AGTO-L080D

antibody from Creative Biolabs
Targeting: IL6R CD126
Provider product page for AGTO-L080D
Functional assay

Antibody data

Product number
AGTO-L080D - Provider product page
Provider
Creative Biolabs
Product name
IL6-DT immunotoxin
Antibody type
Monoclonal
Description
This immunotoxin was achieved by conjugating/fusing the IL6 to Diphtheriatoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to IL6 expressing cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of myeloma.
Reactivity
Human
Host
Human
IL6R protein structure - AGTO-L080D shown in red.