Antibody data

Product number
348301 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#348301, RRID:AB_10551623
Product name
Purified anti-human Notch 2
Antibody type
Monoclonal
Antigen
Human Notch 2-human IgG1 Fc fusion protein
Description
The Notch receptors are a type I transmembrane protein family that share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. They are highly conserved from invertebrates to mammals. Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors (Notch1-4).  Notch1 and Notch 2 are reported to be functionally redundant.  Notch 2 is expressed by Pre-B cells, double negative and CD8 single positive thymocytes, brain, lung cells. Notch 2 functions as a receptor for Jagged and Delta ligands, and may play a role in vascular, renal and hepatic development.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C.
NOTCH2 protein structure - 348301 shown in red.