Antibody data
- Antibody Data
- Antigen structure
- References [58]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 23457-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- IL-6R antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IL-6R antibody (Cat. #23457-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cordycepin Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Inhibiting IL-6/IL-6R-Mediated p38 MAPK and NF-κB Activation Through Adenosine A(2A) Receptor Stimulation.
Daucosterol ameliorates acute inflammation and fibrosis following myocardial infarction via regulation of the ZBTB16 protein.
Temporal Effects of Disease Signature Genes and Core Mechanisms in the Hyperacute Phase of Acute Ischemic Stroke: A Bioinformatics Analysis and Experimental Validation.
TGF-β-Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization.
Integrative genetic and multi-omics analysis reveals the interleukin-6 receptor's role in recurrent spontaneous abortion.
Targeting CIRP and IL-6R-mediated microglial inflammation to improve outcomes in intracerebral hemorrhage.
The impact of STAiR18 on multiple myeloma survival rates.
A dual gene-activated dermal scaffolds loaded with nanocomposite particles expressing of VEGF and aFGF: Promoting wound healing by early vascularization.
Impact of adolescent high-fat diet and psychosocial stress on neuroendocrine stress responses and binge eating behavior in adult male Lewis rats.
Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics.
Spinal ADAM17 contributes to the pathogenesis of painful diabetic neuropathy in leptin receptor-deficient mice.
Inhibition of stemness and PD-L1 expression by Pien Tze Huang enhances T cell-mediated killing of colorectal cancer.
Macrophage membrane functionalized composite microspheres promote bone regeneration in periodontitis via manipulating inflammation reversing-osteogenesis coupling.
Macrophage-mimetic liposomes co-delivering ceria and Ac2-26 peptide for penumbra protection in ischemic stroke.
A chimeric peptide promotes immune surveillance of senescent cells in injury, fibrosis, tumorigenesis and aging.
Long intergenic non-coding RNA 01126 activates IL-6/JAK2/STAT3 pathway to promote periodontitis pathogenesis.
Cold atmospheric plasma restores skewed macrophage polarization in triple negative breast cancers via enhancing KAT6A acetylation.
Dan-Shen-Yin against alcohol-induced gastric injury in rats by inhibiting apoptosis via IP3R-controlled calcium release.
Physically engineered extracellular vesicles targeted delivering miR-21-5p to promote renoprotection after renal ischemia-reperfusion injury.
Distinctive genes and signaling pathways associated with type 2 diabetes-related periodontitis: Preliminary study.
Ginsenoside Rh2 regulates triple-negative breast cancer proliferation and apoptosis via the IL-6/JAK2/STAT3 pathway.
Autologous cryo-shocked neutrophils enable targeted therapy of sepsis via broad-spectrum neutralization of pro-inflammatory cytokines and endotoxins.
Long non-coding RNA FKSG29 regulates oxidative stress and endothelial dysfunction in obstructive sleep apnea.
A bispecific nanosystem activates endogenous natural killer cells in the bone marrow for haematologic malignancies therapy.
Impact of adolescent high-fat diet and psychosocial stress on neuroendocrine stress responses and binge eating behavior in adult male Lewis rats.
Mesenchymal stem cells-derived IL-6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK-STAT3 signalling.
Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity.
Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats.
Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells.
Kuijieling decoction regulates the Treg/Th17 cell balance in ulcerative colitis through the RA/RARα signaling pathway.
Swimming upregulates APOL3 through regulating macrophage polarization to inhibit glycolysis and the development of melanoma.
Zishen Qingre Lishi Huayu Recipe May Ameliorate the Symptoms of PCOS Model Rats via Alleviating Systemic and Ovarian Inflammation.
Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice.
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Inhibition of PRMT1 alleviates sepsis-induced acute kidney injury in mice by blocking the TGF-β1 and IL-6 trans-signaling pathways.
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms.
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation.
Molecular and immune signatures, and pathological trajectories of fatal COVID-19 lungs defined by in situ spatial single-cell transcriptome analysis.
Ethanol extracts of Rhaponticum uniflorum (L.) DC inflorescence ameliorate LPS-mediated acute lung injury by alleviating inflammatory responses via the Nrf2/HO-1 signaling pathway.
Cancer cell intrinsic TIM-3 induces glioblastoma progression.
Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.
Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin.
Prevention of IL-6 signaling ameliorates toluene diisocyanate-induced steroid-resistant asthma.
Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis.
Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.
Chemerin promotes microangiopathy in diabetic retinopathy via activation of ChemR23 in rat primary microvascular endothelial cells.
Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved.
Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation.
Gelsolin Governs the Neuroendocrine Transdifferentiation of Prostate Cancer Cells and Suppresses the Apoptotic Machinery.
Cerebral Immunohistochemical Characterization of the H(2)S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma.
Upregulated MELK Leads to Doxorubicin Chemoresistance and M2 Macrophage Polarization via the miR-34a/JAK2/STAT3 Pathway in Uterine Leiomyosarcoma.
MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.
MicroRNA-34a deficiency leads to impaired wound closure by augmented inflammation in mice.
Nicotinamide N-Methyltransferase and Its Precursor Substrate Methionine Directly and Indirectly Control Malignant Metabolism During Progression of Renal Cell Carcinoma.
Human cancer cells suppress behaviors of endothelial progenitor cells through miR-21 targeting IL6R.
Inducible microRNA-590-5p inhibits host antiviral response by targeting the soluble interleukin-6 (IL6) receptor.
Death receptor 6 (DR6) is required for mouse B16 tumor angiogenesis via the NF-κB, P38 MAPK and STAT3 pathways.
Liao Y, Wei W, Qin F, Ruan Y, He T, He J, Wang M, Liu T, Chen J
Drug design, development and therapy 2026;20:575035
Drug design, development and therapy 2026;20:575035
Daucosterol ameliorates acute inflammation and fibrosis following myocardial infarction via regulation of the ZBTB16 protein.
Sheng S, Wu P, Wu C, Su H, Guo Z, Wang R, Li J, Duan Y, Zhang S, Ma L
British journal of pharmacology 2026 Jan;183(2):313-332
British journal of pharmacology 2026 Jan;183(2):313-332
Temporal Effects of Disease Signature Genes and Core Mechanisms in the Hyperacute Phase of Acute Ischemic Stroke: A Bioinformatics Analysis and Experimental Validation.
Ding PL, Zhang KX, Yao F, Cui WQ, Liu ZL, Wang YR, Wang XY, Liu W, Zhao HY, Wu HY, Wang YH, Xu XQ
Mediators of inflammation 2025;2025:6808184
Mediators of inflammation 2025;2025:6808184
TGF-β-Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization.
Ma W, Ma Y, Bai Y, Guo C, Zhang Q, Su X
Open medicine (Warsaw, Poland) 2025;20(1):20251279
Open medicine (Warsaw, Poland) 2025;20(1):20251279
Integrative genetic and multi-omics analysis reveals the interleukin-6 receptor's role in recurrent spontaneous abortion.
Ma W, Gu Z, Lin Q, Cao M, Zhong J, Li X, Li H, Lin Y, Lin H, Xu M, Liu J, Du L, Song G
Frontiers in immunology 2025;16:1659251
Frontiers in immunology 2025;16:1659251
Targeting CIRP and IL-6R-mediated microglial inflammation to improve outcomes in intracerebral hemorrhage.
Ye L, Tang X, Liu F, Wei T, Xu T, Jiang Z, Xu L, Xiang C, Yuan X, Shen L, Gu J, Luo Q, Wang G
Journal of advanced research 2025 Sep 9;
Journal of advanced research 2025 Sep 9;
The impact of STAiR18 on multiple myeloma survival rates.
Wu Y, Wang H, Luo J, Lin J, Wu Y, Zheng S, Gao Y, Chen J, Che F, Shi J, Zhong L
Journal of translational medicine 2025 Nov 7;23(1):1243
Journal of translational medicine 2025 Nov 7;23(1):1243
A dual gene-activated dermal scaffolds loaded with nanocomposite particles expressing of VEGF and aFGF: Promoting wound healing by early vascularization.
Wang J, Liu H, Liu M, Shen T, Weng T, He F, Wang X
International journal of biological macromolecules 2025 May;307(Pt 1):141831
International journal of biological macromolecules 2025 May;307(Pt 1):141831
Impact of adolescent high-fat diet and psychosocial stress on neuroendocrine stress responses and binge eating behavior in adult male Lewis rats.
Sierra J, Simon TB, Hilal DA, Torres YA, Santiago Santana JM, Figueroa JD
Hormones and behavior 2025 May;171:105744
Hormones and behavior 2025 May;171:105744
Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics.
Wang C, Feng Y, Liu X, Sun H, Guo Z, Shao J, Li K, Chen J, Shu K, Kong D, Wang J, Li Y, Lei X, Li C, Liu B, Sun W, Lai Z
BMC medicine 2025 May 1;23(1):254
BMC medicine 2025 May 1;23(1):254
Spinal ADAM17 contributes to the pathogenesis of painful diabetic neuropathy in leptin receptor-deficient mice.
Nemoto W, Yamagata R, Nakagawasai O, Hoshi T, Kobayashi R, Watanabe M, Tan-No K
Biochemical pharmacology 2025 Mar;233:116780
Biochemical pharmacology 2025 Mar;233:116780
Inhibition of stemness and PD-L1 expression by Pien Tze Huang enhances T cell-mediated killing of colorectal cancer.
Lu Q, Zhang Z, Liu S, Wang J, Yang X, Yan T, Yang Y, Chen X, Li L, Liu G, Du J, Cao Z
Journal of ethnopharmacology 2025 Mar 13;343:119447
Journal of ethnopharmacology 2025 Mar 13;343:119447
Macrophage membrane functionalized composite microspheres promote bone regeneration in periodontitis via manipulating inflammation reversing-osteogenesis coupling.
Song R, Wan Z, Yuan X, Wang N, Gao Y, Zhang L, Ren H, Jin Y, Liu X, Sang J, Yuan Z, Zhao Y
Materials today. Bio 2025 Jun;32:101789
Materials today. Bio 2025 Jun;32:101789
Macrophage-mimetic liposomes co-delivering ceria and Ac2-26 peptide for penumbra protection in ischemic stroke.
Bai L, Li N, Li H, Dai Y, Bai Y, Ma F, Sha D, Xia S, Xu Y, Cao X
Journal of nanobiotechnology 2025 Jul 5;23(1):488
Journal of nanobiotechnology 2025 Jul 5;23(1):488
A chimeric peptide promotes immune surveillance of senescent cells in injury, fibrosis, tumorigenesis and aging.
Ming X, Yang Z, Huang Y, Wang Z, Zhang Q, Lu C, Sun Y, Chen Y, Zhang L, Wu J, Shou H, Lu Z, Wang B
Nature aging 2025 Jan;5(1):28-47
Nature aging 2025 Jan;5(1):28-47
Long intergenic non-coding RNA 01126 activates IL-6/JAK2/STAT3 pathway to promote periodontitis pathogenesis.
Tang S, Zhong Y, Li J, Ji P, Zhang X
Oral diseases 2025 Jan;31(1):193-205
Oral diseases 2025 Jan;31(1):193-205
Cold atmospheric plasma restores skewed macrophage polarization in triple negative breast cancers via enhancing KAT6A acetylation.
Zhu K, Lv Q, Lu X, Wang Y, Dai X
Free radical biology & medicine 2025 Jan;226:364-373
Free radical biology & medicine 2025 Jan;226:364-373
Dan-Shen-Yin against alcohol-induced gastric injury in rats by inhibiting apoptosis via IP3R-controlled calcium release.
Zhou Z, Dong J, Lei P, Zhang Q, Jiang M
Journal of ethnopharmacology 2025 Feb 27;342:119413
Journal of ethnopharmacology 2025 Feb 27;342:119413
Physically engineered extracellular vesicles targeted delivering miR-21-5p to promote renoprotection after renal ischemia-reperfusion injury.
Wu D, Ma W, Wang L, Long C, Chen S, Liu J, Qian Y, Zhao J, Zhou C, Jia R
Materials today. Bio 2025 Apr;31:101528
Materials today. Bio 2025 Apr;31:101528
Distinctive genes and signaling pathways associated with type 2 diabetes-related periodontitis: Preliminary study.
Duarte PM, Gurgel BCV, Miranda TS, Sardenberg J, Gu T, Aukhil I
PloS one 2024;19(1):e0296925
PloS one 2024;19(1):e0296925
Ginsenoside Rh2 regulates triple-negative breast cancer proliferation and apoptosis via the IL-6/JAK2/STAT3 pathway.
Ding R, Kan Q, Wang T, Xiao R, Song Y, Li D
Frontiers in pharmacology 2024;15:1483896
Frontiers in pharmacology 2024;15:1483896
Autologous cryo-shocked neutrophils enable targeted therapy of sepsis via broad-spectrum neutralization of pro-inflammatory cytokines and endotoxins.
Gao Q, Yan Y, Zhang J, Li X, Wang J, Feng Y, Li P, Wang H, Zhang Y, He L, Shan Z, Li B
Frontiers in chemistry 2024;12:1359946
Frontiers in chemistry 2024;12:1359946
Long non-coding RNA FKSG29 regulates oxidative stress and endothelial dysfunction in obstructive sleep apnea.
Chen YC, Hsu PY, Su MC, Chen YL, Chang YT, Chin CH, Lin IC, Chen YM, Wang TY, Lin YY, Lee CP, Lin MC, Hsiao CC
Molecular and cellular biochemistry 2024 Oct;479(10):2723-2740
Molecular and cellular biochemistry 2024 Oct;479(10):2723-2740
A bispecific nanosystem activates endogenous natural killer cells in the bone marrow for haematologic malignancies therapy.
Zhang Y, Deng Y, Zhai Y, Li Y, Li Y, Li J, Gu Y, Li S
Nature nanotechnology 2024 Oct;19(10):1558-1568
Nature nanotechnology 2024 Oct;19(10):1558-1568
Impact of adolescent high-fat diet and psychosocial stress on neuroendocrine stress responses and binge eating behavior in adult male Lewis rats.
Sierra J, Simon TB, Hilal DA, Torres YA, Santana JMS, Figueroa JD
bioRxiv : the preprint server for biology 2024 Nov 14;
bioRxiv : the preprint server for biology 2024 Nov 14;
Mesenchymal stem cells-derived IL-6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK-STAT3 signalling.
Liu C, Zhou J, Zhang S, Fu J, Li Y, Hao Y, Yuan J, Tang F, Ge W, He H, Chen Q
Oral diseases 2024 May;30(4):2097-2109
Oral diseases 2024 May;30(4):2097-2109
Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity.
Zhu W, Lian N, Wang J, Zhao F, Liu B, Sheng J, Zhang C, Zhou X, Gao W, Xie C, Gu H, Zhang Y, Bian M, Jiang M, Li Y
Chinese medicine 2024 Jun 14;19(1):85
Chinese medicine 2024 Jun 14;19(1):85
Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats.
Gao C, Wang Q, Ding Y, Kwong CHT, Liu J, Xie B, Wei J, Lee SMY, Mok GSP, Wang R
Nature communications 2024 Jan 6;15(1):328
Nature communications 2024 Jan 6;15(1):328
Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells.
Blaszczak W, White B, Monterisi S, Swietach P
Cell reports 2024 Jan 23;43(1):113612
Cell reports 2024 Jan 23;43(1):113612
Kuijieling decoction regulates the Treg/Th17 cell balance in ulcerative colitis through the RA/RARα signaling pathway.
Xiao S, Yan Y, Shao M, Zhou X, Niu Z, Wu Y, Li Y, Cui Y, Long Y, Du Q
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116909
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116909
Swimming upregulates APOL3 through regulating macrophage polarization to inhibit glycolysis and the development of melanoma.
Lyu Z, Mahenderan A, Radhakrishnan AKGK, Chin YS, Yin C
3 Biotech 2024 Dec;14(12):307
3 Biotech 2024 Dec;14(12):307
Zishen Qingre Lishi Huayu Recipe May Ameliorate the Symptoms of PCOS Model Rats via Alleviating Systemic and Ovarian Inflammation.
Li X, Yi Y, Ren Y, Zhang Y, Wang CC, Liu C, Liu S, Zhan X, Yu X, Liang R
American journal of reproductive immunology (New York, N.Y. : 1989) 2024 Aug;92(2):e13918
American journal of reproductive immunology (New York, N.Y. : 1989) 2024 Aug;92(2):e13918
Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice.
Xia LX, Xiao YY, Jiang WJ, Yang XY, Tao H, Mandukhail SR, Qin JF, Pan QR, Zhu YG, Zhao LX, Huang LJ, Li Z, Yu XY
Acta pharmacologica Sinica 2024 Aug;45(8):1644-1659
Acta pharmacologica Sinica 2024 Aug;45(8):1644-1659
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Xie X, Wang K, Shen X, Li X, Wang S, Yuan S, Li B, Wang Z
Journal of hazardous materials 2024 Aug 15;475:134854
Journal of hazardous materials 2024 Aug 15;475:134854
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Xu L, Zeng Z, Niu C, Liu D, Lin S, Liu X, Szabó G, Lu J, Zheng S, Zhou P
Frontiers in cardiovascular medicine 2023;10:1126391
Frontiers in cardiovascular medicine 2023;10:1126391
Inhibition of PRMT1 alleviates sepsis-induced acute kidney injury in mice by blocking the TGF-β1 and IL-6 trans-signaling pathways.
Zhu Y, Wang L, Liu R, Ding X, Yin S, Chen Y, Zhu C, Wang Z, Li W
FEBS open bio 2023 Oct;13(10):1859-1873
FEBS open bio 2023 Oct;13(10):1859-1873
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms.
Jia N, Gao Y, Li M, Liang Y, Li Y, Lin Y, Huang S, Lin Q, Sun X, He Q, Yao Y, Zhang B, Zhang Z, Zhang L
Signal transduction and targeted therapy 2023 Jul 28;8(1):280
Signal transduction and targeted therapy 2023 Jul 28;8(1):280
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation.
Saha K, Subramenium Ganapathy A, Wang A, Arumugam P, Michael Morris N, Harris L, Yochum G, Koltun W, Perdew GH, Nighot M, Ma T, Nighot P
Mucosal immunology 2023 Dec;16(6):826-842
Mucosal immunology 2023 Dec;16(6):826-842
Molecular and immune signatures, and pathological trajectories of fatal COVID-19 lungs defined by in situ spatial single-cell transcriptome analysis.
Das A, Meng W, Liu Z, Hasib MM, Galloway H, Ramos da Silva S, Chen L, Sica GL, Paniz-Mondolfi A, Bryce C, Grimes Z, Sordillo EM, Cordon-Cardo C, Rivera KP, Flores M, Chiu YC, Huang Y, Gao SJ
Journal of medical virology 2023 Aug;95(8):e29009
Journal of medical virology 2023 Aug;95(8):e29009
Ethanol extracts of Rhaponticum uniflorum (L.) DC inflorescence ameliorate LPS-mediated acute lung injury by alleviating inflammatory responses via the Nrf2/HO-1 signaling pathway.
Zhen D, Liu C, Huang T, Fu D, Bai X, Ma Q, Jiang M, Gong G
Journal of ethnopharmacology 2022 Oct 5;296:115497
Journal of ethnopharmacology 2022 Oct 5;296:115497
Cancer cell intrinsic TIM-3 induces glioblastoma progression.
Guo Q, Shen S, Guan G, Zhu C, Zou C, Cao J, Cheng W, Xu X, Yu J, Lin Z, Wang G, Chen L, Cheng P, Wu A
iScience 2022 Nov 18;25(11):105329
iScience 2022 Nov 18;25(11):105329
Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.
Huo Y, Yang J, Zheng J, Xu D, Yang M, Tao L, Yao H, Fu X, Yang J, Liu D, Hua R, Zhang J, Sun Y, Hu L, Liu W
Cell proliferation 2022 May;55(5):e13237
Cell proliferation 2022 May;55(5):e13237
Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin.
Wang L, Zhang T, Liu S, Mo Q, Jiang N, Chen Q, Yang J, Han YW, Chen JP, Huang FH, Li H, Zhou J, Luo JS, Wu JM
Pharmacological research 2022 Mar;177:106096
Pharmacological research 2022 Mar;177:106096
Prevention of IL-6 signaling ameliorates toluene diisocyanate-induced steroid-resistant asthma.
Chen S, Chen Z, Deng Y, Zha S, Yu L, Li D, Liang Z, Yang K, Liu S, Chen R
Allergology international : official journal of the Japanese Society of Allergology 2022 Jan;71(1):73-82
Allergology international : official journal of the Japanese Society of Allergology 2022 Jan;71(1):73-82
Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis.
Jin Y, Kang Y, Wang M, Wu B, Su B, Yin H, Tang Y, Li Q, Wei W, Mei Q, Hu G, Lukacs-Kornek V, Li J, Wu K, Yuan X, Wang W
Signal transduction and targeted therapy 2022 Feb 23;7(1):52
Signal transduction and targeted therapy 2022 Feb 23;7(1):52
Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.
Sha X, Dai Y, Chong L, Wei M, Xing M, Zhang C, Li J
Journal of nanobiotechnology 2022 Dec 1;20(1):506
Journal of nanobiotechnology 2022 Dec 1;20(1):506
Chemerin promotes microangiopathy in diabetic retinopathy via activation of ChemR23 in rat primary microvascular endothelial cells.
Jun L, Lin-Lin S, Hui S
Molecular vision 2021;27:575-587
Molecular vision 2021;27:575-587
Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved.
Zhang Z, Xue Z, Yang H, Zhao F, Liu C, Chen J, Lu S, Zou Z, Zhou Y, Zhang X
Food & function 2021 Mar 1;12(4):1803-1817
Food & function 2021 Mar 1;12(4):1803-1817
Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation.
Du W, Hua F, Li X, Zhang J, Li S, Wang W, Zhou J, Wang W, Liao P, Yan Y, Li G, Wei S, Grove S, Vatan L, Zgodziński W, Majewski M, Wallner G, Chen H, Kryczek I, Fang JY, Zou W
Cancer discovery 2021 Jul;11(7):1826-1843
Cancer discovery 2021 Jul;11(7):1826-1843
Gelsolin Governs the Neuroendocrine Transdifferentiation of Prostate Cancer Cells and Suppresses the Apoptotic Machinery.
Oelrich F, Junker H, Stope MB, Erb HHH, Walther R, Venz S, Zimmermann U
Anticancer research 2021 Aug;41(8):3717-3729
Anticancer research 2021 Aug;41(8):3717-3729
Cerebral Immunohistochemical Characterization of the H(2)S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma.
Denoix N, Merz T, Unmuth S, Hoffmann A, Nespoli E, Scheuerle A, Huber-Lang M, Gündel H, Waller C, Radermacher P, McCook O
Frontiers in neurology 2020;11:649
Frontiers in neurology 2020;11:649
Upregulated MELK Leads to Doxorubicin Chemoresistance and M2 Macrophage Polarization via the miR-34a/JAK2/STAT3 Pathway in Uterine Leiomyosarcoma.
Zhang Z, Sun C, Li C, Jiao X, Griffin BB, Dongol S, Wu H, Zhang C, Cao W, Dong R, Yang X, Zhang Q, Kong B
Frontiers in oncology 2020;10:453
Frontiers in oncology 2020;10:453
MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.
Yang QY, Yang KP, Li ZZ
The Kaohsiung journal of medical sciences 2020 Jan;36(1):20-26
The Kaohsiung journal of medical sciences 2020 Jan;36(1):20-26
MicroRNA-34a deficiency leads to impaired wound closure by augmented inflammation in mice.
Zhao N, Wang G, Long S, Hu M, Gao J, Ran X, Wang J, Su Y, Wang T
Annals of translational medicine 2020 Apr;8(7):447
Annals of translational medicine 2020 Apr;8(7):447
Nicotinamide N-Methyltransferase and Its Precursor Substrate Methionine Directly and Indirectly Control Malignant Metabolism During Progression of Renal Cell Carcinoma.
Holstein S, Venz S, Junker H, Walther R, Stope MB, Zimmermann U
Anticancer research 2019 Oct;39(10):5427-5436
Anticancer research 2019 Oct;39(10):5427-5436
Human cancer cells suppress behaviors of endothelial progenitor cells through miR-21 targeting IL6R.
Wang W, Yuan X, Xu A, Zhu X, Zhan Y, Wang S, Liu M
Microvascular research 2018 Nov;120:21-28
Microvascular research 2018 Nov;120:21-28
Inducible microRNA-590-5p inhibits host antiviral response by targeting the soluble interleukin-6 (IL6) receptor.
Zhou Y, Xia Z, Cheng Z, Xu G, Yang X, Liu S, Zhu Y
The Journal of biological chemistry 2018 Nov 23;293(47):18168-18179
The Journal of biological chemistry 2018 Nov 23;293(47):18168-18179
Death receptor 6 (DR6) is required for mouse B16 tumor angiogenesis via the NF-κB, P38 MAPK and STAT3 pathways.
Yang X, Shi B, Li L, Xu Z, Ge Y, Shi J, Liu Y, Zheng D
Oncogenesis 2016 Mar 7;5(3):e206
Oncogenesis 2016 Mar 7;5(3):e206
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The IL6R antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human IL6R. This antibody recognizes human, mouse antigen. The IL6R antibody has been validated for the following applications: ELISA, WB analysis.