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- Antigen structure
- References [15]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11285-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11285-1-AP, RRID:AB_2143351
- Product name
- RNF156 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RNF156 antibody (Cat. #11285-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references "Design principles of a membrane-spanning ubiquitin ligase".
The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters.
Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation.
An MGRN1-Based Biomarker Combination Accurately Predicts Melanoma Patient Survival.
The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters.
Endoplasmic reticulum stress related super-enhancers suppress cuproptosis via glycolysis reprogramming in lung adenocarcinoma.
MGRN1 depletion promotes intercellular adhesion in melanoma by upregulation of E-cadherin and inhibition of CDC42.
Promoter Methylation of the MGRN1 Gene Predicts Prognosis and Response to Chemotherapy of High-Grade Serous Ovarian Cancer Patients.
Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.
A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development.
Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis.
Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.
MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4.
Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.
Abnormal regulation of TSG101 in mice with spongiform neurodegeneration.
Williams C, Nocka LM, Hedger G, Parashara P, Pardon E, Latorraca NR, Pusapati GV, Lartey D, Gao L, Milenkovic L, Chalk R, Steyaert J, Marqusee S, Carrique L, Bazan JF, Rouse SL, Kong JH, Siebold C, Rohatgi R
bioRxiv : the preprint server for biology 2025 Sep 16;
bioRxiv : the preprint server for biology 2025 Sep 16;
The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters.
Parashara P, Gao L, Riglos A, Sidhu SB, Lartey D, Marks T, Williams C, Siauw G, Ostrem AIL, Siebold C, Kinnebrew M, Riffle M, Gunn TM, Kong JH
bioRxiv : the preprint server for biology 2025 Mar 26;
bioRxiv : the preprint server for biology 2025 Mar 26;
Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation.
He G, Shao W, Wang W, Sun L, Gao B, Wei J
Cellular and molecular life sciences : CMLS 2025 Jul 3;82(1):270
Cellular and molecular life sciences : CMLS 2025 Jul 3;82(1):270
An MGRN1-Based Biomarker Combination Accurately Predicts Melanoma Patient Survival.
Sánchez-Beltrán J, Soler Díaz J, Herraiz C, Olivares C, Cerdido S, Cerezuela-Fuentes P, García-Borrón JC, Jiménez-Cervantes C
International journal of molecular sciences 2025 Feb 18;26(4)
International journal of molecular sciences 2025 Feb 18;26(4)
The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters.
Parashara P, Gao L, Riglos A, Lartey D, Sidhu SB, Marks T, Williams C, Siauw G, Lee KJ, Ostrem AIL, Siebold C, Riffle M, Kinnebrew M, Gunn TM, Kong JH
Journal of cell science 2025 Dec 1;138(23)
Journal of cell science 2025 Dec 1;138(23)
Endoplasmic reticulum stress related super-enhancers suppress cuproptosis via glycolysis reprogramming in lung adenocarcinoma.
Gu Y, Wang H, Xue W, Zhu L, Fu C, Zhang W, Mu G, Xia Y, Wei K, Wang J
Cell death & disease 2025 Apr 19;16(1):316
Cell death & disease 2025 Apr 19;16(1):316
MGRN1 depletion promotes intercellular adhesion in melanoma by upregulation of E-cadherin and inhibition of CDC42.
Cerdido S, Abrisqueta M, Sánchez-Beltrán J, Lambertos A, Castejón-Griñán M, Muñoz C, Olivares C, García-Borrón JC, Jiménez-Cervantes C, Herraiz C
Cancer letters 2024 Jan 28;581:216484
Cancer letters 2024 Jan 28;581:216484
Promoter Methylation of the MGRN1 Gene Predicts Prognosis and Response to Chemotherapy of High-Grade Serous Ovarian Cancer Patients.
Li XF, Sun HY, Hua T, Zhang HB, Tian YJ, Li Y, Kang S
Frontiers in oncology 2021;11:659254
Frontiers in oncology 2021;11:659254
Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength.
Kong JH, Young CB, Pusapati GV, Espinoza FH, Patel CB, Beckert F, Ho S, Patel BB, Gabriel GC, Aravind L, Bazan JF, Gunn TM, Lo CW, Rohatgi R
Development (Cambridge, England) 2021 Oct 1;148(19)
Development (Cambridge, England) 2021 Oct 1;148(19)
A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development.
Kong JH, Young CB, Pusapati GV, Patel CB, Ho S, Krishnan A, Lin JI, Devine W, Moreau de Bellaing A, Athni TS, Aravind L, Gunn TM, Lo CW, Rohatgi R
Developmental cell 2020 Nov 23;55(4):432-449.e12
Developmental cell 2020 Nov 23;55(4):432-449.e12
Chronic and age-dependent effects of the spongiform neurodegeneration-associated MGRN1 E3 ubiquitin ligase on mitochondrial homeostasis.
Gunn TM, Silvius D, Lester A, Gibbs B
Mammalian genome : official journal of the International Mammalian Genome Society 2019 Jun;30(5-6):151-165
Mammalian genome : official journal of the International Mammalian Genome Society 2019 Jun;30(5-6):151-165
Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival.
Benvegnù S, Mateo MI, Palomer E, Jurado-Arjona J, Dotti CG
Molecular cell 2017 May 4;66(3):358-372.e7
Molecular cell 2017 May 4;66(3):358-372.e7
MGRN1-dependent pigment-type switching requires its ubiquitination activity but not its interaction with TSG101 or NEDD4.
Gunn TM, Silvius D, Bagher P, Sun K, Walker KK
Pigment cell & melanoma research 2013 Mar;26(2):263-8
Pigment cell & melanoma research 2013 Mar;26(2):263-8
Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein.
Overton JD, Leibel RL
The Journal of biological chemistry 2011 May 27;286(21):18914-29
The Journal of biological chemistry 2011 May 27;286(21):18914-29
Abnormal regulation of TSG101 in mice with spongiform neurodegeneration.
Jiao J, Sun K, Walker WP, Bagher P, Cota CD, Gunn TM
Biochimica et biophysica acta 2009 Oct;1792(10):1027-35
Biochimica et biophysica acta 2009 Oct;1792(10):1027-35
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 11285-1-AP(MGRN1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RNF156 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RNF156. This antibody recognizes human,mouse,rat antigen. The RNF156 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
