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- Product number
- 17914-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17914-1-AP, RRID:AB_2143683
- Product name
- MDMX antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MDMX antibody (Cat. #17914-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN.
miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway.
Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach.
Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state.
LASS2 enhances p53 protein stability and nuclear import to suppress liver cancer progression through interaction with MDM2/MDMX.
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1.
Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma.
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.
Structure-based discovery of novel α-aminoketone derivatives as dual p53-MDM2/MDMX inhibitors for the treatment of cancer.
Dual Targeting of MDM4 and FTH1 by MMRi71 for Induced Protein Degradation and p53-Independent Apoptosis in Leukemia Cells.
MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity.
RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with DNMT3A Mutations.
miR-1307-5p suppresses proliferation and tumorigenesis of bladder cancer via targeting MDM4 and the Hippo signaling pathway.
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.
Small-Molecule MMRi62 Induces Ferroptosis and Inhibits Metastasis in Pancreatic Cancer via Degradation of Ferritin Heavy Chain and Mutant p53.
Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors.
Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegeneration.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
MiR-1205 functions as a tumor suppressor by disconnecting the synergy between KRAS and MDM4/E2F1 in non-small cell lung cancer.
Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma.
Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells.
Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Mdm2 Splice isoforms regulate the p53/Mdm2/Mdm4 regulatory circuit via RING domain-mediated ubiquitination of p53 and Mdm4.
EZH2 inhibition re-sensitizes multidrug resistant B-cell lymphomas to etoposide mediated apoptosis.
Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.
Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells.
FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX.
Ellison V, Polotskaia A, Xiao G, Leybengrub P, Qiu W, Lee R, Hendrickson R, Hu W, Bargonetti J
bioRxiv : the preprint server for biology 2024 Jan 23;
bioRxiv : the preprint server for biology 2024 Jan 23;
miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway.
Wei J, Chen Y, Feng T, Wei Y, Yang C, Zhang C, Li W, Liu G
Functional & integrative genomics 2024 Feb 20;24(2):37
Functional & integrative genomics 2024 Feb 20;24(2):37
Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach.
Li K, Hu W, Wang Y, Chen W, Wen H, Liu J, Li W, Wang B
Journal of enzyme inhibition and medicinal chemistry 2024 Dec;39(1):2288810
Journal of enzyme inhibition and medicinal chemistry 2024 Dec;39(1):2288810
Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state.
Wang P, Liu X, Yao Z, Chen Y, Luo L, Liang K, Tan JE, Chua MJ, Chua YB, Ma S, Zhang L, Ma W, Liu S, Cao W, Guo L, Guang L, Wang Y, Zhao H, Ai N, Li Y, Li C, Wang RR, Teh BT, Jiang L, Yu K, Shyh-Chang N
Cell research 2023 Sep;33(9):712-726
Cell research 2023 Sep;33(9):712-726
LASS2 enhances p53 protein stability and nuclear import to suppress liver cancer progression through interaction with MDM2/MDMX.
Zhao Q, He W, Liu Z, Huang L, Yang X, Liu Y, Chen R, Min X, Yang Y
Cell death discovery 2023 Nov 14;9(1):414
Cell death discovery 2023 Nov 14;9(1):414
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1.
Wang D, Liang W, Huo D, Wang H, Wang Y, Cong C, Zhang C, Yan S, Gao M, Su X, Tan X, Zhang W, Han L, Zhang D, Feng H
Cell death and differentiation 2023 Feb;30(2):369-382
Cell death and differentiation 2023 Feb;30(2):369-382
Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma.
Gong Y, Zou S, Deng D, Wang L, Hu H, Qiu Z, Wei T, Yang P, Zhou J, Zhang Y, Zhu W, Xie X, Liao Z, Yang J, Zhang S, Liu A, Jiang Y, Zou Z, Bai X
Developmental cell 2023 Feb 6;58(3):192-210.e11
Developmental cell 2023 Feb 6;58(3):192-210.e11
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.
Cheng J, Yan Z, Jiang K, Liu C, Xu D, Lyu X, Hu X, Zhang S, Zhou Y, Li J, Zhao Y
Journal of medicinal chemistry 2023 Dec 28;66(24):16991-17025
Journal of medicinal chemistry 2023 Dec 28;66(24):16991-17025
Structure-based discovery of novel α-aminoketone derivatives as dual p53-MDM2/MDMX inhibitors for the treatment of cancer.
Luo HJ, Si DJ, Sun XJ, Wang MY, Yang YB, Wang B, Wen HM, Li W, Liu J
European journal of medicinal chemistry 2023 Apr 5;252:115282
European journal of medicinal chemistry 2023 Apr 5;252:115282
Dual Targeting of MDM4 and FTH1 by MMRi71 for Induced Protein Degradation and p53-Independent Apoptosis in Leukemia Cells.
Lama R, Galster SL, Xu C, Davison LW, Chemler SR, Wang X
Molecules (Basel, Switzerland) 2022 Nov 8;27(22)
Molecules (Basel, Switzerland) 2022 Nov 8;27(22)
MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity.
Chinnam M, Xu C, Lama R, Zhang X, Cedeno CD, Wang Y, Stablewski AB, Goodrich DW, Wang X
PLoS genetics 2022 May;18(5):e1010171
PLoS genetics 2022 May;18(5):e1010171
RNAi-Mediated Screen of Primary AML Cells Nominates MDM4 as a Therapeutic Target in NK-AML with DNMT3A Mutations.
Sidorova OA, Sayed S, Paszkowski-Rogacz M, Seifert M, Camgöz A, Roeder I, Bornhäuser M, Thiede C, Buchholz F
Cells 2022 Mar 2;11(5)
Cells 2022 Mar 2;11(5)
miR-1307-5p suppresses proliferation and tumorigenesis of bladder cancer via targeting MDM4 and the Hippo signaling pathway.
Huang W, Zhang C, Xiong S, Zhou X, Wang G, Guo J
Discover oncology 2022 Jul 1;13(1):57
Discover oncology 2022 Jul 1;13(1):57
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
Huang W, Wen F, Gu P, Liu J, Xia Y, Li Y, Zhou J, Song S, Ruan S, Gu S, Chen X, Shu P
Chinese medicine 2022 Aug 9;17(1):93
Chinese medicine 2022 Aug 9;17(1):93
Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells.
Zhang S, Yan Z, Li Y, Gong Y, Lyu X, Lou J, Zhang D, Meng X, Zhao Y
Journal of medicinal chemistry 2022 Apr 28;65(8):6207-6230
Journal of medicinal chemistry 2022 Apr 28;65(8):6207-6230
Small-Molecule MMRi62 Induces Ferroptosis and Inhibits Metastasis in Pancreatic Cancer via Degradation of Ferritin Heavy Chain and Mutant p53.
Li J, Lama R, Galster SL, Inigo JR, Wu J, Chandra D, Chemler SR, Wang X
Molecular cancer therapeutics 2022 Apr 1;21(4):535-545
Molecular cancer therapeutics 2022 Apr 1;21(4):535-545
Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors.
Si D, Luo H, Zhang X, Yang K, Wen H, Li W, Liu J
Bioorganic chemistry 2021 Oct;115:105268
Bioorganic chemistry 2021 Oct;115:105268
Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegeneration.
Kim H, Shin JY, Jo A, Kim JH, Park S, Choi JY, Kang HC, Dawson VL, Dawson TM, Shin JH, Lee Y
Brain : a journal of neurology 2021 Dec 31;144(12):3674-3691
Brain : a journal of neurology 2021 Dec 31;144(12):3674-3691
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
MiR-1205 functions as a tumor suppressor by disconnecting the synergy between KRAS and MDM4/E2F1 in non-small cell lung cancer.
Yan H, Chen X, Li Y, Fan L, Tai Y, Zhou Y, Chen Y, Qi X, Huang R, Ren J
American journal of cancer research 2019;9(2):312-329
American journal of cancer research 2019;9(2):312-329
Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma.
Wu Z, Chen D, Wang K, Cao C, Xu X
Frontiers in oncology 2019;9:1260
Frontiers in oncology 2019;9:1260
Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells.
Gao C, Xiao G, Piersigilli A, Gou J, Ogunwobi O, Bargonetti J
Breast cancer research : BCR 2019 Jan 14;21(1):5
Breast cancer research : BCR 2019 Jan 14;21(1):5
Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein.
Sun Y, Liu W, Wang C, Meng Q, Liu Z, Huo X, Yang X, Sun P, Sun H, Ma X, Peng J, Liu K
Journal of cellular physiology 2019 Apr;234(4):3685-3696
Journal of cellular physiology 2019 Apr;234(4):3685-3696
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
Mdm2 Splice isoforms regulate the p53/Mdm2/Mdm4 regulatory circuit via RING domain-mediated ubiquitination of p53 and Mdm4.
Fan C, Wang X
Cell cycle (Georgetown, Tex.) 2017 Apr 3;16(7):660-664
Cell cycle (Georgetown, Tex.) 2017 Apr 3;16(7):660-664
EZH2 inhibition re-sensitizes multidrug resistant B-cell lymphomas to etoposide mediated apoptosis.
Smonskey M, Lasorsa E, Rosario S, Kirk JS, Hernandez-Ilizaliturri FJ, Ellis L
Oncoscience 2016;3(1):21-30
Oncoscience 2016;3(1):21-30
Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.
Jiang YQ, Xu XP, Guo QM, Xu XC, Liu QY, An SH, Xu JL, Su F, Tai JB
Genetics and molecular research : GMR 2016 Sep 2;15(3)
Genetics and molecular research : GMR 2016 Sep 2;15(3)
Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells.
Wu W, Xu C, Ling X, Fan C, Buckley BP, Chernov MV, Ellis L, Li F, Muñoz IG, Wang X
Cell death & disease 2015 Dec 31;6(12):e2035
Cell death & disease 2015 Dec 31;6(12):e2035
FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX.
Ling X, Xu C, Fan C, Zhong K, Li F, Wang X
Cancer research 2014 Dec 15;74(24):7487-97
Cancer research 2014 Dec 15;74(24):7487-97
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MDMX antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MDMX. This antibody recognizes human,mouse,rat antigen. The MDMX antibody has been validated for the following applications: ELISA, WB analysis.
