HPA027262

antibody from Atlas Antibodies

Targeting: CERS2 FLJ10243, LASS2, SP260

Western blot (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA027262

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA027262, RRID:AB_1852717

Product name

Anti-CERS2

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human CERS2, Gene description: ceramide synthase 2, Alternative Gene Names: FLJ10243, LASS2, SP260, Validated applications: IHC, ICC, WB, Uniprot ID: Q96G23, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.3 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Cholesterol-dependent homeostatic regulation of very long chain sphingolipid synthesis

Kim Y, Mavodza G, Senkal C, Burd C
Journal of Cell Biology 2023;222(12)

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Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer

Kim S, Seo I, Kim M, Park J, Kim S, Park W
Lipids in Health and Disease 2023;22(1)

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LASP1, CERS6, and Actin Form a Ternary Complex That Promotes Cancer Cell Migration

Niimi A, Limsirichaikul S, Kano K, Mizutani Y, Takeuchi T, Sawangsri P, Tran D, Kawamoto Y, Suzuki M
Cancers 2023;15(10):2781

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Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death

Schmidt S, Gallego S, Zelnik I, Kovalchuk S, Albæk N, Sprenger R, Øverup C, Pewzner-Jung Y, Futerman A, Lindholm M, Jensen O, Ejsing C
Molecular Therapy 2022;30(4):1661-1674

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Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer

Lee W, Maaß M, Quach A, Poscic N, Prangley H, Pallott E, Kim J, Pierce J, Ogretmen B, Futerman A, Thévenod F
Journal of Biological Chemistry 2022;298(2):101492

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Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study

Nicholson R, Poss A, Maschek J, Cox J, Hopkins P, Hunt S, Playdon M, Holland W, Summers S
The Journal of Clinical Endocrinology & Metabolism 2021;106(8):e3098-e3109

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Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis

Pathak D, Mehendale N, Singh S, Mallik R, Kamat S
ACS Chemical Biology 2018;13(8):2280-2287

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Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency

Spassieva S, Ji X, Liu Y, Gable K, Bielawski J, Dunn T, Bieberich E, Zhao L
Proceedings of the National Academy of Sciences 2016;113(21):5928-5933

Immunocytochemistry

Supportive validation

Submitted by

Atlas Antibodies (provider)

Main image

Experimental details

Immunofluorescent staining of human cell line A-431 shows localization to nuclear membrane & endoplasmic reticulum.

Sample type

Human