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Protein structure
VPS72
Vacuolar protein sorting 72 homologSwc2, TCFL1, YL-1, YL1
The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Top validated antibodies |
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| LSBio |  LS-C800552 |
Polyclonal |
WB
EL
ICC
IHC
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| Proteintech Group | 15143-1-AP |
2 references | Polyclonal |
WB
EL
IP
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| Boster Biological Technology | A11502-1 |
Polyclonal |
WB
EL
ICC
IHC
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| Affinity Biosciences | AF0508 |
Polyclonal |
WB
EL
ICC
IHC
|
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| Cusabio Biotech Co., Ltd | CSB-PA050222 |
Polyclonal |
WB
EL
ICC
IHC
|
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