10338-1-AP

antibody from Proteintech Group

Targeting: MLPH exophilin-3, l(1)-3Rk, l1Rk3, ln, Slac-2a

Provider product page for 10338-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [19]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 10338-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10338-1-AP, RRID:AB_2146104
Product name: Melanophilin antibody
Antibody type: Polyclonal
Description: KD/KO validated Melanophilin antibody (Cat. #10338-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MLPH protein structure - 10338-1-AP shown in red.

Submitted references Anti-melanogenic effect of exosomes derived from human dermal fibroblasts (BJ-5ta-Ex) in C57BL/6 mice and B16F10 melanoma cells.

Lee JM, Lee JO, Kim Y, Jang YN, Yeon Park A, Kim SY, Han HS, Kim BJ, Yoo KH
Pigment cell & melanoma research 2024 Mar;37(2):232-246

O-GlcNAcylation of melanophilin enhances radiation resistance in glioblastoma via suppressing TRIM21 mediated ubiquitination.

Xu L, Ye Y, Tao Z, Wang T, Wei Y, Cai W, Wan X, Zhao P, Gu W, Gu B, Zhang L, Tian Y, Liu N, Tu Y, Ji J
Oncogene 2024 Jan;43(1):61-75

Senescent melanocytes driven by glycolytic changes are characterized by melanosome transport dysfunction.

Park YJ, Kim JC, Kim Y, Kim YH, Park SS, Muther C, Tessier A, Lee G, Gendronneau G, Forestier S, Ben-Khalifa Y, Park TJ, Kang HY
Theranostics 2023;13(12):3914-3924

Phosphorylation of glucocorticoid receptor induced by 16-kauren-2-beta-18, 19-triol decreases expression of Melanophilin through JNK signalling.

Myung CH, Jo CS, Hwang JS
Experimental dermatology 2023 Sep;32(9):1394-1401

Chemical Composition and Skin-Whitening Activities of Siegesbeckia glabrescens Makino Flower Absolute in Melanocytes.

Lee DK, Won KJ, Kim DY, Kim YY, Lee HM
Plants (Basel, Switzerland) 2023 Nov 22;12(23)

Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis.

Zhao K, Matsunaga K, Mizuno K, Wang H, Okunishi K, Izumi T
eLife 2023 Feb 21;12

Identification of a Novel MLPH Missense Mutation in a Chinese Griscelli Syndrome 3 Patient.

Huang Q, Yuan Y, Gong J, Zhang T, Qi Z, Yang X, Li W, Wei A
Frontiers in medicine 2022;9:896943

Coal dust exposure triggers heterogeneity of transcriptional profiles in mouse pneumoconiosis and Vitamin D remedies.

Mu M, Li B, Zou Y, Wang W, Cao H, Zhang Y, Sun Q, Chen H, Ge D, Tao H, Hu D, Yuan L, Tao X, Wang J
Particle and fibre toxicology 2022 Jan 20;19(1):7

Regulation of Melanophilin (Mlph) gene expression by the glucocorticoid receptor (GR).

Myung CH, Lee JE, Jo CS, Park JI, Hwang JS
Scientific reports 2021 Aug 19;11(1):16813

MLPH Accelerates the Epithelial-Mesenchymal Transition in Prostate Cancer.

Zhang T, Sun Y, Zheng T, Wang R, Jia D, Zhang W
OncoTargets and therapy 2020;13:701-708

A novel function of Prohibitin on melanosome transport in melanocytes.

Jo CS, Park HI, Jung HJ, Park JI, Lee JE, Myung CH, Hwang JS
Theranostics 2020;10(9):3880-3891

16-Kauren-2-beta-18,19-triol inhibits melanosome transport in melanocytes by down-regulation of melanophilin expression.

Myung CH, Kim K, Park JI, Lee JE, Lee JA, Hong SC, Lim KM, Hwang JS
Journal of dermatological science 2020 Feb;97(2):101-108

Identification of MicroRNA Targeting Mlph and Affecting Melanosome Transport.

Lee JA, Hwang SJ, Hong SC, Myung CH, Lee JE, Park JI, Hwang JS
Biomolecules 2019 Jul 8;9(7)

Inhibitory effect of 2-methyl-naphtho[1,2,3-de]quinolin-8-one on melanosome transport and skin pigmentation.

Park JI, Lee HY, Lee JE, Myung CH, Hwang JS
Scientific reports 2016 Jul 6;6:29189

Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding.

Cetica V, Hackmann Y, Grieve S, Sieni E, Ciambotti B, Coniglio ML, Pende D, Gilmour K, Romagnoli P, Griffiths GM, Aricò M
The Journal of allergy and clinical immunology 2015 May;135(5):1310-8.e1

Cellular and clinical report of new Griscelli syndrome type III cases.

Westbroek W, Klar A, Cullinane AR, Ziegler SG, Hurvitz H, Ganem A, Wilson K, Dorward H, Huizing M, Tamimi H, Vainshtein I, Berkun Y, Lavie M, Gahl WA, Anikster Y
Pigment cell & melanoma research 2012 Jan;25(1):47-56

Differential gene expression in normal esophagus and Barrett's esophagus.

Wang J, Qin R, Ma Y, Wu H, Peters H, Tyska M, Shaheen NJ, Chen X
Journal of gastroenterology 2009;44(9):897-911

Knockdown of myosin Va isoforms by RNAi as a tool to block melanosome transport in primary human melanocytes.

Van Gele M, Geusens B, Schmitt AM, Aguilar L, Lambert J
The Journal of investigative dermatology 2008 Oct;128(10):2474-84

A novel missense mutation (G43S) in the switch I region of Rab27A causing Griscelli syndrome.

Westbroek W, Tuchman M, Tinloy B, De Wever O, Vilboux T, Hertz JM, Hasle H, Heilmann C, Helip-Wooley A, Kleta R, Gahl WA
Molecular genetics and metabolism 2008 Jun;94(2):248-54

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: A375 cells were subjected to SDS PAGE followed by western blot with 10338-1-AP(MLPH antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of MCF-7 cells, using MLPH antibody 10338-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line