BS7936
antibody from Bioworld Technology, Inc
Targeting: P4HTM
EGLN4, FLJ20262, HIFPH4, P4H-TM, PH-4, PH4, PHD4
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS7936 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- P4HTM polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human P4HTM.
- Description
- The EF-hand domain is a twelve amino acid loop motif that is commonly found in proteins that participate in calcium-binding events within the cell. EF-hand domains generally exist in a pair that, together, form a stable four-helix bundle that enables the binding of calcium ions. PH-4, also known as P4HTM (prolyl 4-hydroxylase, transmembrane), PHD4 or EGLN4, is a 502 amino acid single-pass type II membrane protein that localizes to the endoplasmic reticulum and contains one PKHD domain and two EF-hand domains. Expressed in a variety of tissues with highest expression in heart, brain, kidney, placenta and skeletal muscle, PH-4 uses iron as a cofactor to catalyze the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, thereby playing an important role in hypoxia adaptation and cellular oxygen sensing. Multiple isoforms of PH-4 exist due to alternative splicing events.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- WesternBlot (WB) analysis of P4HTM polyclonal antibody