Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Immunocytochemistry [1]
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Validation data
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- Product number
- HPA027262 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA027262, RRID:AB_1852717
- Product name
- Anti-CERS2
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human CERS2, Gene description: ceramide synthase 2, Alternative Gene Names: FLJ10243, LASS2, SP260, Validated applications: IHC, ICC, WB, Uniprot ID: Q96G23, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.3 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Cholesterol-dependent homeostatic regulation of very long chain sphingolipid synthesis
Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer
LASP1, CERS6, and Actin Form a Ternary Complex That Promotes Cancer Cell Migration
Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death
Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer
Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study
Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis
Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency
Kim Y, Mavodza G, Senkal C, Burd C
Journal of Cell Biology 2023;222(12)
Journal of Cell Biology 2023;222(12)
Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer
Kim S, Seo I, Kim M, Park J, Kim S, Park W
Lipids in Health and Disease 2023;22(1)
Lipids in Health and Disease 2023;22(1)
LASP1, CERS6, and Actin Form a Ternary Complex That Promotes Cancer Cell Migration
Niimi A, Limsirichaikul S, Kano K, Mizutani Y, Takeuchi T, Sawangsri P, Tran D, Kawamoto Y, Suzuki M
Cancers 2023;15(10):2781
Cancers 2023;15(10):2781
Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death
Schmidt S, Gallego S, Zelnik I, Kovalchuk S, Albæk N, Sprenger R, Øverup C, Pewzner-Jung Y, Futerman A, Lindholm M, Jensen O, Ejsing C
Molecular Therapy 2022;30(4):1661-1674
Molecular Therapy 2022;30(4):1661-1674
Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer
Lee W, Maaß M, Quach A, Poscic N, Prangley H, Pallott E, Kim J, Pierce J, Ogretmen B, Futerman A, Thévenod F
Journal of Biological Chemistry 2022;298(2):101492
Journal of Biological Chemistry 2022;298(2):101492
Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study
Nicholson R, Poss A, Maschek J, Cox J, Hopkins P, Hunt S, Playdon M, Holland W, Summers S
The Journal of Clinical Endocrinology & Metabolism 2021;106(8):e3098-e3109
The Journal of Clinical Endocrinology & Metabolism 2021;106(8):e3098-e3109
Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis
Pathak D, Mehendale N, Singh S, Mallik R, Kamat S
ACS Chemical Biology 2018;13(8):2280-2287
ACS Chemical Biology 2018;13(8):2280-2287
Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency
Spassieva S, Ji X, Liu Y, Gable K, Bielawski J, Dunn T, Bieberich E, Zhao L
Proceedings of the National Academy of Sciences 2016;113(21):5928-5933
Proceedings of the National Academy of Sciences 2016;113(21):5928-5933
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescent staining of human cell line A-431 shows localization to nuclear membrane & endoplasmic reticulum.
- Sample type
- Human