BS7936

antibody from Bioworld Technology, Inc
Targeting: P4HTM EGLN4, FLJ20262, HIFPH4, P4H-TM, PH-4, PH4, PHD4
Provider product page for BS7936
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7936 - Provider product page
Provider
Bioworld Technology, Inc
Product name
P4HTM polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human P4HTM.
Description
The EF-hand domain is a twelve amino acid loop motif that is commonly found in proteins that participate in calcium-binding events within the cell. EF-hand domains generally exist in a pair that, together, form a stable four-helix bundle that enables the binding of calcium ions. PH-4, also known as P4HTM (prolyl 4-hydroxylase, transmembrane), PHD4 or EGLN4, is a 502 amino acid single-pass type II membrane protein that localizes to the endoplasmic reticulum and contains one PKHD domain and two EF-hand domains. Expressed in a variety of tissues with highest expression in heart, brain, kidney, placenta and skeletal muscle, PH-4 uses iron as a cofactor to catalyze the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, thereby playing an important role in hypoxia adaptation and cellular oxygen sensing. Multiple isoforms of PH-4 exist due to alternative splicing events.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
P4HTM protein structure - BS7936 shown in red.