Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS4842 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- LKB1 (phospho S428) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic phosphopeptide derived from human LKB1 around the phosphorylation site of Serine 428.
- Description
- LKB1, a member of the serine/threonine kinase family, is a tumor suppressor. Physically associates with p53, it regulates specific p53 dependent apoptosis pathways. LKB1 protein is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. Restoring LKB1 activity into cancer cell lines defective for its expression results in a G1 cell cycle arrest.Mutations in LKB1 gene are associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of p-LKB1 (S428) pAb at 1:500 dilutionLane1:Hela cell lysate treated with UV(24h)Lane2:NIH-3T3 cell lysate treated with UV(24h)Lane3:PC12 cell lysate treated with UV(24h)