Antibody data
- Antibody Data
- Antigen structure
- References [29]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 23457-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- IL-6R antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IL-6R antibody (Cat. #23457-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Distinctive genes and signaling pathways associated with type 2 diabetes-related periodontitis: Preliminary study.
Autologous cryo-shocked neutrophils enable targeted therapy of sepsis via broad-spectrum neutralization of pro-inflammatory cytokines and endotoxins.
Long non-coding RNA FKSG29 regulates oxidative stress and endothelial dysfunction in obstructive sleep apnea.
Mesenchymal stem cells-derived IL-6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK-STAT3 signalling.
Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells.
Kuijieling decoction regulates the Treg/Th17 cell balance in ulcerative colitis through the RA/RARα signaling pathway.
Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice.
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Inhibition of PRMT1 alleviates sepsis-induced acute kidney injury in mice by blocking the TGF-β1 and IL-6 trans-signaling pathways.
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms.
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation.
Molecular and immune signatures, and pathological trajectories of fatal COVID-19 lungs defined by in situ spatial single-cell transcriptome analysis.
Ethanol extracts of Rhaponticum uniflorum (L.) DC inflorescence ameliorate LPS-mediated acute lung injury by alleviating inflammatory responses via the Nrf2/HO-1 signaling pathway.
Cancer cell intrinsic TIM-3 induces glioblastoma progression.
Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.
Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin.
Prevention of IL-6 signaling ameliorates toluene diisocyanate-induced steroid-resistant asthma.
Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis.
Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.
Chemerin promotes microangiopathy in diabetic retinopathy via activation of ChemR23 in rat primary microvascular endothelial cells.
Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved.
Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation.
Gelsolin Governs the Neuroendocrine Transdifferentiation of Prostate Cancer Cells and Suppresses the Apoptotic Machinery.
Upregulated MELK Leads to Doxorubicin Chemoresistance and M2 Macrophage Polarization via the miR-34a/JAK2/STAT3 Pathway in Uterine Leiomyosarcoma.
MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.
MicroRNA-34a deficiency leads to impaired wound closure by augmented inflammation in mice.
Human cancer cells suppress behaviors of endothelial progenitor cells through miR-21 targeting IL6R.
Inducible microRNA-590-5p inhibits host antiviral response by targeting the soluble interleukin-6 (IL6) receptor.
Death receptor 6 (DR6) is required for mouse B16 tumor angiogenesis via the NF-κB, P38 MAPK and STAT3 pathways.
Duarte PM, Gurgel BCV, Miranda TS, Sardenberg J, Gu T, Aukhil I
PloS one 2024;19(1):e0296925
PloS one 2024;19(1):e0296925
Autologous cryo-shocked neutrophils enable targeted therapy of sepsis via broad-spectrum neutralization of pro-inflammatory cytokines and endotoxins.
Gao Q, Yan Y, Zhang J, Li X, Wang J, Feng Y, Li P, Wang H, Zhang Y, He L, Shan Z, Li B
Frontiers in chemistry 2024;12:1359946
Frontiers in chemistry 2024;12:1359946
Long non-coding RNA FKSG29 regulates oxidative stress and endothelial dysfunction in obstructive sleep apnea.
Chen YC, Hsu PY, Su MC, Chen YL, Chang YT, Chin CH, Lin IC, Chen YM, Wang TY, Lin YY, Lee CP, Lin MC, Hsiao CC
Molecular and cellular biochemistry 2024 Oct;479(10):2723-2740
Molecular and cellular biochemistry 2024 Oct;479(10):2723-2740
Mesenchymal stem cells-derived IL-6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK-STAT3 signalling.
Liu C, Zhou J, Zhang S, Fu J, Li Y, Hao Y, Yuan J, Tang F, Ge W, He H, Chen Q
Oral diseases 2024 May;30(4):2097-2109
Oral diseases 2024 May;30(4):2097-2109
Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells.
Blaszczak W, White B, Monterisi S, Swietach P
Cell reports 2024 Jan 23;43(1):113612
Cell reports 2024 Jan 23;43(1):113612
Kuijieling decoction regulates the Treg/Th17 cell balance in ulcerative colitis through the RA/RARα signaling pathway.
Xiao S, Yan Y, Shao M, Zhou X, Niu Z, Wu Y, Li Y, Cui Y, Long Y, Du Q
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116909
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116909
Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice.
Xia LX, Xiao YY, Jiang WJ, Yang XY, Tao H, Mandukhail SR, Qin JF, Pan QR, Zhu YG, Zhao LX, Huang LJ, Li Z, Yu XY
Acta pharmacologica Sinica 2024 Aug;45(8):1644-1659
Acta pharmacologica Sinica 2024 Aug;45(8):1644-1659
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Xu L, Zeng Z, Niu C, Liu D, Lin S, Liu X, Szabó G, Lu J, Zheng S, Zhou P
Frontiers in cardiovascular medicine 2023;10:1126391
Frontiers in cardiovascular medicine 2023;10:1126391
Inhibition of PRMT1 alleviates sepsis-induced acute kidney injury in mice by blocking the TGF-β1 and IL-6 trans-signaling pathways.
Zhu Y, Wang L, Liu R, Ding X, Yin S, Chen Y, Zhu C, Wang Z, Li W
FEBS open bio 2023 Oct;13(10):1859-1873
FEBS open bio 2023 Oct;13(10):1859-1873
Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms.
Jia N, Gao Y, Li M, Liang Y, Li Y, Lin Y, Huang S, Lin Q, Sun X, He Q, Yao Y, Zhang B, Zhang Z, Zhang L
Signal transduction and targeted therapy 2023 Jul 28;8(1):280
Signal transduction and targeted therapy 2023 Jul 28;8(1):280
Alpha-tocopherylquinone-mediated activation of the Aryl Hydrocarbon Receptor regulates the production of inflammation-inducing cytokines and ameliorates intestinal inflammation.
Saha K, Subramenium Ganapathy A, Wang A, Arumugam P, Michael Morris N, Harris L, Yochum G, Koltun W, Perdew GH, Nighot M, Ma T, Nighot P
Mucosal immunology 2023 Dec;16(6):826-842
Mucosal immunology 2023 Dec;16(6):826-842
Molecular and immune signatures, and pathological trajectories of fatal COVID-19 lungs defined by in situ spatial single-cell transcriptome analysis.
Das A, Meng W, Liu Z, Hasib MM, Galloway H, Ramos da Silva S, Chen L, Sica GL, Paniz-Mondolfi A, Bryce C, Grimes Z, Sordillo EM, Cordon-Cardo C, Rivera KP, Flores M, Chiu YC, Huang Y, Gao SJ
Journal of medical virology 2023 Aug;95(8):e29009
Journal of medical virology 2023 Aug;95(8):e29009
Ethanol extracts of Rhaponticum uniflorum (L.) DC inflorescence ameliorate LPS-mediated acute lung injury by alleviating inflammatory responses via the Nrf2/HO-1 signaling pathway.
Zhen D, Liu C, Huang T, Fu D, Bai X, Ma Q, Jiang M, Gong G
Journal of ethnopharmacology 2022 Oct 5;296:115497
Journal of ethnopharmacology 2022 Oct 5;296:115497
Cancer cell intrinsic TIM-3 induces glioblastoma progression.
Guo Q, Shen S, Guan G, Zhu C, Zou C, Cao J, Cheng W, Xu X, Yu J, Lin Z, Wang G, Chen L, Cheng P, Wu A
iScience 2022 Nov 18;25(11):105329
iScience 2022 Nov 18;25(11):105329
Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.
Huo Y, Yang J, Zheng J, Xu D, Yang M, Tao L, Yao H, Fu X, Yang J, Liu D, Hua R, Zhang J, Sun Y, Hu L, Liu W
Cell proliferation 2022 May;55(5):e13237
Cell proliferation 2022 May;55(5):e13237
Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin.
Wang L, Zhang T, Liu S, Mo Q, Jiang N, Chen Q, Yang J, Han YW, Chen JP, Huang FH, Li H, Zhou J, Luo JS, Wu JM
Pharmacological research 2022 Mar;177:106096
Pharmacological research 2022 Mar;177:106096
Prevention of IL-6 signaling ameliorates toluene diisocyanate-induced steroid-resistant asthma.
Chen S, Chen Z, Deng Y, Zha S, Yu L, Li D, Liang Z, Yang K, Liu S, Chen R
Allergology international : official journal of the Japanese Society of Allergology 2022 Jan;71(1):73-82
Allergology international : official journal of the Japanese Society of Allergology 2022 Jan;71(1):73-82
Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis.
Jin Y, Kang Y, Wang M, Wu B, Su B, Yin H, Tang Y, Li Q, Wei W, Mei Q, Hu G, Lukacs-Kornek V, Li J, Wu K, Yuan X, Wang W
Signal transduction and targeted therapy 2022 Feb 23;7(1):52
Signal transduction and targeted therapy 2022 Feb 23;7(1):52
Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect.
Sha X, Dai Y, Chong L, Wei M, Xing M, Zhang C, Li J
Journal of nanobiotechnology 2022 Dec 1;20(1):506
Journal of nanobiotechnology 2022 Dec 1;20(1):506
Chemerin promotes microangiopathy in diabetic retinopathy via activation of ChemR23 in rat primary microvascular endothelial cells.
Jun L, Lin-Lin S, Hui S
Molecular vision 2021;27:575-587
Molecular vision 2021;27:575-587
Differential effects of EPA and DHA on DSS-induced colitis in mice and possible mechanisms involved.
Zhang Z, Xue Z, Yang H, Zhao F, Liu C, Chen J, Lu S, Zou Z, Zhou Y, Zhang X
Food & function 2021 Mar 1;12(4):1803-1817
Food & function 2021 Mar 1;12(4):1803-1817
Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation.
Du W, Hua F, Li X, Zhang J, Li S, Wang W, Zhou J, Wang W, Liao P, Yan Y, Li G, Wei S, Grove S, Vatan L, Zgodziński W, Majewski M, Wallner G, Chen H, Kryczek I, Fang JY, Zou W
Cancer discovery 2021 Jul;11(7):1826-1843
Cancer discovery 2021 Jul;11(7):1826-1843
Gelsolin Governs the Neuroendocrine Transdifferentiation of Prostate Cancer Cells and Suppresses the Apoptotic Machinery.
Oelrich F, Junker H, Stope MB, Erb HHH, Walther R, Venz S, Zimmermann U
Anticancer research 2021 Aug;41(8):3717-3729
Anticancer research 2021 Aug;41(8):3717-3729
Upregulated MELK Leads to Doxorubicin Chemoresistance and M2 Macrophage Polarization via the miR-34a/JAK2/STAT3 Pathway in Uterine Leiomyosarcoma.
Zhang Z, Sun C, Li C, Jiao X, Griffin BB, Dongol S, Wu H, Zhang C, Cao W, Dong R, Yang X, Zhang Q, Kong B
Frontiers in oncology 2020;10:453
Frontiers in oncology 2020;10:453
MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.
Yang QY, Yang KP, Li ZZ
The Kaohsiung journal of medical sciences 2020 Jan;36(1):20-26
The Kaohsiung journal of medical sciences 2020 Jan;36(1):20-26
MicroRNA-34a deficiency leads to impaired wound closure by augmented inflammation in mice.
Zhao N, Wang G, Long S, Hu M, Gao J, Ran X, Wang J, Su Y, Wang T
Annals of translational medicine 2020 Apr;8(7):447
Annals of translational medicine 2020 Apr;8(7):447
Human cancer cells suppress behaviors of endothelial progenitor cells through miR-21 targeting IL6R.
Wang W, Yuan X, Xu A, Zhu X, Zhan Y, Wang S, Liu M
Microvascular research 2018 Nov;120:21-28
Microvascular research 2018 Nov;120:21-28
Inducible microRNA-590-5p inhibits host antiviral response by targeting the soluble interleukin-6 (IL6) receptor.
Zhou Y, Xia Z, Cheng Z, Xu G, Yang X, Liu S, Zhu Y
The Journal of biological chemistry 2018 Nov 23;293(47):18168-18179
The Journal of biological chemistry 2018 Nov 23;293(47):18168-18179
Death receptor 6 (DR6) is required for mouse B16 tumor angiogenesis via the NF-κB, P38 MAPK and STAT3 pathways.
Yang X, Shi B, Li L, Xu Z, Ge Y, Shi J, Liu Y, Zheng D
Oncogenesis 2016 Mar 7;5(3):e206
Oncogenesis 2016 Mar 7;5(3):e206
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IL6R antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human IL6R. This antibody recognizes human, mouse antigen. The IL6R antibody has been validated for the following applications: ELISA, WB analysis.