Antibody data

Product number
12-5786-82 - Provider product page
Provider
Invitrogen Antibodies
Product name
NOTCH2 Monoclonal Antibody (16F11), PE, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This 16F11 monoclonal antibody reacts with the extracellular domain of human and mouse Notch2, one of four members of the Notch family of receptors. Notch receptors are 300-kDa single-pass transmembrane proteins. While the extracellular domain contains numerous epidermal growth factor-like repeats for ligand binding, the intracellular domain is involved in cell signaling. Upon binding its membrane-bound ligand (either Delta or Jagged), the Notch receptor undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, heterodimerizes with the DNA-binding protein RBP-J, recruits co-activator molecules, and ultimately activates transcription.
Conjugate
Yellow dye
Antibody clone number
16F11
Concentration
0.2 mg/mL
NOTCH2 protein structure - 12-5786-82 shown in red.