Antibody data
- Antibody Data
- Antigen structure
- References [45]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 10746-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10746-1-AP, RRID:AB_2271311
- Product name
- STK11/ LKB1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated STK11/ LKB1 antibody (Cat. #10746-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Chronic intermittent hypoxia aggravated diabetic cardiomyopathy through LKB1/AMPK/Nrf2 signaling pathway.
An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK.
A Mammalian Conserved Circular RNA CircLARP1B Regulates Hepatocellular Carcinoma Metastasis and Lipid Metabolism.
MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy.
HSP90/CDC37 inactivation promotes degradation of LKB1 protein to suppress AMPK signaling in bronchial epithelial cells exposed to sulfur mustard analog, 2-chloroethyl ethyl sulfide.
Theaflavine inhibits hepatic stellate cell activation by modulating the PKA/LKB1/AMPK/GSK3β cascade and subsequently enhancing Nrf2 signaling.
A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress.
CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.
Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2.
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
6-Gingerol Ameliorates Hepatic Steatosis, Inflammation and Oxidative Stress in High-Fat Diet-Fed Mice through Activating LKB1/AMPK Signaling.
Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high-fat diet.
Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysis.
A novel small molecule AdipoR2 agonist ameliorates experimental hepatic steatosis in hamsters and mice.
Exogenous NADPH exerts a positive inotropic effect and enhances energy metabolism via SIRT3 in pathological cardiac hypertrophy and heart failure.
Glycyrrhizic Acid Protects Glomerular Podocytes Induced by High Glucose by Modulating SNARK/AMPK Signaling Pathway.
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
Lanthanum Chloride Induces Axon Abnormality Through LKB1-MARK2 and LKB1-STK25-GM130 Signaling Pathways.
Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.
Rho-associated, coiled-coil-containing protein kinase 1 regulates development of diabetic kidney disease via modulation of fatty acid metabolism.
IK(Ca) channels control breast cancer metabolism including AMPK-driven autophagy.
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells.
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
The lactate receptor GPR81 mediates hepatic lipid metabolism and the therapeutic effect of metformin on experimental NAFLDs.
Free Fatty Acid Impairs Myogenic Differentiation through the AMPKα-MicroRNA 206 Pathway.
MDM2-mediated ubiquitination of LKB1 contributes to the development of diabetic cataract.
Kinsenoside Alleviates Alcoholic Liver Injury by Reducing Oxidative Stress, Inhibiting Endoplasmic Reticulum Stress, and Regulating AMPK-Dependent Autophagy.
CARS senses cysteine deprivation to activate AMPK for cell survival.
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.
Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.
Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes.
Human papillomavirus 16 (HPV 16) E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7.
Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice.
l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
Tim-4 Inhibits NLRP3 Inflammasome via the LKB1/AMPKα Pathway in Macrophages.
Aldolase promotes the development of cardiac hypertrophy by targeting AMPK signaling.
Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway.
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells.
Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma.
The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
Liu B, Si J, Qi K, Li D, Li T, Tang Y, Ji E, Yang S
PloS one 2024;19(3):e0296792
PloS one 2024;19(3):e0296792
An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK.
Toma T, Miyakawa N, Tateishi M, Todaka M, Kondo T, Fujita M, Otsuka M, Araki E, Tateishi H
Journal of pharmacological sciences 2024 Jan;154(1):37-46
Journal of pharmacological sciences 2024 Jan;154(1):37-46
A Mammalian Conserved Circular RNA CircLARP1B Regulates Hepatocellular Carcinoma Metastasis and Lipid Metabolism.
Li J, Wang X, Shi L, Liu B, Sheng Z, Chang S, Cai X, Shan G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(2):e2305902
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(2):e2305902
MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy.
Yu X, Feng M, Guo J, Wang H, Yu J, Zhang A, Wu J, Han Y, Sun Z, Liao Y, Zhao Q
Cell death and differentiation 2024 Aug;31(8):1085-1098
Cell death and differentiation 2024 Aug;31(8):1085-1098
HSP90/CDC37 inactivation promotes degradation of LKB1 protein to suppress AMPK signaling in bronchial epithelial cells exposed to sulfur mustard analog, 2-chloroethyl ethyl sulfide.
Ye F, Wang X, Liu H, Dong X, Cheng J, Chen M, Dan G, Sai Y, Zou Z
Chemico-biological interactions 2023 Sep 1;382:110643
Chemico-biological interactions 2023 Sep 1;382:110643
Theaflavine inhibits hepatic stellate cell activation by modulating the PKA/LKB1/AMPK/GSK3β cascade and subsequently enhancing Nrf2 signaling.
Shu G, Sun H, Zhang T, Zhu A, Lei X, Wang C, Song A, Deng X
European journal of pharmacology 2023 Oct 5;956:175964
European journal of pharmacology 2023 Oct 5;956:175964
A mitochondrial EglN1-AMPKα axis drives breast cancer progression by enhancing metabolic adaptation to hypoxic stress.
Jiang W, Zhang M, Gao C, Yan C, Gao R, He Z, Wei X, Xiong J, Ruan Z, Yang Q, Li J, Li Q, Zhong Z, Zhang M, Yuan Q, Hu H, Wang S, Hu MM, Cai C, Wu GS, Jiang C, Zhang YL, Zhang CS, Zhang J
The EMBO journal 2023 Oct 16;42(20):e113743
The EMBO journal 2023 Oct 16;42(20):e113743
CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.
Gao D, Wang R, Gong Y, Yu X, Niu Q, Yang E, Fan G, Ma J, Chen C, Tao Y, Lu J, Wang Z
Free radical biology & medicine 2023 Nov 1;208:587-601
Free radical biology & medicine 2023 Nov 1;208:587-601
Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2.
Liu X, Yang Y, Shao H, Liu S, Niu Y, Fu L
Sports medicine and health science 2023 Mar;5(1):34-41
Sports medicine and health science 2023 Mar;5(1):34-41
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
Chen Y, Liu Y, Jiang K, Wen Z, Cao X, Wu S
Journal of orthopaedic translation 2023 Mar;39:1-11
Journal of orthopaedic translation 2023 Mar;39:1-11
6-Gingerol Ameliorates Hepatic Steatosis, Inflammation and Oxidative Stress in High-Fat Diet-Fed Mice through Activating LKB1/AMPK Signaling.
Liu Y, Li D, Wang S, Peng Z, Tan Q, He Q, Wang J
International journal of molecular sciences 2023 Mar 27;24(7)
International journal of molecular sciences 2023 Mar 27;24(7)
Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high-fat diet.
Zhang Y, Zhu W, Wang M, Xi P, Wang H, Tian D
IUBMB life 2023 Jun;75(6):548-562
IUBMB life 2023 Jun;75(6):548-562
Clinicopathological and prognostic significance of LKB1 expression in gastric cancer: a systematic review and meta-analysis.
Tan G, Liu B
Scientific reports 2023 Jun 1;13(1):8937
Scientific reports 2023 Jun 1;13(1):8937
A novel small molecule AdipoR2 agonist ameliorates experimental hepatic steatosis in hamsters and mice.
Zhao Y, Sun N, Song X, Zhu J, Wang T, Wang Z, Yu Y, Ren J, Chen H, Zhan T, Tian J, Ma C, Huang J, Wang J, Zhang Y, Yang B
Free radical biology & medicine 2023 Jul;203:69-85
Free radical biology & medicine 2023 Jul;203:69-85
Exogenous NADPH exerts a positive inotropic effect and enhances energy metabolism via SIRT3 in pathological cardiac hypertrophy and heart failure.
Qian K, Tang J, Ling YJ, Zhou M, Yan XX, Xie Y, Zhu LJ, Nirmala K, Sun KY, Qin ZH, Sheng R
EBioMedicine 2023 Dec;98:104863
EBioMedicine 2023 Dec;98:104863
Glycyrrhizic Acid Protects Glomerular Podocytes Induced by High Glucose by Modulating SNARK/AMPK Signaling Pathway.
Zhao TQ, Li Y, Zhang M, Zhao MC, Cao X, Hou SZ
Current medical science 2023 Aug;43(4):696-707
Current medical science 2023 Aug;43(4):696-707
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
Yan C, Xiong J, Zhou Z, Li Q, Gao C, Zhang M, Yu L, Li J, Hu MM, Zhang CS, Cai C, Zhang H, Zhang J
eLife 2023 Aug 17;12
eLife 2023 Aug 17;12
Lanthanum Chloride Induces Axon Abnormality Through LKB1-MARK2 and LKB1-STK25-GM130 Signaling Pathways.
Song Z, Mao H, Liu J, Sun W, Wu S, Lu X, Jin C, Yang J
Cellular and molecular neurobiology 2023 Apr;43(3):1181-1196
Cellular and molecular neurobiology 2023 Apr;43(3):1181-1196
Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.
Zhang FK, Ni QZ, Wang K, Cao HJ, Guan DX, Zhang EB, Ma N, Wang YK, Zheng QW, Xu S, Zhu B, Chen TW, Xia J, Qiu XS, Ding XF, Jiang H, Qiu L, Wang X, Chen W, Cheng SQ, Xie D, Li JJ
Cellular and molecular gastroenterology and hepatology 2022;14(1):101-127
Cellular and molecular gastroenterology and hepatology 2022;14(1):101-127
Rho-associated, coiled-coil-containing protein kinase 1 regulates development of diabetic kidney disease via modulation of fatty acid metabolism.
Nagai Y, Matoba K, Takeda Y, Yako H, Akamine T, Sekiguchi K, Kanazawa Y, Yokota T, Sango K, Kawanami D, Utsunomiya K, Nishimura R
Kidney international 2022 Sep;102(3):536-545
Kidney international 2022 Sep;102(3):536-545
IK(Ca) channels control breast cancer metabolism including AMPK-driven autophagy.
Gross D, Bischof H, Maier S, Sporbeck K, Birkenfeld AL, Malli R, Ruth P, Proikas-Cezanne T, Lukowski R
Cell death & disease 2022 Oct 27;13(10):902
Cell death & disease 2022 Oct 27;13(10):902
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
Tang K, Qin W, Wei R, Jiang Y, Fan L, Wang Z, Tan N
Pharmacological research 2022 May;179:106123
Pharmacological research 2022 May;179:106123
Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells.
Wang Y, Wang Y, Li F, Zou J, Li X, Xu M, Yu D, Ma Y, Huang W, Sun X, Zhang Y
Cells 2022 Mar 22;11(7)
Cells 2022 Mar 22;11(7)
Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury.
Zhong Y, Sun D, Yao Y, Liu Q, Guo T, Wang X, Peng X
Chemico-biological interactions 2022 Mar 1;355:109850
Chemico-biological interactions 2022 Mar 1;355:109850
The lactate receptor GPR81 mediates hepatic lipid metabolism and the therapeutic effect of metformin on experimental NAFLDs.
Wu G, Dai Y, Yan Y, Zheng X, Zhang H, Li H, Chen W
European journal of pharmacology 2022 Jun 5;924:174959
European journal of pharmacology 2022 Jun 5;924:174959
Free Fatty Acid Impairs Myogenic Differentiation through the AMPKα-MicroRNA 206 Pathway.
Jiang A, Guo H, Zhang L, Jiang X, Zhang X, Wu W, Liu H
Molecular and cellular biology 2022 Jan 20;42(1):e0032721
Molecular and cellular biology 2022 Jan 20;42(1):e0032721
MDM2-mediated ubiquitination of LKB1 contributes to the development of diabetic cataract.
Li X, Sun X, Li L, Luo Y, Chi Y, Zheng G
Experimental cell research 2022 Aug 1;417(1):113191
Experimental cell research 2022 Aug 1;417(1):113191
Kinsenoside Alleviates Alcoholic Liver Injury by Reducing Oxidative Stress, Inhibiting Endoplasmic Reticulum Stress, and Regulating AMPK-Dependent Autophagy.
Gao L, Chen X, Fu Z, Yin J, Wang Y, Sun W, Ren H, Zhang Y
Frontiers in pharmacology 2021;12:747325
Frontiers in pharmacology 2021;12:747325
CARS senses cysteine deprivation to activate AMPK for cell survival.
Yuan M, Yan R, Zhang Y, Qiu Y, Jiang Z, Liu H, Wang Y, Sun L, Zhang H, Gao P
The EMBO journal 2021 Nov 2;40(21):e108028
The EMBO journal 2021 Nov 2;40(21):e108028
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Lin L, Zeng L, Liu A, Yuan D, Peng Y, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Nutrients 2021 Nov 17;13(11)
Nutrients 2021 Nov 17;13(11)
LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells.
Jin C, Xue W, Liu Q, Han J, Luo R, Feng J, Liu J, Guo T, Peng X, Hu T
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Aug;154:112350
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Aug;154:112350
Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.
Dai J, Chen Q, Huang W, Shi K, Zhang Y, Li T, Mou T, Huang Z, Wu Z
Acta biochimica et biophysica Sinica 2021 Apr 15;53(5):601-611
Acta biochimica et biophysica Sinica 2021 Apr 15;53(5):601-611
Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes.
Li X, Zhu Q, Zheng R, Yan J, Wei M, Fan Y, Deng Y, Zhong Y
Frontiers in physiology 2020;11:73
Frontiers in physiology 2020;11:73
Human papillomavirus 16 (HPV 16) E6 but not E7 inhibits the antitumor activity of LKB1 in lung cancer cells by downregulating the expression of KIF7.
Hu Y, Wu MZ, Gu NJ, Xu HT, Li QC, Wu GP
Thoracic cancer 2020 Nov;11(11):3175-3180
Thoracic cancer 2020 Nov;11(11):3175-3180
Sirt3 modulates fatty acid oxidation and attenuates cisplatin-induced AKI in mice.
Li M, Li CM, Ye ZC, Huang J, Li Y, Lai W, Peng H, Lou TQ
Journal of cellular and molecular medicine 2020 May;24(9):5109-5121
Journal of cellular and molecular medicine 2020 May;24(9):5109-5121
l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways.
Lin L, Zeng L, Liu A, Peng Y, Yuan D, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Food & function 2020 Feb 26;11(2):1798-1809
Food & function 2020 Feb 26;11(2):1798-1809
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.
Li Q, Wang Y, Wu S, Zhou Z, Ding X, Shi R, Thorne RF, Zhang XD, Hu W, Wu M
Cell metabolism 2019 Jul 2;30(1):157-173.e7
Cell metabolism 2019 Jul 2;30(1):157-173.e7
Tim-4 Inhibits NLRP3 Inflammasome via the LKB1/AMPKα Pathway in Macrophages.
Liu W, Bai F, Wang H, Liang Y, Du X, Liu C, Cai D, Peng J, Zhong G, Liang X, Ma C, Gao L
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):990-1000
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):990-1000
Aldolase promotes the development of cardiac hypertrophy by targeting AMPK signaling.
Li Y, Zhang D, Kong L, Shi H, Tian X, Gao L, Liu Y, Wu L, Du B, Huang Z, Liang C, Wang Z, Yao R, Zhang Y
Experimental cell research 2018 Sep 1;370(1):78-86
Experimental cell research 2018 Sep 1;370(1):78-86
Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway.
Ji J, Xue TF, Guo XD, Yang J, Guo RB, Wang J, Huang JY, Zhao XJ, Sun XL
Aging cell 2018 Aug;17(4):e12774
Aging cell 2018 Aug;17(4):e12774
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
Zhao Z, Zhang L, Guo XD, Cao LL, Xue TF, Zhao XJ, Yang DD, Yang J, Ji J, Huang JY, Sun XL
Frontiers in molecular neuroscience 2017;10:293
Frontiers in molecular neuroscience 2017;10:293
Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells.
Zhao F, Huang W, Zhang Z, Mao L, Han Y, Yan J, Lei M
Oncotarget 2016 Feb 2;7(5):5366-82
Oncotarget 2016 Feb 2;7(5):5366-82
Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma.
Yang JY, Jiang SH, Liu DJ, Yang XM, Huo YM, Li J, Hua R, Zhang ZG, Sun YW
Scientific reports 2015 May 27;5:10575
Scientific reports 2015 May 27;5:10575
The LKB1 tumor suppressor as a biomarker in mouse and human tissues.
Nakada Y, Stewart TG, Peña CG, Zhang S, Zhao N, Bardeesy N, Sharpless NE, Wong KK, Hayes DN, Castrillon DH
PloS one 2013;8(9):e73449
PloS one 2013;8(9):e73449
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10746-1-AP(STK11 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LKB1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LKB1. This antibody recognizes human,mouse,rat antigen. The LKB1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.