Ab105163

antibody from Aladdin Scientific
Targeting: ARHGEF2 GEF-H1, GEFH1, KIAA0651, Lfc, LFP40, P40
Provider product page for Ab105163

Antibody data

Product number
Ab105163 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant GEF H1 Antibody
Antibody type
Recombinant
Description
Rabbit anti Human GEF H1 Antibody, Recombinant, could be used for WB and so on.Application:WB: 1/500 Ð 1/1000Protein FunctionActivates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 956-986
Vial size
100_l,10_l,1ml,50_l
Concentration
0,48 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
ARHGEF2 protein structure - Ab105163 shown in red.