AF1257

antibody from Novus Biologicals

Targeting: FCGR1A CD64, CD64A

Western blot (Data presented on provider website)

Blocking/Neutralizing (Data presented on provider website)

Antibody Data

Product number

AF1257

Provider

Novus Biologicals

Product name

Goat Polyclonal Fc gamma RI/CD64 Antibody

Antibody type

Polyclonal

Description

Antigen Affinity-purified. Detects human Fc gamma RI/CD64 in direct ELISAs and Western blots. In direct ELISAs, approximately 40% cross-reactivity with recombinant mouse Fc gamma RI is observed and 10% cross-reactivity with recombinant human (rh) Fc gamma RIIA and rhFc gamma RIIIB is observed.

Reactivity

Human

Host

Goat

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

References

Submitted references

Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.

Chauhan AK, Chen C, Moore TL, DiPaolo RJ
The Journal of biological chemistry 2015 Feb 20;290(8):5127-5140

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Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer.

Forget MA, Voorhees JL, Cole SL, Dakhlallah D, Patterson IL, Gross AC, Moldovan L, Mo X, Evans R, Marsh CB, Eubank TD
PloS one 2014;9(6):e98623

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C-reactive protein induces G2/M phase cell cycle arrest and apoptosis in monocytes through the upregulation of B-cell translocation gene 2 expression.

Kim Y, Ryu J, Ryu MS, Lim S, Han KO, Lim IK, Han KH
FEBS letters 2014 Feb 14;588(4):625-31

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Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human CD4(+) T cells.

Chauhan AK, Moore TL
Clinical and experimental immunology 2012 Feb;167(2):235-45

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C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.

Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY
Diabetologia 2011 Oct;54(10):2713-23

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C-reactive protein (CRP) induces chemokine secretion via CD11b/ICAM-1 interaction in human adherent monocytes.

Montecucco F, Steffens S, Burger F, Pelli G, Monaco C, Mach F
Journal of leukocyte biology 2008 Oct;84(4):1109-19