Chen Y, Qian B, Wang Y, Li L
Biochemical and biophysical research communications 2024 Dec 17;738:150524

Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications.

Xu XF, Chen J, Long LH, Zhang AM, Yang JW, Li YJ, Chen L, Zhong XL, Xu Y, Cao WY
Journal of affective disorders 2024 Dec 1;366:262-272

LncRNA CCRR maintains Ca(2+) homeostasis against myocardial infarction through the FTO-SERCA2a pathway.

Yang H, Xuan L, Wang S, Luo H, Duan X, Guo J, Cui S, Xin J, Hao J, Li X, Chen J, Sun F, Hu X, Li S, Zhang Y, Jiao L, Yang B, Sun L
Science China. Life sciences 2024 Aug;67(8):1601-1619

FTO blocks RNA translational activity via the loss of N6-methyladenosine methylation at 5' UTR regulated by RBM5 in cisplatin-resistant NSCLC.

Li L, Qu D, Wang B, Yuan S, Zhao Y, Liu N, Huo F, Zhang D, Zhang L
Journal of cellular physiology 2024 Aug;239(8):e31296

Endogenous RBM4 prevents Ang II-induced cardiomyocyte hypertrophy via downregulating the expression of PTBP1.

Sun W, Fang X, Zhang H, Lu Y, Wang P, Li J, Li M
Acta biochimica et biophysica Sinica 2024 Aug 7;57(3):365-377

Inhibitor of FTO, Rhein, Restrains the Differentiation of Myoblasts and Delays Skeletal Muscle Regeneration.

Li R, Cao Y, Wu W, Liu H, Xu S
Animals : an open access journal from MDPI 2024 Aug 22;14(16)

The RNA Demethylases ALKBH5 and FTO Regulate the Translation of ATF4 mRNA in Sorafenib-Treated Hepatocarcinoma Cells.

Adjibade P, Di-Marco S, Gallouzi IE, Mazroui R
Biomolecules 2024 Aug 1;14(8)

Highly pathogenic PRRSV upregulates IL-13 production through nonstructural protein 9-mediated inhibition of N6-methyladenosine demethylase FTO.

Gong X, Liang Y, Wang J, Pang Y, Wang F, Chen X, Zhang Q, Song C, Wang Y, Zhang C, Fang X, Chen X
The Journal of biological chemistry 2024 Apr;300(4):107199

CHOP regulated by METTL14-m6A affects cell cycle arrest and regorafenib sensitivity in HCC cells.

Pan Y, You B, Zhao X, Zhang S, Li W
BMC cancer 2024 Apr 25;24(1):525

ALKBH5-PYCR2 Positive Feedback Loop Promotes Proneural-Mesenchymal Transition Via Proline Synthesis In GBM.

Li L, Yang M, Pu X, Tang Y, Fei F, Li Z, Hou H, Chen Q, Wang Q, Wu Y, Zhang Y, Ren C, Gong A
Journal of Cancer 2023;14(9):1579-1591

ALKBH5 inhibitors as a potential treatment strategy in heart failure-inferences from gene expression profiling.

Komal S, Gohar A, Althobaiti S, Ahmad Khan I, Cui LG, Zhang LR, Han SN, Shakeel M
Frontiers in cardiovascular medicine 2023;10:1194311

Exploring the role of m6A methylation regulators in glioblastoma multiforme and their impact on the tumor immune microenvironment.

Deng X, Sun X, Hu Z, Wu Y, Zhou C, Sun J, Gao X, Huang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23155

ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.

An X, Wu W, Yang L, Dong J, Liu B, Guo J, Chen J, Guo B, Cao W, Jiang Q
Translational research : the journal of laboratory and clinical medicine 2023 Sep;259:62-71

HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.

Huo FC, Zhu ZM, Du WQ, Pan YJ, Jiang X, Kang MJ, Liu BW, Mou J, Pei DS
Pharmacological research 2023 Sep;195:106863

Multi-Omics Analysis Reveals Translational Landscapes and Regulations in Mouse and Human Oocyte Aging.

Huang J, Chen P, Jia L, Li T, Yang X, Liang Q, Zeng Y, Liu J, Wu T, Hu W, Kee K, Zeng H, Liang X, Zhou C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(26):e2301538

Site-specific Atg13 methylation-mediated autophagy regulates epithelial inflammation in PM2.5-induced pulmonary fibrosis.

Ning J, Pei Z, Wang M, Hu H, Chen M, Liu Q, Wu M, Yang P, Geng Z, Zheng J, Du Z, Hu W, Wang Q, Pang Y, Bao L, Niu Y, Leng S, Zhang R
Journal of hazardous materials 2023 Sep 5;457:131791

AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.

Qiu T, Wu C, Yao X, Han Q, Wang N, Yuan W, Zhang J, Shi Y, Jiang L, Liu X, Yang G, Sun X
Cell biology and toxicology 2023 Oct;39(5):2165-2181

Differential epitranscriptome and proteome modulation in the brain of neonatal mice exposed to isoflurane or sevoflurane.

Wu Y, Yang Z, Su S, Xu X, Li Y, Li X, Gao Y, Sun D, Wan S, Pen M, Jin W, Ke C
Cell biology and toxicology 2023 Oct;39(5):2133-2148

Comprehensive Transcriptomic Profiling of m6A Modification in Age-Related Hearing Loss.

Feng M, Zhou X, Hu Y, Zhang J, Yang T, Chen Z, Yuan W
Biomolecules 2023 Oct 18;13(10)

METTL3/IGF2BP2 axis affects the progression of colorectal cancer by regulating m6A modification of STAG3.

Yi J, Peng F, Zhao J, Gong X
Scientific reports 2023 Oct 12;13(1):17292

Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m(6) A RNA methylation in ocular melanoma.

Zhuang A, Gu X, Ge T, Wang S, Ge S, Chai P, Jia R, Fan X
Cancer communications (London, England) 2023 Nov;43(11):1185-1206

Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway.

Sun J, Zhou H, Chen Z, Zhang H, Cao Y, Yao X, Chen X, Liu B, Gao Z, Shen Y, Qi L, Sun H
Journal of translational medicine 2023 Nov 23;21(1):845

N(6)-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice.

Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature communications 2023 Mar 2;14(1):1185

The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.

Wang X, Li X, Yang P, Qin X, Yu J, Cheng Y, Zhang G, Tang L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Jun;55(6):815-822

Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.

Yuan W, Hou Y, Wang Q, Lv T, Ren J, Fan L, Cai J, Xiang B, Lin Q, Liao M, Ding C, Chen L, Ren T
Veterinary microbiology 2023 Jun;281:109747

High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m(6)A demethylation: a potential mechanism for diabetic cognitive dysfunction.

Qu M, Zuo L, Zhang M, Cheng P, Guo Z, Yang J, Li C, Wu J
Cell death & disease 2023 Jun 29;14(6):385

Therapeutic m(6)A Eraser ALKBH5 mRNA-Loaded Exosome-Liposome Hybrid Nanoparticles Inhibit Progression of Colorectal Cancer in Preclinical Tumor Models.

Wu S, Yun J, Tang W, Familiari G, Relucenti M, Wu J, Li X, Chen H, Chen R
ACS nano 2023 Jun 27;17(12):11838-11854

Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.

Zhong J, Wu X, Gao Y, Chen J, Zhang M, Zhou H, Yang J, Xiao F, Yang X, Huang N, Qi H, Wang X, Bai F, Shi Y, Zhang N
Nature communications 2023 Jul 25;14(1):4467

ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner.

Wang W, Huang Q, Liao Z, Zhang H, Liu Y, Liu F, Chen X, Zhang B, Chen Y, Zhu P
Experimental hematology & oncology 2023 Jan 6;12(1):1

FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.

Li B, Xi W, Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J, Han B, Yao H
Nature communications 2023 Jan 30;14(1):489

The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.

Du P, Meng L, Liao X, Liu Y, Mo X, Gong M, Liao Y
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116

The m6A demethylase FTO promotes keloid formation by up-regulating COL1A1.

Ren S, Ji Y, Wang M, Ye M, Huang L, Cai X
Annals of translational medicine 2023 Jan 15;11(1):15

ALKBH5 ALLEVIATES HYPOXIA POSTCONDITIONING INJURY IN d -GALACTOSE-INDUCED SENESCENT CARDIOMYOCYTES BY REGULATING STAT3.

Zhang X, Li F, Ma J, Zhang X, Yin Y
Shock (Augusta, Ga.) 2023 Jan 1;59(1):91-98

IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway.

Li N, Luo R, Zhang W, Wu Y, Hu C, Liu M, Jiang D, Jiang Z, Zhao X, Wang Y, Li Q
Biogerontology 2023 Feb;24(1):99-110

ALKBH1-mediated m(1) A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression.

Chen W, Wang H, Mi S, Shao L, Xu Z, Xue M
Molecular oncology 2023 Feb;17(2):344-364

N(6) -methyladenosine RNA demethylase FTO regulates extracellular matrix-related genes and promotes pancreatic cancer cell migration and invasion.

Wang W, He Y, Wu L, Zhai LL, Chen LJ, Yao LC, Yu KH, Tang ZG
Cancer medicine 2023 Feb;12(3):3731-3743

Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction.

Gao X, Liang X, Liu B, Hong Y, He H, Shen Y, Chen J, Huang X, Hu B, Li W, Li X, Zhang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23294

ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression.

Ye G, Li J, Yu W, Xie Z, Zheng G, Liu W, Wang S, Cao Q, Lin J, Su Z, Li D, Che Y, Fan S, Wang P, Wu Y, Shen H
Experimental & molecular medicine 2023 Aug;55(8):1743-1756

The disordered C terminus of ALKBH5 promotes phase separation and paraspeckles assembly.

Qin X, Long Y, Bai X, Cao L, Yan H, Zhang K, Wang B, Wu X
The Journal of biological chemistry 2023 Aug;299(8):105071

Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.

Ai S, Li D, Gu X, Xu Y, Wang Y, Wang HL, Chen XT
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821

Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2-dependent mechanism.

Ni WJ, Zhou H, Lu H, Ma NN, Hou BB, Li W, Kong FX, Yu JT, Hou R, Jin J, Wen JG, Zhang T, Meng XM
Clinical and translational medicine 2023 Aug;13(8):e1359

WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata.

Gu Z, Liu J, Qin L, Zhang Y, Cui W, Huang H, Liu L, Cao Y, Zhang H
Journal of dermatological science 2023 Aug;111(2):43-51

Characterization of m(6)A modifiers and RNA modifications in uterine fibroids.

George JW, Cancino RA, Miller JLG, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
bioRxiv : the preprint server for biology 2023 Aug 9;

A lncRNA from the FTO locus acts as a suppressor of the m(6)A writer complex and p53 tumor suppression signaling.

Zhang J, Wei J, Sun R, Sheng H, Yin K, Pan Y, Jimenez R, Chen S, Cui XL, Zou Z, Yue Z, Emch MJ, Hawse JR, Wang L, He HH, Xia S, Han B, He C, Huang H
Molecular cell 2023 Aug 3;83(15):2692-2708.e7

Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.

Park J, Wu Y, Shao W, Gendron TF, van der Spek SJF, Sultanakhmetov G, Basu A, Castellanos Otero P, Jones CJ, Jansen-West K, Daughrity LM, Phanse S, Del Rosso G, Tong J, Castanedes-Casey M, Jiang L, Libera J, Oskarsson B, Dickson DW, Sanders DW, Brangwynne CP, Emili A, Wolozin B, Petrucelli L, Zhang YJ
Cell reports 2023 Aug 29;42(8):112822

METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.

Hou X, Li Y, Song J, Peng L, Zhang W, Liu R, Yuan H, Feng T, Li J, Li W, Zhu C
Hepatology communications 2023 Aug 1;7(8)

Epitranscriptic regulation of HRAS by N(6)-methyladenosine drives tumor progression.

Pan Y, Gu Y, Liu T, Zhang Q, Yang F, Duan L, Cheng S, Zhu X, Xi Y, Chang X, Ye Q, Gao S
Proceedings of the National Academy of Sciences of the United States of America 2023 Apr 4;120(14):e2302291120

3D-Printed β-Tricalcium Phosphate Scaffolds Promote Osteogenic Differentiation of Bone Marrow-Deprived Mesenchymal Stem Cells in an N6-methyladenosine-Dependent Manner.

Jiao X, Sun X, Li W, Chu W, Zhang Y, Li Y, Wang Z, Zhou X, Ma J, Xu C, Dai K, Wang J, Gan Y
International journal of bioprinting 2022;8(2):544

METTL14 Regulates Intestine Cellular Senescence through m(6)A Modification of Lamin B Receptor.

Zhang Z, Xue M, Chen J, Wang Z, Ju F, Ni J, Sun J, Wu H, Zheng H, Lou Z, Zhang Y, Yang X, Chen S, Xi Y, Wang L
Oxidative medicine and cellular longevity 2022;2022:9096436

ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression.

You Y, Wen D, Zeng L, Lu J, Xiao X, Chen Y, Song H, Liu Z
International journal of biological sciences 2022;18(13):5001-5018

The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.

Wu Q, Zhang H, Yang D, Min Q, Wang Y, Zhang W, Zhan Q
International journal of biological sciences 2022;18(13):4824-4836

Identification and Characterization of a Glucometabolic Prognostic Gene Signature in Neuroblastoma based on N6-methyladenosine Eraser ALKBH5.

Tan K, Wu W, Zhu K, Lu L, Lv Z
Journal of Cancer 2022;13(7):2105-2125

Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis.

Tian C, Chai J, Liu W, Zhang X, Li Y, Zuo H, Yuan G, Zhang H, Liu H, Chen Z
Frontiers in physiology 2022;13:923185

Novel insight of N(6)-methyladenosine modified subtypes in abdominal aortic aneurysm.

Wang K, Kan Q, Ye Y, Qiu J, Huang L, Wu R, Yao C
Frontiers in genetics 2022;13:1055396

Decreased RNA m(6)A methylation enhances the process of the epithelial mesenchymal transition and vasculogenic mimicry in glioblastoma.

Tao M, Li X, He L, Rong X, Wang H, Pan J, Lu Z, Zhang X, Peng Y
American journal of cancer research 2022;12(2):893-906

The Maternal Microbiome Programs the m(6)A Epitranscriptome of the Mouse Fetal Brain and Intestine.

Xiao Z, Liu S, Li Z, Cui J, Wang H, Wang Z, Ren Q, Xia L, Wang Z, Li Y
Frontiers in cell and developmental biology 2022;10:882994

M(6)A RNA Methylation Mediates NOD1/NF-kB Signaling Activation in the Liver of Piglets Challenged with Lipopolysaccharide.

Xu M, Zhuo R, Tao S, Liang Y, Liu C, Liu Q, Wang T, Zhong X
Antioxidants (Basel, Switzerland) 2022 Sep 30;11(10)

Aberrant DNA and RNA Methylation Occur in Spinal Cord and Skeletal Muscle of Human SOD1 Mouse Models of ALS and in Human ALS: Targeting DNA Methylation Is Therapeutic.

Martin LJ, Adams DA, Niedzwiecki MV, Wong M
Cells 2022 Oct 31;11(21)

m(6)A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress.

Wang L, Zhan G, Maimaitiyiming Y, Su Y, Lin S, Liu J, Su K, Lin J, Shen S, He W, Wang F, Chen J, Sun S, Xue Y, Gu J, Chen X, Zhang J, Zhang L, Wang Q, Chang KJ, Chiou SH, Björklund M, Naranmandura H, Cheng X, Hsu CH
Cell reports 2022 Oct 25;41(4):111546

Metformin combats obesity by targeting FTO in an m(6)A-YTHDF2-dependent manner.

Liao X, Liu J, Chen Y, Liu Y, Chen W, Zeng B, Liu Y, Luo Y, Huang C, Guo G, Wang Y, Wang X
Journal of drug targeting 2022 Nov;30(9):983-991

m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.

Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T
The Journal of biological chemistry 2022 Nov;298(11):102554

Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.

Yang Y, Qian Cai Q, Sheng Fu L, Wei Dong Y, Fan F, Zhong Wu X
Chemistry & biodiversity 2022 Nov;19(11):e202200333

N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3.

Shi HZ, Xiong JS, Gan L, Zhang Y, Zhang CC, Kong YQ, Miao QJ, Tian CC, Li R, Liu JQ, Zhang EJ, Bu WB, Wang Y, Cheng XF, Sun JF, Chen H
Clinical and translational medicine 2022 Nov;12(11):e1075

Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.

Kong F, Wang K, Wang L
Discover oncology 2022 Nov 25;13(1):131

CircRNA CDR1as promotes cardiomyocyte apoptosis through activating hippo signaling pathway in diabetic cardiomyopathy.

Shao Y, Li M, Yu Q, Gong M, Wang Y, Yang X, Liu L, Liu D, Tan Z, Zhang Y, Qu Y, Li H, Wang Y, Jiao L, Zhang Y
European journal of pharmacology 2022 May 5;922:174915

Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.

Yan R, Dai W, Wu R, Huang H, Shu M
Cancer letters 2022 May 28;534:215615

MiR-155 regulates m(6)A level and cell progression by targeting FTO in clear cell renal cell carcinoma.

Yang W, Xie L, Wang P, Zhuang C
Cellular signalling 2022 Mar;91:110217

Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.

Qi Z, Wang S, Li J, Wen Y, Cui R, Zhang K, Liu Y, Yang X, Zhang L, Xu B, Liu W, Xu Z, Deng Y
Journal of hazardous materials 2022 Mar 15;426:128099

Fusobacterium nucleatum reduces METTL3-mediated m(6)A modification and contributes to colorectal cancer metastasis.

Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W
Nature communications 2022 Mar 10;13(1):1248

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.

Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6

The proteasome-dependent degradation of ALKBH5 regulates ECM deposition in PM(2.5) exposure-induced pulmonary fibrosis of mice.

Zhang Y, Liu Q, Ning J, Jiang T, Kang A, Li L, Pang Y, Zhang B, Huang X, Wang Q, Bao L, Niu Y, Zhang R
Journal of hazardous materials 2022 Jun 15;432:128655

N6-methyladenosine RNA demethylase ALKBH5 is testis-specifically downregulated in hybrid male sterile dzo and is a target gene of bta-miR-200a.

Chen H, Zhang J, Yan Y, Zhu C, Wang L, Fu S, Zuo F, Zhang GW
Theriogenology 2022 Jul 15;187:51-57

Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.

Liu Z, Cai Y, Deng M, Li D, Leng Q, Shi L, Tang Y, Wang F, Wan Y
Cell and tissue research 2022 Jan;387(1):131-142

Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Li Z, Xu Q, Huangfu N, Chen X, Zhu J
Journal of clinical laboratory analysis 2022 Jan;36(1):e24019

m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.

Gao M, Qi Z, Feng W, Huang H, Xu Z, Dong Z, Xu M, Han J, Kloeber JA, Huang J, Lou Z, Liu S
The Journal of biological chemistry 2022 Feb;298(2):101563

RNA m(6)A Alterations Induced by Biomineralization Nanoparticles: A Proof-of-Concept Study of Epitranscriptomics for Nanotoxicity Evaluation.

Pan J, Wang J, Fang K, Hou W, Li B, Zhao J, Ma X
Nanoscale research letters 2022 Feb 5;17(1):23

Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification.

Hu Y, Gong C, Li Z, Liu J, Chen Y, Huang Y, Luo Q, Wang S, Hou Y, Yang S, Xiao Y
Molecular cancer 2022 Feb 3;21(1):34

The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.

Li M, Zhong X, Zhao Z, Zeng Z, Yuan Q, Xiao X, Zu X, Liu J
Brain research 2022 Feb 15;1777:147766

ALKBH5-mediated m6A modification of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription.

Liang L, Zhu Y, Li J, Zeng J, Wu L
Journal of experimental & clinical cancer research : CR 2022 Aug 26;41(1):261

PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.

Tao X, Du R, Guo S, Feng X, Yu T, OuYang Q, Chen Q, Fan X, Wang X, Guo C, Li X, Xue F, Chen S, Tong M, Lazarus M, Zuo S, Yu Y, Shen Y
The EMBO journal 2022 Aug 16;41(16):e110439

RNA m(6)A demethylase ALKBH5 regulates the development of γδ T cells.

Ding C, Xu H, Yu Z, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W, Flavell RA, Li HB
Proceedings of the National Academy of Sciences of the United States of America 2022 Aug 16;119(33):e2203318119

Comprehensive analysis of RNA m6A methylation in pressure overload-induced cardiac hypertrophy.

Li W, Xing C, Bao L, Han S, Luo T, Wang Z, Fan H
BMC genomics 2022 Aug 11;23(1):576

Downregulated ALKBH5 contributes to myocardial ischemia/reperfusion injury by increasing m(6)A modification of Trio mRNA.

Li J, Chen J, Zhao M, Li Z, Liu N, Fang H, Fang M, Zhu P, Lei L, Chen C
Annals of translational medicine 2022 Apr;10(7):417

The Phytochemical Rhein Mediates M(6)A-Independent Suppression of Adipocyte Differentiation.

Huang L, Zhang J, Zhu X, Mi X, Li Q, Gao J, Zhou J, Zhou J, Liu XM
Frontiers in nutrition 2021;8:756803

YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways.

Fang C, He M, Li D, Xu Q
Cellular signalling 2021 Sep;85:110060

Transcriptome-wide m(6)A methylome during osteogenic differentiation of human adipose-derived stem cells.

Sun W, Song Y, Xia K, Yu L, Huang X, Zhao Z, Liu J
Stem cell research & therapy 2021 Sep 1;12(1):489

METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse.

He B, Wang J
Aging 2021 Oct 5;13(19):23108-23118

Streptozotocin-Induced Astrocyte Mitochondrial Dysfunction Is Ameliorated by FTO Inhibitor MO-I-500.

Cockova Z, Honc O, Telensky P, Olsen MJ, Novotny J
ACS chemical neuroscience 2021 Oct 20;12(20):3818-3828

Human m(6)A-mRNA and lncRNA epitranscriptomic microarray reveal function of RNA methylation in hemoglobin H-constant spring disease.

Ruan H, Yang F, Deng L, Yang D, Zhang X, Li X, Pang L
Scientific reports 2021 Oct 14;11(1):20478

Genome-wide map of N(6)-methyladenosine circular RNAs identified in mice model of severe acute pancreatitis.

Wu J, Yuan XH, Jiang W, Lu YC, Huang QL, Yang Y, Qie HJ, Liu JT, Sun HY, Tang LJ
World journal of gastroenterology 2021 Nov 21;27(43):7530-7545

Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m(6) A-dependent manner.

Chen Y, Wu R, Chen W, Liu Y, Liao X, Zeng B, Guo G, Lou F, Xiang Y, Wang Y, Wang X
EMBO reports 2021 May 5;22(5):e52146

mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis.

Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I
Molecular cell 2021 May 20;81(10):2076-2093.e9

Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer.

Zhang D, Ning J, Okon I, Zheng X, Satyanarayana G, Song P, Xu S, Zou MH
Cell death & disease 2021 May 20;12(6):518

AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.

Bian X, Shi D, Xing K, Zhou H, Lu L, Yu D, Wu W
Clinical and translational medicine 2021 Mar;11(3):e352

Epitranscriptomic addition of m(6)A regulates HIV-1 RNA stability and alternative splicing.

Tsai K, Bogerd HP, Kennedy EM, Emery A, Swanstrom R, Cullen BR
Genes & development 2021 Jul 1;35(13-14):992-1004

Upregulation of METTL3 expression and m6A RNA methylation in placental trophoblasts in preeclampsia.

Gu Y, Chu X, Morgan JA, Lewis DF, Wang Y
Placenta 2021 Jan 1;103:43-49

Relaxed initiation pausing of ribosomes drives oncogenic translation.

Dong L, Mao Y, Zhou A, Liu XM, Zhou J, Wan J, Qian SB
Science advances 2021 Feb;7(8)

m(6)A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Chen Y, Wang J, Xu D, Xiang Z, Ding J, Yang X, Li D, Han X
Autophagy 2021 Feb;17(2):457-475

Remodeling of the m(6)A landscape in the heart reveals few conserved post-transcriptional events underlying cardiomyocyte hypertrophy.

Hinger SA, Wei J, Dorn LE, Whitson BA, Janssen PML, He C, Accornero F
Journal of molecular and cellular cardiology 2021 Feb;151:46-55

ALKBH5-mediated m(6)A demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN/AKT signaling.

He Y, Yue H, Cheng Y, Ding Z, Xu Z, Lv C, Wang Z, Wang J, Yin C, Hao H, Chen C
Cell death & disease 2021 Dec 1;12(12):1121

The m(6)A methylome of SARS-CoV-2 in host cells.

Liu J, Xu YP, Li K, Ye Q, Zhou HY, Sun H, Li X, Yu L, Deng YQ, Li RT, Cheng ML, He B, Zhou J, Li XF, Wu A, Yi C, Qin CF
Cell research 2021 Apr;31(4):404-414

The role of RNA m(6)A methylation in the regulation of postnatal hypoxia-induced pulmonary hypertension.

Xu S, Xu X, Zhang Z, Yan L, Zhang L, Du L
Respiratory research 2021 Apr 26;22(1):121

Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m(6)A RNA Methylation.

Wu J, Li Y, Yu J, Gan Z, Wei W, Wang C, Zhang L, Wang T, Zhong X
Frontiers in pharmacology 2020;11:568006

N(6)-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2.

Li Y, Xia L, Tan K, Ye X, Zuo Z, Li M, Xiao R, Wang Z, Liu X, Deng M, Cui J, Yang M, Luo Q, Liu S, Cao X, Zhu H, Liu T, Hu J, Shi J, Xiao S, Xia L
Nature genetics 2020 Sep;52(9):870-877

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA.

Gao XQ, Zhang YH, Liu F, Ponnusamy M, Zhao XM, Zhou LY, Zhai M, Liu CY, Li XM, Wang M, Shan C, Shan PP, Wang Y, Dong YH, Qian LL, Yu T, Ju J, Wang T, Wang K, Chen XZ, Wang YH, Zhang J, Li PF, Wang K
Nature cell biology 2020 Nov;22(11):1319-1331

N(6)-Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons.

Li Y, Guo X, Sun L, Xiao J, Su S, Du S, Li Z, Wu S, Liu W, Mo K, Xia S, Chang YJ, Denis D, Tao YX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2020 Jul;7(13):1902402

Alteration of N(6)-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.

Li X, Fan X, Yin X, Liu H, Yang Y
Epigenomics 2020 Jul;12(14):1157-1173

The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.

Yu J, Shen L, Liu Y, Ming H, Zhu X, Chu M, Lin J
Molecular and cellular biochemistry 2020 Jan;463(1-2):203-210

METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export.

Li D, Cai L, Meng R, Feng Z, Xu Q
International journal of molecular sciences 2020 Feb 28;21(5)

Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.

Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644

Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m(6)A-Based Epitranscriptomic Mechanism.

Liu X, Gonzalez G, Dai X, Miao W, Yuan J, Huang M, Bade D, Li L, Sun Y, Wang Y
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Dec 2;28(12):2593-2604

AMPK facilitates intestinal long-chain fatty acid uptake by manipulating CD36 expression and translocation.

Wu W, Wang S, Liu Q, Shan T, Wang X, Feng J, Wang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4852-4869

Resveratrol Attenuates Aflatoxin B(1)-Induced ROS Formation and Increase of m(6)A RNA Methylation.

Wu J, Gan Z, Zhuo R, Zhang L, Wang T, Zhong X
Animals : an open access journal from MDPI 2020 Apr 13;10(4)

Elevated N-methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform.

Li J, You S, Zhang S, Hu Q, Wang F, Chi X, Zhao W, Xie C, Zhang C, Yu Y, Liu J, Zhao Y, Liu P, Zhang Y, Wei X, Li Q, Wang X, Yin Z
Molecular oncology 2019 Sep;13(9):1993-2009

m(6)A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2.

Mao Y, Dong L, Liu XM, Guo J, Ma H, Shen B, Qian SB
Nature communications 2019 Nov 25;10(1):5332

EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis.

Lang F, Singh RK, Pei Y, Zhang S, Sun K, Robertson ES
PLoS pathogens 2019 Jun;15(6):e1007796

Mettl3 Regulates Osteogenic Differentiation and Alternative Splicing of Vegfa in Bone Marrow Mesenchymal Stem Cells.

Tian C, Huang Y, Li Q, Feng Z, Xu Q
International journal of molecular sciences 2019 Jan 28;20(3)

METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling.

Zhang Y, Gu X, Li D, Cai L, Xu Q
International journal of molecular sciences 2019 Dec 27;21(1)

HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N(6)-methyladenosine.

Miao W, Li L, Zhao Y, Dai X, Chen X, Wang Y
Nature communications 2019 Aug 9;10(1):3613

N(6)-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.

Zhou J, Wan J, Shu XE, Mao Y, Liu XM, Yuan X, Zhang X, Hess ME, Brüning JC, Qian SB
Molecular cell 2018 Feb 15;69(4):636-647.e7

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ALKBH5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ALKBH5. This antibody recognizes human,mouse,rat antigen. The ALKBH5 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 16837-1-AP.pdf

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