HPA012306

antibody from Atlas Antibodies

Targeting: POSTN OSF-2, periostin, PN

Provider product page for HPA012306

Western blot

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [18]
Comments [0]
Validations
Immunohistochemistry [1]

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Product number: HPA012306 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA012306, RRID:AB_1854827
Product name: Anti-POSTN
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human POSTN, Gene description: periostin, osteoblast specific factor, Alternative Gene Names: OSF-2, periostin, PN, Validated applications: IHC, WB, Uniprot ID: Q15063, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.1 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

POSTN protein structure - HPA012306 shown in red.

Submitted references FAT1 upregulation is correlated with an immunosuppressive tumor microenvironment and predicts unfavorable outcome of immune checkpoint therapy in non-small cell lung cancer

Chen C, Li Y, Liu H, Liao M, Yang J, Liu J
Heliyon 2024;10(7):e28356

Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer

Hanley C, Waise S, Ellis M, Lopez M, Pun W, Taylor J, Parker R, Kimbley L, Chee S, Shaw E, West J, Alzetani A, Woo E, Ottensmeier C, Rose-Zerilli M, Thomas G
Nature Communications 2023;14(1)

Single‐cell and spatial transcriptomics reveal POSTN+ cancer‐associated fibroblasts correlated with immune suppression and tumour progression in non‐small cell lung cancer

Chen C, Guo Q, Liu Y, Hou Q, Liao M, Guo Y, Zang Y, Wang F, Liu H, Luan X, Liang Y, Guan Z, Li Y, Liu H, Dong X, Zhang X, Liu J, Xu Q
Clinical and Translational Medicine 2023;13(12)

Collagen‐Specific HSP47 + Myofibroblasts and CD163 + Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS‐CoV‐2 Infections

Puzyrenko A, Jacobs E, Padilla N, Devine A, Aljadah M, Gantner B, Pan A, Lai S, Dai Q, Rubenstein J, North P, Simpson P, Willoughby R, O'Meara C, Flinn M, Lough J, Ibrahim E, Zheng Z, Sun Y, Felix J, Hunt B, Ross G, Rui H, Benjamin I
Journal of the American Heart Association 2023;12(4)

Periostin in lymph node pre-metastatic niches governs lymphatic endothelial cell functions and metastatic colonization

Gillot L, Lebeau A, Baudin L, Pottier C, Louis T, Durré T, Longuespée R, Mazzucchelli G, Nizet C, Blacher S, Kridelka F, Noël A
Cellular and Molecular Life Sciences 2022;79(6)

The Effects of Periostin Expression on Fibroid-Like Transition of Myometrial Cells

Lenis Y, George J, Lind S, Balboula A, Teixeira J, Patterson A
Reproductive Sciences 2022;30(5):1616-1624

Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN

Paunas F, Finne K, Leh S, Marti H, Berven F, Vikse B
BMC Nephrology 2022;23(1)

Molecular Signature of Tumor-Associated High Endothelial Venules That Can Predict Breast Cancer Survival

Sawada J, Hiraoka N, Qi R, Jiang L, Fournier-Goss A, Yoshida M, Kawashima H, Komatsu M
Cancer Immunology Research 2022;10(4):468-481

TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer

Lecker L, Berlato C, Maniati E, Delaine-Smith R, Pearce O, Heath O, Nichols S, Trevisan C, Novak M, McDermott J, Brenton J, Cutillas P, Rajeeve V, Hennino A, Drapkin R, Loessner D, Balkwill F
Cancer Research 2021;81(22):5706-5719

Microneedle patch for the ultrasensitive quantification of protein biomarkers in interstitial fluid

Wang Z, Luan J, Seth A, Liu L, You M, Gupta P, Rathi P, Wang Y, Cao S, Jiang Q, Zhang X, Gupta R, Zhou Q, Morrissey J, Scheller E, Rudra J, Singamaneni S
Nature Biomedical Engineering 2021;5(1):64-76

Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding

Boehm M, Tian X, Mao Y, Ichimura K, Dufva M, Ali K, Dannewitz Prosseda S, Shi Y, Kuramoto K, Reddy S, Kheyfets V, Metzger R, Spiekerkoetter E
Cardiovascular Research 2020;116(10):1700-1709

Characterization of glomerular extracellular matrix in IgA nephropathy by proteomic analysis of laser-captured microdissected glomeruli

Paunas F, Finne K, Leh S, Osman T, Marti H, Berven F, Vikse B
BMC Nephrology 2019;20(1)

Low periostin expression predicts poor survival in intestinal type gastric cancer patients

Zhang T, Han Z, Chandoo A, Huang X, Sun X, Ye L, Hu C, Xue X, Huang Y, Shen X, Chang W, Lin X
Cancer Management and Research 2018;Volume 11

Overexpression of POSTN in Tumor Stroma Is a Poor Prognostic Indicator of Colorectal Cancer

Oh H, Bae J, Wen X, Cho N, Kim J, Kang G
Journal of Pathology and Translational Medicine 2017;51(3):306-313

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

Calon A, Lonardo E, Berenguer-Llergo A, Espinet E, Hernando-Momblona X, Iglesias M, Sevillano M, Palomo-Ponce S, Tauriello D, Byrom D, Cortina C, Morral C, Barceló C, Tosi S, Riera A, Attolini C, Rossell D, Sancho E, Batlle E
Nature Genetics 2015;47(4):320-329

Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase‐13

Attur M, Yang Q, Shimada K, Tachida Y, Nagase H, Mignatti P, Statman L, Palmer G, Kirsch T, Beier F, Abramson S
The FASEB Journal 2015;29(10):4107-4121

Stromal gene expression defines poor-prognosis subtypes in colorectal cancer

CD99 is a novel prognostic stromal marker in non‐small cell lung cancer

Edlund K, Lindskog C, Saito A, Berglund A, Pontén F, Göransson‐Kultima H, Isaksson A, Jirström K, Planck M, Johansson L, Lambe M, Holmberg L, Nyberg F, Ekman S, Bergqvist M, Landelius P, Lamberg K, Botling J, Östman A, Micke P
International Journal of Cancer 2012;131(10):2264-2273

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Supportive validation

Submitted by: Atlas Antibodies (provider)
Enhanced method: Orthogonal validation
Main image
Experimental details: Immunohistochemistry analysis in human skin and pancreas tissues using Anti-POSTN antibody. Corresponding POSTN RNA-seq data are presented for the same tissues.
Sample type: Human
Protocol: Protocol
Orthogonal method: Orthogonal validation of protein expression using IHC by comparison to RNA-seq data of corresponding target in high and low expression tissues.

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