19157-1-AP

antibody from Proteintech Group

Targeting: TEK CD202b, TIE-2, TIE2, VMCM, VMCM1

Provider product page for 19157-1-AP

Western blot

ELISA

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [37]
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Validations
Western blot [1]

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Product number: 19157-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#19157-1-AP, RRID:AB_10644297
Product name: Tie2 antibody
Antibody type: Polyclonal
Description: Tie2 antibody (Cat. #19157-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TEK protein structure - 19157-1-AP shown in red.

Submitted references Qideng Mingmu Capsules Ameliorates Retinal Neovascularization by Regulating Ang/Tie2 Signaling Pathway.

Liu CM, Wang JY, Gao MX, Ding S, Zhang FW
Chinese journal of integrative medicine 2026 Mar;32(3):213-222

Simultaneous Determination of Six Components in Zhuqi Piantan Granules and the Protective Effect of Combined Electroacupuncture on Cerebral Injury in Rats With Ischemic Stroke.

Yang P, Wang Z, Kong L, Hao D, Liu W, Gu N, Li N, Zhang T, Wang X, Zhang L, Bi Y
Dose-response : a publication of International Hormesis Society 2026 Jan-Mar;24(1):15593258261418851

Wnt10a exhibit spatiotemporal singularity in the temporal changes of angiogenesis in regenerated pulp-like tissue.

Iida N, Hayashi Y, Futenma T, Sakatoku S, Sugita Y, Nakamura K, Nawa H
Inflammation and regeneration 2026 Jan 27;46(1):6

Green coffee bean extract rich in chlorogenic acids prevents muscle capillary regression via inhibiting oxidative stress and enhancing angiogenesis.

Xing J, Lin H, Nakanishi R, Iwai K, Maeshige N, Kondo H, Fujino H
Biomedical research (Tokyo, Japan) 2025;46(1):15-25

Enhancing Quercetin's Potential: A Nanoliposome Delivery System for High Altitude Pulmonary Edema.

Lin L, Shen B, Cui J, Gao Y, Wang L, Yang T, Weng J, Lai C, Tang X, Xiao C, Shen X, Gao Y
Drug design, development and therapy 2025;19:9151-9167

Scutellarin attenuates hypoxia-induced retinal neovascularization through bidirectional modulation of the VEGF/Ang/Tie2 pathway.

Ding S, Wang W, Liu C, Zhang W, Wang J, Zhang F
Frontiers in pharmacology 2025;16:1631316

Shikonin as a therapeutic agent in renal cell carcinoma: insights from TEK-related causal association with glaucoma.

Jia R, Liang Y, Zou B, Li X, Chen T, Zhang C, Bian J, Guo R
Frontiers in pharmacology 2025;16:1580704

Protective effect of brain microvascular endothelial cell-derived exosomes on blood-brain barrier induced by ischemia-reperfusion injury in vivo and in vitro.

Sun J, Wang M, Guo L, Cao Y, Su L, Wang S, Chai L, Yuan Q, Hu L
Frontiers in pharmacology 2025;16:1548122

Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction.

Yao Z, He J, Hu M, Yan P, Xu Q, Zhang Q, Lin Y, Liao J, Cai X, Liu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157086

The relationship between high serum UA levels and decidualization and angiogenesis in endometrium.

Li J, He M, Huang M, Xiang J, Zhang L, Liu Y, Ma Y, Zeng X, Sun X
Scientific reports 2025 Nov 4;15(1):38574

RBX1 mitigates ferroptosis by inhibiting NCOA4-mediated ferritinophagy and contributes to the attenuation of intervertebral disc degeneration.

Zhou LP, Kang L, Zhang ZG, Jia CY, Zhao CH, Zhang XL, Zhang HQ, Zhang RJ, Shen CL
Journal of translational medicine 2025 May 7;23(1):514

Identification and Validation of Circadian Rhythm-Related Genes Involved in Intervertebral Disc Degeneration and Analysis of Immune Cell Infiltration via Machine Learning.

Zhang Y, Chen L, Yang S, Dai R, Sun H, Zhang L
JOR spine 2025 Jun;8(2):e70066

Angiogenesis promotion of the transplantation of human amniotic mesenchymal stem cells via the Ang-1/Tie-2 signaling pathways in Alzheimer's disease model.

Wu R, Guo J, Liu Y, Huang S, Wu P, Liu W
Journal of Alzheimer's disease : JAD 2025 Jul;106(2):646-652

Doxorubicin-loaded PEGylated liposome modified with ANGPT2-specific peptide for integrative glioma-targeted imaging and therapy.

Li H, Gan R, Liu J, Xu D, Zhang Q, Tian H, Guo H, Wang H, Wang Z, Zeng X
Materials today. Bio 2025 Feb;30:101455

Impaired decidualization and angiogenesis in eutopic endometrium of endometriosis: insights from in vitro models†.

Qin R, Zhong X, Lin J, Li C, Liu X, Qin A, Zheng F
Biology of reproduction 2025 Dec 16;113(6):1539-1548

3-D Sustained-Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells.

Luo L, Zhang S, Gong J, Zhang J, Xie P, Yin J, Zhang M, Zhang C, Chen H, Liu Y, Ni B, Li C, Tian Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2410151

Uterine Immunoprivileged Cells Restore Cardiac Function of Male Recipients After Myocardial Infarction.

Peng Z, Ludke A, Wu J, Li S, Alibhai FJ, Zhang Y, Fan Y, Song H, He S, Xie J, Li RK
Stem cells (Dayton, Ohio) 2024 May 15;42(5):430-444

Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease.

Cao Y, Su H, Zeng J, Xie Y, Liu Z, Liu F, Qiu Y, Yi F, Lin J, Hammes HP, Zhang C
Translational research : the journal of laboratory and clinical medicine 2024 Mar;265:36-50

Hydrogen sulfide attenuates atherosclerosis induced by low shear stress by sulfhydrylating endothelium NFIL3 to restrain MEST mediated endothelial mesenchymal transformation.

Zhou K, Luo W, Gui DD, Ren Z, Wei DH, Liu LS, Li GH, Tang ZH, Xiong WH, Hu HJ, Jiang ZS
Nitric oxide : biology and chemistry 2024 Jan 1;142:47-57

Gestational exposure to bisphenol AF causes endocrine disorder of corpus luteum by altering ovarian SIRT-1/Nrf2/NF-kB expressions and macrophage proangiogenic function in mice.

Lu S, Liu M, Liu H, Yang C, Zhu J, Ling Y, Kuang H
Biochemical pharmacology 2024 Feb;220:115954

Hydrogel and Microgel Collaboration for Spatiotemporal Delivery of Biofactors to Awaken Nucleus Pulposus-Derived Stem Cells for Endogenous Repair of Disc.

Wang J, Huang Y, Luan T, Shi P, Guo L, Zhang Q, Shi G, Hao Z, Chen T, Zhang L, Li J
Small (Weinheim an der Bergstrasse, Germany) 2024 Dec;20(49):e2404732

Notoginsenoside R(1) decreases intraplaque neovascularization by governing pericyte-endothelial cell communication via Ang1/Tie2 axis in atherosclerosis.

Li Y, Zhang L, Yang W, Lin L, Pan J, Lu M, Zhang Z, Li Y, Li C
Phytotherapy research : PTR 2024 Aug;38(8):4036-4052

Electroacupuncture facilitates vascular normalization by inhibiting Glyoxalase1 in endothelial cells to attenuate glycolysis and angiogenesis in triple-negative breast cancer.

Wan YX, Qi XW, Lian YY, Liu ZY, Wang H, Qiu YQ, Zhang CG, Li WN, Jiang HL, Yang DH, Zhao W, Chen ZS, Huang JC
Cancer letters 2024 Aug 28;598:217094

Optimizing human endometrial mesenchymal stem cells for maximal induction of angiogenesis.

Zhang J, Song H, Fan X, He S, Yin W, Peng Z, Zhai X, Yang K, Gong H, Wang Z, Ping Y, Zhang S, Li RK, Xie J
Molecular and cellular biochemistry 2023 Jun;478(6):1191-1204

Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway.

Zhou F, Sun J, Ye L, Jiang T, Li W, Su C, Ren S, Wu F, Zhou C, Gao G
Experimental hematology & oncology 2023 Jul 19;12(1):61

Astragaloside IV drug-loaded exosomes (AS-IV EXOs) derived from endothelial progenitor cells improve the viability and tube formation in high-glucose impaired human endothelial cells by promoting miR-214 expression.

Zou X, Xiao H, Bai X, Zou Y, Hu W, Lin X, Zhu C, Liang Y, Xiong W
Endokrynologia Polska 2022;73(2):336-345

The Effect of Qingre Huayu Recipe on Wound Healing after Anal Fistulotomy in Sprague-Dawley Rats.

Gao J, Wang J, Chen P, Ding P, Tian L, Liang B, Shi Z
Computational and mathematical methods in medicine 2022;2022:9397478

Human placenta-based genome-wide mRNA sequencing to identify TEK/IGF1/CSF1/ANGPT2 as crucial segments in the pathogenesis of pre-eclampsia.

Wang L, Zhang L, Fan Y, Peng Y, Song D, Fu J, Wang X
Frontiers in genetics 2022;13:944932

Matrine inhibits synovial angiogenesis in collagen-induced arthritis rats by regulating HIF-VEGF-Ang and inhibiting the PI3K/Akt signaling pathway.

Ao L, Gao H, Jia L, Liu S, Guo J, Liu B, Dong Q
Molecular immunology 2022 Jan;141:13-20

Angiopoietin2-mediated caveolin1 phosphorylation regulating transcytosis of renal tubular epithelial cell contributes to the occurrence of albuminuria under high glucose exposure.

Liu J, Yao J, Zhao Y, Su J, Ye J, Wang Y
Journal of translational medicine 2022 Apr 25;20(1):185

Development and external validation of a composite immune-clinical prognostic model associated with EGFR mutation in East-Asian patients with lung adenocarcinoma.

Liu C, Zheng S, Wang S, Wang X, Feng X, Sun N, He J
Therapeutic advances in medical oncology 2021;13:17588359211006949

Human endometrium-derived stem cell improves cardiac function after myocardial ischemic injury by enhancing angiogenesis and myocardial metabolism.

Fan X, He S, Song H, Yin W, Zhang J, Peng Z, Yang K, Zhai X, Zhao L, Gong H, Ping Y, Jiao X, Zhang S, Yan C, Wang H, Li RK, Xie J
Stem cell research & therapy 2021 Jun 10;12(1):344

Inhibiting Heat Shock Protein 90 Protects Nucleus Pulposus-Derived Stem/Progenitor Cells From Compression-Induced Necroptosis and Apoptosis.

Hu B, Zhang S, Liu W, Wang P, Chen S, Lv X, Shi D, Ma K, Wang B, Wu Y, Shao Z
Frontiers in cell and developmental biology 2020;8:685

BMP9 attenuates occurrence of venous malformation by maintaining endothelial quiescence and strengthening vessel walls via SMAD1/5/ID1/α-SMA pathway.

Li Y, Shang Q, Li P, Yang Z, Yang J, Shi J, Ge S, Wang Y, Fan X, Jia R
Journal of molecular and cellular cardiology 2020 Oct;147:92-107

Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats.

Zhou PT, Wang LP, Qu MJ, Shen H, Zheng HR, Deng LD, Ma YY, Wang YY, Wang YT, Tang YH, Tian HL, Zhang ZJ, Yang GY
CNS neuroscience & therapeutics 2019 Jun;25(6):748-758

MicroRNA-9 modified bone marrow-derived mesenchymal stem cells (BMSCs) repair severe acute pancreatitis (SAP) via inducing angiogenesis in rats.

Qian D, Song G, Ma Z, Wang G, Jin L, Hu M, Song Z, Wang X
Stem cell research & therapy 2018 Oct 25;9(1):282

JQ1 Induces DNA Damage and Apoptosis, and Inhibits Tumor Growth in a Patient-Derived Xenograft Model of Cholangiocarcinoma.

Garcia PL, Miller AL, Gamblin TL, Council LN, Christein JD, Arnoletti JP, Heslin MJ, Reddy S, Richardson JH, Cui X, van Waardenburg RCAM, Bradner JE, Yang ES, Yoon KJ
Molecular cancer therapeutics 2018 Jan;17(1):107-118

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Tie2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Tie2. This antibody recognizes human,mouse,rat antigen. The Tie2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 19157-1-AP.pdf

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