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- References [14]
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- Product number
- 12228-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12228-1-AP, RRID:AB_2147565
- Product name
- MVK antibody
- Antibody type
- Polyclonal
- Description
- MVK antibody (Cat. #12228-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SP600125 decreases cAMP/PKA-dependent steroid production through ATF4/DDIT3 activation in MA-10 Leydig cells.
Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPases.
The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.
CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors.
Tylophora yunnanensis extract inhibits cholesterol biosynthesis to suppress triple negative breast cancer.
Advanced N-glycoproteomics and proteomics approach revealed sexually dimorphic molecular signatures in primary mouse hepatocyte.
Effects of Paeoniae Radix Rubra on lowering lipid via bioinformatics and gut microbiome.
Acute heat stress regulates estradiol synthesis in ovine ovarian granulosa cells through the SREBPs/MVK-LHR pathway.
MVK, induced by Kras, represses cGAS-Sting signalling in lung adenocarcinoma.
Gypenoside L inhibits hepatocellular carcinoma by targeting the SREBP2-HMGCS1 axis and enhancing immune response.
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway.
Sinapic and ferulic acid phenethyl esters increase the expression of steroidogenic genes in MA-10 tumor Leydig cells.
Gigantol Improves Cholesterol Metabolism and Progesterone Biosynthesis in MA-10 Leydig Cells.
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
Basque A, Izichkis LS, Martin LJ
Molecular and cellular endocrinology 2025 Sep 15;607:112613
Molecular and cellular endocrinology 2025 Sep 15;607:112613
Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPases.
Liu C, Zhang H, Mao J, Zhang S, Tian X, Zhu Y, Wang C, Fang J, Pan H, Kang N, Zhang Y, Zhou J, Zhen X, Yan G, Li C, Hu Y, Ye C, Xie R, So C, Sun H, Ding L
Nature aging 2025 Oct;5(10):2022-2038
Nature aging 2025 Oct;5(10):2022-2038
The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism.
Rattani A, Anderson C, Trim WV, Garita E, Imada S, Khawaled S, Shin H, Zhang J, Yilmaz ÖH, Kirschner M
bioRxiv : the preprint server for biology 2025 Nov 18;
bioRxiv : the preprint server for biology 2025 Nov 18;
CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors.
Chen F, Li H, Wang Y, Tang X, Lin K, Li Q, Meng C, Shi W, Leo J, Liang X, Zhang J, Van V, Mahmud I, Wei B, Lorenzi PL, Raso MG, Aparicio A, Lu Y, Frigo DE, Gan B, Zhao D
Nature cancer 2025 May;6(5):854-873
Nature cancer 2025 May;6(5):854-873
Tylophora yunnanensis extract inhibits cholesterol biosynthesis to suppress triple negative breast cancer.
Feng ZH, Li WY, Li QZ, Zhao FB, Zhang HJ, Zhang L, Zhang H
Journal of ethnopharmacology 2025 May 28;348:119877
Journal of ethnopharmacology 2025 May 28;348:119877
Advanced N-glycoproteomics and proteomics approach revealed sexually dimorphic molecular signatures in primary mouse hepatocyte.
Yang Q, Zhang Y, Zhang H, Yang Z, Feng Y, Ye B, Gong P, Qian G, Li D
Analytical and bioanalytical chemistry 2025 Jul;417(17):3893-3908
Analytical and bioanalytical chemistry 2025 Jul;417(17):3893-3908
Effects of Paeoniae Radix Rubra on lowering lipid via bioinformatics and gut microbiome.
Lin Z, Luo H, Pan S, Li Y, Zhou X, Zhao J, Xu X, Li X, Wang Y, Lv G, Lin Z, Lin H, Qi W
Scientific reports 2025 Jul 1;15(1):21117
Scientific reports 2025 Jul 1;15(1):21117
Acute heat stress regulates estradiol synthesis in ovine ovarian granulosa cells through the SREBPs/MVK-LHR pathway.
Li Y, Li F, Shu J, Meng C, Zhang J, Zhang J, Qian Y, Wang H, Ding Q, Cao S
Animal reproduction science 2025 Jan;272:107649
Animal reproduction science 2025 Jan;272:107649
MVK, induced by Kras, represses cGAS-Sting signalling in lung adenocarcinoma.
Zhou C, Liu J, Hu X, Lu L, Hou J, Wang J, Jiang L, Huang S, Lin Y, Liu L, Cui L, Liu Y, Huang Y
European journal of medical research 2025 Jan 22;30(1):43
European journal of medical research 2025 Jan 22;30(1):43
Gypenoside L inhibits hepatocellular carcinoma by targeting the SREBP2-HMGCS1 axis and enhancing immune response.
Xiao MY, Pei WJ, Li S, Li FF, Xie P, Luo HT, Hyun Yoo H, Piao XL
Bioorganic chemistry 2024 Sep;150:107539
Bioorganic chemistry 2024 Sep;150:107539
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway.
Xing K, Bian X, Shi D, Dong S, Zhou H, Xiao S, Bai J, Wu W
Journal of hepatocellular carcinoma 2023;10:2173-2185
Journal of hepatocellular carcinoma 2023;10:2173-2185
Sinapic and ferulic acid phenethyl esters increase the expression of steroidogenic genes in MA-10 tumor Leydig cells.
Basque A, Touaibia M, Martin LJ
Toxicology in vitro : an international journal published in association with BIBRA 2023 Feb;86:105505
Toxicology in vitro : an international journal published in association with BIBRA 2023 Feb;86:105505
Gigantol Improves Cholesterol Metabolism and Progesterone Biosynthesis in MA-10 Leydig Cells.
Basque A, Nguyen HT, Touaibia M, Martin LJ
Current issues in molecular biology 2021 Dec 23;44(1):73-93
Current issues in molecular biology 2021 Dec 23;44(1):73-93
Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.
Li M, Min W, Wang J, Wang L, Li Y, Zhou N, Yang Z, Qian Q
Experimental and therapeutic medicine 2020 Apr;19(4):2861-2870
Experimental and therapeutic medicine 2020 Apr;19(4):2861-2870
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MVK antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MVK. This antibody recognizes human, mouse, rat antigen. The MVK antibody has been validated for the following applications: ELISA, WB analysis.
