Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations [0]
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- Product number
- AF370 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal ALK-1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects human ALK-1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant mouse ALK-1 is observed and less than 1% cross-reactivity with recombinant human (rh) Activin RIA and rhActivin RIB is observed.
- Reactivity
- Human
- Host
- Goat
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Key role of the endothelial TGF-β/ALK1/endoglin signaling pathway in humans and rodents pulmonary hypertension.
Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting.
Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations.
Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH.
Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.
Activin receptor-like kinase 1 inhibits human microvascular endothelial cell migration: potential roles for JNK and ERK.
Cyclic stretch controls the expression of CD40 in endothelial cells by changing their transforming growth factor-beta1 response.
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.
The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension.
Gore B, Izikki M, Mercier O, Dewachter L, Fadel E, Humbert M, Dartevelle P, Simonneau G, Naeije R, Lebrin F, Eddahibi S
PloS one 2014;9(6):e100310
PloS one 2014;9(6):e100310
Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting.
van Meeteren LA, Thorikay M, Bergqvist S, Pardali E, Stampino CG, Hu-Lowe D, Goumans MJ, ten Dijke P
The Journal of biological chemistry 2012 May 25;287(22):18551-61
The Journal of biological chemistry 2012 May 25;287(22):18551-61
Functional analysis of the BMP9 response of ALK1 mutants from HHT2 patients: a diagnostic tool for novel ACVRL1 mutations.
Ricard N, Bidart M, Mallet C, Lesca G, Giraud S, Prudent R, Feige JJ, Bailly S
Blood 2010 Sep 2;116(9):1604-12
Blood 2010 Sep 2;116(9):1604-12
Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH.
Mahmoud M, Borthwick GM, Hislop AA, Arthur HM
Laboratory investigation; a journal of technical methods and pathology 2009 Jan;89(1):15-25
Laboratory investigation; a journal of technical methods and pathology 2009 Jan;89(1):15-25
Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production.
Tabata T, Kawakatsu H, Maidji E, Sakai T, Sakai K, Fang-Hoover J, Aiba M, Sheppard D, Pereira L
The American journal of pathology 2008 Apr;172(4):1127-40
The American journal of pathology 2008 Apr;172(4):1127-40
Activin receptor-like kinase 1 inhibits human microvascular endothelial cell migration: potential roles for JNK and ERK.
David L, Mallet C, Vailhé B, Lamouille S, Feige JJ, Bailly S
Journal of cellular physiology 2007 Nov;213(2):484-9
Journal of cellular physiology 2007 Nov;213(2):484-9
Cyclic stretch controls the expression of CD40 in endothelial cells by changing their transforming growth factor-beta1 response.
Korff T, Aufgebauer K, Hecker M
Circulation 2007 Nov 13;116(20):2288-97
Circulation 2007 Nov 13;116(20):2288-97
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells.
David L, Mallet C, Mazerbourg S, Feige JJ, Bailly S
Blood 2007 Mar 1;109(5):1953-61
Blood 2007 Mar 1;109(5):1953-61
The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension.
Zakrzewicz A, Kouri FM, Nejman B, Kwapiszewska G, Hecker M, Sandu R, Dony E, Seeger W, Schermuly RT, Eickelberg O, Morty RE
The European respiratory journal 2007 Jun;29(6):1094-104
The European respiratory journal 2007 Jun;29(6):1094-104
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