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- Antibody Data
- Antigen structure
- References [44]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 17880-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17880-1-AP, RRID:AB_2068826
- Product name
- CAMSAP2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CAMSAP2 antibody (Cat. #17880-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CAMSAPs and nucleation-promoting factors control microtubule release from γ-TuRC.
CAMSAP2 and CAMSAP3 localize at microtubule intersections to regulate the spatial distribution of microtubules.
Map-1a regulates Sertoli cell BTB dynamics through the cytoskeletal organization of microtubule and F-actin.
The Planar Cell Polarity Protein Fat1 in Sertoli Cell Function.
Slow kinesin-dependent microtubular transport facilitates ribbon synapse assembly in developing cochlear inner hair cells.
Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release.
Centrins control chicken cone cell lipid droplet dynamics through lipid-droplet-localized SPDL1.
The CEP170B-KIF2A complex destabilizes microtubule minus ends to generate polarized microtubule network.
Regulation of Sertoli cell function by planar cell polarity (PCP) protein Fjx1.
CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway.
Opto-katanin, an optogenetic tool for localized, microtubule disassembly.
The mechanism of acentrosomal spindle assembly in human oocytes.
The Reduction in Microtubule Arrays Caused by the Dysplasia of the Non-Centrosomal Microtubule-Organizing Center Leads to a Malformed Organ of Corti in the Cx26-Null Mouse.
CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation.
Self-assembly of pericentriolar material in interphase cells lacking centrioles.
AKAP9 supports spermatogenesis through its effects on microtubule and actin cytoskeletons in the rat testis.
The Golgi microtubules regulate single cell durotaxis.
WDR47 protects neuronal microtubule minus ends from katanin-mediated severing.
The Non-hormonal Male Contraceptive Adjudin Exerts its Effects via MAPs and Signaling Proteins mTORC1/rpS6 and FAK-Y407.
A chemical genetics approach to examine the functions of AAA proteins.
KIF15 supports spermatogenesis via its effects on Sertoli cell microtubule, actin, vimentin, and septin cytoskeletons.
NC1-Peptide From Collagen α3 (IV) Chains in the Basement Membrane of Testes Regulates Spermatogenesis via p-FAK-Y407.
Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization.
Golgi-associated microtubules are fast cargo tracks and required for persistent cell migration.
Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development.
Regulation of BTB Dynamics in Spermatogenesis-Insights From the Adjudin Model.
CAMSAP2 Is a Microtubule Minus-End Targeting Protein That Regulates BTB Dynamics Through Cytoskeletal Organization.
Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity.
Loss of CAMSAP3 promotes EMT via the modification of microtubule-Akt machinery.
Structural centrosome aberrations promote non-cell-autonomous invasiveness.
APC2 controls dendrite development by promoting microtubule dynamics.
EB1 and EB3 regulate microtubule minus end organization and Golgi morphology.
Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres.
Noncentrosomal microtubules regulate autophagosome transport through CAMSAP2-EB1 cross-talk.
Control of apico-basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7.
Sliding of centrosome-unattached microtubules defines key features of neuronal phenotype.
Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation.
Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment.
TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays.
Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development.
Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.
Katanin p80 regulates human cortical development by limiting centriole and cilia number.
Cell cycle regulation of microtubule interactomes: multi-layered regulation is critical for the interphase/mitosis transition.
Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules.
Rai D, Song Y, Hua S, Stecker K, Monster JL, Yin V, Stucchi R, Xu Y, Zhang Y, Chen F, Katrukha EA, Altelaar M, Heck AJR, Wieczorek M, Jiang K, Akhmanova A
Nature cell biology 2024 Mar;26(3):404-420
Nature cell biology 2024 Mar;26(3):404-420
CAMSAP2 and CAMSAP3 localize at microtubule intersections to regulate the spatial distribution of microtubules.
Zhang R, Gu L, Chen W, Tanaka N, Zhou Z, Xu H, Xu T, Ji W, Liang X, Meng W
Journal of molecular cell biology 2024 Jan 17;15(8)
Journal of molecular cell biology 2024 Jan 17;15(8)
Map-1a regulates Sertoli cell BTB dynamics through the cytoskeletal organization of microtubule and F-actin.
Wang L, Yan M, Bu T, Wu X, Li L, Silvestrini B, Sun F, Cheng CY, Chen H
Reproductive biology and endocrinology : RB&E 2024 Apr 3;22(1):36
Reproductive biology and endocrinology : RB&E 2024 Apr 3;22(1):36
The Planar Cell Polarity Protein Fat1 in Sertoli Cell Function.
Bu T, Wang L, Wu X, Gao S, Li X, Yun D, Yang X, Li L, Cheng CY, Sun F
Endocrinology 2024 Apr 29;165(6)
Endocrinology 2024 Apr 29;165(6)
Slow kinesin-dependent microtubular transport facilitates ribbon synapse assembly in developing cochlear inner hair cells.
Voorn RA, Sternbach M, Jarysta A, Rankovic V, Tarchini B, Wolf F, Vogl C
bioRxiv : the preprint server for biology 2024 Apr 15;
bioRxiv : the preprint server for biology 2024 Apr 15;
Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release.
Adrian M, Weber M, Tsai MC, Glock C, Kahn OI, Phu L, Cheung TK, Meilandt WJ, Rose CM, Hoogenraad CC
Nature communications 2023 Oct 9;14(1):6322
Nature communications 2023 Oct 9;14(1):6322
Centrins control chicken cone cell lipid droplet dynamics through lipid-droplet-localized SPDL1.
Pan H, Qin Y, Zhu J, Wang W, Liu Z, Huang X, Lam SM, Shui G, Wang Y, Jiang Y, Huang X
Developmental cell 2023 Nov 20;58(22):2528-2544.e8
Developmental cell 2023 Nov 20;58(22):2528-2544.e8
The CEP170B-KIF2A complex destabilizes microtubule minus ends to generate polarized microtubule network.
Guan C, Hua S, Jiang K
The EMBO journal 2023 Jun 1;42(11):e112953
The EMBO journal 2023 Jun 1;42(11):e112953
Regulation of Sertoli cell function by planar cell polarity (PCP) protein Fjx1.
Bu T, Li X, Wang L, Wu X, Gao S, Yun D, Li L, Sun F, Cheng CY
Molecular and cellular endocrinology 2023 Jul 1;571:111936
Molecular and cellular endocrinology 2023 Jul 1;571:111936
CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway.
Wang X, Liu Y, Ding Y, Feng G
Scientific reports 2022 Oct 7;12(1):16899
Scientific reports 2022 Oct 7;12(1):16899
Opto-katanin, an optogenetic tool for localized, microtubule disassembly.
Meiring JCM, Grigoriev I, Nijenhuis W, Kapitein LC, Akhmanova A
Current biology : CB 2022 Nov 7;32(21):4660-4674.e6
Current biology : CB 2022 Nov 7;32(21):4660-4674.e6
The mechanism of acentrosomal spindle assembly in human oocytes.
Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X, Sang Q, Wang L
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
The Reduction in Microtubule Arrays Caused by the Dysplasia of the Non-Centrosomal Microtubule-Organizing Center Leads to a Malformed Organ of Corti in the Cx26-Null Mouse.
Qiu Y, Xu K, Xie L, Chen S, Sun Y
Biomedicines 2022 Jun 9;10(6)
Biomedicines 2022 Jun 9;10(6)
CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation.
Imasaki T, Kikkawa S, Niwa S, Saijo-Hamano Y, Shigematsu H, Aoyama K, Mitsuoka K, Shimizu T, Aoki M, Sakamoto A, Tomabechi Y, Sakai N, Shirouzu M, Taguchi S, Yamagishi Y, Setsu T, Sakihama Y, Nitta E, Takeichi M, Nitta R
eLife 2022 Jun 28;11
eLife 2022 Jun 28;11
Self-assembly of pericentriolar material in interphase cells lacking centrioles.
Chen F, Wu J, Iwanski MK, Jurriens D, Sandron A, Pasolli M, Puma G, Kromhout JZ, Yang C, Nijenhuis W, Kapitein LC, Berger F, Akhmanova A
eLife 2022 Jul 5;11
eLife 2022 Jul 5;11
AKAP9 supports spermatogenesis through its effects on microtubule and actin cytoskeletons in the rat testis.
Wu S, Li L, Wu X, Wong CKC, Sun F, Cheng CY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Oct;35(10):e21925
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Oct;35(10):e21925
The Golgi microtubules regulate single cell durotaxis.
Rong Y, Yang W, Hao H, Wang W, Lin S, Shi P, Huang Y, Li B, Sun Y, Liu Z, Wu C
EMBO reports 2021 Mar 3;22(3):e51094
EMBO reports 2021 Mar 3;22(3):e51094
WDR47 protects neuronal microtubule minus ends from katanin-mediated severing.
Buijs RR, Hummel JJA, Burute M, Pan X, Cao Y, Stucchi R, Altelaar M, Akhmanova A, Kapitein LC, Hoogenraad CC
Cell reports 2021 Jul 13;36(2):109371
Cell reports 2021 Jul 13;36(2):109371
The Non-hormonal Male Contraceptive Adjudin Exerts its Effects via MAPs and Signaling Proteins mTORC1/rpS6 and FAK-Y407.
Wang L, Yan M, Li H, Wu S, Ge R, Wong CKC, Silvestrini B, Sun F, Cheng CY
Endocrinology 2021 Jan 1;162(1)
Endocrinology 2021 Jan 1;162(1)
A chemical genetics approach to examine the functions of AAA proteins.
Cupido T, Jones NH, Grasso MJ, Pisa R, Kapoor TM
Nature structural & molecular biology 2021 Apr;28(4):388-397
Nature structural & molecular biology 2021 Apr;28(4):388-397
KIF15 supports spermatogenesis via its effects on Sertoli cell microtubule, actin, vimentin, and septin cytoskeletons.
Wu S, Lv L, Li L, Wang L, Mao B, Li J, Shen X, Ge R, Wong CKC, Sun F, Cheng CY
Endocrinology 2021 Apr 1;162(4)
Endocrinology 2021 Apr 1;162(4)
NC1-Peptide From Collagen α3 (IV) Chains in the Basement Membrane of Testes Regulates Spermatogenesis via p-FAK-Y407.
Li H, Liu S, Wu S, Ge R, Cheng CY
Endocrinology 2020 Oct 1;161(10)
Endocrinology 2020 Oct 1;161(10)
Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization.
Cao Y, Lipka J, Stucchi R, Burute M, Pan X, Portegies S, Tas R, Willems J, Will L, MacGillavry H, Altelaar M, Kapitein LC, Harterink M, Hoogenraad CC
Current biology : CB 2020 Mar 9;30(5):899-908.e6
Current biology : CB 2020 Mar 9;30(5):899-908.e6
Golgi-associated microtubules are fast cargo tracks and required for persistent cell migration.
Hao H, Niu J, Xue B, Su QP, Liu M, Yang J, Qin J, Zhao S, Wu C, Sun Y
EMBO reports 2020 Mar 4;21(3):e48385
EMBO reports 2020 Mar 4;21(3):e48385
Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development.
Nakagawa N, Plestant C, Yabuno-Nakagawa K, Li J, Lee J, Huang CW, Lee A, Krupa O, Adhikari A, Thompson S, Rhynes T, Arevalo V, Stein JL, Molnár Z, Badache A, Anton ES
Neuron 2019 Sep 4;103(5):836-852.e5
Neuron 2019 Sep 4;103(5):836-852.e5
Regulation of BTB Dynamics in Spermatogenesis-Insights From the Adjudin Model.
Mao BP, Li L, Yan M, Ge R, Lian Q, Cheng CY
Toxicological sciences : an official journal of the Society of Toxicology 2019 Nov 1;172(1):75-88
Toxicological sciences : an official journal of the Society of Toxicology 2019 Nov 1;172(1):75-88
CAMSAP2 Is a Microtubule Minus-End Targeting Protein That Regulates BTB Dynamics Through Cytoskeletal Organization.
Mao BP, Li L, Ge R, Li C, Wong CKC, Silvestrini B, Lian Q, Cheng CY
Endocrinology 2019 Jun 1;160(6):1448-1467
Endocrinology 2019 Jun 1;160(6):1448-1467
Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity.
Farías GG, Fréal A, Tortosa E, Stucchi R, Pan X, Portegies S, Will L, Altelaar M, Hoogenraad CC
Neuron 2019 Apr 3;102(1):184-201.e8
Neuron 2019 Apr 3;102(1):184-201.e8
Loss of CAMSAP3 promotes EMT via the modification of microtubule-Akt machinery.
Pongrakhananon V, Wattanathamsan O, Takeichi M, Chetprayoon P, Chanvorachote P
Journal of cell science 2018 Oct 29;131(21)
Journal of cell science 2018 Oct 29;131(21)
Structural centrosome aberrations promote non-cell-autonomous invasiveness.
Ganier O, Schnerch D, Oertle P, Lim RY, Plodinec M, Nigg EA
The EMBO journal 2018 May 2;37(9)
The EMBO journal 2018 May 2;37(9)
APC2 controls dendrite development by promoting microtubule dynamics.
Kahn OI, Schätzle P, van de Willige D, Tas RP, Lindhout FW, Portegies S, Kapitein LC, Hoogenraad CC
Nature communications 2018 Jul 17;9(1):2773
Nature communications 2018 Jul 17;9(1):2773
EB1 and EB3 regulate microtubule minus end organization and Golgi morphology.
Yang C, Wu J, de Heus C, Grigoriev I, Liv N, Yao Y, Smal I, Meijering E, Klumperman J, Qi RZ, Akhmanova A
The Journal of cell biology 2017 Oct 2;216(10):3179-3198
The Journal of cell biology 2017 Oct 2;216(10):3179-3198
Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres.
Goldspink DA, Rookyard C, Tyrrell BJ, Gadsby J, Perkins J, Lund EK, Galjart N, Thomas P, Wileman T, Mogensen MM
Open biology 2017 Feb;7(2)
Open biology 2017 Feb;7(2)
Noncentrosomal microtubules regulate autophagosome transport through CAMSAP2-EB1 cross-talk.
Wei J, Xu H, Meng W
FEBS letters 2017 Aug;591(16):2379-2393
FEBS letters 2017 Aug;591(16):2379-2393
Control of apico-basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7.
Noordstra I, Liu Q, Nijenhuis W, Hua S, Jiang K, Baars M, Remmelzwaal S, Martin M, Kapitein LC, Akhmanova A
Journal of cell science 2016 Nov 15;129(22):4278-4288
Journal of cell science 2016 Nov 15;129(22):4278-4288
Sliding of centrosome-unattached microtubules defines key features of neuronal phenotype.
Rao AN, Falnikar A, O'Toole ET, Morphew MK, Hoenger A, Davidson MW, Yuan X, Baas PW
The Journal of cell biology 2016 May 9;213(3):329-41
The Journal of cell biology 2016 May 9;213(3):329-41
Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation.
Yau KW, Schätzle P, Tortosa E, Pagès S, Holtmaat A, Kapitein LC, Hoogenraad CC
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Jan 27;36(4):1071-85
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Jan 27;36(4):1071-85
Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment.
Kuijpers M, van de Willige D, Freal A, Chazeau A, Franker MA, Hofenk J, Rodrigues RJ, Kapitein LC, Akhmanova A, Jaarsma D, Hoogenraad CC
Neuron 2016 Feb 3;89(3):461-71
Neuron 2016 Feb 3;89(3):461-71
TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays.
van Beuningen SFB, Will L, Harterink M, Chazeau A, van Battum EY, Frias CP, Franker MAM, Katrukha EA, Stucchi R, Vocking K, Antunes AT, Slenders L, Doulkeridou S, Sillevis Smitt P, Altelaar AFM, Post JA, Akhmanova A, Pasterkamp RJ, Kapitein LC, de Graaff E, Hoogenraad CC
Neuron 2015 Dec 16;88(6):1208-1226
Neuron 2015 Dec 16;88(6):1208-1226
Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development.
Yau KW, van Beuningen SF, Cunha-Ferreira I, Cloin BM, van Battum EY, Will L, Schätzle P, Tas RP, van Krugten J, Katrukha EA, Jiang K, Wulf PS, Mikhaylova M, Harterink M, Pasterkamp RJ, Akhmanova A, Kapitein LC, Hoogenraad CC
Neuron 2014 Jun 4;82(5):1058-73
Neuron 2014 Jun 4;82(5):1058-73
Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.
Jiang K, Hua S, Mohan R, Grigoriev I, Yau KW, Liu Q, Katrukha EA, Altelaar AF, Heck AJ, Hoogenraad CC, Akhmanova A
Developmental cell 2014 Feb 10;28(3):295-309
Developmental cell 2014 Feb 10;28(3):295-309
Katanin p80 regulates human cortical development by limiting centriole and cilia number.
Hu WF, Pomp O, Ben-Omran T, Kodani A, Henke K, Mochida GH, Yu TW, Woodworth MB, Bonnard C, Raj GS, Tan TT, Hamamy H, Masri A, Shboul M, Al Saffar M, Partlow JN, Al-Dosari M, Alazami A, Alowain M, Alkuraya FS, Reiter JF, Harris MP, Reversade B, Walsh CA
Neuron 2014 Dec 17;84(6):1240-57
Neuron 2014 Dec 17;84(6):1240-57
Cell cycle regulation of microtubule interactomes: multi-layered regulation is critical for the interphase/mitosis transition.
Syred HM, Welburn J, Rappsilber J, Ohkura H
Molecular & cellular proteomics : MCP 2013 Nov;12(11):3135-47
Molecular & cellular proteomics : MCP 2013 Nov;12(11):3135-47
Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules.
Tanaka N, Meng W, Nagae S, Takeichi M
Proceedings of the National Academy of Sciences of the United States of America 2012 Dec 4;109(49):20029-34
Proceedings of the National Academy of Sciences of the United States of America 2012 Dec 4;109(49):20029-34
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 17880-1-AP(CAMSAP1L1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 17880-1-AP(CAMSAP1L1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CAMSAP1L1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CAMSAP1L1. This antibody recognizes human, mouse, rat antigen. The CAMSAP1L1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
