66491-1-Ig

antibody from Proteintech Group

Targeting: POSTN OSF-2, periostin, PN

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66491-1-Ig

Provider

Proteintech Group

Product name

Periostin antibody

Antibody type

Monoclonal

Description

Periostin antibody (Cat. #66491-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse, Rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1A11A3

Vial size

20ul, 150ul

References

Submitted references

Lumican-mediated fibroblast differentiation in skin fibrosis.

Dou S, Wang X, He Y, Deng Y, Du P, Zhang G, Yang G, Zeng Y, Li W, Liu W
Matrix biology : journal of the International Society for Matrix Biology 2026 May;145:57-74

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CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels.

Lu Q, Zheng Q, Zhou Z, Chen Y, Chen Y, Chen W, Wang J, Guo R, Wu R, Chen L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(14):e22295

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Decoding the Cellular Heterogeneity and Malignant Progression of Human Penile Squamous Cell Carcinoma by Single-Cell RNA Sequencing.

Hu X, Shi W, Dong L, Huang L, Zhang X, Feng Y, Sun J, Liu L, Liu T, Fu J, Zhong B, Leng Q, Wu X, Chen M, Li L, Li Y, Jin X, Wang L, Cao J, Li X, Yin M, Chen X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(14):e03894

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TWIST1-Mediated Induction of AEBP1 in Fibroblast-Like Synoviocytes Activates Transforming Growth Factor β Signaling to Drive Angiogenesis and Promote Rheumatoid Arthritis.

Li Z, Cai M, Huang W, Wen X, Li Y, Sun J, Zhu C, Yang C, Chen Z
Arthritis & rheumatology (Hoboken, N.J.) 2026 Mar 5;

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Fibroblast-derived POSTN promotes colorectal cancer progression under high-fat diet by reprogramming fatty acid metabolism in tumor cell.

Li B, Hou S, Tian T, Yuan S, Li A, Feng Y, Liu Z, Mi J, Cheng Z, Lv S, Yang J, Lu Y, Qi X, Song S, Zha Z, Yuan Q
Cell communication and signaling : CCS 2026 Jan 8;24(1):91

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Tenascin C(+) myofibroblasts exacerbate vascular neointimal hyperplasia by propagation of nerve-macrophage interactions in mice.

Tong X, Shi G, Fang Z, Tang S, Zhou B, Meng Q, Zhang P, Li H, Cai X, Wang Z, Zheng X, Chen W, Jiang G, Wang H, Jiang D, Li Q
Nature communications 2026 Jan 30;17(1)

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SFRP4 Knockdown Attenuates Dsg2-Deficient Arrhythmogenic Cardiomyopathy by Down-Regulating TGF-β and Smad3.

Li W, Wang M, Ruan Z, Ren Y, Zhu L, Zhang B
Biochemical genetics 2026 Feb;64(1):1002-1017

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Three-Year Follow-Up of Neoadjuvant Tislelizumab with Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Adenocarcinoma: Revealing Cancer-Associated Fibroblast Heterogeneity Corresponding to PD-1 Blockade Efficacy.

Lin Y, Sun X, Li C, Yang M, Wu K, Liu K, Li A, Shuai X, Cai K, Wang Z, Wang G, Zhang P, Shen J, Tao K, Yin Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(9):e08433

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Valvular Leaflets Are Not Innocent Bystanders: Divergent Fibrotic Remodeling Accompanies Functional Mitral and Tricuspid Regurgitation.

Shi H, Shu S, Chen X, Chen X, Wang X, Wang W, Wang X, Song S, Hu H, Han K, Song J, Liu J
Arteriosclerosis, thrombosis, and vascular biology 2026 Apr;46(4):e324134

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Comprehensive Analysis of N6-Methyladenosine Modification Profiling in Diabetic Erectile Dysfunction.

Yuan P, Deng W, Cao H, Liu Y, Cui L, Li T, Meng Q, Sun T
The world journal of men's health 2026 Apr;44(2):413-426

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Therapeutic efficacy of dendritic cell vaccination in a novel syngeneic mouse model of diffuse hemispheric glioma, H3 G34-mutant.

Owens GC, Contreras EM, Kienzler JC, Treger J, Soto H, Orpilla JR, Qiao C, Chang JW, Lee A, Kim WJ, Sun MZ, Peeters SF, Bethel JA, Kondajji AM, Holland EC, Becher OJ, Liau LM, Prins RM, Wang AC
Journal of neuro-oncology 2026 Apr 2;177(2)

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Macrophage-myofibroblast transition as a novel therapeutic target in shoulder stiffness: multi-omics study and experimental validation.

Qi B, Yu W, Wang H, Li Y, Deng S, Yi C
Frontiers in cell and developmental biology 2025;13:1727624

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POSTN+ Cancer-Associated Fibroblasts Promote Gastric Cancer Invasion by Activating AKT Signaling.

Xu X, You T, Sun Z, Bai C, Han Q, Zhao RC
Stem cells and development 2025 Nov;34(21-22):483-491

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VGF and the VGF-derived peptide AQEE30 stimulate osteoblastic bone formation through the C3a receptor.

Moon SA, Kim JM, Lee YS, Cho HJ, Choi YJ, Yoon JH, Kim D, Che X, Jin X, Baek IJ, Lee SH, Choi JY, Koh JM
Experimental & molecular medicine 2025 Mar;57(3):637-651

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1,6-Digalloyl glucose in Emblica officinalis increases the proliferation of human keratinocytes and fibroblasts with upregulated expression of periostin.

Yamakami Y, Morino K, Kanaly RA, Irie R, Oikawa M, Takauji Y, Miki K, Hossain MN, Ayusawa D, Fujii M
Bioscience, biotechnology, and biochemistry 2025 Jul 23;89(8):1092-1105

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Transcriptional profile of the rat cardiovascular system at single-cell resolution.

Arduini A, Fleming SJ, Xiao L, Hall AW, Akkad AD, Chaffin MD, Bendinelli KJ, Tucker NR, Papangeli I, Mantineo H, Flores-Bringas P, Babadi M, Stegmann CM, García-Cardeña G, Lindsay ME, Klattenhoff C, Ellinor PT
Cell reports 2025 Jan 28;44(1):115091

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Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in breast cancer lymphatic node, bone, and brain metastases.

Zhu L, Liu M, Shang Y, Cheng J, Zhao H, Zhang J, Shen D
Scientific reports 2025 Jan 17;15(1):2217

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Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy.

Huang CQ, Xiao WT, Yao XR, Li ZM, He JY
Scientific reports 2025 Feb 4;15(1):4174

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Different Intensities of Exercise Affect the Prognosis of Ventricular Aneurysm in Mice by Regulating the Progression of Cardiac Fibrosis.

Qi RQ, Song J, Ma HB, Nie ML, Su LH, Dai CL, Zhou FG, Li SJ
Cardiovascular toxicology 2025 Dec;25(12):1891-1902

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Screening and identification of differentially expressed miRNA and mRNA for intervertebral disc degeneration on bioinformatics.

Yan J, Gao Y, Chen R, Miao S, Gong Y, Zhu Y, Zhou Q
European journal of medical research 2025 Dec 7;31(1):1

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POSTN Enhances the Proliferation of Goat Skin Fibroblasts Through the TGFβ Pathway Activation.

Xu X, Yan W, Song M, Li L, Zhang H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 15;39(23):e71269

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Using Multi-Omics Analysis to Explore Diagnostic Tool and Optimize Drug Therapy Selection for Patients with Glioma Based on Cross-Talk Gene Signature.

Yang Y, Hu C, Lei S, Bao X, Zeng Z, Cao W
Oncology research 2024;32(12):1921-1934

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Hypoxia reconstructed colorectal tumor microenvironment weakening anti-tumor immunity: construction of a new prognosis predicting model through transcriptome analysis.

Zhang R, Gao Y, Li C, Tao R, Mao G, Song T, Nie W, Liu S, Tao K, Li W
Frontiers in immunology 2024;15:1425687

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Single cell analyses reveal the PD-1 blockade response-related immune features in hepatocellular carcinoma.

Li Y, Li F, Xu L, Shi X, Xue H, Liu J, Bai S, Wu Y, Yang Z, Xue F, Xia Y, Dong H, Shen F, Wang K
Theranostics 2024;14(9):3526-3547

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Branched-chain amino acids deficiency promotes diabetic cardiomyopathy by activating autophagy of cardiac fibroblasts.

Zhou ZY, Song K, Liu ZY, Ke YF, Shi Y, Cai K, Zhao R, Sun X, Tao H, Zhao JY
Theranostics 2024;14(19):7333-7348

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Single-cell RNA sequencing of OSCC primary tumors and lymph nodes reveals distinct origin and phenotype of fibroblasts.

Zhang Q, Ding L, Li J, Liu K, Xia C, Chen S, Huang X, Pu Y, Song Y, Hu Q, Wang Y
Cancer letters 2024 Sep 28;600:217180

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Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction.

Liu Y, Chen S, Wan X, Wang R, Luo H, Chang C, Dai P, Gan Y, Guo Y, Hou Y, Sun Y, Teng Y, Cui X, Liu M
Cancer communications (London, England) 2024 Nov;44(11):1261-1286

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Genetic and therapeutic heterogeneity shape the baseline and longitudinal immune ecosystem of ovarian clear cell carcinoma.

Xia S, Chen L, Yu M, Li J, Chen J, Xu F, Ni M, Liu C, Wu X, Chen X, Li J
Journal for immunotherapy of cancer 2024 Nov 27;12(11)

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Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periosti.

Xie W, Gan J, Zhou X, Tian H, Pan X, Liu W, Li X, Du J, Xu A, Zheng M, Wu F, Li Y, Lin Z
Cell metabolism 2024 Jun 4;36(6):1269-1286.e9

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Periostin drives extracellular matrix degradation, stemness, and chemoresistance by activating the MAPK/ERK signaling pathway in triple-negative breast cancer cells.

Wu J, Li J, Xu H, Qiu N, Huang X, Li H
Lipids in health and disease 2023 Sep 16;22(1):153

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An immune signature to predict the prognosis of ATRX-wildtype glioma patients and guide immune checkpoint blockade therapy.

Cao W, Sun P, Luo S, Zeng Z, Xiao C, Yu W, Lei S
Aging 2023 Oct 6;15(19):10453-10472

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WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.

Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931

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Single-nucleus RNA sequencing reveals heterogenous microenvironments and specific drug response between cervical squamous cell carcinoma and adenocarcinoma.

Lin S, Sun Y, Cao C, Zhu Z, Xu Y, Liu B, Hu B, Peng T, Zhi W, Xu M, Ding W, Ren F, Ma D, Li G, Wu P
EBioMedicine 2023 Nov;97:104846

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Bioinformatics analysis and identification of dysregulated POSTN in the pathogenesis of keloid.

Xu H, Wang Z, Yang H, Zhu J, Hu Z
International wound journal 2023 May;20(5):1700-1711

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Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single-Cell Resolution.

Zhou T, Chen Y, Liao Z, Zhang L, Su D, Li Z, Yang X, Ke X, Liu H, Chen Y, Weng R, Shen H, Xu C, Wan Y, Xu R, Su P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2206296

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SPARC in cancer-associated fibroblasts is an independent poor prognostic factor in non-metastatic triple-negative breast cancer and exhibits pro-tumor activity.

Alcaraz LB, Mallavialle A, Mollevi C, Boissière-Michot F, Mansouri H, Simony-Lafontaine J, Laurent-Matha V, Chardès T, Jacot W, Turtoi A, Roger P, Guiu S, Liaudet-Coopman E
International journal of cancer 2023 Mar 15;152(6):1243-1258

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Ciclopirox Inhibition of eIF5A Hypusination Attenuates Fibroblast Activation and Cardiac Fibrosis.

Subbaiah KCV, Wu J, Tang WHW, Yao P
Journal of cardiovascular development and disease 2023 Jan 29;10(2)

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IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice.

Ma ZG, Yuan YP, Fan D, Zhang X, Teng T, Song P, Kong CY, Hu C, Wei WY, Tang QZ
Nature communications 2023 Aug 16;14(1):4967

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Micro/nano-topography promotes osteogenic differentiation of bone marrow stem cells by regulating periostin expression.

Li J, Hou W, Yang Y, Deng Q, Fu H, Yin Y, Duan K, Feng B, Guo T, Weng J
Colloids and surfaces. B, Biointerfaces 2022 Oct;218:112700

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Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration.

Wu J, Chen Y, Liao Z, Liu H, Zhang S, Zhong D, Qiu X, Chen T, Su D, Ke X, Wan Y, Zhou T, Su P
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Oct 5;30(10):3241-3256

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Periostin promotes the proliferation and metastasis of osteosarcoma by increasing cell survival and activates the PI3K/Akt pathway.

Xu C, Wang Z, Zhang L, Feng Y, Lv J, Wu Z, Yang R, Wu T, Li J, Zhou R, Tian Z, Bai J, Zhang H, Lan Y, Lv Z
Cancer cell international 2022 Jan 20;22(1):34

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Changed PGA and POSTN levels in choroid plexus are associated with depressive-like behaviors in mice.

Liu J, He Y, Cheng K, Xie P
Biochemical and biophysical research communications 2020 Mar 26;524(1):231-235

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Periostin Mediates Right Ventricular Failure through Induction of Inducible Nitric Oxide Synthase Expression in Right Ventricular Fibroblasts from Monocrotaline-Induced Pulmonary Arterial Hypertensive Rats.

Imoto K, Okada M, Yamawaki H
International journal of molecular sciences 2018 Dec 24;20(1)