Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [33]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 11521-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11521-1-AP, RRID:AB_2261964
- Product name
- ECM1 antibody
- Antibody type
- Polyclonal
- Description
- ECM1 antibody (Cat. #11521-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Sparc-driven p62-dependent mitochondrial oxidative stress exacerbates myocardial ischemia and is attenuated by ginsenoside CK.
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.
A comprehensive analysis of supermere, exomere, and extracellular vesicle isolation and cargo in colorectal cancer.
Liver metastasis or peritoneal metastasis: single-cell RNA sequencing reveals the organotropism in colorectal cancer is driven by distinct partial-EMT processes.
Crip2 affects vascular development by fine-tuning endothelial cell aggregation and proliferation.
Osteoblast-Derived ECM1 Promotes Anti-Androgen Resistance in Bone Metastatic Prostate Cancer.
TRPV4 drives the progression of leiomyosarcoma by promoting ECM1 generation and co-activating the FAK/PI3K/AKT/GSK3β pathway.
Mechanistic study of celastrol-mediated inhibition of proinflammatory activation of macrophages in IgA nephropathy via down-regulating ECM1.
Establishment of a tumor-associated fibroblast associated gene score based on scRNA-seq to predict prognosis in patients with triple-negative breast cancer.
ECM1 and ANXA1 in urinary extracellular vesicles serve as biomarkers for breast cancer.
Qizhu anticancer prescription enhances immunosurveillance of liver cancer cells by regulating p21-dependent secretory phenotypes.
TET2-mediated ECM1 hypomethylation promotes the neovascularization in active proliferative diabetic retinopathy.
DKK3's protective role in prostate cancer is partly due to the modulation of immune-related pathways.
Endometrial extracellular matrix components do not change over the course of embryonic diapause and reactivation in the roe deer (Capreolus capreolus).
Antigestagens Mediate the Expression of Decidualization Markers, Extracellular Matrix Factors and Connexin 43 in Decidualized Dog Uterine Stromal (DUS) Cells.
4D-quantitative proteomics signature of asthenozoospermia and identification of extracellular matrix protein 1 as a novel biomarker for sperm motility.
ECM1 modified HF-MSCs targeting HSC attenuate liver cirrhosis by inhibiting the TGF-β/Smad signaling pathway.
Global proteome profiling of human livers upon ischemia/reperfusion treatment.
ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma.
Canine decidualization in vitro: extracellular matrix modification, progesterone mediated effects and selective blocking of prostaglandin E2 receptors.
miR-23a-5p inhibits cell proliferation and invasion in pancreatic ductal adenocarcinoma by suppressing ECM1 expression.
MiR-92a antagonized the facilitation effect of extracellular matrix protein 1 in GC metastasis through targeting its 3'UTR region.
Uterine and placental distribution of selected extracellular matrix (ECM) components in the dog.
Extracellular matrix protein 1 promotes cell metastasis and glucose metabolism by inducing integrin β4/FAK/SOX2/HIF-1α signaling pathway in gastric cancer.
Spatial Control of Primary Ciliogenesis by Subdistal Appendages Alters Sensation-Associated Properties of Cilia.
ECM1 promotes migration and invasion of hepatocellular carcinoma by inducing epithelial-mesenchymal transition.
Differential expression of connective tissue growth factor and extracellular matrix proteins in lichen sclerosus.
Effects of dehydroepiandrosterone on proliferation, migration, and death of breast cancer cells.
Extracellular matrix protein 1, a novel prognostic factor, is associated with metastatic potential of hepatocellular carcinoma.
Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin.
Quantitative proteomic analysis by iTRAQ(R) for the identification of candidate biomarkers in ovarian cancer serum.
Expression of extracellular matrix proteins in reticular variant of mid-dermal elastolysis.
ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain.
Liu Z, Su W, Li X, Guo L, Gao W
Free radical biology & medicine 2026 May;248:127-142
Free radical biology & medicine 2026 May;248:127-142
Nobiletin and polydatin synergistically alleviate triple-negative breast cancer liver metastasis via suppressing ECM1a-mediated fatty acid biosynthesis.
Wang J, Liu WW, Huang QL, Ning HJ, Wang JY, Han XH
Acta pharmacologica Sinica 2026 Mar;47(3):735-749
Acta pharmacologica Sinica 2026 Mar;47(3):735-749
A comprehensive analysis of supermere, exomere, and extracellular vesicle isolation and cargo in colorectal cancer.
Tutanov OS, Massick C, Ramirez M, Higginbotham JN, Jimenez L, Castleberry M, Cao Z, John E, Hamilton MS, Zhang Q, Jeppesen DK, Michell DL, Glass SE, Patel P, Rose KL, Krystofiak E, Chen HC, Sheng Q, Liu Q, Patton JG, Weaver AM, Franklin JL, Vickers KC, Coffey RJ
Cell reports 2025 Oct 28;44(10):116287
Cell reports 2025 Oct 28;44(10):116287
Liver metastasis or peritoneal metastasis: single-cell RNA sequencing reveals the organotropism in colorectal cancer is driven by distinct partial-EMT processes.
Yu C, Lu W, Wu J, Fang X, Wang X, Zhang G, Chen S, Mei Y, Chen H, Ye F, Yang H, Qian Y, Kong X, Zhang P, Wang J, Guo G, Ding K
Cancer letters 2025 Oct 1;629:217880
Cancer letters 2025 Oct 1;629:217880
Crip2 affects vascular development by fine-tuning endothelial cell aggregation and proliferation.
Yang S, Zhang X, Li X, Li H
Cellular and molecular life sciences : CMLS 2025 Mar 13;82(1):110
Cellular and molecular life sciences : CMLS 2025 Mar 13;82(1):110
Osteoblast-Derived ECM1 Promotes Anti-Androgen Resistance in Bone Metastatic Prostate Cancer.
Wang X, Wang M, Lin Q, He L, Zhang B, Chen X, Chen G, Du H, Lang C, Peng X, Dai Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2407662
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2407662
TRPV4 drives the progression of leiomyosarcoma by promoting ECM1 generation and co-activating the FAK/PI3K/AKT/GSK3β pathway.
Zhou Q, You Y, Zhao Y, Xiao S, Song Z, Huang C, Qian J, Lu W, Tong H, Zhang Y, Wang Z, Li W, Zhang C, Guo X, Luo R, Hou Y, Cui J, Lu L, Zhou Y
Cellular oncology (Dordrecht, Netherlands) 2025 Apr;48(2):455-470
Cellular oncology (Dordrecht, Netherlands) 2025 Apr;48(2):455-470
Mechanistic study of celastrol-mediated inhibition of proinflammatory activation of macrophages in IgA nephropathy via down-regulating ECM1.
Zhao J, Liu H, Chen Q, Xia M, Wan L, Yu W, Liu C, Hao X, Tang C, Chen G, Liu Y, Yuan F, Liu H
International journal of biological sciences 2024;20(14):5731-5746
International journal of biological sciences 2024;20(14):5731-5746
Establishment of a tumor-associated fibroblast associated gene score based on scRNA-seq to predict prognosis in patients with triple-negative breast cancer.
Yu H, Peng Z, Li X, Zhang Y
PloS one 2024;19(10):e0311801
PloS one 2024;19(10):e0311801
ECM1 and ANXA1 in urinary extracellular vesicles serve as biomarkers for breast cancer.
Huang H, Wan J, Ao X, Qu S, Jia M, Zhao K, Liang J, Zen K, Liang H
Frontiers in oncology 2024;14:1408492
Frontiers in oncology 2024;14:1408492
Qizhu anticancer prescription enhances immunosurveillance of liver cancer cells by regulating p21-dependent secretory phenotypes.
Hu R, Li J, Huang Q, Zhong X, Sun J, Yi J, Peng L, Liu X, Yang Y, Yang W, Wang Y, Ma W, Feng W, Xu Y, Zhou X
Journal of ethnopharmacology 2024 Oct 28;333:118400
Journal of ethnopharmacology 2024 Oct 28;333:118400
TET2-mediated ECM1 hypomethylation promotes the neovascularization in active proliferative diabetic retinopathy.
Cai C, Gu C, He S, Meng C, Lai D, Zhang J, Qiu Q
Clinical epigenetics 2024 Jan 3;16(1):6
Clinical epigenetics 2024 Jan 3;16(1):6
DKK3's protective role in prostate cancer is partly due to the modulation of immune-related pathways.
Shareef ZA, Hachim MY, Talaat IM, Bhamidimarri PM, Ershaid MNA, Ilce BY, Venkatachalam T, Eltayeb A, Hamoudi R, Hachim IY
Frontiers in immunology 2023;14:978236
Frontiers in immunology 2023;14:978236
Endometrial extracellular matrix components do not change over the course of embryonic diapause and reactivation in the roe deer (Capreolus capreolus).
Rüegg AB, Kowalewski MP, Ulbrich SE
Reproduction in domestic animals = Zuchthygiene 2023 May;58(5):594-604
Reproduction in domestic animals = Zuchthygiene 2023 May;58(5):594-604
Antigestagens Mediate the Expression of Decidualization Markers, Extracellular Matrix Factors and Connexin 43 in Decidualized Dog Uterine Stromal (DUS) Cells.
Kazemian A, Tavares Pereira M, Hoffmann B, Kowalewski MP
Animals : an open access journal from MDPI 2022 Mar 22;12(7)
Animals : an open access journal from MDPI 2022 Mar 22;12(7)
4D-quantitative proteomics signature of asthenozoospermia and identification of extracellular matrix protein 1 as a novel biomarker for sperm motility.
Yang J, Liu Q, Yu B, Han B, Yang B
Molecular omics 2022 Jan 17;18(1):83-91
Molecular omics 2022 Jan 17;18(1):83-91
ECM1 modified HF-MSCs targeting HSC attenuate liver cirrhosis by inhibiting the TGF-β/Smad signaling pathway.
Liu Q, Lv C, Huang Q, Zhao L, Sun X, Ning D, Liu J, Jiang Y, Jin S
Cell death discovery 2022 Feb 8;8(1):51
Cell death discovery 2022 Feb 8;8(1):51
Global proteome profiling of human livers upon ischemia/reperfusion treatment.
Cai H, Qi S, Yan Q, Ling J, Du J, Chen L
Clinical proteomics 2021 Jan 6;18(1):3
Clinical proteomics 2021 Jan 6;18(1):3
ROBO2 hampers malignant biological behavior and predicts a better prognosis in pancreatic adenocarcinoma.
Ding C, Li Y, Wang S, Xing C, Chen L, Zhang H, Wang Y, Dai M
Scandinavian journal of gastroenterology 2021 Aug;56(8):955-964
Scandinavian journal of gastroenterology 2021 Aug;56(8):955-964
Canine decidualization in vitro: extracellular matrix modification, progesterone mediated effects and selective blocking of prostaglandin E2 receptors.
Graubner FR, Tavares Pereira M, Boos A, Kowalewski MP
The Journal of reproduction and development 2020 Aug 20;66(4):319-329
The Journal of reproduction and development 2020 Aug 20;66(4):319-329
miR-23a-5p inhibits cell proliferation and invasion in pancreatic ductal adenocarcinoma by suppressing ECM1 expression.
Huang W, Huang Y, Gu J, Zhang J, Yang J, Liu S, Xie C, Fan Y, Wang H
American journal of translational research 2019;11(5):2983-2994
American journal of translational research 2019;11(5):2983-2994
MiR-92a antagonized the facilitation effect of extracellular matrix protein 1 in GC metastasis through targeting its 3'UTR region.
Liu LQ, Hu L, Hu XB, Xu J, Wu AM, Chen H, Gu PY, Hu SL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 Nov;133:110779
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2019 Nov;133:110779
Uterine and placental distribution of selected extracellular matrix (ECM) components in the dog.
Graubner FR, Boos A, Aslan S, Kücükaslan I, Kowalewski MP
Reproduction (Cambridge, England) 2018 May;155(5):403-421
Reproduction (Cambridge, England) 2018 May;155(5):403-421
Extracellular matrix protein 1 promotes cell metastasis and glucose metabolism by inducing integrin β4/FAK/SOX2/HIF-1α signaling pathway in gastric cancer.
Gan L, Meng J, Xu M, Liu M, Qi Y, Tan C, Wang Y, Zhang P, Weng W, Sheng W, Huang M, Wang Z
Oncogene 2018 Feb 8;37(6):744-755
Oncogene 2018 Feb 8;37(6):744-755
Spatial Control of Primary Ciliogenesis by Subdistal Appendages Alters Sensation-Associated Properties of Cilia.
Mazo G, Soplop N, Wang WJ, Uryu K, Tsou MF
Developmental cell 2016 Nov 21;39(4):424-437
Developmental cell 2016 Nov 21;39(4):424-437
ECM1 promotes migration and invasion of hepatocellular carcinoma by inducing epithelial-mesenchymal transition.
Chen H, Jia W, Li J
World journal of surgical oncology 2016 Jul 27;14(1):195
World journal of surgical oncology 2016 Jul 27;14(1):195
Differential expression of connective tissue growth factor and extracellular matrix proteins in lichen sclerosus.
Gambichler T, Skrygan M, Czempiel V, Tigges C, Kobus S, Meier JJ, Köhler CU, Scola N, Stücker M, Altmeyer P, Kreuter A
Journal of the European Academy of Dermatology and Venereology : JEADV 2012 Feb;26(2):207-12
Journal of the European Academy of Dermatology and Venereology : JEADV 2012 Feb;26(2):207-12
Effects of dehydroepiandrosterone on proliferation, migration, and death of breast cancer cells.
López-Marure R, Contreras PG, Dillon JS
European journal of pharmacology 2011 Jun 25;660(2-3):268-74
European journal of pharmacology 2011 Jun 25;660(2-3):268-74
Extracellular matrix protein 1, a novel prognostic factor, is associated with metastatic potential of hepatocellular carcinoma.
Chen H, Jia WD, Li JS, Wang W, Xu GL, Ma JL, Ren WH, Ge YS, Yu JH, Liu WB, Zhang CH, Wang YC
Medical oncology (Northwood, London, England) 2011 Dec;28 Suppl 1:S318-25
Medical oncology (Northwood, London, England) 2011 Dec;28 Suppl 1:S318-25
Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin.
Merregaert J, Van Langen J, Hansen U, Ponsaerts P, El Ghalbzouri A, Steenackers E, Van Ostade X, Sercu S
The Journal of biological chemistry 2010 Nov 26;285(48):37823-37
The Journal of biological chemistry 2010 Nov 26;285(48):37823-37
Quantitative proteomic analysis by iTRAQ(R) for the identification of candidate biomarkers in ovarian cancer serum.
Boylan KL, Andersen JD, Anderson LB, Higgins L, Skubitz AP
Proteome science 2010 Jun 14;8:31
Proteome science 2010 Jun 14;8:31
Expression of extracellular matrix proteins in reticular variant of mid-dermal elastolysis.
Gambichler T, Stücker M, Kreuter A, Matip R, Gaifullina R, Scola N, Skrygan M
Journal of the European Academy of Dermatology and Venereology : JEADV 2010 Dec;24(12):1481-4
Journal of the European Academy of Dermatology and Venereology : JEADV 2010 Dec;24(12):1481-4
ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain.
Sercu S, Lambeir AM, Steenackers E, El Ghalbzouri A, Geentjens K, Sasaki T, Oyama N, Merregaert J
Matrix biology : journal of the International Society for Matrix Biology 2009 Apr;28(3):160-9
Matrix biology : journal of the International Society for Matrix Biology 2009 Apr;28(3):160-9
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 11521-1-AP(ECM1 antibody) at dilution of 1:1500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human thyroid cancer using 11521-1-AP(ECM1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ECM1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ECM1. This antibody recognizes human,mouse,rat antigen. The ECM1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
