Tissue expression
Cell line expression
Protein structure
PACRG
Parkin coregulatedFLJ32724, Glup, HAK005771, PARK2CRG
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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OriGene | AP07237PU-N | 1 references | Polyclonal |
WB
EL
IHC
|
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Biorbyt | orb1249789 | Polyclonal |
WB
EL
ICC
IHC |
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antibodies-online | ABIN2492328 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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Novus Biologicals | NBP1-03274 | Polyclonal |
WB
EL
IHC
|
||
NovoPro Bioscience Inc. | 127517 | Polyclonal |
WB
EL
IHC
|
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