Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations [0]
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- Product number
- ABIN303290 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-serine/threonine Kinase 11 (STK11) (N-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide correponding to 15 Amino Acid peptide from near the amino terminus ofHuman LKB1/STK11.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Vial size
- 50 µg
- Concentration
- 1.0 mg/ml
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Dilute only prior to immediate use. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Submitted references The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
The LKB1 tumor suppressor negatively regulates mTOR signaling.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.
Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.
Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome.
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer.
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC
Proceedings of the National Academy of Sciences of the United States of America 2004 Mar 9;101(10):3329-35
Proceedings of the National Academy of Sciences of the United States of America 2004 Mar 9;101(10):3329-35
The LKB1 tumor suppressor negatively regulates mTOR signaling.
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC
Cancer cell 2004 Jul;6(1):91-9
Cancer cell 2004 Jul;6(1):91-9
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proceedings of the National Academy of Sciences of the United States of America 2002 Dec 24;99(26):16899-903
Proceedings of the National Academy of Sciences of the United States of America 2002 Dec 24;99(26):16899-903
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.
Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J
Molecular cell 2001 Jun;7(6):1307-19
Molecular cell 2001 Jun;7(6):1307-19
Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.
Westerman AM, Entius MM, Boor PP, Koole R, de Baar E, Offerhaus GJ, Lubinski J, Lindhout D, Halley DJ, de Rooij FW, Wilson JH
Human mutation 1999;13(6):476-81
Human mutation 1999;13(6):476-81
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.
Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Müller O, Back W, Zimmer M
Nature genetics 1998 Jan;18(1):38-43
Nature genetics 1998 Jan;18(1):38-43
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.
Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, Bignell G, Warren W, Aminoff M, Höglund P, Järvinen H, Kristo P, Pelin K, Ridanpää M, Salovaara R, Toro T, Bodmer W, Olschwang S, Olsen AS, Stratton MR, de la Chapelle A, Aaltonen LA
Nature 1998 Jan 8;391(6663):184-7
Nature 1998 Jan 8;391(6663):184-7
Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome.
Nakagawa H, Koyama K, Miyoshi Y, Ando H, Baba S, Watatani M, Yasutomi M, Matsuura N, Monden M, Nakamura Y
Human genetics 1998 Aug;103(2):168-72
Human genetics 1998 Aug;103(2):168-72
Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer.
Bignell GR, Barfoot R, Seal S, Collins N, Warren W, Stratton MR
Cancer research 1998 Apr 1;58(7):1384-6
Cancer research 1998 Apr 1;58(7):1384-6
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