BS1235

antibody from Bioworld Technology, Inc

Targeting: MMP19 MMP18, RASI-1

Immunohistochemistry

Antibody data

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Validation data

Product number: BS1235 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS1235, RRID:AB_1663256
Product name: MMP 19 (G44) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 12-60 of Human MMP-19.
Description: MMP-19 (RASI-1, MMP-18) is a 508 amino acid peptide, originally isolated as an autoantigen from the synovium of a patient suffering from rheumatoid arthritis (RA). Its presence on the surface of activated PBMCs, TH1 lymphocytes, and Jurkat T lymphoma cells in the synovium of acute RA patients, suggests that MMP-19 plays a role in RA-associated joint tissue destruction. MMP-19 exists in the smooth muscle cells of the tunica media of large blood vessels of the RA patient, but not in the endothelial cell layer. Acutely inflamed tissue synovial capillaries strongly express MMP-19 in the cytoplasm. Regulated induction of MMP-19 in capillary endothelial cells during acute inflammation suggest a role in angiogenesis. MMP-19 is a single 2.7kb transcript found in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis, colon, and heart.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

MMP19 protein structure - BS1235 shown in red.