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- Antibody Data
- Antigen structure
- References [21]
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- Product number
- MAB227 - Provider product page
- Provider
- R&D Systems
- Product name
- Anti-Human IL-6 R alpha Monoclonal Antibody (Clone 17506)
- Antibody type
- Monoclonal
- Antigen
- S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-6 R, Leu20-Asp339
- Description
- Protein A or G purified from hybridoma culture supernatant
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
P08887- Isotype
- IgG
- Vial size
- 500 µg
Submitted references The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies.
IL-6 trans-signaling is another pathway to upregulate Osteopontin.
Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium.
Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells.
Contact-dependent depletion of hydrogen peroxide by catalase is a novel mechanism of myeloid-derived suppressor cell induction operating in human hepatic stellate cells.
Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation.
Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells.
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.
Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle.
trans fatty acids and systemic inflammation in heart failure.
Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.
Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.
Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells.
Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells.
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells.
Rolvering C, Zimmer AD, Ginolhac A, Margue C, Kirchmeyer M, Servais F, Hermanns HM, Hergovits S, Nazarov PV, Nicot N, Kreis S, Haan S, Behrmann I, Haan C
Journal of leukocyte biology 2018 Nov;104(5):969-985
Journal of leukocyte biology 2018 Nov;104(5):969-985
IL-6 trans-signaling is another pathway to upregulate Osteopontin.
Uchibori T, Matsuda K, Shimodaira T, Sugano M, Uehara T, Honda T
Cytokine 2017 Feb;90:88-95
Cytokine 2017 Feb;90:88-95
Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium.
Munir H, Luu NT, Clarke LS, Nash GB, McGettrick HM
PloS one 2016;11(5):e0155161
PloS one 2016;11(5):e0155161
Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells.
Sommer A, Fabri M
PloS one 2015;10(6):e0130395
PloS one 2015;10(6):e0130395
Contact-dependent depletion of hydrogen peroxide by catalase is a novel mechanism of myeloid-derived suppressor cell induction operating in human hepatic stellate cells.
Resheq YJ, Li KK, Ward ST, Wilhelm A, Garg A, Curbishley SM, Blahova M, Zimmermann HW, Jitschin R, Mougiakakos D, Mackensen A, Weston CJ, Adams DH
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar 15;194(6):2578-86
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar 15;194(6):2578-86
Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.
Becker TM, Boyd SC, Mijatov B, Gowrishankar K, Snoyman S, Pupo GM, Scolyer RA, Mann GJ, Kefford RF, Zhang XD, Rizos H
Oncogene 2014 Feb 27;33(9):1158-66
Oncogene 2014 Feb 27;33(9):1158-66
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.
Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F
Nature 2012 Apr 26;484(7395):514-8
Nature 2012 Apr 26;484(7395):514-8
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada SD, Peter ME, Gwin K, Lengyel E
Nature medicine 2011 Oct 30;17(11):1498-503
Nature medicine 2011 Oct 30;17(11):1498-503
IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation.
Kolliputi N, Waxman AB
American journal of respiratory cell and molecular biology 2009 Mar;40(3):314-24
American journal of respiratory cell and molecular biology 2009 Mar;40(3):314-24
Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells.
Ara T, Song L, Shimada H, Keshelava N, Russell HV, Metelitsa LS, Groshen SG, Seeger RC, DeClerck YA
Cancer research 2009 Jan 1;69(1):329-37
Cancer research 2009 Jan 1;69(1):329-37
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F
Nature immunology 2009 Aug;10(8):857-63
Nature immunology 2009 Aug;10(8):857-63
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.
Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F
Nature immunology 2007 Sep;8(9):942-9
Nature immunology 2007 Sep;8(9):942-9
Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle.
Ammit AJ, Moir LM, Oliver BG, Hughes JM, Alkhouri H, Ge Q, Burgess JK, Black JL, Roth M
American journal of physiology. Lung cellular and molecular physiology 2007 Jan;292(1):L199-206
American journal of physiology. Lung cellular and molecular physiology 2007 Jan;292(1):L199-206
trans fatty acids and systemic inflammation in heart failure.
Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC
The American journal of clinical nutrition 2004 Dec;80(6):1521-5
The American journal of clinical nutrition 2004 Dec;80(6):1521-5
Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.
Erices A, Conget P, Rojas C, Minguell JJ
Experimental cell research 2002 Oct 15;280(1):24-32
Experimental cell research 2002 Oct 15;280(1):24-32
Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.
Erices A, Conget P, Rojas C, Minguell JJ
Experimental cell research 2002 Oct 15;280(1):24-32
Experimental cell research 2002 Oct 15;280(1):24-32
Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells.
Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA
Journal of immunology (Baltimore, Md. : 1950) 2002 Nov 1;169(9):5244-51
Journal of immunology (Baltimore, Md. : 1950) 2002 Nov 1;169(9):5244-51
Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells.
Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA
Journal of immunology (Baltimore, Md. : 1950) 2002 Nov 1;169(9):5244-51
Journal of immunology (Baltimore, Md. : 1950) 2002 Nov 1;169(9):5244-51
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA
Immunity 2001 Jun;14(6):705-14
Immunity 2001 Jun;14(6):705-14
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA
Immunity 2001 Jun;14(6):705-14
Immunity 2001 Jun;14(6):705-14
Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells.
Asou H, Said JW, Yang R, Munker R, Park DJ, Kamada N, Koeffler HP
Blood 1998 Apr 1;91(7):2475-81
Blood 1998 Apr 1;91(7):2475-81
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