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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Flow cytometry [1]
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- Product number
- 331502 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#331502, RRID:AB_1088995
- Product name
- Purified anti-human CD1c
- Antibody type
- Monoclonal
- Antigen
- CD1c
- Description
- CD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in human. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and a non-covalent associated with β2-microglobulin, belonging to Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells with tightly regulated manner. The function of CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10-producing suppressive CD4+ T cells.
Li D, Romain G, Flamar AL, Duluc D, Dullaers M, Li XH, Zurawski S, Bosquet N, Palucka AK, Le Grand R, O'Garra A, Zurawski G, Banchereau J, Oh S
The Journal of experimental medicine 2012 Jan 16;209(1):109-21
The Journal of experimental medicine 2012 Jan 16;209(1):109-21
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with purified L161, followed by anti-mouse IgG FITC
- Conjugate
- Unconjugated
