Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- MAB2561-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human beta-NGF Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human beta-NGF in direct ELISAs. In direct ELISAs, 100% cross-reactivity with recombinant mouse (rm) beta-NGF and recombinant rat (rr) beta-NGF is observed, and no cross-reactivity with recombinant human (rh) BDNF, rhNT-3, or rhNT-4 is observed. This antibody neutralizes the bioactivity of rh beta-NGF, rm beta-NGF, and rr beta-NGF.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
CAA36832
- Isotype
- IgG
- Antibody clone number
- 25617
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references The role of nerve growth factor in hyperosmolar stress induced apoptosis.
Nerve growth factor beta/pro-nerve growth factor and their receptors in normal human oral mucosa.
Chang EJ, Im YS, Kay EP, Kim JY, Lee JE, Lee HK
Journal of cellular physiology 2008 Jul;216(1):69-77
Journal of cellular physiology 2008 Jul;216(1):69-77
Nerve growth factor beta/pro-nerve growth factor and their receptors in normal human oral mucosa.
Hayashi K, Storesund T, Schreurs O, Khuu C, Husvik C, Karatsaidis A, Helgeland K, Martin-Zanca D, Schenck K
European journal of oral sciences 2007 Oct;115(5):344-54
European journal of oral sciences 2007 Oct;115(5):344-54
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Supportive validation
- Submitted by
- R&D Systems (provider)
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- Experimental details
- Cell Proliferation Induced by beta-NGF and Neutralization by Human beta-NGF Antibody. Recombinant Human beta-NGF (Catalog # 256-GF) stimulates proliferation in the TF-1 human erythroleukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human beta-NGF (5 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human beta-NGF Monoclonal Antibody (Catalog # MAB2561). The ND50 is typically 0.4-2.4 µg/mL.