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- References [236]
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- Product number
- 24169-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- ATF6 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ATF6 antibody (Cat. #24169-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Astragaloside IV ameliorated neuroinflammation and improved neurological functions in mice exposed to traumatic brain injury by modulating the PERK-eIF2α-ATF4 signaling pathway.
Mechanism of Qili Qiangxin Capsule for Heart Failure Based on miR133a-Endoplasmic Reticulum Stress.
Doxorubicin‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways.
African swine fever virus maintains de novo global cellular protein synthesis and inhibits stress granules formation via dephosphorylating eIF2α.
X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity.
Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke.
Polystyrene microplastic-induced extracellular vesicles cause kidney-related effects in the crosstalk between tubular cells and fibroblasts.
Molecular characterization of the ER stress-inducible factor CRELD2.
Inhibition of HDAC6 with CAY10603 alleviates acute and chronic kidney injury by suppressing the ATF6 branch of UPR.
Arecoline induces neurotoxicity in HT22 cells via the promotion of endoplasmic reticulum stress and downregulation of the Nrf2/HO-1 pathway.
Mammalian IRE1α dynamically and functionally coalesces with stress granules.
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling.
Dietary α-Ketoglutarate Alleviates Escherichia coli LPS-Induced Intestinal Barrier Injury by Modulating the Endoplasmic Reticulum-Mitochondrial System Pathway in Piglets.
Membranal Expression of Calreticulin Induced by Unfolded Protein Response in Melanocytes: A Mechanism Underlying Oxidative Stress-Induced Autoimmunity in Vitiligo.
Mitofusin2 Ameliorated Endoplasmic Reticulum Stress and Mitochondrial Reactive Oxygen Species Through Maintaining Mitochondria-Associated Endoplasmic Reticulum Membrane Integrity in Cisplatin-Induced Acute Kidney Injury.
Suppression of endoplasmic reticulum stress by 4-PBA enhanced atherosclerotic plaque stability via up-regulating CLOCK expression.
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants.
UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation.
Increased fatty acid synthesis and disturbed lipid metabolism in Neuro2a cells after repeated cocaine exposure: A preliminary study.
Lysine demethylase KDM3A alleviates hyperoxia-induced bronchopulmonary dysplasia in mice by promoting ETS1 expression.
ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression.
ATF6 protects against protein misfolding during cardiac hypertrophy.
Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression.
CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance.
Panobinostat (LBH589) combined with AM1241 induces cervical cancer cell apoptosis through autophagy pathway.
ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions.
CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria.
Corneal neuroepithelial compartmentalized microfluidic chip model for evaluation of toxicity-induced dry eye.
Exposure to nonylphenol in early life causes behavioural deficits related with autism spectrum disorders in rats.
3-Acetyldeoxynivalenol induces apoptosis, barrier dysfunction and endoplasmic reticulum stress by inhibiting mTORC1-dependent autophagy in porcine enterocytes.
Fusaric acid inhibits proliferation and induces apoptosis through triggering endoplasmic reticulum stress in MCF-7 human breast cancer cells.
Linderalactone mitigates diabetic cardiomyopathy in mice via suppressing the MAPK/ATF6 pathway.
Precisely Regulating M2 Subtype Macrophages for Renal Fibrosis Resolution.
Establishment of a novel ER-stress induced myopia model in mice.
Role of selenoprotein M knockdown in the melatonin antagonism of nickel-induced apoptosis and endoplasmic reticulum stress in mouse heart.
Endoplasmic reticulum stress promotes sepsis-induced muscle atrophy via activation of STAT3 and Smad3.
Deficiency of Perry syndrome-associated p150(Glued) in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.
Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy.
Atorvastatin prevents endoplasmic reticulum stress-mediated apoptosis via the Nrf2/HO-1 signaling pathway in TBI mice.
EETs alleviate alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress through the Trim25/Keap1/Nrf2 axis.
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress.
Betulinic acid mitigates zearalenone-induced liver injury by ERS/MAPK/Nrf2 signaling pathways in mice.
Hypothermic oxygenated perfusion attenuates DCD liver ischemia-reperfusion injury by activating the JAK2/STAT3/HAX1 pathway to regulate endoplasmic reticulum stress.
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Inhibition of the Activating Transcription Factor 6 Branch of Endoplasmic Reticulum Stress Ameliorates Brain Injury after Deep Hypothermic Circulatory Arrest.
Discovery of rafoxanide as a novel agent for the treatment of non-small cell lung cancer.
Secretome of hESC-Derived MSC-like Immune and Matrix Regulatory Cells Mitigate Pulmonary Fibrosis through Antioxidant and Anti-Inflammatory Effects.
The Activation of Reticulophagy by ER Stress through the ATF4-MAP1LC3A-CCPG1 Pathway in Ovarian Granulosa Cells Is Linked to Apoptosis and Necroptosis.
Quercetin alleviates cadmium-induced BRL-3A cell apoptosis by inhibiting oxidative stress and the PERK/IRE1α/ATF6 signaling pathway.
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation.
ER Stress-Perturbed Intracellular Protein O-GlcNAcylation Aggravates Podocyte Injury in Diabetes Nephropathy.
Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia.
XBP1s gene of endoplasmic reticulum stress enhances proliferation and osteogenesis of human periodontal ligament cells.
The therapeutic effect of tanshinone IIA in mouse astrocytes after treatment with Angiostrongylus cantonensis fifth-stage larval excretory-secretory products.
Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1.
Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy.
4-phenylbutyric acid re-trafficking hERG/G572R channel protein by modulating the endoplasmic reticulum stress-associated chaperones and endoplasmic reticulum-associated degradation gene.
Targeting intratumor heterogeneity suppresses colorectal cancer chemoresistance and metastasis.
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
Modulation of the endoplasmic reticulum stress and unfolded protein response mitigates the behavioral effects of early-life stress.
FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
Tissue Proteogenomic Landscape Reveals the Role of Uncharacterized SEL1L3 in Progression and Immunotherapy Response in Lung Adenocarcinoma.
Protective Effects of Selenium Nanoparticles against Bisphenol A-Induced Toxicity in Porcine Intestinal Epithelial Cells.
Citrinin Exposure Induced Testicular Damage and Spermatogenesis Disorder by Triggering Endoplasmic Reticulum Stress.
Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
The ZIP9-centered androgen pathway compensates for the 2605 MHz radiofrequency electromagnetic radiation-mediated reduction in resistance to H(2)O(2) damage in Sertoli cells of adult rats.
Saikosaponin D Inducing Apoptosis and Autophagy through the Activation of Endoplasmic Reticulum Stress in Glioblastoma.
Deletion of ACLY Disrupts Histone Acetylation and IL-10 Secretion in Trophoblasts, Which Inhibits M2 Polarization of Macrophages: A Possible Role in Recurrent Spontaneous Abortion.
A Novel ER Stress Mediator TMTC3 Promotes Squamous Cell Carcinoma Progression by Activating GRP78/PERK Signaling Pathway.
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
TM9SF4 Is a Crucial Regulator of Inflammation and ER Stress in Inflammatory Bowel Disease.
Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway.
Acacetin antagonized lipotoxicity in pancreatic β-cells via ameliorating oxidative stress and endoplasmic reticulum stress.
Substitution of SERCA2 Cys(674) accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis.
ATF4 protects against sorafenib-induced cardiotoxicity by suppressing ferroptosis.
Activating PPARβ/δ Protects against Endoplasmic Reticulum Stress-Induced Astrocytic Apoptosis via UCP2-Dependent Mitophagy in Depressive Model.
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
Substitution of the SERCA2 Cys(674) reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation.
Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity.
Pterostilbene Prevents Tunicamycin-Induced Intestinal Barrier Damage by Targeting Endoplasmic Reticulum Stress, Oxidative Stress, Autophagy, and Gut Microbiota.
Expression analysis and functional characterization of thioredoxin domain-containing protein 11.
Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington's Disease.
Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy.
Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans.
α-Ketoglutarate Restores Intestinal Barrier Function through Promoting Intestinal Stem Cells-Mediated Epithelial Regeneration in Colitis.
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Signal Sequence-Dependent Orientation of Signal Peptide Fragments to Exosomes.
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress.
Autophagy flux inhibition mediated by lysosomal dysfunction participates in the cadmium exposure-induced cardiotoxicity in swine.
Podophyllotoxin-combined 5-aminolevulinic acid photodynamic therapy significantly promotes HR-HPV-infected cell death.
Peste des petits ruminants virus induces ERS-mediated autophagy to promote virus replication.
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis.
The Role of Ferroptosis in the Damage of Human Proximal Tubule Epithelial Cells Caused by Perfluorooctane Sulfonate.
Selective activation of cannabinoid receptor-2 reduces white matter injury via PERK signaling in a rat model of traumatic brain injury.
Nrf2 loss of function exacerbates endoplasmic reticulum stress-induced apoptosis in TBI mice.
Cinacalcet Improves Bone Parameters Through Regulation of Osteoclast Endoplasmic Reticulum Stress, Autophagy, and Apoptotic Pathways in Chronic Kidney Disease-Mineral and Bone Disorder.
EI24 promotes cell adaption to ER stress by coordinating IRE1 signaling and calcium homeostasis.
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-κB Signaling Pathway.
Fatty acid palmitate suppresses FoxO1 expression via PERK and IRE1 unfolded protein response in C2C12 myotubes.
Corynoxine suppresses pancreatic cancer growth primarily via ROS-p38 mediated cytostatic effects.
African Swine Fever Virus MGF110-7L Induces Host Cell Translation Suppression and Stress Granule Formation by Activating the PERK/PKR-eIF2α Pathway.
YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis.
Protein palmitoylation-mediated palmitic acid sensing causes blood-testis barrier damage via inducing ER stress.
Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.
LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis.
ATF6 deficiency damages the development of spermatogenesis in male Atf6 knockout mice.
IRE-1-Targeting Caged Prodrug with Endoplasmic Reticulum Stress-Inducing and XBP-1S-Inhibiting Activities for Cancer Therapy.
Dietary Tryptophan Supplementation Improves Antioxidant Status and Alleviates Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Pyroptosis in the Intestine of Piglets after Lipopolysaccharide Challenge.
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Chlorogenic acid improves the intestinal barrier by relieving endoplasmic reticulum stress and inhibiting ROCK/MLCK signaling pathways.
Interleukin-10 Mitigates Doxorubicin-Induced Endoplasmic Reticulum Stress as Well as Cardiomyopathy.
Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.
Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats.
Ginkgo Biloba Extract EGB761 Ameliorates the Extracellular Matrix Accumulation and Mesenchymal Transformation of Renal Tubules in Diabetic Kidney Disease by Inhibiting Endoplasmic Reticulum Stress.
The Downregulation of ADAM17 Exerts Protective Effects against Cardiac Fibrosis by Regulating Endoplasmic Reticulum Stress and Mitophagy.
Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.
Dl-3-n-Butylphthalide Ameliorates Diabetic Nephropathy by Ameliorating Excessive Fibrosis and Podocyte Apoptosis.
Knockdown of Oligosaccharyltransferase Subunit Ribophorin 1 Induces Endoplasmic-Reticulum-Stress-Dependent Cell Apoptosis in Breast Cancer.
Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine.
Hypothermic oxygenated perfusion with defatting cocktail further improves steatotic liver grafts in a transplantation rat model.
Role of UPR Sensor Activation in Cell Death-Survival Decision of Colon Cancer Cells Stressed by DPE Treatment.
Inhibition of the unfolded protein response reduces arrhythmia risk after myocardial infarction.
Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca(2+) homeostasis.
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
Cytotoxic BODIPY-Appended Half-Sandwich Iridium(III) Complex Forms Protein Adducts and Induces ER Stress.
Downregulation of activating transcription factor 4 attenuates lysophosphatidycholine-induced inflammation via the NF-κB pathway.
In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR.
The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice.
The role of ATF6 in Cr(VI)-induced apoptosis in DF-1 cells.
Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice.
Nesfatin-1 inhibits myocardial ischaemia/reperfusion injury through activating Akt/ERK pathway-dependent attenuation of endoplasmic reticulum stress.
4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation.
iPLA(2)β Contributes to ER Stress-Induced Apoptosis during Myocardial Ischemia/Reperfusion Injury.
Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells.
Secretion of signal peptides via extracellular vesicles.
Polybrominated diphenyl ethers quinone-induced intracellular protein oxidative damage triggers ubiquitin-proteasome and autophagy-lysosomal system activation in LO2 cells.
Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons.
Microcystin-leucine arginine induced the apoptosis of GnRH neurons by activating the endoplasmic reticulum stress resulting in a decrease of serum testosterone level in mice.
Metformin alleviates high glucose-induced ER stress and inflammation by inhibiting the interaction between caveolin1 and AMPKα in rat astrocytes.
MicroRNA-211-5p attenuates spinal cord injury via targeting of activating transcription factor 6.
Activation of the G Protein-Coupled Estrogen Receptor Prevented the Development of Acute Colitis by Protecting the Crypt Cell.
Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324.
Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors.
The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
Curcumin inhibits classical swine fever virus replication by interfering with lipid metabolism.
Characterization of an endoplasmic reticulum stress-related signature to evaluate immune features and predict prognosis in glioma.
Therapeutic Effect of Endothelin-Converting Enzyme Inhibitor on Chronic Kidney Disease through the Inhibition of Endoplasmic Reticulum Stress and the NLRP3 Inflammasome.
Alpha-1 Antitrypsin-Induced Endoplasmic Reticulum Stress Promotes Invasion by Extravillous Trophoblasts.
Antrodia Cinnamomea Attenuates Non-Alcoholic Steatohepatitis by Suppressing NLRP3 Inflammasome Activation In Vitro and In Vivo.
Salvianolic Acid B Protects Against Fatty Acid-Induced Renal Tubular Injury via Inhibition of Endoplasmic Reticulum Stress.
Role of Endoplasmic Reticulum Stress in Otitis Media.
Endoplasmic Reticulum Stress Activation in Alport Syndrome Varies Between Genotype and Cell Type.
Apigetrin ameliorates streptozotocin-induced pancreatic β-cell damages via attenuating endoplasmic reticulum stress.
Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy.
Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway.
Berberine inhibits proliferation and apoptosis of vascular smooth muscle cells induced by mechanical stretch via the PDI/ERS and MAPK pathways.
MiR-185-5p ameliorates endoplasmic reticulum stress and renal fibrosis by downregulation of ATF6.
Acupuncture protects against cerebral ischemia-reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway.
Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling.
Pancreatic cancer-derived exosomes induce apoptosis of T lymphocytes through the p38 MAPK-mediated endoplasmic reticulum stress.
SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response.
Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats.
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma.
The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts.
TUDCA inhibits HSV-1 replication by the modulating unfolded protein response pathway.
Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21(Cip1) and p27(Kip1).
FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis.
The kinase PERK represses translation of the G-protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.
Congenital Tufting Enteropathy-Associated Mutant of Epithelial Cell Adhesion Molecule Activates the Unfolded Protein Response in a Murine Model of the Disease.
A Novel Rhynchophylline Analog, Y396, Inhibits Endothelial Dysfunction Induced by Oxidative Stress in Diabetes Through Epidermal Growth Factor Receptor.
Unfolded Protein Response Pathways Correlatively Modulate Endoplasmic Reticulum Stress Responses in Rat Retinal Müller Cells.
The IRE1α-XBP1 pathway function in hypoxia-induced pulmonary vascular remodeling, is upregulated by quercetin, inhibits apoptosis and partially reverses the effect of quercetin in PASMCs.
LncRNA LUCRC Regulates Colorectal Cancer Cell Growth and Tumorigenesis by Targeting Endoplasmic Reticulum Stress Response.
Cilostazol ameliorates ischemia/reperfusion-induced tight junction disruption in brain endothelial cells by inhibiting endoplasmic reticulum stress.
Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.
Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress.
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.
Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1.
Endoplasmic reticulum stress induces apoptosis of arginine vasopressin neurons in central diabetes insipidus via PI3K/Akt pathway.
Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection.
Flaccidoxide-13-Acetate-Induced Apoptosis in Human Bladder Cancer Cells is through Activation of p38/JNK, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress Regulated Pathway.
Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo.
Exosomes from Microglia Attenuate Photoreceptor Injury and Neovascularization in an Animal Model of Retinopathy of Prematurity.
C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes.
A pectic polysaccharide from water decoction of Xinjiang Lycium barbarum fruit protects against intestinal endoplasmic reticulum stress.
APS could potentially activate hepatic insulin signaling in HFD-induced IR mice.
Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells.
The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration.
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.
Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos.
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress.
Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress.
LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.
Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats.
Proteomic analysis of retinal pigment epithelium cells after exposure to UVA radiation.
Nitrosative stress drives heart failure with preserved ejection fraction.
Maternal Protein Restriction Induces Alterations in Hepatic Unfolded Protein Response-Related Molecules in Adult Rat Offspring.
Salvianolic Acid A Attenuates Endoplasmic Reticulum Stress and Protects Against Cholestasis-Induced Liver Fibrosis via the SIRT1/HSF1 Pathway.
Preconditioning the uterine unfolded protein response maintains non-apoptotic Caspase 3-dependent quiescence during pregnancy.
BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.
NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway.
Bi-allelic CCDC47 Variants Cause a Disorder Characterized by Woolly Hair, Liver Dysfunction, Dysmorphic Features, and Global Developmental Delay.
Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway.
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction.
Exogenous H(2)S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm.
Involvement of endoplasmic reticulum stress in formalin-induced pain is attenuated by 4-phenylbutyric acid.
β-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1α/ATF6 pathway.
Effect of Subcellular Translocation of Protein Disulfide Isomerase on Tetrachlorobenzoquinone-Induced Signaling Shift from Endoplasmic Reticulum Stress to Apoptosis.
Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress.
Identification of Novel SCIRR69-Interacting Proteins During ER Stress Using SILAC-Immunoprecipitation Quantitative Proteomics Approach.
ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart.
Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.
RCAD/BiP pathway is necessary for the proper synthesis of digestive enzymes and secretory function of the exocrine pancreas.
Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
Imaging specific newly synthesized proteins within cells by fluorescence resonance energy transfer.
Activation of UPR Signaling Pathway is Associated With the Malignant Progression and Poor Prognosis in Prostate Cancer.
PDI regulates seizure activity via NMDA receptor redox in rats.
A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells.
Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase.
Cytotoxicity of 11-epi-Sinulariolide Acetate Isolated from Cultured Soft Corals on HA22T Cells through the Endoplasmic Reticulum Stress Pathway and Mitochondrial Dysfunction.
Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.
Vaspin attenuates the progression of atherosclerosis by inhibiting ER stress-induced macrophage apoptosis in apoE‑/‑ mice.
Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking.
Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release.
Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats.
Zhao J, Zhao G, Lang J, Sun B, Feng S, Li D, Sun G
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2024 Oct;72(7):747-762
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2024 Oct;72(7):747-762
Mechanism of Qili Qiangxin Capsule for Heart Failure Based on miR133a-Endoplasmic Reticulum Stress.
Ji XD, Yang D, Cui XY, Lou LX, Nie B, Zhao JL, Zhao MJ, Wu AM
Chinese journal of integrative medicine 2024 May;30(5):398-407
Chinese journal of integrative medicine 2024 May;30(5):398-407
Doxorubicin‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways.
Malik A, Bagchi AK, Jassal DS, Singal PK
Molecular medicine reports 2024 May;29(5)
Molecular medicine reports 2024 May;29(5)
African swine fever virus maintains de novo global cellular protein synthesis and inhibits stress granules formation via dephosphorylating eIF2α.
Gao H, Gao X, Liu X, Luo Y, Zhong J, Liu J, Yan L, Wang H, Gong L, Zhang G, Zheng Z, Sun Y
Veterinary microbiology 2024 Mar;290:109988
Veterinary microbiology 2024 Mar;290:109988
X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity.
Hong Y, Zhou X, Li Q, Chen J, Wei Y, Long C, Shen L, Zheng X, Li D, Wang X, Yu C, Wu S, Wei G
Genes & diseases 2024 Mar;11(2):935-951
Genes & diseases 2024 Mar;11(2):935-951
Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke.
Xie J, Zhang Y, Li B, Xi W, Wang Y, Li L, Liu C, Shen L, Han B, Kong Y, Yao H, Zhang Z
Journal of translational medicine 2024 Mar 7;22(1):248
Journal of translational medicine 2024 Mar 7;22(1):248
Polystyrene microplastic-induced extracellular vesicles cause kidney-related effects in the crosstalk between tubular cells and fibroblasts.
Wang YL, Huang CC, Zheng CM, Liu WC, Lee YH, Chiu HW
Ecotoxicology and environmental safety 2024 Mar 15;273:116098
Ecotoxicology and environmental safety 2024 Mar 15;273:116098
Molecular characterization of the ER stress-inducible factor CRELD2.
Hinaga S, Kandeel M, Oh-Hashi K
Cell biochemistry and biophysics 2024 Jun;82(2):1463-1475
Cell biochemistry and biophysics 2024 Jun;82(2):1463-1475
Inhibition of HDAC6 with CAY10603 alleviates acute and chronic kidney injury by suppressing the ATF6 branch of UPR.
Kan S, Hou Q, Yang R, Yang F, Zhang M, Liu Z, Jiang S
Archives of biochemistry and biophysics 2024 Jun;756:110009
Archives of biochemistry and biophysics 2024 Jun;756:110009
Arecoline induces neurotoxicity in HT22 cells via the promotion of endoplasmic reticulum stress and downregulation of the Nrf2/HO-1 pathway.
Yan H, Ding J, Li X, Li S, Zhang D
Environmental toxicology 2024 Jun;39(6):3410-3424
Environmental toxicology 2024 Jun;39(6):3410-3424
Mammalian IRE1α dynamically and functionally coalesces with stress granules.
Liu S, Zhang X, Yao X, Wang G, Huang S, Chen P, Tang M, Cai J, Wu Z, Zhang Y, Xu R, Liu K, He K, Wang Y, Jiang L, Wang QA, Rui L, Liu J, Liu Y
Nature cell biology 2024 Jun;26(6):917-931
Nature cell biology 2024 Jun;26(6):917-931
Ntsr1 contributes to pulmonary hypertension by enhancing endoplasmic reticulum stress via JAK2-STAT3-Thbs1 signaling.
Wei ZX, Cai XX, Fei YD, Wang Q, Hu XL, Li C, Hou JW, Yang YL, Wang YP, Li YG
Translational research : the journal of laboratory and clinical medicine 2024 Jul;269:64-75
Translational research : the journal of laboratory and clinical medicine 2024 Jul;269:64-75
Dietary α-Ketoglutarate Alleviates Escherichia coli LPS-Induced Intestinal Barrier Injury by Modulating the Endoplasmic Reticulum-Mitochondrial System Pathway in Piglets.
Lu J, Liu G, Sun W, Jia G, Zhao H, Chen X, Wang J
The Journal of nutrition 2024 Jul;154(7):2087-2096
The Journal of nutrition 2024 Jul;154(7):2087-2096
Membranal Expression of Calreticulin Induced by Unfolded Protein Response in Melanocytes: A Mechanism Underlying Oxidative Stress-Induced Autoimmunity in Vitiligo.
Song P, Zhang W, Guo S, Wang G, Gao T, Li C, Liu L
The Journal of investigative dermatology 2024 Jul;144(7):1622-1632.e5
The Journal of investigative dermatology 2024 Jul;144(7):1622-1632.e5
Mitofusin2 Ameliorated Endoplasmic Reticulum Stress and Mitochondrial Reactive Oxygen Species Through Maintaining Mitochondria-Associated Endoplasmic Reticulum Membrane Integrity in Cisplatin-Induced Acute Kidney Injury.
Liu YT, Zhang H, Duan SB, Wang JW, Chen H, Zhan M, Zhang W, Li AM, Liu Y, Yang Y, Yang S
Antioxidants & redox signaling 2024 Jan;40(1-3):16-39
Antioxidants & redox signaling 2024 Jan;40(1-3):16-39
Suppression of endoplasmic reticulum stress by 4-PBA enhanced atherosclerotic plaque stability via up-regulating CLOCK expression.
Zhu G, Gao H, Li Y, Li X, Yang X, Wang C, Guo Z, Fan H, Fan L
Pathology, research and practice 2024 Jan;253:154969
Pathology, research and practice 2024 Jan;253:154969
Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.
Jia C, Xiang Z, Zhang P, Liu L, Zhu X, Yu R, Liu Z, Wang S, Liu K, Wang Z, Vasilev K, Zhou S, Geng Z, Liu X, Zhao Y, Gao Y, Cheng L, Li Y
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
Cellular and molecular life sciences : CMLS 2024 Jan 22;81(1):49
Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants.
Zhang PP, Benske TM, Ahn LY, Schaffer AE, Paton JC, Paton AW, Mu TW, Wang YJ
Acta pharmacologica Sinica 2024 Feb;45(2):282-297
Acta pharmacologica Sinica 2024 Feb;45(2):282-297
UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation.
Ahlstedt BA, Ganji R, Mukkavalli S, Paulo JA, Gygi SP, Raman M
EMBO reports 2024 Feb;25(2):672-703
EMBO reports 2024 Feb;25(2):672-703
Increased fatty acid synthesis and disturbed lipid metabolism in Neuro2a cells after repeated cocaine exposure: A preliminary study.
Nomura M, Wen S, Unuma K, Funakoshi T, Aki T, Uemura K
Biochemical and biophysical research communications 2024 Feb 5;695:149438
Biochemical and biophysical research communications 2024 Feb 5;695:149438
Lysine demethylase KDM3A alleviates hyperoxia-induced bronchopulmonary dysplasia in mice by promoting ETS1 expression.
Yang M, Chen Y, Huang X, Shen F, Meng Y
Experimental cell research 2024 Feb 15;435(2):113945
Experimental cell research 2024 Feb 15;435(2):113945
ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression.
Benedetti R, Romeo MA, Arena A, Gilardini Montani MS, D'Orazi G, Cirone M
Autophagy 2024 Aug;20(8):1854-1867
Autophagy 2024 Aug;20(8):1854-1867
ATF6 protects against protein misfolding during cardiac hypertrophy.
Hofmann C, Aghajani M, Alcock CD, Blackwood EA, Sandmann C, Herzog N, Groß J, Plate L, Wiseman RL, Kaufman RJ, Katus HA, Jakobi T, Völkers M, Glembotski CC, Doroudgar S
Journal of molecular and cellular cardiology 2024 Apr;189:12-24
Journal of molecular and cellular cardiology 2024 Apr;189:12-24
Large HBV Surface Protein-Induced Unfolded Protein Response Dynamically Regulates p27 Degradation in Hepatocellular Carcinoma Progression.
Guo Y, Shao J, Zhang R, Han M, Kong L, Liu Z, Li H, Wei D, Lu M, Zhang S, Zhang C, Wei H, Chen Z, Bian H
International journal of molecular sciences 2023 Sep 7;24(18)
International journal of molecular sciences 2023 Sep 7;24(18)
CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance.
Takasugi M, Ohtani N, Takemura K, Emmrich S, Zakusilo FT, Yoshida Y, Kutsukake N, Mariani JN, Windrem MS, Chandler-Militello D, Goldman SA, Satoh J, Ito S, Seluanov A, Gorbunova V
Cell reports 2023 Sep 26;42(9):113130
Cell reports 2023 Sep 26;42(9):113130
Panobinostat (LBH589) combined with AM1241 induces cervical cancer cell apoptosis through autophagy pathway.
Sheng B, Wang W, Xia D, Qu X
BMC pharmacology & toxicology 2023 Sep 22;24(1):45
BMC pharmacology & toxicology 2023 Sep 22;24(1):45
ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions.
Sun MH, Jiang WJ, Li XH, Lee SH, Heo G, Zhou D, Chen Z, Cui XS
Zoological research 2023 Sep 18;44(5):848-859
Zoological research 2023 Sep 18;44(5):848-859
CARMA3 Deficiency Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysm Development Interacting Between Endoplasmic Reticulum and Mitochondria.
Yao Y, Cao Y, Xu Y, Chen G, Liu Y, Jiang H, Fan R, Qin W, Wang X, Chai H, Chen X, Qiu Z, Chen W
The Canadian journal of cardiology 2023 Oct;39(10):1449-1462
The Canadian journal of cardiology 2023 Oct;39(10):1449-1462
Corneal neuroepithelial compartmentalized microfluidic chip model for evaluation of toxicity-induced dry eye.
Bonneau N, Potey A, Vitoux MA, Magny R, Guerin C, Baudouin C, Peyrin JM, Brignole-Baudouin F, Réaux-Le Goazigo A
The ocular surface 2023 Oct;30:307-319
The ocular surface 2023 Oct;30:307-319
Exposure to nonylphenol in early life causes behavioural deficits related with autism spectrum disorders in rats.
You M, Li S, Yan S, Yao D, Wang T, Wang Y
Environment international 2023 Oct;180:108228
Environment international 2023 Oct;180:108228
3-Acetyldeoxynivalenol induces apoptosis, barrier dysfunction and endoplasmic reticulum stress by inhibiting mTORC1-dependent autophagy in porcine enterocytes.
Zhang T, Bai J, Chen G, Chen Z, Zeng S, Yang Y, Wu Z
Chemico-biological interactions 2023 Oct 1;384:110695
Chemico-biological interactions 2023 Oct 1;384:110695
Fusaric acid inhibits proliferation and induces apoptosis through triggering endoplasmic reticulum stress in MCF-7 human breast cancer cells.
Zhang J, Yuan H, Li W, Chen S, Liu S, Li C, Yao X
Mycotoxin research 2023 Nov;39(4):347-364
Mycotoxin research 2023 Nov;39(4):347-364
Linderalactone mitigates diabetic cardiomyopathy in mice via suppressing the MAPK/ATF6 pathway.
Han X, Zhou W, Zhang J, Tu Y, Wei J, Zheng R, Zhu J, Xu D, Ying H, Wu G, Shi Q, Liang G
International immunopharmacology 2023 Nov;124(Pt B):110984
International immunopharmacology 2023 Nov;124(Pt B):110984
Precisely Regulating M2 Subtype Macrophages for Renal Fibrosis Resolution.
Luo L, Wang S, Hu Y, Wang L, Jiang X, Zhang J, Liu X, Guo X, Luo Z, Zhu C, Xie M, Li Y, You J, Yang F
ACS nano 2023 Nov 28;17(22):22508-22526
ACS nano 2023 Nov 28;17(22):22508-22526
Establishment of a novel ER-stress induced myopia model in mice.
Kang L, Ikeda SI, Yang Y, Jeong H, Chen J, Zhang Y, Negishi K, Tsubota K, Kurihara T
Eye and vision (London, England) 2023 Nov 1;10(1):44
Eye and vision (London, England) 2023 Nov 1;10(1):44
Role of selenoprotein M knockdown in the melatonin antagonism of nickel-induced apoptosis and endoplasmic reticulum stress in mouse heart.
Zhang X, Gai X, Xu L, Ma W, Liu Q, Shi B, Fang C, Cai J, Zhang Z
Journal of Zhejiang University. Science. B 2023 May 15;24(5):406-417
Journal of Zhejiang University. Science. B 2023 May 15;24(5):406-417
Endoplasmic reticulum stress promotes sepsis-induced muscle atrophy via activation of STAT3 and Smad3.
Zheng Y, Dai H, Chen R, Zhong Y, Zhou C, Wang Y, Zhan C, Luo J
Journal of cellular physiology 2023 Mar;238(3):582-596
Journal of cellular physiology 2023 Mar;238(3):582-596
Deficiency of Perry syndrome-associated p150(Glued) in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities.
Yu J, Yang X, Zheng J, Sgobio C, Sun L, Cai H
NPJ Parkinson's disease 2023 Mar 7;9(1):35
NPJ Parkinson's disease 2023 Mar 7;9(1):35
Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy.
Tu Z, Wang C, Hu Q, Tao C, Fang Z, Lin L, Lei K, Luo M, Sheng Y, Long X, Li J, Wu L, Huang K, Zhu X
Journal of experimental & clinical cancer research : CR 2023 Mar 30;42(1):77
Journal of experimental & clinical cancer research : CR 2023 Mar 30;42(1):77
Atorvastatin prevents endoplasmic reticulum stress-mediated apoptosis via the Nrf2/HO-1 signaling pathway in TBI mice.
Feng Y, Lang J, Sun B, Yan Z, Zhao Z, Sun G
Neurological research 2023 Jun;45(6):590-602
Neurological research 2023 Jun;45(6):590-602
EETs alleviate alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress through the Trim25/Keap1/Nrf2 axis.
Zhang CY, Zhong WJ, Liu YB, Duan JX, Jiang N, Yang HH, Ma SC, Jin L, Hong JR, Zhou Y, Guan CX
Redox biology 2023 Jul;63:102765
Redox biology 2023 Jul;63:102765
Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress.
Dang TT, Kim MJ, Lee YY, Le HT, Kim KH, Nam S, Hyun SH, Kim HL, Chung SW, Chung HT, Jho EH, Yoshida H, Kim K, Park CY, Lee MS, Back SH
Autophagy 2023 Jul;19(7):2111-2142
Autophagy 2023 Jul;19(7):2111-2142
Betulinic acid mitigates zearalenone-induced liver injury by ERS/MAPK/Nrf2 signaling pathways in mice.
Wu J, Li J, Wu Y, Yang M, Chen Y, Wang N, Wang J, Yuan Z, Yi J, Yang C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113811
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113811
Hypothermic oxygenated perfusion attenuates DCD liver ischemia-reperfusion injury by activating the JAK2/STAT3/HAX1 pathway to regulate endoplasmic reticulum stress.
Yue P, Lv X, You J, Zou Y, Luo J, Lu Z, Cao H, Liu Z, Fan X, Ye Q
Cellular & molecular biology letters 2023 Jul 12;28(1):55
Cellular & molecular biology letters 2023 Jul 12;28(1):55
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress-Mediated IRE1α-TXNIP-NLRP3 Axis and Pyroptosis.
Tian Y, Feng X, Zhou Z, Qin S, Chen S, Zhao J, Hou J, Liu D
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Journal of agricultural and food chemistry 2023 Jan 25;71(3):1499-1509
Inhibition of the Activating Transcription Factor 6 Branch of Endoplasmic Reticulum Stress Ameliorates Brain Injury after Deep Hypothermic Circulatory Arrest.
Zhang YP, Yang Q, Li YA, Yu MH, He GW, Zhu YX, Liu ZG, Liu XC
Journal of clinical medicine 2023 Jan 19;12(3)
Journal of clinical medicine 2023 Jan 19;12(3)
Discovery of rafoxanide as a novel agent for the treatment of non-small cell lung cancer.
Hu A, Liu J, Wang Y, Zhang M, Guo Y, Qin Y, Liu T, Men Y, Chen Q, Liu T
Scientific reports 2023 Jan 13;13(1):693
Scientific reports 2023 Jan 13;13(1):693
Secretome of hESC-Derived MSC-like Immune and Matrix Regulatory Cells Mitigate Pulmonary Fibrosis through Antioxidant and Anti-Inflammatory Effects.
Hu W, Yang J, Xue J, Ma J, Wu S, Wang J, Xu R, Wei J, Wang Y, Wang S, Liu X
Biomedicines 2023 Feb 5;11(2)
Biomedicines 2023 Feb 5;11(2)
The Activation of Reticulophagy by ER Stress through the ATF4-MAP1LC3A-CCPG1 Pathway in Ovarian Granulosa Cells Is Linked to Apoptosis and Necroptosis.
Li H, Jing Y, Qu X, Yang J, Pan P, Liu X, Gao H, Pei X, Zhang C, Yang Y
International journal of molecular sciences 2023 Feb 1;24(3)
International journal of molecular sciences 2023 Feb 1;24(3)
Quercetin alleviates cadmium-induced BRL-3A cell apoptosis by inhibiting oxidative stress and the PERK/IRE1α/ATF6 signaling pathway.
Ding L, Zhu H, Wang K, Huang R, Yu W, Yan B, Zhou B, Wang H, Yang Z, Liu Z, Wang J
Environmental science and pollution research international 2023 Dec;30(60):125790-125805
Environmental science and pollution research international 2023 Dec;30(60):125790-125805
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule.
Lu D, Liu Y, Huang H, Hu M, Li T, Wang S, Shen S, Wu R, Cai W, Lu T, Lu Z
Translational stroke research 2023 Dec;14(6):910-928
Translational stroke research 2023 Dec;14(6):910-928
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation.
Dai B, Liu S, Shen W, Chen L, Zhou Q, Han L, Zhang Q, Shan L
Biological research 2023 Dec 2;56(1):64
Biological research 2023 Dec 2;56(1):64
ER Stress-Perturbed Intracellular Protein O-GlcNAcylation Aggravates Podocyte Injury in Diabetes Nephropathy.
Song S, Hu T, Shi X, Jin Y, Liu S, Li X, Zou W, Wang C
International journal of molecular sciences 2023 Dec 18;24(24)
International journal of molecular sciences 2023 Dec 18;24(24)
Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia.
Xie F, Qu J, Lin D, Feng K, Tan M, Liao H, Zeng L, Xiong Q, Huang J, Chen W
Molecular biology reports 2023 Dec 12;51(1):10
Molecular biology reports 2023 Dec 12;51(1):10
XBP1s gene of endoplasmic reticulum stress enhances proliferation and osteogenesis of human periodontal ligament cells.
Cui Z, Qin R, Feng J, Liu Y, Zhou X, Qin X, Li Y, Zhang Z, He X
Tissue & cell 2023 Aug;83:102139
Tissue & cell 2023 Aug;83:102139
The therapeutic effect of tanshinone IIA in mouse astrocytes after treatment with Angiostrongylus cantonensis fifth-stage larval excretory-secretory products.
Chen KY, Chen YJ, Cheng CJ, Jhan KY, Chiu CH, Wang LC
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2023 Aug;56(4):853-862
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2023 Aug;56(4):853-862
Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1.
Wu S, Lu D, Gajendran B, Hu Q, Zhang J, Wang S, Han M, Xu Y, Shen X
Phytotherapy research : PTR 2023 Aug;37(8):3543-3558
Phytotherapy research : PTR 2023 Aug;37(8):3543-3558
Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy.
Liu Z, Nan P, Gong Y, Tian L, Zheng Y, Wu Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114897
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114897
4-phenylbutyric acid re-trafficking hERG/G572R channel protein by modulating the endoplasmic reticulum stress-associated chaperones and endoplasmic reticulum-associated degradation gene.
Tang W, Cai D, Fu Y, Zheng Z, Huang X, Khouzam RN, Song Y, Lian J
Journal of thoracic disease 2023 Aug 31;15(8):4472-4485
Journal of thoracic disease 2023 Aug 31;15(8):4472-4485
Targeting intratumor heterogeneity suppresses colorectal cancer chemoresistance and metastasis.
Chao S, Zhang F, Yan H, Wang L, Zhang L, Wang Z, Xue R, Wang L, Wu Z, Jiang B, Shi G, Xue Y, Du J, Bu P
EMBO reports 2023 Aug 3;24(8):e56416
EMBO reports 2023 Aug 3;24(8):e56416
Cordycepin reprogramming lipid metabolism to block metastasis and EMT via ERO1A/mTOR/SREBP1 axis in cholangiocarcinoma.
Zhou X, Li Y, Yang C, Chen D, Wang T, Liu T, Yan W, Su Z, Peng B, Ren X
Life sciences 2023 Aug 15;327:121698
Life sciences 2023 Aug 15;327:121698
Modulation of the endoplasmic reticulum stress and unfolded protein response mitigates the behavioral effects of early-life stress.
Solarz-Andrzejewska A, Majcher-Maślanka I, Kryst J, Chocyk A
Pharmacological reports : PR 2023 Apr;75(2):293-319
Pharmacological reports : PR 2023 Apr;75(2):293-319
FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response.
Wang Z, Tan C, Duan C, Wu J, Zhou D, Hou L, Qian W, Han C, Hou X
Redox biology 2023 Apr;60:102618
Redox biology 2023 Apr;60:102618
Tissue Proteogenomic Landscape Reveals the Role of Uncharacterized SEL1L3 in Progression and Immunotherapy Response in Lung Adenocarcinoma.
Shen CY, Chang WH, Chen YJ, Weng CW, Regmi P, Kier MKK, Su KY, Chang GC, Chen JS, Chen YJ, Yu SL
Journal of proteome research 2023 Apr 7;22(4):1056-1070
Journal of proteome research 2023 Apr 7;22(4):1056-1070
Protective Effects of Selenium Nanoparticles against Bisphenol A-Induced Toxicity in Porcine Intestinal Epithelial Cells.
Pan Z, Huang J, Hu T, Zhang Y, Zhang L, Zhang J, Cui D, Li L, Wang J, Wu Q
International journal of molecular sciences 2023 Apr 14;24(8)
International journal of molecular sciences 2023 Apr 14;24(8)
Citrinin Exposure Induced Testicular Damage and Spermatogenesis Disorder by Triggering Endoplasmic Reticulum Stress.
Wu J, Wu Y, Fan H, Yang C, Yang M, Kong X, Ning C, Wang S, Xiao W, Wang N, Yi J, Yuan Z
Foods (Basel, Switzerland) 2023 Apr 11;12(8)
Foods (Basel, Switzerland) 2023 Apr 11;12(8)
Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
Li J, Bai J, Si X, Jia H, Wu Z
Chemico-biological interactions 2023 Apr 1;374:110386
Chemico-biological interactions 2023 Apr 1;374:110386
The ZIP9-centered androgen pathway compensates for the 2605 MHz radiofrequency electromagnetic radiation-mediated reduction in resistance to H(2)O(2) damage in Sertoli cells of adult rats.
Yu G, Zhu Y, Song C, Chen L, Tang Z, Wu T
Ecotoxicology and environmental safety 2023 Apr 1;254:114733
Ecotoxicology and environmental safety 2023 Apr 1;254:114733
Saikosaponin D Inducing Apoptosis and Autophagy through the Activation of Endoplasmic Reticulum Stress in Glioblastoma.
Liu G, Guan Y, Liu Y, Wang Y, Zhang J, Liu Y, Liu X
BioMed research international 2022;2022:5489553
BioMed research international 2022;2022:5489553
Deletion of ACLY Disrupts Histone Acetylation and IL-10 Secretion in Trophoblasts, Which Inhibits M2 Polarization of Macrophages: A Possible Role in Recurrent Spontaneous Abortion.
Chen X, Song QL, Li ZH, Ji R, Wang JY, Ge C, Xiao ZN, Guo DY, Yang J
Oxidative medicine and cellular longevity 2022;2022:5216786
Oxidative medicine and cellular longevity 2022;2022:5216786
A Novel ER Stress Mediator TMTC3 Promotes Squamous Cell Carcinoma Progression by Activating GRP78/PERK Signaling Pathway.
Yuan H, Zhao Z, Guo Z, Ma L, Han J, Song Y
International journal of biological sciences 2022;18(13):4853-4868
International journal of biological sciences 2022;18(13):4853-4868
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Li Y, Li C, Xiong Y, Fang B, Lin X, Huang Q
Drug design, development and therapy 2022;16:1713-1729
Drug design, development and therapy 2022;16:1713-1729
TM9SF4 Is a Crucial Regulator of Inflammation and ER Stress in Inflammatory Bowel Disease.
Xie M, Mak JWY, Yu H, Cheng CTY, Chan HCH, Chan TT, Lau LHS, Wong MTL, Ko WH, Jiang L, Yao X
Cellular and molecular gastroenterology and hepatology 2022;14(2):245-270
Cellular and molecular gastroenterology and hepatology 2022;14(2):245-270
Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway.
Zhang L, Li C, Fu L, Yu Z, Xu G, Zhou J, Shen M, Feng Z, Zhu H, Xie T, Zhou L, Zhou X
PeerJ 2022;10:e12759
PeerJ 2022;10:e12759
Acacetin antagonized lipotoxicity in pancreatic β-cells via ameliorating oxidative stress and endoplasmic reticulum stress.
Wang N, Gao Q, Shi J, Yulan C, Ji W, Sheng X, Zhang R
Molecular biology reports 2022 Sep;49(9):8727-8740
Molecular biology reports 2022 Sep;49(9):8727-8740
Substitution of SERCA2 Cys(674) accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis.
Wang L, Yang Z, Wang S, Que Y, Shu X, Wu F, Liu G, Li S, Hu P, Chen H, Shi J, Tong X
British journal of pharmacology 2022 Sep;179(17):4423-4439
British journal of pharmacology 2022 Sep;179(17):4423-4439
ATF4 protects against sorafenib-induced cardiotoxicity by suppressing ferroptosis.
Jiang H, Wang C, Zhang A, Li Y, Li J, Li Z, Yang X, Hou Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113280
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113280
Activating PPARβ/δ Protects against Endoplasmic Reticulum Stress-Induced Astrocytic Apoptosis via UCP2-Dependent Mitophagy in Depressive Model.
Ji J, Li S, Jiang Z, Yu J, Sun Y, Cai Z, Dong Y, Sun X
International journal of molecular sciences 2022 Sep 16;23(18)
International journal of molecular sciences 2022 Sep 16;23(18)
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
Nature communications 2022 Sep 12;13(1):5351
Nature communications 2022 Sep 12;13(1):5351
Substitution of the SERCA2 Cys(674) reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation.
Su H, Mei Y, Luo S, Wu H, He Y, Shiraishi Y, Hu P, Cohen RA, Tong X
British journal of pharmacology 2022 Oct;179(20):4778-4791
British journal of pharmacology 2022 Oct;179(20):4778-4791
Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity.
Wang R, Shang Y, Chen B, Xu F, Zhang J, Zhang Z, Zhao X, Wan X, Xu A, Wu L, Zhao G
Cell death & disease 2022 Oct 6;13(10):851
Cell death & disease 2022 Oct 6;13(10):851
Pterostilbene Prevents Tunicamycin-Induced Intestinal Barrier Damage by Targeting Endoplasmic Reticulum Stress, Oxidative Stress, Autophagy, and Gut Microbiota.
Chen Y, Zhang H, Li Y, Ji S, Jia P, Wang T
Journal of agricultural and food chemistry 2022 Oct 26;70(42):13661-13675
Journal of agricultural and food chemistry 2022 Oct 26;70(42):13661-13675
Expression analysis and functional characterization of thioredoxin domain-containing protein 11.
Murase R, Yamamoto A, Hirata Y, Oh-Hashi K
Molecular biology reports 2022 Nov;49(11):10541-10556
Molecular biology reports 2022 Nov;49(11):10541-10556
Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington's Disease.
Xu H, Bensalel J, Capobianco E, Lu ML, Wei J
Cellular and molecular neurobiology 2022 Nov;42(8):2757-2771
Cellular and molecular neurobiology 2022 Nov;42(8):2757-2771
Pterostilbene attenuates intrauterine growth retardation-induced colon inflammation in piglets by modulating endoplasmic reticulum stress and autophagy.
Chen Y, Zhang H, Li Y, Ji S, Jia P, Wang T
Journal of animal science and biotechnology 2022 Nov 4;13(1):125
Journal of animal science and biotechnology 2022 Nov 4;13(1):125
Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans.
Song J, Ni Q, Sun J, Xie J, Liu J, Ning G, Wang W, Wang Q
The Journal of clinical endocrinology and metabolism 2022 Nov 25;107(12):3231-3241
The Journal of clinical endocrinology and metabolism 2022 Nov 25;107(12):3231-3241
α-Ketoglutarate Restores Intestinal Barrier Function through Promoting Intestinal Stem Cells-Mediated Epithelial Regeneration in Colitis.
Si X, Song Z, Liu N, Jia H, Liu H, Wu Z
Journal of agricultural and food chemistry 2022 Nov 2;70(43):13882-13892
Journal of agricultural and food chemistry 2022 Nov 2;70(43):13882-13892
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Kang H, Dong Y, Peng R, Liu H, Guo Q, Song K, Zhu M, Yu K, Wu W, Li F
Biochemical pharmacology 2022 Mar;197:114932
Biochemical pharmacology 2022 Mar;197:114932
Signal Sequence-Dependent Orientation of Signal Peptide Fragments to Exosomes.
Ono K, Niwa M, Suzuki H, Kobayashi NB, Yoshida T, Sawada M
International journal of molecular sciences 2022 Mar 15;23(6)
International journal of molecular sciences 2022 Mar 15;23(6)
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress.
Benedetti R, Romeo MA, Arena A, Gilardini Montani MS, Di Renzo L, D'Orazi G, Cirone M
Cell death discovery 2022 Jun 25;8(1):295
Cell death discovery 2022 Jun 25;8(1):295
Autophagy flux inhibition mediated by lysosomal dysfunction participates in the cadmium exposure-induced cardiotoxicity in swine.
Zhao X, Shi X, Yao Y, Li X, Xu S
BioFactors (Oxford, England) 2022 Jul;48(4):946-958
BioFactors (Oxford, England) 2022 Jul;48(4):946-958
Podophyllotoxin-combined 5-aminolevulinic acid photodynamic therapy significantly promotes HR-HPV-infected cell death.
Wang J, Wang Q, Chen P, Li Q, Li Z, Xu M, Zeng K, Li C
Photodermatology, photoimmunology & photomedicine 2022 Jul;38(4):343-353
Photodermatology, photoimmunology & photomedicine 2022 Jul;38(4):343-353
Peste des petits ruminants virus induces ERS-mediated autophagy to promote virus replication.
Wen B, Yang L, Guo J, Chang W, Wei S, Yu S, Qi X, Xue Q, Wang J
Veterinary microbiology 2022 Jul;270:109451
Veterinary microbiology 2022 Jul;270:109451
Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis.
Li C, Wu B, Li Y, Chen J, Ye Z, Tian X, Wang J, Xu X, Pan S, Zheng Y, Cai X, Jiang L, Zhao M
Cell stem cell 2022 Jul 7;29(7):1119-1134.e7
Cell stem cell 2022 Jul 7;29(7):1119-1134.e7
The Role of Ferroptosis in the Damage of Human Proximal Tubule Epithelial Cells Caused by Perfluorooctane Sulfonate.
Wang P, Liu D, Yan S, Liang Y, Cui J, Guo L, Ren S, Chen P
Toxics 2022 Jul 29;10(8)
Toxics 2022 Jul 29;10(8)
Selective activation of cannabinoid receptor-2 reduces white matter injury via PERK signaling in a rat model of traumatic brain injury.
Li L, Luo Q, Shang B, Yang X, Zhang Y, Pan Q, Wu N, Tang W, Du D, Sun X, Jiang L
Experimental neurology 2022 Jan;347:113899
Experimental neurology 2022 Jan;347:113899
Nrf2 loss of function exacerbates endoplasmic reticulum stress-induced apoptosis in TBI mice.
Sun G, Zhao Z, Lang J, Sun B, Zhao Q
Neuroscience letters 2022 Jan 23;770:136400
Neuroscience letters 2022 Jan 23;770:136400
Cinacalcet Improves Bone Parameters Through Regulation of Osteoclast Endoplasmic Reticulum Stress, Autophagy, and Apoptotic Pathways in Chronic Kidney Disease-Mineral and Bone Disorder.
Chiu HW, Hou YC, Lu CL, Lu KC, Liu WC, Shyu JF, Chang JF, Zheng CM
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Feb;37(2):215-225
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Feb;37(2):215-225
EI24 promotes cell adaption to ER stress by coordinating IRE1 signaling and calcium homeostasis.
Xu Y, Chen J, Chen J, Teng J
EMBO reports 2022 Feb 3;23(3):e51679
EMBO reports 2022 Feb 3;23(3):e51679
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Huang Y, Chen S, Pang L, Feng Z, Su H, Zhu W, Wei J
European journal of pharmacology 2022 Feb 15;917:174749
European journal of pharmacology 2022 Feb 15;917:174749
African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-κB Signaling Pathway.
Wang Q, Zhou L, Wang J, Su D, Li D, Du Y, Yang G, Zhang G, Chu B
Viruses 2022 Feb 15;14(2)
Viruses 2022 Feb 15;14(2)
Fatty acid palmitate suppresses FoxO1 expression via PERK and IRE1 unfolded protein response in C2C12 myotubes.
Zhang B, Zhu R, Sun X, Guo Q, Zhang Y, Zhang N, Oh Y, Fan L, Wang C, Gu N
Toxicology in vitro : an international journal published in association with BIBRA 2022 Dec;85:105459
Toxicology in vitro : an international journal published in association with BIBRA 2022 Dec;85:105459
Corynoxine suppresses pancreatic cancer growth primarily via ROS-p38 mediated cytostatic effects.
Wen C, Ruan Q, Li Z, Zhou X, Yang X, Xu P, Akuetteh PDP, Xu Z, Deng J
British journal of cancer 2022 Dec;127(12):2108-2117
British journal of cancer 2022 Dec;127(12):2108-2117
African Swine Fever Virus MGF110-7L Induces Host Cell Translation Suppression and Stress Granule Formation by Activating the PERK/PKR-eIF2α Pathway.
Zhong H, Fan S, Du Y, Zhang Y, Zhang A, Jiang D, Han S, Wan B, Zhang G
Microbiology spectrum 2022 Dec 21;10(6):e0328222
Microbiology spectrum 2022 Dec 21;10(6):e0328222
YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis.
He M, Li D, Fang C, Xu Q
Archives of biochemistry and biophysics 2022 Dec 15;732:109464
Archives of biochemistry and biophysics 2022 Dec 15;732:109464
Protein palmitoylation-mediated palmitic acid sensing causes blood-testis barrier damage via inducing ER stress.
Ge X, He Z, Cao C, Xue T, Jing J, Ma R, Zhao W, Liu L, Jueraitetibaike K, Ma J, Feng Y, Qian Z, Zou Z, Chen L, Fu C, Song N, Yao B
Redox biology 2022 Aug;54:102380
Redox biology 2022 Aug;54:102380
Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.
Ming SL, Zhang S, Wang Q, Zeng L, Zhou LY, Wang MD, Ma YX, Han LQ, Zhong K, Zhu HS, Bai YL, Yang GY, Wang J, Chu BB
Autophagy 2022 Aug;18(8):1801-1821
Autophagy 2022 Aug;18(8):1801-1821
LncRNA H19 inhibits ER stress induced apoptosis and improves diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis.
Wang S, Duan J, Liao J, Wang Y, Xiao X, Li L, Liu Y, Gu H, Yang P, Fu D, Du J, Li X, Shao M
Aging 2022 Aug 30;14(16):6809-6828
Aging 2022 Aug 30;14(16):6809-6828
ATF6 deficiency damages the development of spermatogenesis in male Atf6 knockout mice.
Yu R, Chen X, Zhu X, He B, Lu C, Liu Y, Xu X, Wu X
Andrologia 2022 Apr;54(3):e14350
Andrologia 2022 Apr;54(3):e14350
IRE-1-Targeting Caged Prodrug with Endoplasmic Reticulum Stress-Inducing and XBP-1S-Inhibiting Activities for Cancer Therapy.
Shao A, Xu Q, Kang CW, Cain CF, Lee AC, Tang CA, Del Valle JR, Hu CA
Molecular pharmaceutics 2022 Apr 4;19(4):1059-1067
Molecular pharmaceutics 2022 Apr 4;19(4):1059-1067
Dietary Tryptophan Supplementation Improves Antioxidant Status and Alleviates Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Pyroptosis in the Intestine of Piglets after Lipopolysaccharide Challenge.
Liu G, Tao J, Lu J, Jia G, Zhao H, Chen X, Tian G, Cai J, Zhang R, Wang J
Antioxidants (Basel, Switzerland) 2022 Apr 28;11(5)
Antioxidants (Basel, Switzerland) 2022 Apr 28;11(5)
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Cheng F, Dun Y, Cheng J, Ripley-Gonzalez JW, Jiang W, You B, Liu S
Biochemical and biophysical research communications 2022 Apr 23;601:45-51
Biochemical and biophysical research communications 2022 Apr 23;601:45-51
Chlorogenic acid improves the intestinal barrier by relieving endoplasmic reticulum stress and inhibiting ROCK/MLCK signaling pathways.
Song L, Wu T, Zhang L, Wan J, Ruan Z
Food & function 2022 Apr 20;13(8):4562-4575
Food & function 2022 Apr 20;13(8):4562-4575
Interleukin-10 Mitigates Doxorubicin-Induced Endoplasmic Reticulum Stress as Well as Cardiomyopathy.
Malik A, Bagchi AK, Jassal DS, Singal PK
Biomedicines 2022 Apr 13;10(4)
Biomedicines 2022 Apr 13;10(4)
Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.
Liu Z, Yan M, Lei W, Jiang R, Dai W, Chen J, Wang C, Li L, Wu M, Nian X, Li D, Sun D, Lv X, Wang C, Xie C, Yao L, Wu C, Hu J, Xiao N, Mo W, Wang Z, Zhang L
The Journal of clinical investigation 2022 Apr 1;132(7)
The Journal of clinical investigation 2022 Apr 1;132(7)
Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats.
Cheng N, Shi JH, Jin Y, Shi YB, Liu XD, Zhang HP, Cao SL, Yang H, Guo WZ, Zhang SJ
Frontiers in surgery 2021;8:665260
Frontiers in surgery 2021;8:665260
Ginkgo Biloba Extract EGB761 Ameliorates the Extracellular Matrix Accumulation and Mesenchymal Transformation of Renal Tubules in Diabetic Kidney Disease by Inhibiting Endoplasmic Reticulum Stress.
Han J, Pang X, Shi X, Zhang Y, Peng Z, Xing Y
BioMed research international 2021;2021:6657206
BioMed research international 2021;2021:6657206
The Downregulation of ADAM17 Exerts Protective Effects against Cardiac Fibrosis by Regulating Endoplasmic Reticulum Stress and Mitophagy.
Guan C, Zhang HF, Wang YJ, Chen ZT, Deng BQ, Qiu Q, Chen SX, Wu MX, Chen YX, Wang JF
Oxidative medicine and cellular longevity 2021;2021:5572088
Oxidative medicine and cellular longevity 2021;2021:5572088
Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.
Sun J, Chen W, Li S, Yang S, Zhang Y, Hu X, Qiu H, Wu J, Xu S, Chu T
Frontiers in pharmacology 2021;12:751845
Frontiers in pharmacology 2021;12:751845
Dl-3-n-Butylphthalide Ameliorates Diabetic Nephropathy by Ameliorating Excessive Fibrosis and Podocyte Apoptosis.
Xu J, Tang Z, He Y, Cai S, Wang B, Zhang S, Wu M, Qian K, Zhang K, Chai B, Chen G, Xu K, Ji H, Xiao J, Wu Y
Frontiers in pharmacology 2021;12:628950
Frontiers in pharmacology 2021;12:628950
Knockdown of Oligosaccharyltransferase Subunit Ribophorin 1 Induces Endoplasmic-Reticulum-Stress-Dependent Cell Apoptosis in Breast Cancer.
Ding J, Xu J, Deng Q, Ma W, Zhang R, He X, Liu S, Zhang L
Frontiers in oncology 2021;11:722624
Frontiers in oncology 2021;11:722624
Selenium deficiency causes apoptosis through endoplasmic reticulum stress in swine small intestine.
Zheng Y, Zhang B, Guan H, Jiao X, Yang J, Cai J, Liu Q, Zhang Z
BioFactors (Oxford, England) 2021 Sep;47(5):788-800
BioFactors (Oxford, England) 2021 Sep;47(5):788-800
Hypothermic oxygenated perfusion with defatting cocktail further improves steatotic liver grafts in a transplantation rat model.
Lin F, Zhen F, Yan X, Shaojun Y, Guizhu P, Yanfeng W, Qifa Y
Artificial organs 2021 Sep;45(9):E304-E316
Artificial organs 2021 Sep;45(9):E304-E316
Role of UPR Sensor Activation in Cell Death-Survival Decision of Colon Cancer Cells Stressed by DPE Treatment.
Benedetti R, Gilardini Montani MS, Romeo MA, Arena A, Santarelli R, D'Orazi G, Cirone M
Biomedicines 2021 Sep 18;9(9)
Biomedicines 2021 Sep 18;9(9)
Inhibition of the unfolded protein response reduces arrhythmia risk after myocardial infarction.
Liu M, Liu H, Parthiban P, Kang GJ, Shi G, Feng F, Zhou A, Gu L, Karnopp C, Tolkacheva EG, Dudley SC Jr
The Journal of clinical investigation 2021 Sep 15;131(18)
The Journal of clinical investigation 2021 Sep 15;131(18)
Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response.
Ranjan K, Hedl M, Sinha S, Zhang X, Abraham C
The Journal of clinical investigation 2021 Sep 1;131(17)
The Journal of clinical investigation 2021 Sep 1;131(17)
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca(2+) homeostasis.
Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Peng X
Cell biology and toxicology 2021 Oct;37(5):795-809
Cell biology and toxicology 2021 Oct;37(5):795-809
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
Tan X, Cai D, Chen N, Du S, Qiao D, Yue X, Wang T, Li J, Xie W, Wang H
Toxicology letters 2021 Oct 10;350:98-110
Toxicology letters 2021 Oct 10;350:98-110
Cytotoxic BODIPY-Appended Half-Sandwich Iridium(III) Complex Forms Protein Adducts and Induces ER Stress.
Ramos R, Gilles JF, Morichon R, Przybylski C, Caron B, Botuha C, Karaiskou A, Salmain M, Sobczak-Thépot J
Journal of medicinal chemistry 2021 Nov 25;64(22):16675-16686
Journal of medicinal chemistry 2021 Nov 25;64(22):16675-16686
Downregulation of activating transcription factor 4 attenuates lysophosphatidycholine-induced inflammation via the NF-κB pathway.
Gong Y, Li Q, Ma Z, Jin T, Lin J, Lv Q, Wang M, Fu G, Xu S
European journal of pharmacology 2021 Nov 15;911:174457
European journal of pharmacology 2021 Nov 15;911:174457
In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR.
Charbord J, Ren L, Sharma RB, Johansson A, Ågren R, Chu L, Tworus D, Schulz N, Charbord P, Stewart AF, Wang P, Alonso LC, Andersson O
Nature metabolism 2021 May;3(5):682-700
Nature metabolism 2021 May;3(5):682-700
The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice.
Wang YL, Lee YH, Hsu YH, Chiu IJ, Huang CC, Huang CC, Chia ZC, Lee CP, Lin YF, Chiu HW
Environmental health perspectives 2021 May;129(5):57003
Environmental health perspectives 2021 May;129(5):57003
The role of ATF6 in Cr(VI)-induced apoptosis in DF-1 cells.
Zhang S, Zhao X, Hao J, Zhu Y, Wang Y, Wang L, Guo S, Yi H, Liu Y, Liu J
Journal of hazardous materials 2021 May 15;410:124607
Journal of hazardous materials 2021 May 15;410:124607
Sirtuin 6 ameliorates alcohol-induced liver injury by reducing endoplasmic reticulum stress in mice.
Xin Y, Xu L, Zhang X, Yang C, Wang Q, Xiong X
Biochemical and biophysical research communications 2021 Mar 12;544:44-51
Biochemical and biophysical research communications 2021 Mar 12;544:44-51
Nesfatin-1 inhibits myocardial ischaemia/reperfusion injury through activating Akt/ERK pathway-dependent attenuation of endoplasmic reticulum stress.
Su RY, Geng XY, Yang Y, Yin HS
Journal of cellular and molecular medicine 2021 Jun;25(11):5050-5059
Journal of cellular and molecular medicine 2021 Jun;25(11):5050-5059
4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation.
Yen IC, Tu QW, Chang TC, Lin PH, Li YF, Lee SY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111504
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111504
iPLA(2)β Contributes to ER Stress-Induced Apoptosis during Myocardial Ischemia/Reperfusion Injury.
Jin T, Lin J, Gong Y, Bi X, Hu S, Lv Q, Chen J, Li X, Chen J, Zhang W, Wang M, Fu G
Cells 2021 Jun 9;10(6)
Cells 2021 Jun 9;10(6)
Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells.
Zhu Q, Liu Z, Wang Y, Song E, Song Y
Journal of hazardous materials 2021 Jun 5;411:124958
Journal of hazardous materials 2021 Jun 5;411:124958
Secretion of signal peptides via extracellular vesicles.
Ono K, Niwa M, Suzuki H, Kobayashi NB, Yoshida T, Sawada M
Biochemical and biophysical research communications 2021 Jun 30;560:21-26
Biochemical and biophysical research communications 2021 Jun 30;560:21-26
Polybrominated diphenyl ethers quinone-induced intracellular protein oxidative damage triggers ubiquitin-proteasome and autophagy-lysosomal system activation in LO2 cells.
Wang Y, Xu L, Peng L, Fang C, Qin Q, Lv X, Liu Z, Yang B, Song E, Song Y
Chemosphere 2021 Jul;275:130034
Chemosphere 2021 Jul;275:130034
Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons.
Arioka Y, Shishido E, Kushima I, Suzuki T, Saito R, Aiba A, Mori D, Ozaki N
EBioMedicine 2021 Jan;63:103138
EBioMedicine 2021 Jan;63:103138
Microcystin-leucine arginine induced the apoptosis of GnRH neurons by activating the endoplasmic reticulum stress resulting in a decrease of serum testosterone level in mice.
Jin H, Hou J, Meng X, Ma T, Wang B, Liu Z, Sha X, Ding J, Han X
Ecotoxicology and environmental safety 2021 Jan 15;208:111748
Ecotoxicology and environmental safety 2021 Jan 15;208:111748
Metformin alleviates high glucose-induced ER stress and inflammation by inhibiting the interaction between caveolin1 and AMPKα in rat astrocytes.
Wang G, Cui W, Chen S, Shao Z, Li Y, Wang W, Mao L, Li J, Mei X
Biochemical and biophysical research communications 2021 Jan 1;534:908-913
Biochemical and biophysical research communications 2021 Jan 1;534:908-913
MicroRNA-211-5p attenuates spinal cord injury via targeting of activating transcription factor 6.
Zhang H, Piao M, Guo M, Meng L, Yu H
Tissue & cell 2021 Feb;68:101459
Tissue & cell 2021 Feb;68:101459
Activation of the G Protein-Coupled Estrogen Receptor Prevented the Development of Acute Colitis by Protecting the Crypt Cell.
Wang Q, Li Z, Liu K, Liu J, Chai S, Chen G, Wen S, Ming T, Wang J, Ma Y, Zeng H, Liu C, Xue B
The Journal of pharmacology and experimental therapeutics 2021 Feb;376(2):281-293
The Journal of pharmacology and experimental therapeutics 2021 Feb;376(2):281-293
Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324.
Li J, Xie J, Wang YZ, Gan YR, Wei L, Ding GW, Ding YH, Xie DX
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors.
Ibe NU, Subramanian A, Mukherjee S
Life science alliance 2021 Dec;4(12)
Life science alliance 2021 Dec;4(12)
The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
Wang H, Yi X, Guo S, Wang S, Ma J, Zhao T, Shi Q, Tian Y, Wang H, Jia L, Gao T, Li C, Guo W
The Journal of investigative dermatology 2021 Dec;141(12):2932-2943.e12
The Journal of investigative dermatology 2021 Dec;141(12):2932-2943.e12
Curcumin inhibits classical swine fever virus replication by interfering with lipid metabolism.
Gao Y, Hu JH, Liang XD, Chen J, Liu CC, Liu YY, Cheng Y, Go YY, Zhou B
Veterinary microbiology 2021 Aug;259:109152
Veterinary microbiology 2021 Aug;259:109152
Characterization of an endoplasmic reticulum stress-related signature to evaluate immune features and predict prognosis in glioma.
Zhang Q, Guan G, Cheng P, Cheng W, Yang L, Wu A
Journal of cellular and molecular medicine 2021 Apr;25(8):3870-3884
Journal of cellular and molecular medicine 2021 Apr;25(8):3870-3884
Therapeutic Effect of Endothelin-Converting Enzyme Inhibitor on Chronic Kidney Disease through the Inhibition of Endoplasmic Reticulum Stress and the NLRP3 Inflammasome.
Hsu YH, Zheng CM, Chou CL, Chen YJ, Lee YH, Lin YF, Chiu HW
Biomedicines 2021 Apr 7;9(4)
Biomedicines 2021 Apr 7;9(4)
Alpha-1 Antitrypsin-Induced Endoplasmic Reticulum Stress Promotes Invasion by Extravillous Trophoblasts.
Yoshida K, Kusama K, Fukushima Y, Ohmaru-Nakanishi T, Kato K, Tamura K
International journal of molecular sciences 2021 Apr 1;22(7)
International journal of molecular sciences 2021 Apr 1;22(7)
Antrodia Cinnamomea Attenuates Non-Alcoholic Steatohepatitis by Suppressing NLRP3 Inflammasome Activation In Vitro and In Vivo.
Yen IC, Lin JC, Chen Y, Tu QW, Lee SY
The American journal of Chinese medicine 2020;48(8):1859-1874
The American journal of Chinese medicine 2020;48(8):1859-1874
Salvianolic Acid B Protects Against Fatty Acid-Induced Renal Tubular Injury via Inhibition of Endoplasmic Reticulum Stress.
Mai X, Yin X, Chen P, Zhang M
Frontiers in pharmacology 2020;11:574229
Frontiers in pharmacology 2020;11:574229
Role of Endoplasmic Reticulum Stress in Otitis Media.
Zhao H, Wang Y, Li B, Zheng T, Liu X, Hu BH, Che J, Zhao T, Chen J, Hatzoglou M, Zhang X, Fan Z, Zheng Q
Frontiers in genetics 2020;11:495
Frontiers in genetics 2020;11:495
Endoplasmic Reticulum Stress Activation in Alport Syndrome Varies Between Genotype and Cell Type.
Wang C, Liang S, Xing S, Xu K, Xiao H, Deng H, Wang X, Chen L, Ding J, Wang F
Frontiers in genetics 2020;11:36
Frontiers in genetics 2020;11:36
Apigetrin ameliorates streptozotocin-induced pancreatic β-cell damages via attenuating endoplasmic reticulum stress.
Zhang R, Shi J, Wang T, Qiu X, Liu R, Li Y, Gao Q, Wang N
In vitro cellular & developmental biology. Animal 2020 Sep;56(8):622-634
In vitro cellular & developmental biology. Animal 2020 Sep;56(8):622-634
Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy.
Pang X, Qiao Q, Vonglorkham S, Feng Z, Pang L, Chen S, Wang D, Lao L, Lin X, Wei J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110375
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110375
Melatonin inhibits oxalate-induced endoplasmic reticulum stress and apoptosis in HK-2 cells by activating the AMPK pathway.
Song Q, He Z, Li B, Liu J, Liu L, Liao W, Xiong Y, Song C, Yang S, Liu Y
Cell cycle (Georgetown, Tex.) 2020 Oct;19(20):2600-2610
Cell cycle (Georgetown, Tex.) 2020 Oct;19(20):2600-2610
Berberine inhibits proliferation and apoptosis of vascular smooth muscle cells induced by mechanical stretch via the PDI/ERS and MAPK pathways.
Wang L, Deng L, Lin N, Shi Y, Chen J, Zhou Y, Chen D, Liu S, Li C
Life sciences 2020 Oct 15;259:118253
Life sciences 2020 Oct 15;259:118253
MiR-185-5p ameliorates endoplasmic reticulum stress and renal fibrosis by downregulation of ATF6.
Yuan Q, Xu T, Chen Y, Qu W, Sun D, Liu X, Sun L
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1436-1446
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1436-1446
Acupuncture protects against cerebral ischemia-reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis.
Sun X, Liu H, Sun Z, Zhang B, Wang X, Liu T, Pan T, Gao Y, Jiang X, Li H
Molecular medicine (Cambridge, Mass.) 2020 Nov 10;26(1):105
Molecular medicine (Cambridge, Mass.) 2020 Nov 10;26(1):105
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway.
Ma YY, Di ZM, Cao Q, Xu WS, Bi SX, Yu JS, Shen YJ, Yu YQ, Shen YX, Feng LJ
Acta pharmacologica Sinica 2020 Mar;41(3):404-414
Acta pharmacologica Sinica 2020 Mar;41(3):404-414
Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet‑induced obese mice via endoplasmic reticulum stress and p‑STAT3/STAT3 signaling.
Yao Y
Molecular medicine reports 2020 Mar;21(3):1059-1070
Molecular medicine reports 2020 Mar;21(3):1059-1070
Pancreatic cancer-derived exosomes induce apoptosis of T lymphocytes through the p38 MAPK-mediated endoplasmic reticulum stress.
Shen T, Huang Z, Shi C, Pu X, Xu X, Wu Z, Ding G, Cao L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):8442-8458
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):8442-8458
SHQ1 is an ER stress response gene that facilitates chemotherapeutics-induced apoptosis via sensitizing ER-stress response.
Liu H, Xie S, Fang F, Kalvakolanu DV, Xiao W
Cell death & disease 2020 Jun 10;11(6):445
Cell death & disease 2020 Jun 10;11(6):445
Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats.
Su W, Tai Y, Tang SH, Ye YT, Zhao C, Gao JH, Tuo BG, Tang CW
World journal of gastroenterology 2020 Jul 28;26(28):4094-4107
World journal of gastroenterology 2020 Jul 28;26(28):4094-4107
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, Du G
Cell proliferation 2020 Jan;53(1):e12706
Cell proliferation 2020 Jan;53(1):e12706
Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma.
Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N
Scientific reports 2020 Feb 7;10(1):2160
Scientific reports 2020 Feb 7;10(1):2160
The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts.
Stauffer WT, Blackwood EA, Azizi K, Kaufman RJ, Glembotski CC
International journal of molecular sciences 2020 Feb 18;21(4)
International journal of molecular sciences 2020 Feb 18;21(4)
TUDCA inhibits HSV-1 replication by the modulating unfolded protein response pathway.
Su A, Wang H, Zheng D, Wu Z
Journal of medical virology 2020 Dec;92(12):3628-3637
Journal of medical virology 2020 Dec;92(12):3628-3637
Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21(Cip1) and p27(Kip1).
Zhang D, Fan R, Lei L, Lei L, Wang Y, Lv N, Chen P, Williamson RA, Wang B, Hu J
Journal of cellular and molecular medicine 2020 Aug;24(16):9428-9438
Journal of cellular and molecular medicine 2020 Aug;24(16):9428-9438
FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis.
Zeng Z, Zheng Q, Chen J, Tan X, Li Q, Ding L, Zhang R, Lin X
Experimental cell research 2020 Aug 15;393(2):112108
Experimental cell research 2020 Aug 15;393(2):112108
The kinase PERK represses translation of the G-protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.
Okamoto Y, Saito T, Tani Y, Toki T, Hasebe A, Koido M, Tomida A
The Journal of biological chemistry 2020 Apr 3;295(14):4591-4603
The Journal of biological chemistry 2020 Apr 3;295(14):4591-4603
Congenital Tufting Enteropathy-Associated Mutant of Epithelial Cell Adhesion Molecule Activates the Unfolded Protein Response in a Murine Model of the Disease.
Das B, Okamoto K, Rabalais J, Marchelletta RR, Barrett KE, Das S, Niwa M, Sivagnanam M
Cells 2020 Apr 11;9(4)
Cells 2020 Apr 11;9(4)
A Novel Rhynchophylline Analog, Y396, Inhibits Endothelial Dysfunction Induced by Oxidative Stress in Diabetes Through Epidermal Growth Factor Receptor.
Wang ZJ, Chang LL, Wu J, Pan HM, Zhang QY, Wang MJ, Xin XM, Luo SS, Chen JA, Gu XF, Guo W, Zhu YZ
Antioxidants & redox signaling 2020 Apr 10;32(11):743-765
Antioxidants & redox signaling 2020 Apr 10;32(11):743-765
Unfolded Protein Response Pathways Correlatively Modulate Endoplasmic Reticulum Stress Responses in Rat Retinal Müller Cells.
Wu S, Zhu X, Guo B, Zheng T, Ren J, Zeng W, Chen X, Ke M
Journal of ophthalmology 2019;2019:9028483
Journal of ophthalmology 2019;2019:9028483
The IRE1α-XBP1 pathway function in hypoxia-induced pulmonary vascular remodeling, is upregulated by quercetin, inhibits apoptosis and partially reverses the effect of quercetin in PASMCs.
Cao X, He Y, Li X, Xu Y, Liu X
American journal of translational research 2019;11(2):641-654
American journal of translational research 2019;11(2):641-654
LncRNA LUCRC Regulates Colorectal Cancer Cell Growth and Tumorigenesis by Targeting Endoplasmic Reticulum Stress Response.
Tang GH, Chen X, Ding JC, Du J, Lin XT, Xia L, Lian JB, Ye F, He XS, Liu W
Frontiers in genetics 2019;10:1409
Frontiers in genetics 2019;10:1409
Cilostazol ameliorates ischemia/reperfusion-induced tight junction disruption in brain endothelial cells by inhibiting endoplasmic reticulum stress.
Nan D, Jin H, Deng J, Yu W, Liu R, Sun W, Huang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10152-10164
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Sep;33(9):10152-10164
Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.
Li CF, Pan YK, Gao Y, Shi F, Wang YC, Sun XQ
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):812-825
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):812-825
Icariin improves the cognitive function of APP/PS1 mice via suppressing endoplasmic reticulum stress.
Li F, Zhang Y, Lu X, Shi J, Gong Q
Life sciences 2019 Oct 1;234:116739
Life sciences 2019 Oct 1;234:116739
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.
Gao P, Chai Y, Song J, Liu T, Chen P, Zhou L, Ge X, Guo X, Han J, Yang H
PLoS pathogens 2019 Nov;15(11):e1008169
PLoS pathogens 2019 Nov;15(11):e1008169
Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1.
Cheng FY, Lee YH, Hsu YH, Chiu IJ, Chiu YJ, Lin YF, Chiu HW
Aging 2019 Nov 12;11(21):9875-9892
Aging 2019 Nov 12;11(21):9875-9892
Endoplasmic reticulum stress induces apoptosis of arginine vasopressin neurons in central diabetes insipidus via PI3K/Akt pathway.
Zhou MF, Feng ZP, Ou YC, Peng JJ, Li K, Gong HD, Qiu BH, Liu YW, Wang YJ, Qi ST
CNS neuroscience & therapeutics 2019 May;25(5):562-574
CNS neuroscience & therapeutics 2019 May;25(5):562-574
Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection.
Zhang LK, Wang B, Xin Q, Shang W, Shen S, Xiao G, Deng F, Wang H, Hu Z, Wang M
Journal of virology 2019 May 15;93(10)
Journal of virology 2019 May 15;93(10)
Flaccidoxide-13-Acetate-Induced Apoptosis in Human Bladder Cancer Cells is through Activation of p38/JNK, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress Regulated Pathway.
Wu YJ, Su TR, Dai GF, Su JH, Liu CI
Marine drugs 2019 May 13;17(5)
Marine drugs 2019 May 13;17(5)
Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo.
Hsu YH, Chuang HC, Lee YH, Lin YF, Chen YJ, Hsiao TC, Wu MY, Chiu HW
Free radical biology & medicine 2019 May 1;135:235-244
Free radical biology & medicine 2019 May 1;135:235-244
Exosomes from Microglia Attenuate Photoreceptor Injury and Neovascularization in an Animal Model of Retinopathy of Prematurity.
Xu W, Wu Y, Hu Z, Sun L, Dou G, Zhang Z, Wang H, Guo C, Wang Y
Molecular therapy. Nucleic acids 2019 Jun 7;16:778-790
Molecular therapy. Nucleic acids 2019 Jun 7;16:778-790
C/EBPβ mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes.
Guo Q, Hu H, Liu X, Yang D, Yin Y, Zhang B, He H, Oh Y, Wu Q, Liu C, Gu N
American journal of physiology. Endocrinology and metabolism 2019 Jun 1;316(6):E1081-E1092
American journal of physiology. Endocrinology and metabolism 2019 Jun 1;316(6):E1081-E1092
A pectic polysaccharide from water decoction of Xinjiang Lycium barbarum fruit protects against intestinal endoplasmic reticulum stress.
Huang C, Yao R, Zhu Z, Pang D, Cao X, Feng B, Paulsen BS, Li L, Yin Z, Chen X, Jia R, Song X, Ye G, Luo Q, Chen Z, Zou Y
International journal of biological macromolecules 2019 Jun 1;130:508-514
International journal of biological macromolecules 2019 Jun 1;130:508-514
APS could potentially activate hepatic insulin signaling in HFD-induced IR mice.
Sun J, Liu Y, Yu J, Wu J, Gao W, Ran L, Jiang R, Guo M, Han D, Liu B, Wang N, Li Y, Huang H, Zeng L, Gao Y, Li X, Wu Y
Journal of molecular endocrinology 2019 Jul;63(1):77-91
Journal of molecular endocrinology 2019 Jul;63(1):77-91
Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells.
Zhu Y, Xie M, Meng Z, Leung LK, Chan FL, Hu X, Chi K, Liu C, Yao X
Oncogene 2019 Jul;38(29):5778-5791
Oncogene 2019 Jul;38(29):5778-5791
The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration.
Hong J, Hu Z, Wu Q, Tang C, Hu J, Chen R, Li B, Wang Z
Bioscience reports 2019 Jan 31;39(1)
Bioscience reports 2019 Jan 31;39(1)
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.
Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC
Nature communications 2019 Jan 14;10(1):187
Nature communications 2019 Jan 14;10(1):187
Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos.
Ullah O, Li Z, Ali I, Xu L, Liu H, Jin HZ, Fang YY, Jin QG, Fang N
In vitro cellular & developmental biology. Animal 2019 Feb;55(2):82-93
In vitro cellular & developmental biology. Animal 2019 Feb;55(2):82-93
Catalpol Inhibits Homocysteine-induced Oxidation and Inflammation via Inhibiting Nox4/NF-κB and GRP78/PERK Pathways in Human Aorta Endothelial Cells.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Liu X, Sun H
Inflammation 2019 Feb;42(1):64-80
Inflammation 2019 Feb;42(1):64-80
Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress.
Xu S, Di Z, He Y, Wang R, Ma Y, Sun R, Li J, Wang T, Shen Y, Fang S, Feng L, Shen Y
Journal of neuroinflammation 2019 Feb 13;16(1):35
Journal of neuroinflammation 2019 Feb 13;16(1):35
Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress.
Hu J, Wu Q, Wang Z, Hong J, Chen R, Li B, Hu Z, Hu X, Zhang M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109475
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109475
LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.
Huang C, Hedl M, Ranjan K, Abraham C
Cell reports 2019 Dec 24;29(13):4525-4539.e4
Cell reports 2019 Dec 24;29(13):4525-4539.e4
Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats.
Zhao Y, Yan J, Li AP, Zhang ZL, Li ZR, Guo KJ, Zhao KC, Ruan Q, Guo L
Toxicology letters 2019 Aug;310:31-38
Toxicology letters 2019 Aug;310:31-38
Proteomic analysis of retinal pigment epithelium cells after exposure to UVA radiation.
Chen JL, Hung CT, Keller JJ, Lin HC, Wu YJ
BMC ophthalmology 2019 Aug 2;19(1):168
BMC ophthalmology 2019 Aug 2;19(1):168
Nitrosative stress drives heart failure with preserved ejection fraction.
Schiattarella GG, Altamirano F, Tong D, French KM, Villalobos E, Kim SY, Luo X, Jiang N, May HI, Wang ZV, Hill TM, Mammen PPA, Huang J, Lee DI, Hahn VS, Sharma K, Kass DA, Lavandero S, Gillette TG, Hill JA
Nature 2019 Apr;568(7752):351-356
Nature 2019 Apr;568(7752):351-356
Maternal Protein Restriction Induces Alterations in Hepatic Unfolded Protein Response-Related Molecules in Adult Rat Offspring.
Liu X, Wang J, Gao L, Jiao Y, Liu C
Frontiers in endocrinology 2018;9:676
Frontiers in endocrinology 2018;9:676
Salvianolic Acid A Attenuates Endoplasmic Reticulum Stress and Protects Against Cholestasis-Induced Liver Fibrosis via the SIRT1/HSF1 Pathway.
Zhu J, Wang R, Xu T, Zhang S, Zhao Y, Li Z, Wang C, Zhou J, Gao D, Hu Y, Tian X, Yao J
Frontiers in pharmacology 2018;9:1277
Frontiers in pharmacology 2018;9:1277
Preconditioning the uterine unfolded protein response maintains non-apoptotic Caspase 3-dependent quiescence during pregnancy.
Ingles J, Simpson A, Kyathanahalli C, Anamthathmakula P, Hassan S, Jeyasuria P, Condon JC
Cell death & disease 2018 Sep 17;9(10):933
Cell death & disease 2018 Sep 17;9(10):933
BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.
Kato Y, Kunimasa K, Sugimoto Y, Tomida A
Biochemical and biophysical research communications 2018 Oct 12;504(4):721-726
Biochemical and biophysical research communications 2018 Oct 12;504(4):721-726
NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway.
Deng L, Gao X, Liu B, He X, Xu J, Qiang J, Wu Q, Liu S
Cell death & disease 2018 Nov 16;9(12):1143
Cell death & disease 2018 Nov 16;9(12):1143
Bi-allelic CCDC47 Variants Cause a Disorder Characterized by Woolly Hair, Liver Dysfunction, Dysmorphic Features, and Global Developmental Delay.
Morimoto M, Waller-Evans H, Ammous Z, Song X, Strauss KA, Pehlivan D, Gonzaga-Jauregui C, Puffenberger EG, Holst CR, Karaca E, Brigatti KW, Maguire E, Coban-Akdemir ZH, Amagata A, Lau CC, Chepa-Lotrea X, Macnamara E, Tos T, Isikay S, Nehrebecky M, Overton JD, Klein M, Markello TC, Posey JE, Adams DR, Lloyd-Evans E, Lupski JR, Gahl WA, Malicdan MCV
American journal of human genetics 2018 Nov 1;103(5):794-807
American journal of human genetics 2018 Nov 1;103(5):794-807
Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway.
Niu X, Zhang J, Ling C, Bai M, Peng Y, Sun S, Li Y, Zhang Z
The Journal of international medical research 2018 May;46(5):1717-1733
The Journal of international medical research 2018 May;46(5):1717-1733
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
Tsai TC, Lai KH, Su JH, Wu YJ, Sheu JH
Marine drugs 2018 Mar 26;16(4)
Marine drugs 2018 Mar 26;16(4)
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Wang D, Lao L, Pang X, Qiao Q, Pang L, Feng Z, Bai F, Sun X, Lin X, Wei J
International immunopharmacology 2018 Dec;65:256-267
International immunopharmacology 2018 Dec;65:256-267
Network pharmacology-based identification of major component of Angelica sinensis and its action mechanism for the treatment of acute myocardial infarction.
Niu X, Zhang J, Ni J, Wang R, Zhang W, Sun S, Peng Y, Bai M, Zhang Z
Bioscience reports 2018 Dec 21;38(6)
Bioscience reports 2018 Dec 21;38(6)
Exogenous H(2)S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Sun W, Yang J, Zhang Y, Xi Y, Wen X, Yuan D, Wang Y, Wei C, Wang R, Wu L, Li H, Xu C
Cell & bioscience 2017;7:67
Cell & bioscience 2017;7:67
Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm.
Li Y, Lu G, Sun D, Zuo H, Wang DW, Yan J
PloS one 2017;12(4):e0174821
PloS one 2017;12(4):e0174821
Involvement of endoplasmic reticulum stress in formalin-induced pain is attenuated by 4-phenylbutyric acid.
Zhou F, Zhang W, Zhou J, Li M, Zhong F, Zhang Y, Liu Y, Wang Y
Journal of pain research 2017;10:653-662
Journal of pain research 2017;10:653-662
β-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1α/ATF6 pathway.
Liu Y, Jiang ZY, Zhou YL, Qiu HH, Wang G, Luo Y, Liu JB, Liu XW, Bu WQ, Song J, Cui L, Jia XB, Feng L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Sep;93:490-497
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Sep;93:490-497
Effect of Subcellular Translocation of Protein Disulfide Isomerase on Tetrachlorobenzoquinone-Induced Signaling Shift from Endoplasmic Reticulum Stress to Apoptosis.
Liu Z, Wang Y, Wang Y, Dong W, Xia X, Song E, Song Y
Chemical research in toxicology 2017 Oct 16;30(10):1804-1814
Chemical research in toxicology 2017 Oct 16;30(10):1804-1814
Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress.
Han K, Hassanzadeh S, Singh K, Menazza S, Nguyen TT, Stevens MV, Nguyen A, San H, Anderson SA, Lin Y, Zou J, Murphy E, Sack MN
Scientific reports 2017 May 18;7(1):2093
Scientific reports 2017 May 18;7(1):2093
Identification of Novel SCIRR69-Interacting Proteins During ER Stress Using SILAC-Immunoprecipitation Quantitative Proteomics Approach.
Chen Y, Liu Y, Lin S, Yang S, Que H, Liu S
Neuromolecular medicine 2017 Mar;19(1):81-93
Neuromolecular medicine 2017 Mar;19(1):81-93
ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart.
Jin JK, Blackwood EA, Azizi K, Thuerauf DJ, Fahem AG, Hofmann C, Kaufman RJ, Doroudgar S, Glembotski CC
Circulation research 2017 Mar 3;120(5):862-875
Circulation research 2017 Mar 3;120(5):862-875
Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.
La X, Zhang L, Li Z, Yang P, Wang Y
Oncotarget 2017 Mar 28;8(13):20909-20924
Oncotarget 2017 Mar 28;8(13):20909-20924
RCAD/BiP pathway is necessary for the proper synthesis of digestive enzymes and secretory function of the exocrine pancreas.
Miller C, Cai Y, Patton T, Graves SH, Li H, Sabbatini ME
American journal of physiology. Gastrointestinal and liver physiology 2017 Mar 1;312(3):G314-G326
American journal of physiology. Gastrointestinal and liver physiology 2017 Mar 1;312(3):G314-G326
Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
Yang F, Yu X, Li T, Wu J, Zhao Y, Liu J, Sun A, Dong S, Wu J, Zhong X, Xu C, Lu F, Zhang W
American journal of physiology. Endocrinology and metabolism 2017 Mar 1;312(3):E190-E203
American journal of physiology. Endocrinology and metabolism 2017 Mar 1;312(3):E190-E203
Imaging specific newly synthesized proteins within cells by fluorescence resonance energy transfer.
Sheng L, Cai L, Liu J, Zhang S, Xu JJ, Zhang X, Chen HY
Chemical science 2017 Jan 1;8(1):748-754
Chemical science 2017 Jan 1;8(1):748-754
Activation of UPR Signaling Pathway is Associated With the Malignant Progression and Poor Prognosis in Prostate Cancer.
Liu J, Xiao M, Li J, Wang D, He Y, He J, Gao F, Mai L, Li Y, Liang Y, Liu Y, Zhong X
The Prostate 2017 Feb;77(3):274-281
The Prostate 2017 Feb;77(3):274-281
PDI regulates seizure activity via NMDA receptor redox in rats.
Kim JY, Ko AR, Hyun HW, Min SJ, Kim JE
Scientific reports 2017 Feb 15;7:42491
Scientific reports 2017 Feb 15;7:42491
A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells.
Wang Y, Wu H, Li Z, Yang P, Li Z
Experimental cell research 2017 Feb 1;351(1):24-35
Experimental cell research 2017 Feb 1;351(1):24-35
Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase.
Yue X, Zuo Y, Ke H, Luo J, Lou L, Qin W, Wang Y, Liu Z, Chen D, Sun H, Zheng W, Zhu C, Wang R, Wen G, Du J, Zhou B, Bu X
Biochemical pharmacology 2017 Aug 1;137:29-50
Biochemical pharmacology 2017 Aug 1;137:29-50
Cytotoxicity of 11-epi-Sinulariolide Acetate Isolated from Cultured Soft Corals on HA22T Cells through the Endoplasmic Reticulum Stress Pathway and Mitochondrial Dysfunction.
Lin JJ, Wang RY, Chen JC, Chiu CC, Liao MH, Wu YJ
International journal of molecular sciences 2016 Oct 27;17(11)
International journal of molecular sciences 2016 Oct 27;17(11)
Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu K, Sun H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:63-72
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:63-72
Vaspin attenuates the progression of atherosclerosis by inhibiting ER stress-induced macrophage apoptosis in apoE‑/‑ mice.
Lin Y, Zhuang J, Li H, Zhu G, Zhou S, Li W, Peng W, Xu Y
Molecular medicine reports 2016 Feb;13(2):1509-16
Molecular medicine reports 2016 Feb;13(2):1509-16
Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking.
Zhou Y, Zhang S, Dai C, Tang S, Yang X, Li D, Zhao K, Xiao X
Cell biology and toxicology 2016 Apr;32(2):141-52
Cell biology and toxicology 2016 Apr;32(2):141-52
Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release.
Xu D, Su C, Song X, Shi Q, Fu J, Hu L, Xia X, Song E, Song Y
Chemical research in toxicology 2015 Jun 15;28(6):1326-37
Chemical research in toxicology 2015 Jun 15;28(6):1326-37
Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats.
Yu H, Zheng L, Xu L, Yin L, Lin Y, Li H, Liu K, Peng J
Phytotherapy research : PTR 2015 Feb;29(2):228-40
Phytotherapy research : PTR 2015 Feb;29(2):228-40
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF-7 cells were subjected to SDS PAGE followed by western blot with 24169-1-AP( ATF6 Antibody) at dilution of 1:3000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ATF6 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ATF6. This antibody recognizes human antigen. The ATF6 antibody has been validated for the following applications: ELISA, WB, IF, IHC analysis.
