AGTO-L080E

antibody from Creative Biolabs
Targeting: IL6R CD126
Provider product page for AGTO-L080E
No application information provided.

Antibody data

Product number
AGTO-L080E - Provider product page
Provider
Creative Biolabs
Product name
IL6-PE immunotoxin
Antibody type
Monoclonal
Description
This immunotoxin was achieved by conjugating/fusing the IL6 to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to IL6 expressing cells and enters cells by receptor-mediated endocytosis, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treatment of myeloma.
Reactivity
Human
Host
Human
IL6R protein structure - AGTO-L080E shown in red.