HPA007459

antibody from Atlas Antibodies

Targeting: ROCK2

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA007459

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA007459, RRID:AB_1079828

Product name

Anti-ROCK2

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human ROCK2, Gene description: Rho-associated, coiled-coil containing protein kinase 2, Validated applications: WB, IHC, Uniprot ID: O75116, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Selectivity matters: selective ROCK2 inhibitor ameliorates established liver fibrosis via targeting inflammation, fibrosis, and metabolism

Zanin-Zhorov A, Chen W, Moretti J, Nyuydzefe M, Zhorov I, Munshi R, Ghosh M, Serdjebi C, MacDonald K, Blazar B, Palmer M, Waksal S
Communications Biology 2023;6(1)

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Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through α5 integrin signaling.

Li X, McLain C, Samuel MS, Olson MF, Radice GL
Development (Cambridge, England) 2023 Jan 15;150(2)

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Hexokinase 2-driven glycolysis in pericytes activates their contractility leading to tumor blood vessel abnormalities

Meng Y, Jiang X, Zhao X, Meng Q, Wu S, Chen Y, Kong X, Qiu X, Su L, Huang C, Wang M, Liu C, Wong P
Nature Communications 2021;12(1)

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Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis

Popkirov S, Ayzenberg I, Hahn S, Bauer J, Denno Y, Rieckhoff N, Radzimski C, Hans V, Berg S, Roghmann F, Noldus J, Bien C, Skodda S, Wellmer J, Stöcker W, Krogias C, Gold R, Schlegel U, Probst C, Komorowski L, Miske R, Kleiter I
Acta Neuropathologica Communications 2017;5(1)

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The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma

Govaere O, Petz M, Wouters J, Vandewynckel Y, Scott E, Topal B, Nevens F, Verslype C, Anstee Q, Van Vlierberghe H, Mikulits W, Roskams T
Oncogene 2017;36(47):6605-6616

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Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10

Zanin-Zhorov A, Weiss J, Trzeciak A, Chen W, Zhang J, Nyuydzefe M, Arencibia C, Polimera S, Schueller O, Fuentes-Duculan J, Bonifacio K, Kunjravia N, Cueto I, Soung J, Fleischmann R, Kivitz A, Lebwohl M, Nunez M, Woodson J, Smith S, West R, Berger M, Krueger J, Ryan J, Waksal S
The Journal of Immunology 2017;198(10):3809-3814

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ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings

Weiss J, Chen W, Nyuydzefe M, Trzeciak A, Flynn R, Tonra J, Marusic S, Blazar B, Waksal S, Zanin-Zhorov A
Science Signaling 2016;9(437)

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Inhibition of Rho-associated kinases disturbs the collective cell migration of stratified TE-10 cells.

Mikami T, Yoshida K, Sawada H, Esaki M, Yasumura K, Ono M
Biological research 2015 Sep 2;48(1):48

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Novel signatures of cancer‐associated fibroblasts

Bozóky B, Savchenko A, Csermely P, Korcsmáros T, Dúl Z, Pontén F, Székely L, Klein G
International Journal of Cancer 2013;133(2):286-293