orb386137

antibody from Biorbyt

Targeting: ALPL HOPS, TNALP, TNAP, TNSALP

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb386137

Provider

Biorbyt

Product name

Tissue-nonspecific Alkaline Phosphatase Antibody / ALPL

Antibody type

Monoclonal

Description

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

ALPL/597

Vial size

20 ug

Storage

Store the Alkaline Phosphatase antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).