Antibody data
- Antibody Data
- Antigen structure
- References [73]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 19999-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19999-1-AP, RRID:AB_10646467
- Product name
- TGF beta 2-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TGF beta 2-Specific antibody (Cat. #19999-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mechanistic insights into cadmium-induced hepatotoxicity mediated by dysregulation of microRNA expression.
ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation.
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.
γ-Glutamylcyclotransferase Depletion Induces p15(INK4b) and p21(Cip1)-mediated Senescence via TGF-β2/SMAD3 Pathway Activation in Breast Cancer Cells.
Transcriptomic analysis of zonula occludens-1 (ZO-1) knockout in ovarian cancer cell lines.
S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition.
Intermittent fasting inhibits Tp53-driven glioma through gut microbiota-mediated methionine-m(6)A regulation.
Effects of sheep follicular fluid-derived exosomes and miR-148a on theca cell function in vitro.
Solute carrier family 9 member A5 regulated by TGF-β is necessary for dental enamel formation.
Plasma Exosomal miR-17-5p Regulates Macrophage Polarization by Targeting Bcl11b in Sepsis-Induced Lung Injury.
Reduced level of BMI1 inhibits trophoblast proliferation and migration via the epigenetic enhancement of CSTA and TGFB2 in spontaneous abortion.
Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion.
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.
TIPE regulates TGFB2 expression and induces extracellular M2 polarization in CRC.
PRMT1 inhibition enhances the cardioprotective effect of adipose-derived mesenchymal stem cells against myocardial infarction through RUNX1.
Oridonin Preserves Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates Choroidal Neovascularization.
Injectable DAT-ALG Hydrogel Mitigates Senescence of Loaded DPMSCs and Boosts Healing of Perianal Fistulas in Crohn's Disease.
WFS1 Gene Mutation (c.2389G > A) Induces Immune Disorders by Promoting DC Maturation through Inhibition of TMEM176A.
Deficiency of 2-Oxoglutarate Carrier (Slc25a11) Drives RPE Epithelial-to-Mesenchymal Transition and Exacerbates Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration.
Transforming Growth Factor Beta2 Promotes Migration and Inhibits the Proliferation of Gastric Cancer Cells by Regulating the pSmad2/3-NDRG1 Signaling Pathway.
Upregulation of Long Noncoding RNA MAGOH-DT Mediates TNF-α and High Glucose-Induced Endothelial-Mesenchymal Transition in Arteriosclerosis Obliterans.
TRIM55 restricts the progression of hepatocellular carcinoma through ubiquitin-proteasome-mediated degradation of NF90.
Low Intraocular Pressure Induces Fibrotic Changes in the Trabecular Meshwork and Schlemm's Canal of Sprague Dawley Rats.
ANGPTL4 promotes choroidal neovascularization and subretinal fibrosis through the endothelial‒mesenchymal transition.
microRNA-141-3p Suppressed the Progression of the Clear Cell Renal Cell Carcinoma by Targeting Transforming Growth Factor Beta 2 Gene Expression.
Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages.
Adipose stem cells-derived small extracellular vesicles transport Thrombospondin 1 cargo to promote insulin resistance in gestational diabetes mellitus.
LncRNA ERICD interacts with TROAP to regulate TGF-β signaling in hepatocellular carcinoma.
TS-2021, a third-generation oncolytic adenovirus that carried Ki67 promoter, TGF-β2 5'UTR, and IL-15 against experimental glioblastoma.
Characterization of the Ocular Phenotype in a Col4a3 Knockout Mouse Model of Alport Syndrome.
TGFβ2 mediates oxidative stress-induced epithelial-to-mesenchymal transition of bladder smooth muscle.
Study on the Mechanism of Jiaotai Pill Intervention on Insomnia Animal Model Based on Gut Microbiome and Metabolomics.
FN1 mRNA 3'-UTR supersedes traditional fibronectin 1 in facilitating the invasion and metastasis of gastric cancer through the FN1 3'-UTR-let-7i-5p-THBS1 axis.
The hsa_circ_0004805/hsa_miR-149-5p/TGFB2 axis plays critical roles in the pathophysiology of diabetic retinopathy in vitro and in vivo.
Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.
GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer.
Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis.
Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy.
GSK-3 inhibitor elraglusib enhances tumor-infiltrating immune cell activation in tumor biopsies and synergizes with anti-PD-L1 in a murine model of colorectal cancer.
Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes In Vivo and In Vitro.
Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage.
TGFβ2 is a Prognostic Biomarker for Gastric Cancer and is Associated With Methylation and Immunotherapy Responses.
Nicotinamide N-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE(2) Pathway.
Comparative analyses in transcriptome of human granulosa cells and follicular fluid micro-environment between poor ovarian responders with conventional controlled ovarian or mild ovarian stimulations.
Sodium butyrate alleviates pre-eclampsia in pregnant rats by improving the gut microbiota and short-chain fatty acid metabolites production.
Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.
tRNA-Derived Fragment tRF-Glu-TTC-027 Regulates the Progression of Gastric Carcinoma via MAPK Signaling Pathway.
ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-β.
Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305/TGF-β2/SMAD3 pathway.
Cadmium promotes apoptosis and inflammation via the circ08409/miR-133a/TGFB2 axis in bovine mammary epithelial cells and mouse mammary gland.
USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription.
SALL1 regulates commitment of odontoblast lineages by interacting with RUNX2 to remodel open chromatin regions.
Association of CASC18/miR-20a-3p/TGFB2 ceRNA axis with occult lymph node metastasis in tongue squamous cell carcinoma.
Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase.
LncRNA PART1 promotes cell proliferation and progression in non-small-cell lung cancer cells via sponging miR-17-5p.
Gold Nanoparticles Induce Tumor Vessel Normalization and Impair Metastasis by Inhibiting Endothelial Smad2/3 Signaling.
PPARα-Dependent Effects of Palmitoylethanolamide Against Retinal Neovascularization and Fibrosis.
The Smad3-miR-29b/miR-29c axis mediates the protective effect of macrophage migration inhibitory factor against cardiac fibrosis.
miR-618 Suppresses Metastasis in Gastric Cancer by Downregulating the Expression of TGF-β2.
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
Expression of miR-181a and TGF-β2 in lens epithelial cells of patients with cataractous retinal detachment and its clinical significance.
LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer.
Zoledronate inhibits fibroblasts' proliferation and activation via targeting TGF-β signaling pathway.
EDIL3 depletion suppress epithelial-mesenchymal transition of lens epithelial cells via transforming growth factor β pathway.
Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII-p38MAPK-pS249/T252RB Pathway.
Modulation of TGF‑β activity by latent TGF‑β‑binding protein 1 in human osteoarthritis fibroblast‑like synoviocytes.
High doses of baicalin induces kidney injury and fibrosis through regulating TGF-β/Smad signaling pathway.
Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop.
Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer.
Gender differences in fibrosis remodeling in patients with long-standing persistent atrial fibrillation.
TGF-β2 is involved in the preservation of the chondrocyte phenotype under hypoxic conditions.
SIX1 promotes tumor lymphangiogenesis by coordinating TGFβ signals that increase expression of VEGF-C.
Participation of miR-200a in TGF-β1-mediated hepatic stellate cell activation.
Xu R, Liu Y, Gao R, Zhang Z, Feng Y, Yuan Y, Chen Z, Hu L
Frontiers in cell and developmental biology 2026;14:1787688
Frontiers in cell and developmental biology 2026;14:1787688
ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation.
Yuan Y, Li J, Rao D, Lu X, Chen M, Chen X, Long X, Zhang B, Liang H, Chen Q, Zhao J
Gut 2026 May 12;75(6):1186-1200
Gut 2026 May 12;75(6):1186-1200
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.
Bhamidipati K, McIntyre ABR, Kazerounian S, Ce G, Wong SW, Tran M, Prell SA, Lau R, Khedgikar V, Altmann C, Small A, Madhu R, Presti SR, Anufrieva KS, Blazar PE, Lange JK, Seifert JA, Accelerating Medicines Partnership RA/SLE Network, Accelerating Medicines Partnership: Autoimmune and Immune-Mediated Diseases Network (AMP-AIM), Colorado Interdisciplinary Joint Biology Program (CUIJBP) Consortium, Moreland LW, Croft AP, Smith MH, Donlin LT, Lewis MJ, Jonsson AH, Pitzalis C, Thomas R, Gravallese EM, Brenner MB, Korsunsky I, Wechalekar MD, Wei K
Nature immunology 2026 Mar;27(3):556-571
Nature immunology 2026 Mar;27(3):556-571
γ-Glutamylcyclotransferase Depletion Induces p15(INK4b) and p21(Cip1)-mediated Senescence via TGF-β2/SMAD3 Pathway Activation in Breast Cancer Cells.
Kubota S, Ii H, Isono T, Kusaba T, Nagasawa M, Wada A, Kobayashi K, Yamanaka K, Mori M, Taniguchi K, Nakata S, Kageyama S
Cancer genomics & proteomics 2026 Mar-Apr;23(2):195-209
Cancer genomics & proteomics 2026 Mar-Apr;23(2):195-209
Transcriptomic analysis of zonula occludens-1 (ZO-1) knockout in ovarian cancer cell lines.
An H, Kim H, Kim DY, Yoon HJ, Lee JY, Eo WK, Kim MY, Kim KH, Cha HJ
Genes & genomics 2026 Mar 22;
Genes & genomics 2026 Mar 22;
S100B drives glioblastoma invasion and migration through TGF‑β2‑mediated epithelial‑mesenchymal transition.
Liao X, Xu Y, Zhou H, Yi Q, Dong S, Tan B
Oncology reports 2026 Jan;55(1)
Oncology reports 2026 Jan;55(1)
Intermittent fasting inhibits Tp53-driven glioma through gut microbiota-mediated methionine-m(6)A regulation.
Lin Y, Li S, Xu X, Hu X, Li Y, Liang S, Meng J, Li H, Li Z, Xiong D, Chen H, Lai J, Bao Y, Liu Z, Chu J, Chen X, Zhang X, Liu X, Lee SY, An S
Nature communications 2026 Jan 20;17(1):1804
Nature communications 2026 Jan 20;17(1):1804
Effects of sheep follicular fluid-derived exosomes and miR-148a on theca cell function in vitro.
Liu K, Chi R, Zhang R, Liu Q, Xing F, Liu Y, Chu M
Biological research 2026 Jan 13;59(1):9
Biological research 2026 Jan 13;59(1):9
Solute carrier family 9 member A5 regulated by TGF-β is necessary for dental enamel formation.
Takano H, Chiba-Ohkuma R, Kobayashi S, Yamamoto R, Kataoka R, Miyakawa Y, Asada Y, Yamakoshi Y
Journal of oral biosciences 2026 Feb;68(1):100719
Journal of oral biosciences 2026 Feb;68(1):100719
Plasma Exosomal miR-17-5p Regulates Macrophage Polarization by Targeting Bcl11b in Sepsis-Induced Lung Injury.
Xian Y, Sun Y, Wang L, Lin L, Wu Z, Zhang K, Chen R
Journal of inflammation research 2025;18:10651-10668
Journal of inflammation research 2025;18:10651-10668
Reduced level of BMI1 inhibits trophoblast proliferation and migration via the epigenetic enhancement of CSTA and TGFB2 in spontaneous abortion.
Li H, Wang G, Meng Q, Zhu R, Liu M, Zhang X, Wang J, Li H
Placenta 2025 Sep;169:82-93
Placenta 2025 Sep;169:82-93
Targeting olfactory receptor OR2AT4: An innovative aptamer-based treatment for hair growth promotion.
Mataix M, Illera N, Hidalgo I, Arriba MDC, Martín E, Fernández G, González C, Larcher F, González VM, Rio MD, Jiménez F, Carretero M
Molecular therapy. Nucleic acids 2025 Sep 9;36(3):102608
Molecular therapy. Nucleic acids 2025 Sep 9;36(3):102608
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.
Bhamidipati K, McIntyre ABR, Kazerounian S, Ce G, Tran M, Prell SA, Lau R, Khedgikar V, Altmann C, Small A, Wong V, Madhu R, Presti S, Anufrieva KS, Blazar PE, Lange JK, Seifert J, Accelerating Medicines Partnership: RA/SLE Network, Accelerating Medicines Partnership: Autoimmune and Immune-Mediated Diseases Network (AMP-AIM), Moreland LW, Croft AP, Lewis MJ, Thomas R, Jonsson AH, Pitzalis C, Gravallese EM, Brenner MB, Korsunsky I, Wechalekar MD, Wei K
bioRxiv : the preprint server for biology 2025 Mar 17;
bioRxiv : the preprint server for biology 2025 Mar 17;
TIPE regulates TGFB2 expression and induces extracellular M2 polarization in CRC.
Zhu Q, Zhang S, Yan C, Lin Z, Zhang S, Li H, Ye Y, Liu Z, Zhuang G, Zhang K
Journal of leukocyte biology 2025 Jun 4;117(6)
Journal of leukocyte biology 2025 Jun 4;117(6)
PRMT1 inhibition enhances the cardioprotective effect of adipose-derived mesenchymal stem cells against myocardial infarction through RUNX1.
Du D, Wang T, Sun Y, Zhang Y, Zhang B, Shao J, Yang M, Huang C, Zuo S, Wu N
Stem cell research & therapy 2025 Jun 3;16(1):279
Stem cell research & therapy 2025 Jun 3;16(1):279
Oridonin Preserves Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates Choroidal Neovascularization.
Zhu J, Ding D, Sun T, Zhang Y, Miao H, Gu Y, Dai M, Zhu M
Investigative ophthalmology & visual science 2025 Feb 3;66(2):56
Investigative ophthalmology & visual science 2025 Feb 3;66(2):56
Injectable DAT-ALG Hydrogel Mitigates Senescence of Loaded DPMSCs and Boosts Healing of Perianal Fistulas in Crohn's Disease.
Gao H, Xing D, Wu M, Hu Y, He J, Chen S, Zhang G, Yao F, Ma P, Xue W
ACS biomaterials science & engineering 2025 Feb 10;11(2):1171-1183
ACS biomaterials science & engineering 2025 Feb 10;11(2):1171-1183
WFS1 Gene Mutation (c.2389G > A) Induces Immune Disorders by Promoting DC Maturation through Inhibition of TMEM176A.
Lin W, Qiu Y, Tan C, Liu Z, Yang Y, He Y, Zhao J, Cheng J, Wang Z, Li M, Wang L, Wang M, Zhang M
Inflammation 2025 Dec;48(6):4274-4288
Inflammation 2025 Dec;48(6):4274-4288
Deficiency of 2-Oxoglutarate Carrier (Slc25a11) Drives RPE Epithelial-to-Mesenchymal Transition and Exacerbates Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration.
Wang M, Gao FJ, Tang W, Lei B, Hu F, Ma J, Sadda SR, Kannan R, Sreekumar PG, Xu G
Aging cell 2025 Dec;24(12):e70271
Aging cell 2025 Dec;24(12):e70271
Transforming Growth Factor Beta2 Promotes Migration and Inhibits the Proliferation of Gastric Cancer Cells by Regulating the pSmad2/3-NDRG1 Signaling Pathway.
He FJ, Chen XL, Zhu YF, Pang HY, Li ZD, Liang PP, Jin T, Chen ZW, Chen ZH, Hu JK, Yang K
MedComm 2025 Apr;6(4):e70148
MedComm 2025 Apr;6(4):e70148
Upregulation of Long Noncoding RNA MAGOH-DT Mediates TNF-α and High Glucose-Induced Endothelial-Mesenchymal Transition in Arteriosclerosis Obliterans.
Wang KJ, Zhang YX, Mo ZW, Li ZL, Wang M, Wang R, Wang ZC, Chang GQ, Wu WB
The Tohoku journal of experimental medicine 2024 Sep 27;263(4):227-238
The Tohoku journal of experimental medicine 2024 Sep 27;263(4):227-238
TRIM55 restricts the progression of hepatocellular carcinoma through ubiquitin-proteasome-mediated degradation of NF90.
Luo C, Lu Y, Fang Q, Lu J, Zhan P, Xi W, Wang J, Chen X, Yao Q, Wang F, Yin Z, Xie C
Cell death discovery 2024 Oct 17;10(1):441
Cell death discovery 2024 Oct 17;10(1):441
Low Intraocular Pressure Induces Fibrotic Changes in the Trabecular Meshwork and Schlemm's Canal of Sprague Dawley Rats.
Xu L, Zhao Y, Zhang X, Gang X, Han J, Zhou T, Qi B, Song S, Ren R, Liang Y
Translational vision science & technology 2024 Oct 1;13(10):10
Translational vision science & technology 2024 Oct 1;13(10):10
ANGPTL4 promotes choroidal neovascularization and subretinal fibrosis through the endothelial‒mesenchymal transition.
Chen J, Yang Y, Su S, Zhang S, Huang J, Chen H, Yang X, Sang A
International ophthalmology 2024 Nov 26;44(1):441
International ophthalmology 2024 Nov 26;44(1):441
microRNA-141-3p Suppressed the Progression of the Clear Cell Renal Cell Carcinoma by Targeting Transforming Growth Factor Beta 2 Gene Expression.
Hu X, Li D, Zhan J, Yang C, Wang P, Meng X, Xu S, Che X, Xu L
DNA and cell biology 2024 May;43(5):245-257
DNA and cell biology 2024 May;43(5):245-257
Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages.
Dong M, Zhang X, Peng P, Chen Z, Zhang Y, Wan L, Xiang W, Liu G, Guo Y, Xiao Q, Wang B, Guo D, Zhu M, Yu X, Wan F
Cancer letters 2024 May 28;590:216801
Cancer letters 2024 May 28;590:216801
Adipose stem cells-derived small extracellular vesicles transport Thrombospondin 1 cargo to promote insulin resistance in gestational diabetes mellitus.
Li H, Yang H, Liu J, Yang H, Gao X, Yang X, Liu Z, Qian Q
Diabetology & metabolic syndrome 2024 May 19;16(1):105
Diabetology & metabolic syndrome 2024 May 19;16(1):105
LncRNA ERICD interacts with TROAP to regulate TGF-β signaling in hepatocellular carcinoma.
Xia Y, Zhang B, Chen N, Hu X, Jin X, Lu C, Liang F
Heliyon 2024 Jul 30;10(14):e34810
Heliyon 2024 Jul 30;10(14):e34810
TS-2021, a third-generation oncolytic adenovirus that carried Ki67 promoter, TGF-β2 5'UTR, and IL-15 against experimental glioblastoma.
Wang J, Zhang J, Zhang Q, Zhang W, Zhang Q, Jin G, Liu F
Journal of medical virology 2024 Jan;96(1):e29335
Journal of medical virology 2024 Jan;96(1):e29335
Characterization of the Ocular Phenotype in a Col4a3 Knockout Mouse Model of Alport Syndrome.
Belamkar A, Luo Q, Mahajan N, Abhyankar S, Jones BA, Sodhi RK, Pattabiraman PP, Levi M, Bhatwadekar AD
Investigative ophthalmology & visual science 2024 Dec 2;65(14):29
Investigative ophthalmology & visual science 2024 Dec 2;65(14):29
TGFβ2 mediates oxidative stress-induced epithelial-to-mesenchymal transition of bladder smooth muscle.
Geng J, Zhang X, Zhang Y, Meng X, Sun J, Zhou B, Ma J
In vitro cellular & developmental biology. Animal 2024 Aug;60(7):793-804
In vitro cellular & developmental biology. Animal 2024 Aug;60(7):793-804
Study on the Mechanism of Jiaotai Pill Intervention on Insomnia Animal Model Based on Gut Microbiome and Metabolomics.
Yang Y, Liu J, Ou H, Ma X, Li J, Shao B, Jin R, Zhao J
Evidence-based complementary and alternative medicine : eCAM 2023;2023:2442505
Evidence-based complementary and alternative medicine : eCAM 2023;2023:2442505
FN1 mRNA 3'-UTR supersedes traditional fibronectin 1 in facilitating the invasion and metastasis of gastric cancer through the FN1 3'-UTR-let-7i-5p-THBS1 axis.
Pan S, Zhu J, Liu P, Wei Q, Zhang S, An W, Tong Y, Cheng Z, Liu F
Theranostics 2023;13(14):5130-5150
Theranostics 2023;13(14):5130-5150
The hsa_circ_0004805/hsa_miR-149-5p/TGFB2 axis plays critical roles in the pathophysiology of diabetic retinopathy in vitro and in vivo.
Shao J, Gu W, Ye L, Xin Y
Molecular and cellular endocrinology 2023 Oct 1;576:112042
Molecular and cellular endocrinology 2023 Oct 1;576:112042
Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation.
Goodwin AT, John AE, Joseph C, Habgood A, Tatler AL, Susztak K, Palmer M, Offermanns S, Henderson NC, Jenkins RG
Development (Cambridge, England) 2023 May 1;150(9)
Development (Cambridge, England) 2023 May 1;150(9)
GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer.
Huntington KE, Louie AD, Srinivasan PR, Schorl C, Lu S, Silverberg D, Newhouse D, Wu Z, Zhou L, Borden BA, Giles FJ, Dooner M, Carneiro BA, El-Deiry WS
International journal of molecular sciences 2023 Jun 29;24(13)
International journal of molecular sciences 2023 Jun 29;24(13)
Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis.
Li H, Ren J, Cui H, Wang D, Zhao R, Liu X, Tian S, Wang J, Zhang J, Li P, Thorne RF, Duan S
Cell transplantation 2023 Jan-Dec;32:9636897231177356
Cell transplantation 2023 Jan-Dec;32:9636897231177356
Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy.
Wang L, Wu L, Zhu Z, Zhang Q, Li W, Gonzalez GM, Wang Y, Rana TM
The EMBO journal 2023 Jan 16;42(2):e111673
The EMBO journal 2023 Jan 16;42(2):e111673
GSK-3 inhibitor elraglusib enhances tumor-infiltrating immune cell activation in tumor biopsies and synergizes with anti-PD-L1 in a murine model of colorectal cancer.
Huntington KE, Louie AD, Srinivasan PR, Schorl C, Lu S, Silverberg D, Newhouse D, Wu Z, Zhou L, Borden BA, Giles FJ, Dooner M, Carneiro BA, El-Deiry WS
bioRxiv : the preprint server for biology 2023 Feb 7;
bioRxiv : the preprint server for biology 2023 Feb 7;
Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes In Vivo and In Vitro.
Zha Z, Liu YJ, Liu SS, Zhang N, Li JL, Qi F, Jin LY, Xue B, Yang T, Fan YP, Zhao H, Wang L
Oxidative medicine and cellular longevity 2022;2022:3800004
Oxidative medicine and cellular longevity 2022;2022:3800004
Platelet Derived Vesicles Enhance the TGF-beta Signaling Pathway of M1 Macrophage.
Song N, Pan K, Chen L, Jin K
Frontiers in endocrinology 2022;13:868893
Frontiers in endocrinology 2022;13:868893
TGFβ2 is a Prognostic Biomarker for Gastric Cancer and is Associated With Methylation and Immunotherapy Responses.
Han B, Fang T, Wang Y, Zhang Y, Xue Y
Frontiers in genetics 2022;13:808041
Frontiers in genetics 2022;13:808041
Nicotinamide N-Methyltransferase Remodeled Cell Metabolism and Aggravated Proinflammatory Responses by Activating STAT3/IL1β/PGE(2) Pathway.
Yang C, Wang T, Zhu S, Zong Z, Luo C, Zhao Y, Liu J, Li T, Liu X, Liu C, Deng H
ACS omega 2022 Oct 25;7(42):37509-37519
ACS omega 2022 Oct 25;7(42):37509-37519
Comparative analyses in transcriptome of human granulosa cells and follicular fluid micro-environment between poor ovarian responders with conventional controlled ovarian or mild ovarian stimulations.
Liu X, Mai H, Chen P, Zhang Z, Wu T, Chen J, Sun P, Zhou C, Liang X, Huang R
Reproductive biology and endocrinology : RB&E 2022 Mar 21;20(1):54
Reproductive biology and endocrinology : RB&E 2022 Mar 21;20(1):54
Sodium butyrate alleviates pre-eclampsia in pregnant rats by improving the gut microbiota and short-chain fatty acid metabolites production.
Yong W, Zhao Y, Jiang X, Li P
Journal of applied microbiology 2022 Feb;132(2):1370-1383
Journal of applied microbiology 2022 Feb;132(2):1370-1383
Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.
Wang L, Lin L, Qi H, Chen J, Grossfeld P
Circulation research 2022 Aug 19;131(5):371-387
Circulation research 2022 Aug 19;131(5):371-387
tRNA-Derived Fragment tRF-Glu-TTC-027 Regulates the Progression of Gastric Carcinoma via MAPK Signaling Pathway.
Xu W, Zhou B, Wang J, Tang L, Hu Q, Wang J, Chen H, Zheng J, Yan F, Chen H
Frontiers in oncology 2021;11:733763
Frontiers in oncology 2021;11:733763
ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-β.
Meng L, Zheng Y, Liu S, Ju Y, Ren S, Sang Y, Zhu Y, Gu L, Liu F, Zhao Y, Zhang X, Sang M
Cancer letters 2021 Oct 28;519:117-129
Cancer letters 2021 Oct 28;519:117-129
Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305/TGF-β2/SMAD3 pathway.
Gao L, Tang X, He Q, Sun G, Wang C, Qu H
Cell death discovery 2021 Oct 11;7(1):281
Cell death discovery 2021 Oct 11;7(1):281
Cadmium promotes apoptosis and inflammation via the circ08409/miR-133a/TGFB2 axis in bovine mammary epithelial cells and mouse mammary gland.
Chen Z, Liang Y, Lu Q, Nazar M, Mao Y, Aboragah A, Yang Z, Loor JJ
Ecotoxicology and environmental safety 2021 Oct 1;222:112477
Ecotoxicology and environmental safety 2021 Oct 1;222:112477
USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription.
Jie X, Fong WP, Zhou R, Zhao Y, Zhao Y, Meng R, Zhang S, Dong X, Zhang T, Yang K, Wu G, Xu S
Cell death and differentiation 2021 Jul;28(7):2095-2111
Cell death and differentiation 2021 Jul;28(7):2095-2111
SALL1 regulates commitment of odontoblast lineages by interacting with RUNX2 to remodel open chromatin regions.
Lin Y, Xiao Y, Lin C, Zhang Q, Zhang S, Pei F, Liu H, Chen Z
Stem cells (Dayton, Ohio) 2021 Feb;39(2):196-209
Stem cells (Dayton, Ohio) 2021 Feb;39(2):196-209
Association of CASC18/miR-20a-3p/TGFB2 ceRNA axis with occult lymph node metastasis in tongue squamous cell carcinoma.
Zhou B, Zhou Y, Liu Y, Zhang H, Mao H, Peng M, Xu A, Li Z, Wang H, Tan H, Ren H, Zhou X, Long Y
Molecular medicine (Cambridge, Mass.) 2021 Aug 6;27(1):85
Molecular medicine (Cambridge, Mass.) 2021 Aug 6;27(1):85
Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase.
Wang ZD, Feng Y, Sun L, Gan J, Li X, Ding WF, Chen XM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111241
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111241
LncRNA PART1 promotes cell proliferation and progression in non-small-cell lung cancer cells via sponging miR-17-5p.
Chen Y, Zhou X, Huang C, Li L, Qin Y, Tian Z, He J, Liu H
Journal of cellular biochemistry 2021 Apr;122(3-4):315-325
Journal of cellular biochemistry 2021 Apr;122(3-4):315-325
Gold Nanoparticles Induce Tumor Vessel Normalization and Impair Metastasis by Inhibiting Endothelial Smad2/3 Signaling.
Huang N, Liu Y, Fang Y, Zheng S, Wu J, Wang M, Zhong W, Shi M, Xing M, Liao W
ACS nano 2020 Jul 28;14(7):7940-7958
ACS nano 2020 Jul 28;14(7):7940-7958
PPARα-Dependent Effects of Palmitoylethanolamide Against Retinal Neovascularization and Fibrosis.
Ye S, Chen Q, Jiang N, Liang X, Li J, Zong R, Huang C, Qiu Y, Ma JX, Liu Z
Investigative ophthalmology & visual science 2020 Apr 9;61(4):15
Investigative ophthalmology & visual science 2020 Apr 9;61(4):15
The Smad3-miR-29b/miR-29c axis mediates the protective effect of macrophage migration inhibitory factor against cardiac fibrosis.
Liang JN, Zou X, Fang XH, Xu JD, Xiao Z, Zhu JN, Li H, Yang J, Zeng N, Yuan SJ, Pan R, Fu YH, Zhang M, Luo JF, Wang S, Shan ZX
Biochimica et biophysica acta. Molecular basis of disease 2019 Sep 1;1865(9):2441-2450
Biochimica et biophysica acta. Molecular basis of disease 2019 Sep 1;1865(9):2441-2450
miR-618 Suppresses Metastasis in Gastric Cancer by Downregulating the Expression of TGF-β2.
Shi J, Gong L, Chen L, Luo J, Song G, Xu J, Lv Z, Tao H, Xia Y, Ye Z
Anatomical record (Hoboken, N.J. : 2007) 2019 Jun;302(6):931-940
Anatomical record (Hoboken, N.J. : 2007) 2019 Jun;302(6):931-940
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
Xue K, Zhang J, Li C, Li J, Wang C, Zhang Q, Chen X, Yu X, Sun L, Yu X
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
Expression of miR-181a and TGF-β2 in lens epithelial cells of patients with cataractous retinal detachment and its clinical significance.
Jiang Y, Gong Y, Lin N, Qiu W
Experimental and therapeutic medicine 2019 Jun;17(6):4435-4440
Experimental and therapeutic medicine 2019 Jun;17(6):4435-4440
LncRNA CASC9 interacts with CPSF3 to regulate TGF-β signaling in colorectal cancer.
Luo K, Geng J, Zhang Q, Xu Y, Zhou X, Huang Z, Shi KQ, Pan C, Wu J
Journal of experimental & clinical cancer research : CR 2019 Jun 11;38(1):249
Journal of experimental & clinical cancer research : CR 2019 Jun 11;38(1):249
Zoledronate inhibits fibroblasts' proliferation and activation via targeting TGF-β signaling pathway.
Zhao Z, Shen W, Zhu H, Lin L, Jiang G, Zhu Y, Song H, Wu L
Drug design, development and therapy 2018;12:3021-3031
Drug design, development and therapy 2018;12:3021-3031
EDIL3 depletion suppress epithelial-mesenchymal transition of lens epithelial cells via transforming growth factor β pathway.
Zhang R, Wei YH, Zhao CY, Song HY, Shen N, Cui X, Gao X, Qi ZT, Zhong M, Shen W
International journal of ophthalmology 2018;11(1):18-24
International journal of ophthalmology 2018;11(1):18-24
Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII-p38MAPK-pS249/T252RB Pathway.
Yu-Lee LY, Yu G, Lee YC, Lin SC, Pan J, Pan T, Yu KJ, Liu B, Creighton CJ, Rodriguez-Canales J, Villalobos PA, Wistuba II, de Nadal E, Posas F, Gallick GE, Lin SH
Cancer research 2018 Jun 1;78(11):2911-2924
Cancer research 2018 Jun 1;78(11):2911-2924
Modulation of TGF‑β activity by latent TGF‑β‑binding protein 1 in human osteoarthritis fibroblast‑like synoviocytes.
Wang X, Dong C, Li N, Ma Q, Yun Z, Cai C, An M, Ma B
Molecular medicine reports 2018 Jan;17(1):1893-1900
Molecular medicine reports 2018 Jan;17(1):1893-1900
High doses of baicalin induces kidney injury and fibrosis through regulating TGF-β/Smad signaling pathway.
Cai Y, Ma W, Xiao Y, Wu B, Li X, Liu F, Qiu J, Zhang G
Toxicology and applied pharmacology 2017 Oct 15;333:1-9
Toxicology and applied pharmacology 2017 Oct 15;333:1-9
Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGFβ2 feedback loop.
Lei K, Liang X, Gao Y, Xu B, Xu Y, Li Y, Tao Y, Shi W, Liu J
Biochemical and biophysical research communications 2017 Mar 11;484(3):514-521
Biochemical and biophysical research communications 2017 Mar 11;484(3):514-521
Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer.
Lin SC, Lee YC, Yu G, Cheng CJ, Zhou X, Chu K, Murshed M, Le NT, Baseler L, Abe JI, Fujiwara K, deCrombrugghe B, Logothetis CJ, Gallick GE, Yu-Lee LY, Maity SN, Lin SH
Developmental cell 2017 Jun 5;41(5):467-480.e3
Developmental cell 2017 Jun 5;41(5):467-480.e3
Gender differences in fibrosis remodeling in patients with long-standing persistent atrial fibrillation.
Li Z, Wang Z, Yin Z, Zhang Y, Xue X, Han J, Zhu Y, Zhang J, Emmert MY, Wang H
Oncotarget 2017 Aug 8;8(32):53714-53729
Oncotarget 2017 Aug 8;8(32):53714-53729
TGF-β2 is involved in the preservation of the chondrocyte phenotype under hypoxic conditions.
Das R, Timur UT, Edip S, Haak E, Wruck C, Weinans H, Jahr H
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2015 Mar;198:1-10
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2015 Mar;198:1-10
SIX1 promotes tumor lymphangiogenesis by coordinating TGFβ signals that increase expression of VEGF-C.
Liu D, Li L, Zhang XX, Wan DY, Xi BX, Hu Z, Ding WC, Zhu D, Wang XL, Wang W, Feng ZH, Wang H, Ma D, Gao QL
Cancer research 2014 Oct 1;74(19):5597-607
Cancer research 2014 Oct 1;74(19):5597-607
Participation of miR-200a in TGF-β1-mediated hepatic stellate cell activation.
Sun X, He Y, Ma TT, Huang C, Zhang L, Li J
Molecular and cellular biochemistry 2014 Mar;388(1-2):11-23
Molecular and cellular biochemistry 2014 Mar;388(1-2):11-23
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 19999-1-AP(TGFB2-Specific antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 19999-1-AP(TGFB2-Specific antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The TGF-beta 2-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human TGF-beta 2-Specific. This antibody recognizes human,mouse,rat antigen. The TGF-beta 2-Specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.