Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 14071-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14071-1-AP, RRID:AB_2149583
- Product name
- Nicastrin antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Nicastrin antibody (Cat. #14071-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Gut-derived β-amyloid: Likely a centerpiece of the gut-brain axis contributing to Alzheimer's pathogenesis.
Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer's disease-like mice.
Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner.
Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.
Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation.
Memantine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression.
Jin J, Xu Z, Zhang L, Zhang C, Zhao X, Mao Y, Zhang H, Liang X, Wu J, Yang Y, Zhang J
Gut microbes 2023 Jan-Dec;15(1):2167172
Gut microbes 2023 Jan-Dec;15(1):2167172
Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer's disease-like mice.
Li Q, Peng J, Luo Y, Zhou J, Li T, Cao L, Peng S, Zuo Z, Wang Z
Journal of neuroinflammation 2022 Jun 14;19(1):145
Journal of neuroinflammation 2022 Jun 14;19(1):145
Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner.
Li K, Gao S, Ma L, Sun Y, Peng ZY, Wu J, Du N, Ren H, Tang SC, Sun X
Frontiers in oncology 2021;11:731561
Frontiers in oncology 2021;11:731561
Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.
Inoue Y, Masuda T, Misumi Y, Ando Y, Ueda M
Neuroscience letters 2021 Sep 25;762:136136
Neuroscience letters 2021 Sep 25;762:136136
Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation.
Wang X, Wang X, Xu Y, Yan M, Li W, Chen J, Chen T
Cancer cell international 2020;20:91
Cancer cell international 2020;20:91
Memantine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression.
Inoue Y, Ueda M, Masuda T, Misumi Y, Yamashita T, Ando Y
Molecular neurobiology 2019 Dec;56(12):8573-8588
Molecular neurobiology 2019 Dec;56(12):8573-8588
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The Nicastrin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Nicastrin. This antibody recognizes human,mouse,rat antigen. The Nicastrin antibody has been validated for the following applications: ELISA, WB analysis.