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- Antibody Data
- Antigen structure
- References [35]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 19662-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19662-1-AP, RRID:AB_10859778
- Product name
- Hexokinase 1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Hexokinase 1 antibody (Cat. #19662-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Icariin ameliorates glycolytic dysfunction in Alzheimer's disease models by activating the Wnt/β-catenin signaling pathway.
Generation of human alveolar epithelial type I cells from pluripotent stem cells.
Nanoparticles for inducing Gaucher disease-like damage in cancer cells.
Yu Linzhu alleviates primary ovarian insufficiency in a rat model by improving proliferation and energy metabolism of granulosa cells through hif1α/cx43 pathway.
Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441.
Suppression of hnRNP A1 binding to HK1 RNA leads to glycolytic dysfunction in Alzheimer's disease models.
Depressed Proximal Glycolysis in Myocardium Of Human Heart Failure with Preserved Ejection Fraction.
Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway.
MIR34A modulates lens epithelial cell apoptosis and cataract development via the HK1/caspase 3 signaling pathway.
Glycolytic Plasticity of Metastatic Lung Cancer Captured by Noninvasive (18)F-FDG PET/CT and Serum (1)H-NMR Analysis: An Orthotopic Murine Model Study.
The Effects of Prenatal Dexamethasone Exposure on Brain Metabolic Homeostasis in Adulthood: Implications for Depression.
Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells.
Effects of propranolol on glucose metabolism in hemangioma-derived endothelial cells.
Development and validation of a novel hypoxia-related signature for prognostic and immunogenic evaluation in head and neck squamous cell carcinoma.
Engineering of thick human functional myocardium via static stretching and electrical stimulation.
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.
GM3 synthase deficiency increases brain glucose metabolism in mice.
GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin.
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis.
HIF-1 regulates energy metabolism of the Tibetan chicken brain during embryo development under hypoxia.
Androgen Receptor Stimulates Hexokinase 2 and Induces Glycolysis by PKA/CREB Signaling in Hepatocellular Carcinoma.
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Downregulation of GLUT3 impairs STYK1/NOK-mediated metabolic reprogramming and proliferation in NIH-3T3 cells.
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
JAK2(V617F) Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages.
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
Localisation and function of glucose transporter GLUT1 in chicken (Gallus gallus domesticus) spermatozoa: relationship between ATP production pathways and flagellar motility.
Deoxyelephantopin suppresses hepatic stellate cells activation associated with inhibition of aerobic glycolysis via hedgehog pathway.
Accelerated Metabolite Levels of Aerobic Glycolysis and the Pentose Phosphate Pathway Are Required for Efficient Replication of Infectious Spleen and Kidney Necrosis Virus in Chinese Perch Brain Cells.
The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.
Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis.
The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.
Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule epithelial cells.
Liu J, Wei AH, Liu TT, Ji XH, Zhang Y, Yan F, Chen MX, Hu JB, Zhou SY, Shi JS, Jin H, Jin F
The FEBS journal 2024 May;291(10):2221-2241
The FEBS journal 2024 May;291(10):2221-2241
Generation of human alveolar epithelial type I cells from pluripotent stem cells.
Burgess CL, Huang J, Bawa PS, Alysandratos KD, Minakin K, Ayers LJ, Morley MP, Babu A, Villacorta-Martin C, Yampolskaya M, Hinds A, Thapa BR, Wang F, Matschulat A, Mehta P, Morrisey EE, Varelas X, Kotton DN
Cell stem cell 2024 May 2;31(5):657-675.e8
Cell stem cell 2024 May 2;31(5):657-675.e8
Nanoparticles for inducing Gaucher disease-like damage in cancer cells.
Yue C, Lu W, Fan S, Huang Z, Yang J, Dong H, Zhang X, Shang Y, Lai W, Li D, Dong T, Yuan A, Wu J, Kang L, Hu Y
Nature nanotechnology 2024 Aug;19(8):1203-1215
Nature nanotechnology 2024 Aug;19(8):1203-1215
Yu Linzhu alleviates primary ovarian insufficiency in a rat model by improving proliferation and energy metabolism of granulosa cells through hif1α/cx43 pathway.
Ruan X, Wang P, Wei M, Yang Q, Dong X
Journal of ovarian research 2024 Apr 26;17(1):89
Journal of ovarian research 2024 Apr 26;17(1):89
Magnetic Fields Reduce Apoptosis by Suppressing Phase Separation of Tau-441.
Lin WJ, Shi WP, Ge WY, Chen LL, Guo WH, Shang P, Yin DC
Research (Washington, D.C.) 2023;6:0146
Research (Washington, D.C.) 2023;6:0146
Suppression of hnRNP A1 binding to HK1 RNA leads to glycolytic dysfunction in Alzheimer's disease models.
Ji XH, Liu TT, Wei AH, Lei HP, Chen Y, Wu LN, Liu J, Zhang Y, Yan F, Chen MX, Jin H, Shi JS, Zhou SY, Jin F
Frontiers in aging neuroscience 2023;15:1218267
Frontiers in aging neuroscience 2023;15:1218267
Depressed Proximal Glycolysis in Myocardium Of Human Heart Failure with Preserved Ejection Fraction.
Koleini N, Meddeb M, Keykhaei M, Kwon S, Zhao L, Hahn V, Sharma K, Pearce EL, Kass DA
medRxiv : the preprint server for health sciences 2023 Oct 2;
medRxiv : the preprint server for health sciences 2023 Oct 2;
Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK/SIRT1/NF-κB signaling pathway.
He Y, Wang Y, Jia X, Li Y, Yang Y, Pan L, Zhao R, Han Y, Wang F, Guan X, Hou T
International immunopharmacology 2023 Jun;119:110192
International immunopharmacology 2023 Jun;119:110192
MIR34A modulates lens epithelial cell apoptosis and cataract development via the HK1/caspase 3 signaling pathway.
Feng L, Wei Y, Sun Y, Zhou L, Bi S, Chen W, Xiang W
Aging 2023 Jul 6;15(13):6331-6345
Aging 2023 Jul 6;15(13):6331-6345
Glycolytic Plasticity of Metastatic Lung Cancer Captured by Noninvasive (18)F-FDG PET/CT and Serum (1)H-NMR Analysis: An Orthotopic Murine Model Study.
Chung YH, Hung TH, Yu CF, Tsai CK, Weng CC, Jhang F, Chen FH, Lin G
Metabolites 2023 Jan 9;13(1)
Metabolites 2023 Jan 9;13(1)
The Effects of Prenatal Dexamethasone Exposure on Brain Metabolic Homeostasis in Adulthood: Implications for Depression.
Głombik K, Kukla-Bartoszek M, Curzytek K, Detka J, Basta-Kaim A, Budziszewska B
International journal of molecular sciences 2023 Jan 6;24(2)
International journal of molecular sciences 2023 Jan 6;24(2)
Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells.
Alysandratos KD, Garcia-de-Alba C, Yao C, Pessina P, Huang J, Villacorta-Martin C, Hix OT, Minakin K, Burgess CL, Bawa P, Murthy A, Konda B, Beers MF, Stripp BR, Kim CF, Kotton DN
JCI insight 2023 Jan 10;8(1)
JCI insight 2023 Jan 10;8(1)
Effects of propranolol on glucose metabolism in hemangioma-derived endothelial cells.
Yang K, Li X, Qiu T, Zhou J, Gong X, Lan Y, Ji Y
Biochemical pharmacology 2023 Dec;218:115922
Biochemical pharmacology 2023 Dec;218:115922
Development and validation of a novel hypoxia-related signature for prognostic and immunogenic evaluation in head and neck squamous cell carcinoma.
Li SR, Man QW, Liu B
Frontiers in oncology 2022;12:943945
Frontiers in oncology 2022;12:943945
Engineering of thick human functional myocardium via static stretching and electrical stimulation.
Pretorius D, Kahn-Krell AM, LaBarge WC, Lou X, Zhang J
iScience 2022 Mar 18;25(3):103824
iScience 2022 Mar 18;25(3):103824
Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.
Li X, Zhang Y, Wang X, Lin F, Cheng X, Wang Z, Wang X
Cell biology and toxicology 2022 Dec;38(6):1027-1045
Cell biology and toxicology 2022 Dec;38(6):1027-1045
GM3 synthase deficiency increases brain glucose metabolism in mice.
Bharathi SS, Zhang BB, Paul E, Zhang Y, Schmidt AV, Fowler B, Wu Y, Tiemeyer M, Inamori KI, Inokuchi JI, Goetzman ES
Molecular genetics and metabolism 2022 Dec;137(4):342-348
Molecular genetics and metabolism 2022 Dec;137(4):342-348
GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin.
Ahat E, Bui S, Zhang J, da Veiga Leprevost F, Sharkey L, Reid W, Nesvizhskii AI, Paulson HL, Wang Y
The Journal of biological chemistry 2022 Aug;298(8):102219
The Journal of biological chemistry 2022 Aug;298(8):102219
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Wang L, Lin Y, Zhou X, Chen Y, Li X, Luo W, Zhou Y, Cai L
Cancer letters 2022 Apr 28;532:215586
Cancer letters 2022 Apr 28;532:215586
Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis.
Chen X, Sun N, Li R, Sang X, Li X, Zhao J, Han J, Yang J, Ikezoe T
International journal of biological sciences 2021;17(5):1263-1276
International journal of biological sciences 2021;17(5):1263-1276
HIF-1 regulates energy metabolism of the Tibetan chicken brain during embryo development under hypoxia.
Tang Q, Xu Q, Ding C, Zhang H, Ling Y, Wu C, Fang M
American journal of physiology. Regulatory, integrative and comparative physiology 2021 May 1;320(5):R704-R713
American journal of physiology. Regulatory, integrative and comparative physiology 2021 May 1;320(5):R704-R713
Androgen Receptor Stimulates Hexokinase 2 and Induces Glycolysis by PKA/CREB Signaling in Hepatocellular Carcinoma.
Sun RF, Zhao CY, Chen S, Yu W, Zhou MM, Gao CR
Digestive diseases and sciences 2021 Mar;66(3):802-813
Digestive diseases and sciences 2021 Mar;66(3):802-813
SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis.
Shangguan X, He J, Ma Z, Zhang W, Ji Y, Shen K, Yue Z, Li W, Xin Z, Zheng Q, Cao Y, Pan J, Dong B, Cheng J, Wang Q, Xue W
Nature communications 2021 Mar 22;12(1):1812
Nature communications 2021 Mar 22;12(1):1812
Downregulation of GLUT3 impairs STYK1/NOK-mediated metabolic reprogramming and proliferation in NIH-3T3 cells.
Shi W, Fu Y, Wang Y
Oncology letters 2021 Jul;22(1):527
Oncology letters 2021 Jul;22(1):527
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
Gu M, Zhou X, Sohn JH, Zhu L, Jie Z, Yang JY, Zheng X, Xie X, Yang J, Shi Y, Brightbill HD, Kim JB, Wang J, Cheng X, Sun SC
Nature immunology 2021 Feb;22(2):193-204
Nature immunology 2021 Feb;22(2):193-204
JAK2(V617F) Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages.
Li R, Sun N, Chen X, Li X, Zhao J, Cheng W, Hua H, Fukatsu M, Mori H, Takahashi H, Ohkawara H, Fukami M, Okamoto M, Hamazaki Y, Zheng K, Yang J, Ikezoe T
Frontiers in immunology 2020;11:589048
Frontiers in immunology 2020;11:589048
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, Chan ER, Wang Q, Xu R, Flanagan ME, Pieper AA, Qi X
Science advances 2020 Dec;6(49)
Science advances 2020 Dec;6(49)
Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
He X, Li M, Yu H, Liu G, Wang N, Yin C, Tu Q, Narla G, Tao Y, Cheng S, Yin H
PLoS biology 2020 Dec;18(12):e3000803
PLoS biology 2020 Dec;18(12):e3000803
Localisation and function of glucose transporter GLUT1 in chicken (Gallus gallus domesticus) spermatozoa: relationship between ATP production pathways and flagellar motility.
Setiawan R, Priyadarshana C, Tajima A, Travis AJ, Asano A
Reproduction, fertility, and development 2020 Apr;32(7):697-705
Reproduction, fertility, and development 2020 Apr;32(7):697-705
Deoxyelephantopin suppresses hepatic stellate cells activation associated with inhibition of aerobic glycolysis via hedgehog pathway.
Gao W, Sun J, Wang F, Lu Y, Wen C, Bian Q, Wu H
Biochemical and biophysical research communications 2019 Sep 3;516(4):1222-1228
Biochemical and biophysical research communications 2019 Sep 3;516(4):1222-1228
Accelerated Metabolite Levels of Aerobic Glycolysis and the Pentose Phosphate Pathway Are Required for Efficient Replication of Infectious Spleen and Kidney Necrosis Virus in Chinese Perch Brain Cells.
Guo X, Wu S, Li N, Lin Q, Liu L, Liang H, Niu Y, Huang Z, Fu X
Biomolecules 2019 Sep 2;9(9)
Biomolecules 2019 Sep 2;9(9)
The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.
Lian X, Wu X, Li Z, Zhang Y, Song K, Cai G, Li Q, Lin S, Chen X, Bai XY
British journal of pharmacology 2019 Mar;176(5):711-724
British journal of pharmacology 2019 Mar;176(5):711-724
Inhibition of hexokinases holds potential as treatment strategy for rheumatoid arthritis.
Song G, Lu Q, Fan H, Zhang X, Ge L, Tian R, Wang S, Feng T, Pan J, Feng J, Xiao Y, Yi X, Ren N, Wang L
Arthritis research & therapy 2019 Apr 3;21(1):87
Arthritis research & therapy 2019 Apr 3;21(1):87
The changes in glucose metabolism and cell proliferation in the kidneys of polycystic kidney disease mini-pig models.
Lian X, Zhao J, Wu X, Zhang Y, Li Q, Lin S, Bai XY, Chen X
Biochemical and biophysical research communications 2017 Jun 24;488(2):374-381
Biochemical and biophysical research communications 2017 Jun 24;488(2):374-381
Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule epithelial cells.
Song H, Yoon SP, Kim J
Anatomy & cell biology 2016 Jun;49(2):79-87
Anatomy & cell biology 2016 Jun;49(2):79-87
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 19662-1-AP(HK1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 19662-1-AP(HK1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Hexokinase 1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Hexokinase 1. This antibody recognizes human,mouse,rat antigen. The Hexokinase 1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
