334627

antibody from BioLegend
Targeting: FCER1A FCE1A
Provider product page for 334627

Antibody data

Product number
334627 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#334627, RRID:AB_2566505
Product name
Brilliant Violet 605™ anti-human FcεRIα
Antibody type
Monoclonal
Antigen
Other
Description
High affinity IgE receptor (FcεRI) plays a key role in IgE-mediated allergic immune response. FcεRI is a tetrameric receptor complex, which is composed of one α-subunit (FcεRIα), one β-subunit, and two γ-subunits. FcεRIα directly binds IgE with high affinity, while the β- and γ-chains are responsible for mediating intracellular signals. FcεRIα is a 50 kD transmembrane protein with Ig superfamily structure. It is primarily found on mast cells and basophils. Further studies have indicated that FcεRIα is also expressed on many inflammatory cells including cutaneuos Langerhans cells, dendritic cells, monocytes of patients with allergic disorders, platelets, bronchial epithelial cells, eosinophils produced in hypereosinophilic syndrome, and neutrophils from allergy-induced asthma patients.
Reactivity
Human
Host
Mouse
Conjugate
Yellow dye
Antibody clone number
AER-37 (CRA-1)
Vial size
25 tests
Storage
2°C-8°C
Handling
Ambient RT
FCER1A protein structure - 334627 shown in red.