11231-1-AP

antibody from Proteintech Group

Targeting: SETDB1 ESET, KG1T, KIAA0067, KMT1E, TDRD21

Provider product page for 11231-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [77]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]
Immunohistochemistry [2]

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Product number: 11231-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11231-1-AP, RRID:AB_2186069
Product name: SETDB1 antibody
Antibody type: Polyclonal
Description: KD/KO validated SETDB1 antibody (Cat. #11231-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SETDB1 protein structure - 11231-1-AP shown in red.

Submitted references SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer.

Shi MY, Wang Y, Shi Y, Tian R, Chen X, Zhang H, Wang K, Chen Z, Chen R
Genes & diseases 2024 Mar;11(2):978-992

Discovery of an efficacious KDM5B PROTAC degrader GT-653 up-regulating IFN response genes in prostate cancer.

Guan T, Zhang Y, Li S, Zhang W, Song Y, Li Y, He Y, Chen Y
European journal of medicinal chemistry 2024 Jun 5;272:116494

DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks.

Pinto LM, Pailas A, Bondarchenko M, Sharma AB, Neumann K, Rizzo AJ, Jeanty C, Nicot N, Racca C, Graham MK, Naughton C, Liu Y, Chen CL, Meakin PJ, Gilbert N, Britton S, Meeker AK, Heaphy CM, Larminat F, Van Dyck E
Nucleic acids research 2024 Feb 9;52(3):1136-1155

SETDB1 promotes progression through upregulation of SF3B4 expression and regulates the immunity in ovarian cancer.

Yang H, Sui L, Cai C, Chu H, Diao Y
Journal of ovarian research 2024 Feb 5;17(1):34

Cytoplasmic localization of SETDB1‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma.

Yang W, Wei Y, Wang T, Xu Y, Jin X, Qian H, Yang S, He S
International journal of molecular medicine 2024 Apr;53(4)

SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis.

Shen Y, Cheng L, Xu M, Wang W, Wan Z, Xiong H, Guo W, Cai M, Xu F
Metabolism: clinical and experimental 2023 Sep;146:155657

ATM, KAP1 and the Epstein-Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication.

Xu H, Akinyemi IA, Haley J, McIntosh MT, Bhaduri-McIntosh S
Nucleic acids research 2023 Nov 10;51(20):11104-11122

Mechanism of SUMOylation-Mediated Regulation of Type I IFN Expression.

Du L, Liu W, Rosen ST, Chen Y
Journal of molecular biology 2023 Mar 1;435(5):167968

Nucleoporin Seh1 maintains Schwann cell homeostasis by regulating genome stability and necroptosis.

Wu M, Li M, Liu W, Yan M, Li L, Ding W, Nian X, Dai W, Sun D, Zhu Y, Huang Q, Lu X, Cai Z, Hong F, Li X, Zhang L, Liu Z, Mo W, Zhang X, Zhang L
Cell reports 2023 Jul 25;42(7):112802

Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons.

Liu Y, Hu L, Wu Z, Yuan K, Hong G, Lian Z, Feng J, Li N, Li D, Wong J, Chen J, Liu M, He J, Pang X
Nature communications 2023 Jul 15;14(1):4225

Histone methyltransferase Setdb1 mediates osteogenic differentiation by suppressing the expression of miR-212-3p under mechanical unloading.

Zhang L, Xu L, Wang Y, Zhang X, Xue T, Sun Q, Tang H, Li M, Cao X, Shi F, Zhang G, Zhang S, Hu Z
Cellular signalling 2023 Feb;102:110554

Atf7ip Inhibits Osteoblast Differentiation via Negative Regulation of the Sp7 Transcription Factor.

Hu G, Shi X, Qu X, Han C, Hu A, Jia Z, Yang J, Liu H, Wu Y
International journal of molecular sciences 2023 Feb 21;24(5)

CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer.

Meng X, Xiao W, Sun J, Li W, Yuan H, Yu T, Zhang X, Dong W
Cancer letters 2023 Feb 1;554:216023

ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis.

Shao Q, Zhang Y, Liu Y, Shang Y, Li S, Liu L, Wang G, Zhou X, Wang P, Gao J, Zhou J, Zhang L, Wang S
Cell reports 2023 Aug 29;42(8):112953

POGZ suppresses 2C transcriptional program and retrotransposable elements.

Sun X, Zhang T, Tong B, Cheng L, Jiang W, Sun Y
Cell reports 2023 Aug 29;42(8):112867

DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network.

Carraro M, Hendriks IA, Hammond CM, Solis-Mezarino V, Völker-Albert M, Elsborg JD, Weisser MB, Spanos C, Montoya G, Rappsilber J, Imhof A, Nielsen ML, Groth A
Molecular cell 2023 Apr 6;83(7):1075-1092.e9

Functional dissection of N-terminal nuclear trafficking signals of SETDB1.

Eom J, Jeon K, Park JS, Kang YK
Frontiers in cell and developmental biology 2022;10:1069765

Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation.

Abe H, Yeh YH, Munakata Y, Ishiguro KI, Andreassen PR, Namekawa SH
Nature communications 2022 Nov 28;13(1):7212

Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation.

Aibara D, Takahashi S, Yagai T, Kim D, Brocker CN, Levi M, Matsusue K, Gonzalez FJ
iScience 2022 May 20;25(5):104196

The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents.

Zhang K, Chen S, Yang Q, Guo S, Chen Q, Liu Z, Li L, Jiang M, Li H, Hu J, Pan X, Deng W, Xiao N, Wang B, Wang ZX, Zhang L, Mo W
Nature communications 2022 Mar 17;13(1):1423

Nucleome programming is required for the foundation of totipotency in mammalian germline development.

Nagano M, Hu B, Yokobayashi S, Yamamura A, Umemura F, Coradin M, Ohta H, Yabuta Y, Ishikura Y, Okamoto I, Ikeda H, Kawahira N, Nosaka Y, Shimizu S, Kojima Y, Mizuta K, Kasahara T, Imoto Y, Meehan K, Stocsits R, Wutz G, Hiraoka Y, Murakawa Y, Yamamoto T, Tachibana K, Peters JM, Mirny LA, Garcia BA, Majewski J, Saitou M
The EMBO journal 2022 Jul 4;41(13):e110600

Genome surveillance by HUSH-mediated silencing of intronless mobile elements.

Seczynska M, Bloor S, Cuesta SM, Lehner PJ
Nature 2022 Jan;601(7893):440-445

Expression of SET domain bifurcated histone lysine methyltransferase 1 and its clinical prognostic significance in hepatocellular carcinoma.

Wang C, Xia Z, Li Z, Ye F, Ji S, Lu C, Zhang H
Journal of clinical laboratory analysis 2022 Jan;36(1):e24090

Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex.

Das A, Vijayan M, Walton EM, Stafford VG, Fiflis DN, Asokan A
Journal of virology 2022 Feb 23;96(4):e0203921

SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers.

Barral A, Pozo G, Ducrot L, Papadopoulos GL, Sauzet S, Oldfield AJ, Cavalli G, Déjardin J
Molecular cell 2022 Feb 17;82(4):816-832.e12

Coordinated regulation of microRNA genes in C19MC by SETDB1.

Jeon K, Eom J, Min B, Park JS, Kang YK
Biochemical and biophysical research communications 2022 Dec 31;637:17-22

Structure and functional mapping of the KRAB-KAP1 repressor complex.

Stoll GA, Pandiloski N, Douse CH, Modis Y
The EMBO journal 2022 Dec 15;41(24):e111179

Potential dual protective effects of melatonin on spermatogonia against hexavalent chromium.

Li T, Zheng Y, Li T, Guo M, Wu X, Liu R, Liu Q, You X, Zeng W, Lv Y
Reproductive toxicology (Elmsford, N.Y.) 2022 Aug;111:92-105

SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy.

Pan D, Bao X, Hu M, Jiao M, Li F, Li CY
Cancer research 2022 Aug 3;82(15):2748-2760

SETDB1 interactions with PELP1 contributes to breast cancer endocrine therapy resistance.

Liu Z, Liu J, Ebrahimi B, Pratap UP, He Y, Altwegg KA, Tang W, Li X, Lai Z, Chen Y, Shen L, Sareddy GR, Viswanadhapalli S, Tekmal RR, Rao MK, Vadlamudi RK
Breast cancer research : BCR 2022 Apr 8;24(1):26

HP1 maintains protein stability of H3K9 methyltransferases and demethylases.

Maeda R, Tachibana M
EMBO reports 2022 Apr 5;23(4):e53581

Linkage of methionine addiction, histone lysine hypermethylation, and malignancy.

Yamamoto J, Inubushi S, Han Q, Tashiro Y, Sugisawa N, Hamada K, Aoki Y, Miyake K, Matsuyama R, Bouvet M, Clarke SG, Endo I, Hoffman RM
iScience 2022 Apr 15;25(4):104162

KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements.

Zhang SM, Cai WL, Liu X, Thakral D, Luo J, Chan LH, McGeary MK, Song E, Blenman KRM, Micevic G, Jessel S, Zhang Y, Yin M, Booth CJ, Jilaveanu LB, Damsky W, Sznol M, Kluger HM, Iwasaki A, Bosenberg MW, Yan Q
Nature 2021 Oct;598(7882):682-687

KAP1-Mediated Epigenetic Suppression in Anti-RNA Viral Responses by Direct Targeting RIG-I and MDA5.

Li Q, Qin Y, Wang W, Jia M, Zhao W, Zhao C
Journal of immunology (Baltimore, Md. : 1950) 2021 Oct 1;207(7):1903-1910

The RNA m(6)A reader YTHDC1 silences retrotransposons and guards ES cell identity.

Liu J, Gao M, He J, Wu K, Lin S, Jin L, Chen Y, Liu H, Shi J, Wang X, Chang L, Lin Y, Zhao YL, Zhang X, Zhang M, Luo GZ, Wu G, Pei D, Wang J, Bao X, Chen J
Nature 2021 Mar;591(7849):322-326

METTL3 regulates heterochromatin in mouse embryonic stem cells.

Xu W, Li J, He C, Wen J, Ma H, Rong B, Diao J, Wang L, Wang J, Wu F, Tan L, Shi YG, Shi Y, Shen H
Nature 2021 Mar;591(7849):317-321

Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity.

Griffin GK, Wu J, Iracheta-Vellve A, Patti JC, Hsu J, Davis T, Dele-Oni D, Du PP, Halawi AG, Ishizuka JJ, Kim SY, Klaeger S, Knudsen NH, Miller BC, Nguyen TH, Olander KE, Papanastasiou M, Rachimi S, Robitschek EJ, Schneider EM, Yeary MD, Zimmer MD, Jaffe JD, Carr SA, Doench JG, Haining WN, Yates KB, Manguso RT, Bernstein BE
Nature 2021 Jul;595(7866):309-314

TRIM28 inhibits alternative lengthening of telomere phenotypes by protecting SETDB1 from degradation.

Wang C, Songyang Z, Huang Y
Cell & bioscience 2021 Jul 30;11(1):149

ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.

Ma L, Yu L, Jiang BC, Wang J, Guo X, Huang Y, Ren J, Sun N, Gao DS, Ding H, Lu J, Zhou H, Zou L, Gao Y, Wang L, Sun K, Ming Y, Meng Z, Tao YX, Yan M
The Journal of experimental medicine 2021 Dec 6;218(12)

Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing.

Mochizuki K, Sharif J, Shirane K, Uranishi K, Bogutz AB, Janssen SM, Suzuki A, Okuda A, Koseki H, Lorincz MC
Nature communications 2021 Dec 2;12(1):7020

METTL1-mediated m(7)G modification of Arg-TCT tRNA drives oncogenic transformation.

Orellana EA, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos DA, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes GJL, Fischer ES, Bradley A, Vassiliou GS, Slack FJ, Tzelepis K, Gregory RI
Molecular cell 2021 Aug 19;81(16):3323-3338.e14

ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection.

Cabral JM, Cushman CH, Sodroski CN, Knipe DM
PLoS pathogens 2021 Apr;17(4):e1009567

The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase.

Li X, Chen X, Liu Y, Zhang P, Zheng Y, Zeng W
Frontiers in genetics 2020;11:997

Defect of SLC38A3 promotes epithelial-mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.

Liu R, Hong R, Wang Y, Gong Y, Yeerken D, Yang D, Li J, Fan J, Chen J, Zhang W, Zhan Q
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 2020 Oct 31;32(5):547-563

PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.

He Z, Jing S, Yang T, Chen J, Huang F, Zhang W, Peng Z, Liu B, Ma X, Wu L, Pan T, Zhang X, Li L, Cai W, Tang X, Zhang J, Zhang H
Journal of virology 2020 May 4;94(10)

SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression.

Cao N, Yu Y, Zhu H, Chen M, Chen P, Zhuo M, Mao Y, Li L, Zhao Q, Wu M, Ye M
Cell death & disease 2020 May 11;11(5):351

DICER regulates the expression of major satellite repeat transcripts and meiotic chromosome segregation during spermatogenesis.

Yadav RP, Mäkelä JA, Hyssälä H, Cisneros-Montalvo S, Kotaja N
Nucleic acids research 2020 Jul 27;48(13):7135-7153

Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver.

Price AJ, Manjegowda MC, Kain J, Anandh S, Bochkis IM
Aging cell 2020 Feb;19(2):e13092

SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.

Ogawa S, Fukuda A, Matsumoto Y, Hanyu Y, Sono M, Fukunaga Y, Masuda T, Araki O, Nagao M, Yoshikawa T, Goto N, Hiramatsu Y, Tsuda M, Maruno T, Nakanishi Y, Hussein MS, Tsuruyama T, Takaori K, Uemoto S, Seno H
Gastroenterology 2020 Aug;159(2):682-696.e13

High SET Domain Bifurcated 1 (SETDB1) Expression Predicts Poor Prognosis in Breast Carcinoma.

Zhou Z, Wu B, Tang X, Yang W, Zou Q, Wang H
Medical science monitor : international medical journal of experimental and clinical research 2020 Apr 19;26:e922982

AFF3-DNA methylation interplay in maintaining the mono-allelic expression pattern of XIST in terminally differentiated cells.

Zhang Y, Wang C, Liu X, Yang Q, Ji H, Yang M, Xu M, Zhou Y, Xie W, Luo Z, Lin C
Journal of molecular cell biology 2019 Sep 19;11(9):761-769

SETDB1 induces epithelial‑mesenchymal transition in breast carcinoma by directly binding with Snail promoter.

Yang W, Su Y, Hou C, Chen L, Zhou D, Ren K, Zhou Z, Zhang R, Liu X
Oncology reports 2019 Feb;41(2):1284-1292

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.

Guo J, Dai X, Laurent B, Zheng N, Gan W, Zhang J, Guo A, Yuan M, Liu P, Asara JM, Toker A, Shi Y, Pandolfi PP, Wei W
Nature cell biology 2019 Feb;21(2):226-237

ATF7IP regulates SETDB1 nuclear localization and increases its ubiquitination.

Tsusaka T, Shimura C, Shinkai Y
EMBO reports 2019 Dec 5;20(12):e48297

SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States.

Cossec JC, Theurillat I, Chica C, Búa Aguín S, Gaume X, Andrieux A, Iturbide A, Jouvion G, Li H, Bossis G, Seeler JS, Torres-Padilla ME, Dejean A
Cell stem cell 2018 Nov 1;23(5):742-757.e8

Melatonin protects mouse spermatogonial stem cells against hexavalent chromium-induced apoptosis and epigenetic histone modification.

Lv Y, Zhang P, Guo J, Zhu Z, Li X, Xu D, Zeng W
Toxicology and applied pharmacology 2018 Feb 1;340:30-38

Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex.

Yurkovetskiy L, Guney MH, Kim K, Goh SL, McCauley S, Dauphin A, Diehl WE, Luban J
Nature microbiology 2018 Dec;3(12):1354-1361

SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice.

Hirota T, Blakeley P, Sangrithi MN, Mahadevaiah SK, Encheva V, Snijders AP, ElInati E, Ojarikre OA, de Rooij DG, Niakan KK, Turner JMA
Developmental cell 2018 Dec 3;47(5):645-659.e6

SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling.

Mochizuki K, Tando Y, Sekinaka T, Otsuka K, Hayashi Y, Kobayashi H, Kamio A, Ito-Matsuoka Y, Takehara A, Kono T, Osumi N, Matsui Y
Development (Cambridge, England) 2018 Dec 3;145(23)

Histone Methyltransferase SETDB1 Promotes the Progression of Colorectal Cancer by Inhibiting the Expression of TP53.

Chen K, Zhang F, Ding J, Liang Y, Zhan Z, Zhan Y, Chen LH, Ding Y
Journal of Cancer 2017;8(16):3318-3330

Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway.

Liu T, Chen X, Li T, Li X, Lyu Y, Fan X, Zhang P, Zeng W
Biochimica et biophysica acta. Gene regulatory mechanisms 2017 Oct;1860(10):1094-1102

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G, Kingston RE, Modis Y, Lehner PJ
Nature genetics 2017 Jul;49(7):1035-1044

A Histone Methyltransferase ESET Is Critical for T Cell Development.

Takikita S, Muro R, Takai T, Otsubo T, Kawamura YI, Dohi T, Oda H, Kitajima M, Oshima K, Hattori M, Endo TA, Toyoda T, Weis J, Shinkai Y, Suzuki H
Journal of immunology (Baltimore, Md. : 1950) 2016 Sep 15;197(6):2269-79

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Timms RT, Tchasovnikarova IA, Antrobus R, Dougan G, Lehner PJ
Cell reports 2016 Oct 11;17(3):653-659

Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA.

Sharif J, Endo TA, Nakayama M, Karimi MM, Shimada M, Katsuyama K, Goyal P, Brind'Amour J, Sun MA, Sun Z, Ishikura T, Mizutani-Koseki Y, Ohara O, Shinkai Y, Nakanishi M, Xie H, Lorincz MC, Koseki H
Cell stem cell 2016 Jul 7;19(1):81-94

Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype.

Daxinger L, Oey H, Isbel L, Whitelaw NC, Youngson NA, Spurling A, Vonk KK, Whitelaw E
Scientific reports 2016 Apr 26;6:25004

SETDB1 accelerates tumourigenesis by regulating the WNT signalling pathway.

Sun QY, Ding LW, Xiao JF, Chien W, Lim SL, Hattori N, Goodglick L, Chia D, Mah V, Alavi M, Kim SR, Doan NB, Said JW, Loh XY, Xu L, Liu LZ, Yang H, Hayano T, Shi S, Xie D, Lin DC, Koeffler HP
The Journal of pathology 2015 Mar;235(4):559-70

KMT1E-mediated chromatin modifications at the FcγRIIb promoter regulate thymocyte development.

Martin FJ, Xu Y, Lohmann F, Ciccone DN, Nicholson TB, Loureiro JJ, Chen T, Huang Q
Genes and immunity 2015 Mar;16(2):162-9

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

Tchasovnikarova IA, Timms RT, Matheson NJ, Wals K, Antrobus R, Göttgens B, Dougan G, Dawson MA, Lehner PJ
Science (New York, N.Y.) 2015 Jun 26;348(6242):1481-1485

The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes.

Collins PL, Kyle KE, Egawa T, Shinkai Y, Oltz EM
Proceedings of the National Academy of Sciences of the United States of America 2015 Jul 7;112(27):8367-72

Setdb1 is required for myogenic differentiation of C2C12 myoblast cells via maintenance of MyoD expression.

Song YJ, Choi JH, Lee H
Molecules and cells 2015 Apr;38(4):362-72

Reactivation of maternal SNORD116 cluster via SETDB1 knockdown in Prader-Willi syndrome iPSCs.

Cruvinel E, Budinetz T, Germain N, Chamberlain S, Lalande M, Martins-Taylor K
Human molecular genetics 2014 Sep 1;23(17):4674-85

The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice.

An J, Zhang X, Qin J, Wan Y, Hu Y, Liu T, Li J, Dong W, Du E, Pan C, Zeng W
Cell death & disease 2014 Apr 24;5(4):e1196

Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus.

Kera Y, Katoh Y, Ohta M, Matsumoto M, Takano-Yamamoto T, Igarashi K
The Journal of biological chemistry 2013 May 10;288(19):13592-601

Functional analysis of KAP1 genomic recruitment.

Iyengar S, Ivanov AV, Jin VX, Rauscher FJ 3rd, Farnham PJ
Molecular and cellular biology 2011 May;31(9):1833-47

ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes.

Frietze S, O'Geen H, Blahnik KR, Jin VX, Farnham PJ
PloS one 2010 Dec 8;5(12):e15082

SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state.

Bilodeau S, Kagey MH, Frampton GM, Rahl PB, Young RA
Genes & development 2009 Nov 1;23(21):2484-9

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: MCF7 cells were subjected to SDS PAGE followed by western blot with 11231-1-AP(SETDB1 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-SETDB1 (IP:11231-1-AP, 3ug; Detection:11231-1-AP 1:1000) with MCF-7 cells lysate 2500ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human testis using 11231-1-AP(SETDB1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SETDB1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SETDB1. This antibody recognizes human, mouse antigen. The SETDB1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
Appendix: 11231-1-AP.pdf

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