Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- NBP1-51911 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-51911, RRID:AB_11003608
- Product name
- Goat Polyclonal IRF6 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse
- Host
- Goat
- Antigen sequence
C-TPSMQLPPALPPQ
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 0.5 mg/ml
- Storage
- Store at -20C. Avoid freeze-thaw cycles.
Submitted references IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages.
TGFβ3 regulates periderm removal through ΔNp63 in the developing palate.
Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas.
A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias.
Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes.
Li C, Ying W, Huang Z, Brehm T, Morin A, Vella AT, Zhou B
Endocrinology 2017 Sep 1;158(9):2837-2847
Endocrinology 2017 Sep 1;158(9):2837-2847
TGFβ3 regulates periderm removal through ΔNp63 in the developing palate.
Hu L, Liu J, Li Z, Ozturk F, Gurumurthy C, Romano RA, Sinha S, Nawshad A
Journal of cellular physiology 2015 Jun;230(6):1212-25
Journal of cellular physiology 2015 Jun;230(6):1212-25
Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas.
Botti E, Spallone G, Moretti F, Marinari B, Pinetti V, Galanti S, De Meo PD, De Nicola F, Ganci F, Castrignanò T, Pesole G, Chimenti S, Guerrini L, Fanciulli M, Blandino G, Karin M, Costanzo A
Proceedings of the National Academy of Sciences of the United States of America 2011 Aug 16;108(33):13710-5
Proceedings of the National Academy of Sciences of the United States of America 2011 Aug 16;108(33):13710-5
A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias.
Moretti F, Marinari B, Lo Iacono N, Botti E, Giunta A, Spallone G, Garaffo G, Vernersson-Lindahl E, Merlo G, Mills AA, Ballarò C, Alemà S, Chimenti S, Guerrini L, Costanzo A
The Journal of clinical investigation 2010 May;120(5):1570-7
The Journal of clinical investigation 2010 May;120(5):1570-7
Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes.
Kondo S, Schutte BC, Richardson RJ, Bjork BC, Knight AS, Watanabe Y, Howard E, de Lima RL, Daack-Hirsch S, Sander A, McDonald-McGinn DM, Zackai EH, Lammer EJ, Aylsworth AS, Ardinger HH, Lidral AC, Pober BR, Moreno L, Arcos-Burgos M, Valencia C, Houdayer C, Bahuau M, Moretti-Ferreira D, Richieri-Costa A, Dixon MJ, Murray JC
Nature genetics 2002 Oct;32(2):285-9
Nature genetics 2002 Oct;32(2):285-9
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: IRF6 Antibody [NBP1-51911] - (0.2ug/ml) of Human Ovary lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: IRF6 Antibody [NBP1-51911] - HEK293 overexpressing IRF6 and probed with (mock transfection in first lane).
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: IRF6 Antibody [NBP1-51911] - staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: IRF6 Antibody [NBP1-51911] - Staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.