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Other assayAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Other assay [1]
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- Product number
- BMS135 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD126 Monoclonal Antibody (B-R6), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: Recognizes soluble and membranous human IL-6R. This Antibody has been shown to inhibit IL-6 mediated proliferation of XG-1 cells, and partially blocks binding of IL-6 to its receptor. BMS135 is applicable for FACS analysis
- Antibody clone number
- B-R6
- Concentration
- 0.1 mg/mL
Submitted references Secreted KIAA1199 promotes the progression of rheumatoid arthritis by mediating hyaluronic acid degradation in an ANXA1-dependent manner.
Crohn's Disease Fibroblasts Overproduce the Novel Protein KIAA1199 to Create Proinflammatory Hyaluronan Fragments.
A new strategy to deliver synthetic protein drugs: self-reproducible biologics using minicircles.
Legionella pneumophila type II secretion dampens the cytokine response of infected macrophages and epithelia.
Zhang W, Yin G, Zhao H, Ling H, Xie Z, Xiao C, Chen Y, Lin Y, Jiang T, Jin S, Wang J, Yang X
Cell death & disease 2021 Jan 20;12(1):102
Cell death & disease 2021 Jan 20;12(1):102
Crohn's Disease Fibroblasts Overproduce the Novel Protein KIAA1199 to Create Proinflammatory Hyaluronan Fragments.
Soroosh A, Albeiroti S, West GA, Willard B, Fiocchi C, de la Motte CA
Cellular and molecular gastroenterology and hepatology 2016 May;2(3):358-368.e4
Cellular and molecular gastroenterology and hepatology 2016 May;2(3):358-368.e4
A new strategy to deliver synthetic protein drugs: self-reproducible biologics using minicircles.
Yi H, Kim Y, Kim J, Jung H, Rim YA, Jung SM, Park SH, Ju JH
Scientific reports 2014 Aug 5;4:5961
Scientific reports 2014 Aug 5;4:5961
Legionella pneumophila type II secretion dampens the cytokine response of infected macrophages and epithelia.
McCoy-Simandle K, Stewart CR, Dao J, DebRoy S, Rossier O, Bryce PJ, Cianciotto NP
Infection and immunity 2011 May;79(5):1984-97
Infection and immunity 2011 May;79(5):1984-97
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- Invitrogen Antibodies (provider)
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- Experimental details
- Fig. 6 IL-6 promotes KIAA1199 expression through the PI3K/Akt/NF-kappaB signaling pathway in RA FLS. A - D Relative mRNA expression of KIAA1199 in FLS from healthy subjects ( n = 9) stimulated without (Control) or with 1 and 5 ng/ml TNF-alpha ( A ), IL-1beta ( B ), IL-6 ( C ), and TGF-beta1 ( D ), respectively. E - G Inhibitory effect of IL-6R blocking mAb on the expression of KIAA1199 mRNA ( E ), protein ( F ) in FLS from RA patients ( n = 9), and the formation of LMW-HA in the medium ( G ). H Western blot analysis of cytoplasmic PI3K, p-Akt, toatl-Akt, p-STAT3, total-STAT3, and intranuclear p-P65 in RA FLS stimulated with 5 ng/ml IL-6 at 0, 15, 30 min. I Effect of ly294002, GSK690693, and Stattic on the mRNA expression of KIAA1199 in response to 1 ng/ml IL-6. J , K Effect of siRNA knockdown of PI3K ( J ) and STAT3 ( K ) on the protein expression of KIAA1199 in RA FLS stimulated without or with 1 ng/ml IL-6. All reactions were conducted in triplicate and the data were presented with mean +- SD.
