Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations [0]
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- Product number
- AF770 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse ALK-1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects mouse ALK-1 in ELISAs and Western blots. In sandwich immunoassays, less than 5% cross-reactivity with recombinant human ALK-1 is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q61288
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia.
BMP9/ALK1 inhibits neovascularization in mouse models of age-related macular degeneration.
Endothelial β4 integrin is predominantly expressed in arterioles, where it promotes vascular remodeling in the hypoxic brain.
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth.
Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann A
Nature communications 2016 Nov 29;7:13650
Nature communications 2016 Nov 29;7:13650
BMP9/ALK1 inhibits neovascularization in mouse models of age-related macular degeneration.
Ntumba K, Akla N, Oh SP, Eichmann A, Larrivée B
Oncotarget 2016 Aug 30;7(35):55957-55969
Oncotarget 2016 Aug 30;7(35):55957-55969
Endothelial β4 integrin is predominantly expressed in arterioles, where it promotes vascular remodeling in the hypoxic brain.
Welser-Alves JV, Boroujerdi A, Tigges U, Wrabetz L, Feltri ML, Milner R
Arteriosclerosis, thrombosis, and vascular biology 2013 May;33(5):943-53
Arteriosclerosis, thrombosis, and vascular biology 2013 May;33(5):943-53
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth.
Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran JA, Pearsall RS, Underwood KW, Seehra J, Kumar R
Molecular cancer therapeutics 2010 Feb;9(2):379-88
Molecular cancer therapeutics 2010 Feb;9(2):379-88
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