11865-1-AP

antibody from Proteintech Group

Targeting: ADAMTS4 ADAMTS-2, ADMP-1, KIAA0688

Provider product page for 11865-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [30]
Comments [0]
Validations [0]

Submit

Product number: 11865-1-AP - Provider product page
Provider: Proteintech Group
Product name: ADAMTS4 antibody
Antibody type: Polyclonal
Description: ADAMTS4 antibody (Cat. #11865-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ADAMTS4 protein structure - 11865-1-AP shown in red.

Submitted references Disruption of iron homeostasis by HERC2-FTL axis leads to chondrocyte loss and exacerbates osteoarthritis.

Zhong Y, Duan J, Chen Z, Ye W, Cai W, Wu R, Mao X, Dai X, Dou P
Apoptosis : an international journal on programmed cell death 2026 Mar 19;31(3)

Promoter Methylation of WIF1 is Involved in IL-17-Induced Chondrocyte Inflammatory Injury and Matrix Degradation via Promoting Wnt5a/MAPK-JNK Signaling.

Chen X, Chen X, Xie J, Guo D
Molecular biotechnology 2026 Feb;68(2):496-506

Identification of Autophagy-related Genes of the Osteoarthritis Using Machine Learning Algorithm.

Zhang Z, Wang H, Cheng X, Zhang Z, Hou Z, Liu Z, Gao Y
Biochemical genetics 2026 Apr 21;

Rabbits as preclinical animal models of cam morphology: proof of concept.

Li Z, Wan P, Liu X, Jiang G, Li J, Chen D, Zhang W, Tian K
BMC musculoskeletal disorders 2025 Oct 6;26(1):918

An aptamer specifically targeting mCRP ameliorates experimental arthritis.

Wang Z, Xie D, Zhu P, Guo J, Cao C, Du Y, Lu A, Liang C
Journal of orthopaedic translation 2025 Nov;55:228-244

UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.

Lan W, Chen X, Yu H, Ruan J, Kang J, Nie X, Cao Y, Tang S, Ding C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413709

Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation-Induced Cartilage Injuries in Osteoarthritis.

Zhou Z, Zhang B, Liu L, Yang J, Wang Y, Lv C, Zhang H, Wei Y, Jiang Z, Peng Z, Zhao D, Leng X, Li X, Su H, Dong H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2503909

Mechanical Load-Induced Upregulation of Talin2 through Non-Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis.

Huang Y, Sun H, Chen H, Wang X, Zhao J, Jiao Y, Zhou H, Cai H, Dai J, Huang X, Chen W, Shen J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2501046

miR-708-5p Attenuates Osteoarthritis Progression via Multi-Target Modulation of the NOX4/NF-κB Axis and Cartilage Homeostasis.

Huang SH, Liu ZM, Chen SJ, Tu PY, Tien YC, Lu CC, Wang CC, Chen LM, Shen PC
Cartilage 2025 Jul 30;:19476035251361679

ADAMTS4 Reduction Contributes to Extracellular Matrix Deposition and Impaired Myogenesis in the Skeletal Muscle of Cigarette Smoke-Exposed Mice.

Li D, Pei Y, Liang L, Wang Z, Gai X, Sun Y
Biomedicines 2025 Feb 14;13(2)

Calcified Cartilage Zone Remodeling Induced by IL-1β Derived from Necrotic Subchondral Bone Initiates Cartilage Degeneration in Patients with Glucocorticoids-induced Osteonecrosis of the Femoral Head.

Wang P, Shen L, Yang R, Wang X, Wang X, Zhu Y, Liu R
Inflammation 2025 Dec;48(6):4126-4142

Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.

Kuang B, Geng N, Yi M, Zeng Q, Fan M, Xian M, Deng L, Chen C, Pan Y, Kuang L, Luo F, Xie Y, Liu C, Deng Z, Nie M, Du Y, Guo F
Journal of advanced research 2025 Aug;74:493-511

SERPINF1 knockdown attenuates chondrocyte senescence, hypertrophy, and inflammation in osteoarthritis to offer a potential therapeutic strategy.

Dong L, Yang Z, Liu J, Wu R, Liao Y, Kuang L
Cellular signalling 2025 Aug;132:111840

Dynamics of N6-methyladenosine modification during aging and their potential roles in the degeneration of intervertebral disc.

Liu L, Sun H, Zhang Y, Liu C, Zhuang Y, Liu M, Ai X, Long D, Huang B, Li C, Zhou Y, Dong S, Feng C
JOR spine 2024 Mar;7(1):e1316

ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition.

Li MD, Lu JW, Zhang F, Lei WJ, Pan F, Lin YK, Ling LJ, Myatt L, Wang WS, Sun K
Communications biology 2024 Mar 9;7(1):301

WTAP-mediated m(6)A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis.

An X, Wang R, Lv Z, Wu W, Sun Z, Wu R, Yan W, Jiang Q, Xu X
Experimental & molecular medicine 2024 Feb;56(1):156-167

Inhibition of HOXD11 promotes cartilage degradation and induces osteoarthritis development.

Hong Q, Liu ZX, Liang HF, Wu DG, Chen Y, Yu B
Journal of orthopaedic surgery and research 2024 Feb 2;19(1):111

The Role of the miR-548au-3p/CA12 Axis in Tracheal Chondrogenesis in Congenital Pulmonary Airway Malformations.

Zeng J, Zhang X, Yang Q, Peng J, Wang F, Tang J, Xu Y, Huang D, Liang J, Li L
Oxidative medicine and cellular longevity 2023;2023:6428579

Circular RNA circARPC1B functions as a stabilisation enhancer of Vimentin to prevent high cholesterol-induced articular cartilage degeneration.

Li J, Li X, Zhou S, Wang Y, Ying T, Wang Q, Wu Y, Zhao F
Clinical and translational medicine 2023 Sep;13(9):e1415

The p65-LOC727924-miR-26a/KPNA3-p65 regulatory loop mediates vasoactive intestinal peptide effects on osteoarthritis chondrocytes.

Li Y, Li H, Wang L, Xie W, Yuan D, Wen Z, Zhang T, Lai J, Xiong Z, Shan Y, Jiang W
International immunopharmacology 2023 Sep;122:110518

Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.

Chen X, Chen J, Miao C, Yin G, Zhang Z, Sun R, Ni S
Molecular medicine reports 2023 Nov;28(5)

A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4 Regulates Pulmonary Vascular Hyperpermeability through Destruction of Glycocalyx in Acute Respiratory Distress Syndrome.

Konda M, Kitabatake M, Ouji-Sageshima N, Tonomura R, Furukawa R, Sonobe S, Terada-Ikeda C, Takeda M, Kawaguchi M, Ito T
International journal of molecular sciences 2023 Nov 12;24(22)

Docosahexaenoic acid alleviates the excessive degradation of extracellular matrix in the nucleus pulposus by reducing the content of lncRNA NEAT1 to prevent the progression of intervertebral disc degeneration.

Shang L, Ma H, Zhang X, Mao R, Ma C, Ruan Z
Clinical and experimental pharmacology & physiology 2023 May;50(5):403-414

The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis.

Li W, Tao C, Mao M, Zhu K
Acta biochimica et biophysica Sinica 2023 May 26;55(5):818-830

ROS-responsive magnesium-containing microspheres for antioxidative treatment of intervertebral disc degeneration.

Zhang T, Wang Y, Li R, Xin J, Zheng Z, Zhang X, Xiao C, Zhang S
Acta biomaterialia 2023 Mar 1;158:475-492

Suramin ameliorates osteoarthritis by acting on the Nrf2/HO-1 and NF-κB signaling pathways in chondrocytes and promoting M2 polarization in macrophages.

Shen PC, Huang SH, Liu ZM, Lu CC, Chou SH, Tien YC
International immunopharmacology 2023 Jul;120:110295

MiR-146b-5p enriched bioinspired exosomes derived from fucoidan-directed induction mesenchymal stem cells protect chondrocytes in osteoarthritis by targeting TRAF6.

Lou C, Jiang H, Lin Z, Xia T, Wang W, Lin C, Zhang Z, Fu H, Iqbal S, Liu H, Lin J, Wang J, Pan X, Xue X
Journal of nanobiotechnology 2023 Dec 18;21(1):486

Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage.

Zhao Y, Guo Y, Sun M, Hussion S, Zheng Y, Huang H, Huo X, Zhao Y, Zhang F, Han Y, Ning Q, Xu P, Sun J, Lu S
Journal of bone and mineral metabolism 2022 Nov;40(6):914-926

Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.

Liu ZM, Lu CC, Shen PC, Chou SH, Shih CL, Chen JC, Tien YC
Bone & joint research 2021 Aug;10(8):498-513

Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.

Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734

No comments: Submit comment

No validations: Submit validation data