DPABH-08195

antibody from Creative Diagnostics

Targeting: COPS7B CSN7B

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DPABH-08195

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPABH-08195, RRID:AB_2510419

Product name

Rabbit Anti-Human COPS7B Polyclonal Antibody

Antibody type

Polyclonal

Description

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 _L

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C. Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.