orb639539

antibody from Biorbyt
Targeting: RORC NR1F3, RORG, RZRG, TOR
Provider product page for orb639539
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
orb639539 - Provider product page
Provider
Biorbyt
Product name
RORC Antibody
Antibody type
Monoclonal
Description
This MAb recognizes a protein of 63kDa, identified as ROR-C. Its epitope maps in between aa1-50. The nuclear orphan receptors ROR alpha and ROR gamma are members of the nuclear hormone receptor superfamily. Members of this family act by directly associating with DNA sequences known as hormone response elements (HREs) and typically bind DNA as either homo- or heterodimers. RORalpha and RORgamma are unique in that they bind DNA as monomers. RORalpha has multiple isoforms that share common DNA and putative ligand-binding domains, but differ in their amino terminal domains, which are generated by alternative RNA processing. RORgamma comprises a 560 amino acid protein that shares 50% amino acid identity with RORalpha and is most highly expressed in skeletal muscle. Although these proteins are considered 'orphan receptors,' due to a lack of defined ligands, experimental evidence has shown that melatonin may be the natural ligand for these nuclear receptors.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
RORC/2941
Vial size
20 ug
Storage
Store the RORC antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
RORC protein structure - orb639539 shown in red.