RA0405

antibody from Oursmab

Targeting: IL6R CD126

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0405

Provider

Oursmab

Product name

Levilimab (Biosimilar Reference Antibody) (IL6R)

Antibody type

Monoclonal

Description

Levilimab (also known as BCD-089) is a human monoclonal antibody that functions as an inhibitor of the interleukin-6 receptor (IL-6R). By binding to both soluble and membrane-bound forms of IL-6R, it blocks the interaction between the receptor and its cytokine, interleukin-6 (IL-6). This inhibition prevents downstream pro-inflammatory signaling through the JAK/STAT pathway, thereby reducing the cytokine storm and systemic inflammation. It is approved in Russia for the treatment of moderate-to-severe COVID-19 pneumonia in adults, specifically for those requiring supplemental oxygen, and has also been investigated for autoimmune conditions such as rheumatoid arthritis.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.