CABT-B105
antibody from Creative Diagnostics
Targeting: KDM5B
CT31, JARID1B, PLU-1, PPP1R98, RBBP2H1A
Antibody data
- Antibody Data
- Antigen structure
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- Validations [0]
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- Product number
- CABT-B105 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-JARID1B monoclonal antibody, clone 5550
- Antibody type
- Monoclonal
- Description
- JARID1 (Jumonji AT-rich interactive domain 1) family members include two highly related genes JARID1A/RBP2/KDM5A and JARID1B/PLU1/KDM5B, and two less related genes JARID1C/SMCX/KDM5C and JARID1D/SMCY/KDM5D, on the X- and Y-chromosomes, respectively. The four JARID1 proteins and their orthologs in other organisms have been described as histone demethylases specific to methylated lysine 4 of histone H3 (H3K4). In the absence of JARID1A, JARID1B may be recruited to some of JARID1A target regions. High expression of JARID1B mRNA and protein has been found in all breast cancer cell lines examined, in cells cultured from primary breast cancers and in the invasive and in situ components in primary breast cancers. In breast cancer cells, JARID1B exhibits oncogenic properties and has been linked to repression of BRCA1 and other tumor suppressor genes.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 5550
- Vial size
- 100_L
- Storage
- -20°C or 4°C
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