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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Flow cytometry [1]
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- Product number
- 17-0849-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD84 Monoclonal Antibody (2G7), APC, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The monoclonal antibody 2G7 reacts to CD84, a transmembrane protein of the Ig SLAM superfamily. Expression of CD84 is found on mature B cells, a subset of T cells (mainly CD4+CD45RA+), monocytes and platelets. CD84 is found on a percentage of human hematopoietic progenitor (CD34+) cells. Signaling through CD84 via homotypic interactions involves phosphorylation and recruitment of SAP and EAT-2 leading to production of IFNgamma and T cell activation.
- Antibody clone number
- 2G7
- Concentration
- 5 µL/Test
Submitted references 2B4 (CD244) is expressed and functional on human eosinophils.
The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo.
CD84 leukocyte antigen is a new member of the Ig superfamily.
Munitz A, Bachelet I, Fraenkel S, Katz G, Mandelboim O, Simon HU, Moretta L, Colonna M, Levi-Schaffer F
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 1;174(1):110-8
Journal of immunology (Baltimore, Md. : 1950) 2005 Jan 1;174(1):110-8
The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo.
Lucas AD, Chadwick N, Warren BF, Jewell DP, Gordon S, Powrie F, Greaves DR
The American journal of pathology 2001 Mar;158(3):855-66
The American journal of pathology 2001 Mar;158(3):855-66
CD84 leukocyte antigen is a new member of the Ig superfamily.
de la Fuente MA, Pizcueta P, Nadal M, Bosch J, Engel P
Blood 1997 Sep 15;90(6):2398-405
Blood 1997 Sep 15;90(6):2398-405
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Staining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control APC (Product # 17-4714-81) (blue histogram) or Anti-Human CD84 APC (purple histogram). Cells in the lymphocyte gate were used for analysis.
