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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [16]
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- Validations
- Immunohistochemistry [1]
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- Product number
- HPA027179 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA027179, RRID:AB_1851987
- Product name
- Anti-KDM5B
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human KDM5B, Gene description: lysine (K)-specific demethylase 5B, Alternative Gene Names: CT31, JARID1B, PLU-1, PPP1R98, RBBP2H1A, Validated applications: IHC, Uniprot ID: Q9UGL1, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.3 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references KDM5B predicts temozolomide-resistant subclones in glioblastoma
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements
KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations
KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
KDM5 histone demethylases repress immune response via suppression of STING
Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma.
Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance
An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting
Overexpression of JARID1B is associated with poor prognosis and chemotherapy resistance in epithelial ovarian cancer
The Histone-H3K4-Specific Demethylase KDM5B Binds to Its Substrate and Product through Distinct PHD Fingers
Physical and Functional Interactions between the Histone H3K4 Demethylase KDM5A and the Nucleosome Remodeling and Deacetylase (NuRD) Complex
Histone Demethylase Jumonji AT-rich Interactive Domain 1B (JARID1B) Controls Mammary Gland Development by Regulating Key Developmental and Lineage Specification Genes
JARID1B Is a Luminal Lineage-Driving Oncogene in Breast Cancer
The Human Melanoma Side Population Displays Molecular and Functional Characteristics of Enriched Chemoresistance and Tumorigenesis
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway.
Ullrich V, Ertmer S, Baginska A, Dorsch M, Gull H, Cima I, Berger P, Dobersalske C, Langer S, Meyer L, Dujardin P, Kebir S, Glas M, Blau T, Keyvani K, Rauschenbach L, Sure U, Roesch A, Grüner B, Scheffler B
iScience 2024;27(1):108596
iScience 2024;27(1):108596
KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements
Zhang S, Cai W, Liu X, Thakral D, Luo J, Chan L, McGeary M, Song E, Blenman K, Micevic G, Jessel S, Zhang Y, Yin M, Booth C, Jilaveanu L, Damsky W, Sznol M, Kluger H, Iwasaki A, Bosenberg M, Yan Q
Nature 2021;598(7882):682-687
Nature 2021;598(7882):682-687
KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations
Liu X, Zhang S, McGeary M, Krykbaeva I, Lai L, Jansen D, Kales S, Simeonov A, Hall M, Kelly D, Bosenberg M, Yan Q
Molecular Cancer Therapeutics 2019;18(3):706-717
Molecular Cancer Therapeutics 2019;18(3):706-717
KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
Hinohara K, Wu H, Vigneau S, McDonald T, Igarashi K, Yamamoto K, Madsen T, Fassl A, Egri S, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales S, Lal-Nag M, Rai G, Maloney D, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe J, Jeselsohn R, Gimelbrant A, Michor F, Polyak K
Cancer Cell 2018;34(6):939-953.e9
Cancer Cell 2018;34(6):939-953.e9
KDM5 histone demethylases repress immune response via suppression of STING
Cadwell K, Wu L, Cao J, Cai W, Lang S, Horton J, Jansen D, Liu Z, Chen J, Zhang M, Mott B, Pohida K, Rai G, Kales S, Henderson M, Hu X, Jadhav A, Maloney D, Simeonov A, Zhu S, Iwasaki A, Hall M, Cheng X, Shadel G, Yan Q
PLOS Biology 2018;16(8):e2006134
PLOS Biology 2018;16(8):e2006134
Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma.
Shigekawa Y, Hayami S, Ueno M, Miyamoto A, Suzaki N, Kawai M, Hirono S, Okada KI, Hamamoto R, Yamaue H
Oncotarget 2018 Sep 28;9(76):34320-34335
Oncotarget 2018 Sep 28;9(76):34320-34335
Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A
Szarc vel Szic K, Declerck K, Crans R, Diddens J, Scherf D, Gerhäuser C, Vanden Berghe W
Oncotarget 2017;8(25):40434-40453
Oncotarget 2017;8(25):40434-40453
Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance
Gale M, Sayegh J, Cao J, Norcia M, Gareiss P, Hoyer D, Merkel J, Yan Q
Oncotarget 2016;7(26):39931-39944
Oncotarget 2016;7(26):39931-39944
An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting
Cao J, Wu L, Zhang S, Lu M, Cheung W, Cai W, Gale M, Xu Q, Yan Q
Nucleic Acids Research 2016
Nucleic Acids Research 2016
Overexpression of JARID1B is associated with poor prognosis and chemotherapy resistance in epithelial ovarian cancer
Wang L, Mao Y, Du G, He C, Han S
Tumor Biology 2015;36(4):2465-2472
Tumor Biology 2015;36(4):2465-2472
The Histone-H3K4-Specific Demethylase KDM5B Binds to Its Substrate and Product through Distinct PHD Fingers
Klein B, Piao L, Xi Y, Rincon-Arano H, Rothbart S, Peng D, Wen H, Larson C, Zhang X, Zheng X, Cortazar M, Peña P, Mangan A, Bentley D, Strahl B, Groudine M, Li W, Shi X, Kutateladze T
Cell Reports 2014;6(2):325-335
Cell Reports 2014;6(2):325-335
Physical and Functional Interactions between the Histone H3K4 Demethylase KDM5A and the Nucleosome Remodeling and Deacetylase (NuRD) Complex
Nishibuchi G, Shibata Y, Hayakawa T, Hayakawa N, Ohtani Y, Sinmyozu K, Tagami H, Nakayama J
Journal of Biological Chemistry 2014;289(42):28956-28970
Journal of Biological Chemistry 2014;289(42):28956-28970
Histone Demethylase Jumonji AT-rich Interactive Domain 1B (JARID1B) Controls Mammary Gland Development by Regulating Key Developmental and Lineage Specification Genes
Zou M, Cao J, Liu Z, Huh S, Polyak K, Yan Q
Journal of Biological Chemistry 2014;289(25):17620-17633
Journal of Biological Chemistry 2014;289(25):17620-17633
JARID1B Is a Luminal Lineage-Driving Oncogene in Breast Cancer
Yamamoto S, Wu Z, Russnes H, Takagi S, Peluffo G, Vaske C, Zhao X, Moen Vollan H, Maruyama R, Ekram M, Sun H, Kim J, Carver K, Zucca M, Feng J, Almendro V, Bessarabova M, Rueda O, Nikolsky Y, Caldas C, Liu X, Polyak K
Cancer Cell 2014;25(6):762-777
Cancer Cell 2014;25(6):762-777
The Human Melanoma Side Population Displays Molecular and Functional Characteristics of Enriched Chemoresistance and Tumorigenesis
Tjwa M, Wouters J, Stas M, Gremeaux L, Govaere O, Van den broeck A, Maes H, Agostinis P, Roskams T, van den Oord J, Vankelecom H
PLoS ONE 2013;8(10):e76550
PLoS ONE 2013;8(10):e76550
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway.
Hayami S, Yoshimatsu M, Veerakumarasivam A, Unoki M, Iwai Y, Tsunoda T, Field HI, Kelly JD, Neal DE, Yamaue H, Ponder BA, Nakamura Y, Hamamoto R
Molecular cancer 2010 Mar 13;9:59
Molecular cancer 2010 Mar 13;9:59
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human testis and skeletal muscle tissues using HPA027179 antibody. Corresponding KDM5B RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
