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- Antigen structure
- References [66]
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- Product number
- 12330-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12330-2-AP, RRID:AB_2140101
- Product name
- TAK1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TAK1 antibody (Cat. #12330-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, hamster, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Hamster
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lactucopicrin promotes the autophagic degradation of MAP2K4/MKK4 by mediating CCDC50 palmitoylation to alleviate osteoarthritis progression.
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
MALT1 Knockdown Alleviates Multiorgan Injury and Inflammation Through Inhibiting TAK1/NF-κB Signaling Pathway-Mediated T-Helper 1 and 17 Differentiations in LPS-induced Inflammation.
miR-17195 promotes infectious bronchitis virus proliferation and macrophage-mediated inflammation via the PLCβ2-TAK1 axis.
Bone morphogenetic protein receptor 2 signaling mediates mitochondrial Ca(2+) transport through its regulation of TAK1 splice variant.
Saikosaponin-d Attenuates Irinotecan-Induced Intestinal Toxicity via TAK1/NF-κB Pathway and Enhances Antitumor Efficacy.
Mycobacterium tuberculosis Rv2521 promotes ferroptosis-dependent pathogenicity by inhibiting NF-κB activation.
The deubiquitinase OTUD4 suppresses TAK1 kinase-dependent NF-κB signaling and inflammation.
Exercise increases bone mass by lactate/Gpr81 signaling pathway.
ITGA5 drives angiogenesis in diabetic retinopathy via TAK-1/NF-kB activation.
Panoptosis Targets the Mechanism of PRDX1 Involvement in Acute Myocardial Infarction via ZBP1.
Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.
Colchicine alleviates ischemic white matter lesions and cognitive deficits by inhibiting microglia inflammation via the TAK1/MAPK/NF-κB signaling pathway.
Platelet NLRP6 protects against microvascular thrombosis in sepsis.
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway.
Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα.
DUSP14 attenuates airway inflammation and mucus hypersecretion in allergic asthma by regulating TAK1 activity.
Desulfovibrio vulgaris flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway.
MSC exosomes attenuate sterile inflammation and necroptosis associated with TAK1-pJNK-NFKB mediated cardiomyopathy in diabetic ApoE KO mice.
NMDA receptor blockade attenuates Japanese encephalitis virus infection-induced microglia activation.
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors.
Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.
Thrombin receptor activating peptide-6 decreases acute graft-versus-host disease through activating GPR15.
Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI.
Lactoferrin ameliorated obesity-induced endothelial dysfunction by inhibiting the Tak1/IL-18/eNOS pathway between PVAT and vascular endothelium.
Tak1 licenses mitochondrial transfer from astrocytes to POMC neurons to maintain glucose and cholesterol homeostasis.
USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells.
Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation.
Herb pair of Rhubarb-Astragalus mitigates renal interstitial fibrosis through downregulation of autophagy via p38-MAPK/TGF-β1 and p38-MAPK/smad2/3 pathways.
NLRP6 induces RIP1 kinase-dependent necroptosis via TAK1-mediated p38(MAPK)/MK2 phosphorylation in S. typhimurium infection.
Repurposing crizotinib to target RIPK1-dependent cell death.
RIP2 inhibition alleviates lipopolysaccharide-induced septic cardiomyopathy via regulating TAK1 signaling.
microRNA-149-5p mediates the PM(2.5)-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro.
Danzhi Jiangtang capsule reduces renal injury in rats with diabetes induced by high fat diet and streptozotocin downregulating toll-like receptor 4-nuclear factor-κB pathway and apoptosis.
Decrease in MAP3Ks expression enhances the cell death caused by hyperthermia.
Wnt5a protects motor neurons in amyotrophic lateral sclerosis by regulating the Wnt/Ca(2+) signaling pathway.
Inhibitory effect of main phenolic acid components of Jacobaea cannabifolia (Less.) on inflammation caused by PM(2.5).
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Taraxasterol inhibits inflammation in osteoarthritis rat model by regulating miRNAs and NF-κB signaling pathway.
The WNT/Ca(2+) pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling in isolated beating rat atria.
Recombinant porcine beta defensin 2 alleviates inflammatory responses induced by Escherichia coli in IPEC-J2 cells.
Pseudorabies Virus ICP0 Abolishes Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Degrading P65.
Inducible MicroRNA-132 Inhibits the Production of Inflammatory Cytokines by Targeting TRAF6, TAK1, and TAB1 in Teleost Fish.
Ginsenoside compound K inhibits obesity-induced insulin resistance by regulation of macrophage recruitment and polarization via activating PPARγ.
ARRB1 Drives Gallbladder Cancer Progression by Facilitating TAK1/MAPK Signaling Activation.
Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex.
Hepatic P38 Activation Modulates Systemic Metabolism Through Fgf21-Mediated Interorgan Communication.
CARS senses cysteine deprivation to activate AMPK for cell survival.
Natural molecule Munronoid I attenuates LPS-induced acute lung injury by promoting the K48-linked ubiquitination and degradation of TAK1.
Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity.
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
Resveratrol affects the expression of uric acid transporter by improving inflammation.
Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells.
Inducible MicroRNA-217 Inhibits NF-κB- and IRF3-Driven Immune Responses in Lower Vertebrates through Targeting TAK1.
Protein phosphatase 6 is a key factor regulating spermatogenesis.
TRIM14 promotes endothelial activation via activating NF-κB signaling pathway.
Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway.
JAZF1 Suppresses Papillary Thyroid Carcinoma Cell Proliferation and Facilitates Apoptosis via Regulating TAK1/NF-κB Pathways.
Conjugated Linoleic Acid Ameliorates High Fructose-Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway.
DHA-phospholipids (DHA-PL) and EPA-phospholipids (EPA-PL) prevent intestinal dysfunction induced by chronic stress.
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure.
Quantitative proteomic dissection of a native 14-3-3ε interacting protein complex associated with hepatocellular carcinoma.
Li W, Sun Q, Hu K, Tang D, Yang C, Xie Y, Peng X, Deng Y, Lu J, Qi Y, Lin Y, Sun H, Tian Q, Xu C, Tian X, Jiang H
Autophagy 2026 Mar;22(3):526-544
Autophagy 2026 Mar;22(3):526-544
Transducin-like enhancer of split 3 protects against lipopolysaccharide-induced inflammation through DEAD-box helicase 5-activating transcription factor 1-protein phosphatase 2 regulatory subunit 5A signaling.
Fan D, Zhong Y, Dong Y, Du M, Huang K, Li X
Journal of advanced research 2026 Jan;79:661-677
Journal of advanced research 2026 Jan;79:661-677
MALT1 Knockdown Alleviates Multiorgan Injury and Inflammation Through Inhibiting TAK1/NF-κB Signaling Pathway-Mediated T-Helper 1 and 17 Differentiations in LPS-induced Inflammation.
Huang Q, Luo Y, Chen Q, Cui Y
Inflammation 2026 Jan 26;49(1):69
Inflammation 2026 Jan 26;49(1):69
miR-17195 promotes infectious bronchitis virus proliferation and macrophage-mediated inflammation via the PLCβ2-TAK1 axis.
Wang Z, Liu C, Chen X, Li J, Li W, Duoji Z, Yang Q, Xu T, Zhang A, Ma P, Wang H
Veterinary microbiology 2026 Feb;313:110834
Veterinary microbiology 2026 Feb;313:110834
Bone morphogenetic protein receptor 2 signaling mediates mitochondrial Ca(2+) transport through its regulation of TAK1 splice variant.
Toussaint A, Singh M, Chiou H, Wang G, Jia D, Driscoll M, Bhatt V, Ndong JC, Shuaib S, Zoltowski H, Gilleran J, Peng Y, Tsymbal A, Roberge J, Guo JY, Herranz D, Langenfeld J
Cell communication and signaling : CCS 2026 Feb 11;24(1)
Cell communication and signaling : CCS 2026 Feb 11;24(1)
Saikosaponin-d Attenuates Irinotecan-Induced Intestinal Toxicity via TAK1/NF-κB Pathway and Enhances Antitumor Efficacy.
Zheng P, Ma R, Liu X, Song L, Ma B, Zou G
Journal of inflammation research 2025;18:7973-7988
Journal of inflammation research 2025;18:7973-7988
Mycobacterium tuberculosis Rv2521 promotes ferroptosis-dependent pathogenicity by inhibiting NF-κB activation.
Liu W, Zhu C, Zhang L, Wang Y, Zhang X, Shang X, Zhao J, Li Z, Jia H, Zhang Z, Pan L
International journal of biological macromolecules 2025 Sep;321(Pt 4):146294
International journal of biological macromolecules 2025 Sep;321(Pt 4):146294
The deubiquitinase OTUD4 suppresses TAK1 kinase-dependent NF-κB signaling and inflammation.
Liu Z, Wang X, Wu L, Min L, Sheng Y, Sun Z, Deng Y, Miao L, Liu Y, Li J, Zhao Y
The Journal of biological chemistry 2025 Nov;301(11):110784
The Journal of biological chemistry 2025 Nov;301(11):110784
Exercise increases bone mass by lactate/Gpr81 signaling pathway.
Guo Y, He L, Xue A, Sun Y, Liu R, Zhang M, Liu Y, Yu F, Guo P, Zhao Y, Tang L, Li X, Lu W, Li Y, Sun P
Communications biology 2025 Nov 10;8(1):1548
Communications biology 2025 Nov 10;8(1):1548
ITGA5 drives angiogenesis in diabetic retinopathy via TAK-1/NF-kB activation.
Kan F, Wang D, Li S, Gao Y, Wang J
Human cell 2025 May 23;38(4):105
Human cell 2025 May 23;38(4):105
Panoptosis Targets the Mechanism of PRDX1 Involvement in Acute Myocardial Infarction via ZBP1.
Sun Y, Ji C, Zhang Y, Liu S, Ye Y, Li T, Wu S, Sun T, Yin H, Yan W, Jin W
Journal of cellular biochemistry 2025 Mar;126(3):e70026
Journal of cellular biochemistry 2025 Mar;126(3):e70026
Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1.
Zhang X, Tang X, Gao T, Guo Y, Lu G, Liu Q, Li J, Wang J, Liu M, Zhang D, Tang Y, Gu J
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3591-3610
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3591-3610
Colchicine alleviates ischemic white matter lesions and cognitive deficits by inhibiting microglia inflammation via the TAK1/MAPK/NF-κB signaling pathway.
Liu Y, Zhai Y, Ma L, Wang Z, Wang J, Hu B, Tang Y
Behavioural brain research 2025 Jul 26;490:115619
Behavioural brain research 2025 Jul 26;490:115619
Platelet NLRP6 protects against microvascular thrombosis in sepsis.
Jiang H, Chen S, Gui X, Li Y, Sun Y, Zhu H, Dai Y, Zhang J, Li X, Ju W, Li Z, Zeng L, Xu K, Qiao J
Blood 2025 Jul 17;146(3):382-395
Blood 2025 Jul 17;146(3):382-395
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway.
Duah M, Zheng F, Shen J, Xu Y, Cao S, Yan Z, Lan Q, Wang Y, Xu K, Pan B
Acta pharmaceutica Sinica. B 2025 Jan;15(1):224-238
Acta pharmaceutica Sinica. B 2025 Jan;15(1):224-238
Genome-wide screen based on 2DG activated NLRP3 inflammasome reveals the priming signal of TLR2/4 to IKKβ but not IKKα.
Gao H, Sun M, Gao H, Sun Y, Chen W, Dong N
International immunopharmacology 2025 Jan 3;145:113781
International immunopharmacology 2025 Jan 3;145:113781
DUSP14 attenuates airway inflammation and mucus hypersecretion in allergic asthma by regulating TAK1 activity.
Kong R, Bai J, Yao Q, Xu X
Immunology letters 2025 Dec;276:107047
Immunology letters 2025 Dec;276:107047
Desulfovibrio vulgaris flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway.
Dong Y, Meng F, Wang J, Wei J, Zhang K, Qin S, Li M, Wang F, Wang B, Liu T, Zhong W, Cao H
Gut microbes 2025 Dec;17(1):2446376
Gut microbes 2025 Dec;17(1):2446376
MSC exosomes attenuate sterile inflammation and necroptosis associated with TAK1-pJNK-NFKB mediated cardiomyopathy in diabetic ApoE KO mice.
Banerjee A, Singla DK
Frontiers in immunology 2024;15:1348043
Frontiers in immunology 2024;15:1348043
NMDA receptor blockade attenuates Japanese encephalitis virus infection-induced microglia activation.
Chang CY, Wu CC, Tzeng CY, Li JR, Chen YF, Chen WY, Kuan YH, Liao SL, Chen CJ
Journal of neuroinflammation 2024 Nov 7;21(1):291
Journal of neuroinflammation 2024 Nov 7;21(1):291
SMAD7 expression in CAR-T cells improves persistence and safety for solid tumors.
Liang S, Zheng R, Zuo B, Li J, Wang Y, Han Y, Dong H, Zhao X, Zhang Y, Wang P, Meng R, Jia L, Yang A, Yan B
Cellular & molecular immunology 2024 Mar;21(3):213-226
Cellular & molecular immunology 2024 Mar;21(3):213-226
Effect of lipopolysaccharide on TAK1-mediated hepatocyte PANoptosis through Toll-like receptor 4 during acute liver failure.
Li W, Zhang W, Zhang D, Shi C, Wang Y
International immunopharmacology 2024 Mar 10;129:111612
International immunopharmacology 2024 Mar 10;129:111612
Thrombin receptor activating peptide-6 decreases acute graft-versus-host disease through activating GPR15.
Liu C, Lan Q, Cao S, Zheng F, Liang Y, Shen J, Wang Y, Ikezoe T, Xu K, Pan B
Leukemia 2024 Jun;38(6):1390-1402
Leukemia 2024 Jun;38(6):1390-1402
Axonal injury mediated by neuronal p75NTR/TRAF6/JNK pathway contributes to cognitive impairment after repetitive mTBI.
Liu G, He M, Wu C, Lv P, Sun H, Wang H, Xin X, Liao H
Experimental neurology 2024 Feb;372:114618
Experimental neurology 2024 Feb;372:114618
Lactoferrin ameliorated obesity-induced endothelial dysfunction by inhibiting the Tak1/IL-18/eNOS pathway between PVAT and vascular endothelium.
Chen C, Yan Y, Wu Y, Lu M, Xing Y, Bai Y, Zhao H, Ding L, Wu Y, Xu J, Qin L, Lv H, Zhang Z
Free radical biology & medicine 2024 Feb 20;212:309-321
Free radical biology & medicine 2024 Feb 20;212:309-321
Tak1 licenses mitochondrial transfer from astrocytes to POMC neurons to maintain glucose and cholesterol homeostasis.
Yin K, Zhang T, Lu X, Shen Q, Gu K, Huang Y, Li C, Hou J, Li J, Zhang G
Cell reports 2024 Dec 24;43(12):114983
Cell reports 2024 Dec 24;43(12):114983
USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells.
Yan XH, Zhu YN, Zhu YT
Current medical science 2024 Aug;44(4):707-717
Current medical science 2024 Aug;44(4):707-717
Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation.
Yan Z, Yue J, Zhang Y, Hou Z, Li D, Yang Y, Li X, Idris A, Li H, Li S, Xie J, Feng R
Virologica Sinica 2024 Aug;39(4):587-599
Virologica Sinica 2024 Aug;39(4):587-599
Herb pair of Rhubarb-Astragalus mitigates renal interstitial fibrosis through downregulation of autophagy via p38-MAPK/TGF-β1 and p38-MAPK/smad2/3 pathways.
Li J, Qin X, Xu W, Zhang H, Huang S, Yang Y, Qin M, Mi Z, Zhong X
The international journal of biochemistry & cell biology 2024 Apr;169:106549
The international journal of biochemistry & cell biology 2024 Apr;169:106549
NLRP6 induces RIP1 kinase-dependent necroptosis via TAK1-mediated p38(MAPK)/MK2 phosphorylation in S. typhimurium infection.
Deng Q, Yang S, Huang K, Zhu Y, Sun L, Cao Y, Dong K, Li Y, Wu S, Huang R
iScience 2024 Apr 19;27(4):109339
iScience 2024 Apr 19;27(4):109339
Repurposing crizotinib to target RIPK1-dependent cell death.
Yu Y, Li M, Fu S, He X, Hu X, Zhu G, Wang J, You X, Mou Y, Ye Z, Wei J, Zha Y
International immunology 2023 May 8;35(5):221-230
International immunology 2023 May 8;35(5):221-230
RIP2 inhibition alleviates lipopolysaccharide-induced septic cardiomyopathy via regulating TAK1 signaling.
Lin Z, Liao HH, Zhou ZY, Zhang N, Li WJ, Tang QZ
European journal of pharmacology 2023 May 15;947:175679
European journal of pharmacology 2023 May 15;947:175679
microRNA-149-5p mediates the PM(2.5)-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro.
Li Q, Li S, Xu C, Zhao J, Hou L, Jiang F, Zhu Z, Wang Y, Tian L
Cell biology and toxicology 2023 Jun;39(3):703-717
Cell biology and toxicology 2023 Jun;39(3):703-717
Danzhi Jiangtang capsule reduces renal injury in rats with diabetes induced by high fat diet and streptozotocin downregulating toll-like receptor 4-nuclear factor-κB pathway and apoptosis.
Jing X, Zheng BI, Sihai W, Guoming S, Zhaohui F
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Apr;43(2):312-321
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Apr;43(2):312-321
Decrease in MAP3Ks expression enhances the cell death caused by hyperthermia.
Enomoto A, Fukasawa T, Terunuma H, Nakagawa K, Yoshizaki A, Sato S, Miyagawa K
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2022;39(1):200-208
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2022;39(1):200-208
Wnt5a protects motor neurons in amyotrophic lateral sclerosis by regulating the Wnt/Ca(2+) signaling pathway.
Liu J, Zhou F, Chen Y, Guan Y, Meng F, Zhao Z, Wang X, Gao X, Jiang X, Zhang H, Wang Q, Zhou S, Wang X
American journal of translational research 2022;14(8):5343-5362
American journal of translational research 2022;14(8):5343-5362
Inhibitory effect of main phenolic acid components of Jacobaea cannabifolia (Less.) on inflammation caused by PM(2.5).
Xu BL, Wang YY, Jiang LL, Liu Z, Liu DR, Zhao H, Li SL, Wang XB
Frontiers in pharmacology 2022;13:1096137
Frontiers in pharmacology 2022;13:1096137
Synthesis and anti-inflammatory activity of paeonol derivatives with etherized aryl urea by regulating TLR4/MyD88 signaling pathway in RAW264.7 cell.
Gong X, He Y, Yang D, Yang S, Li J, Zhao H, Chen Q, Ren Q, Zhang B
Bioorganic chemistry 2022 Oct;127:105939
Bioorganic chemistry 2022 Oct;127:105939
Taraxasterol inhibits inflammation in osteoarthritis rat model by regulating miRNAs and NF-κB signaling pathway.
Xie Z, Wang B, Zheng C, Qu Y, Xu J, Wang B, Gao Y, Shen P
Acta biochimica Polonica 2022 Nov 26;69(4):811-818
Acta biochimica Polonica 2022 Nov 26;69(4):811-818
The WNT/Ca(2+) pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling in isolated beating rat atria.
Li ZY, Liu Y, Han ZN, Li X, Wang YY, Cui X, Zhang Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):469-478
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):469-478
Recombinant porcine beta defensin 2 alleviates inflammatory responses induced by Escherichia coli in IPEC-J2 cells.
Zhang K, Lian S, Shen X, Zhao X, Zhao W, Li C
International journal of biological macromolecules 2022 May 31;208:890-900
International journal of biological macromolecules 2022 May 31;208:890-900
Pseudorabies Virus ICP0 Abolishes Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Degrading P65.
Zhang X, Xie J, Gao M, Yan Z, Chen L, Wei S, Feng R
Viruses 2022 May 2;14(5)
Viruses 2022 May 2;14(5)
Inducible MicroRNA-132 Inhibits the Production of Inflammatory Cytokines by Targeting TRAF6, TAK1, and TAB1 in Teleost Fish.
Cui J, Zheng W, Sun Y, Xu T
Infection and immunity 2022 May 19;90(5):e0012022
Infection and immunity 2022 May 19;90(5):e0012022
Ginsenoside compound K inhibits obesity-induced insulin resistance by regulation of macrophage recruitment and polarization via activating PPARγ.
Xu J, Dong J, Ding H, Wang B, Wang Y, Qiu Z, Yao F
Food & function 2022 Mar 21;13(6):3561-3571
Food & function 2022 Mar 21;13(6):3561-3571
ARRB1 Drives Gallbladder Cancer Progression by Facilitating TAK1/MAPK Signaling Activation.
Zhang X, Kong Z, Xu X, Yun X, Chao J, Ding D, Li T, Gao Y, Guan N, Zhu C, Qin X
Journal of Cancer 2021;12(7):1926-1935
Journal of Cancer 2021;12(7):1926-1935
Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex.
Deng F, Xu G, Cheng Z, Huang Y, Ma C, Luo C, Yu C, Wang J, Xu X, Liu S, Zhu Y
Frontiers in immunology 2021;12:618196
Frontiers in immunology 2021;12:618196
Hepatic P38 Activation Modulates Systemic Metabolism Through Fgf21-Mediated Interorgan Communication.
Liu W, Sun C, Yan Y, Cao H, Niu Z, Shen S, Liu S, Wu Y, Li Y, Hui L, Li Y, Zhao L, Hu C, Ding Q, Jiang J, Ying H
Diabetes 2021 Oct 21;
Diabetes 2021 Oct 21;
CARS senses cysteine deprivation to activate AMPK for cell survival.
Yuan M, Yan R, Zhang Y, Qiu Y, Jiang Z, Liu H, Wang Y, Sun L, Zhang H, Gao P
The EMBO journal 2021 Nov 2;40(21):e108028
The EMBO journal 2021 Nov 2;40(21):e108028
Natural molecule Munronoid I attenuates LPS-induced acute lung injury by promoting the K48-linked ubiquitination and degradation of TAK1.
Ma X, Li X, Di Q, Zhao X, Zhang R, Xiao Y, Sun P, Tang H, Quan J, Xiao W, Chen W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111543
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111543
Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity.
Wang J, Ge P, Lei Z, Lu Z, Qiang L, Chai Q, Zhang Y, Zhao D, Li B, Su J, Peng R, Pang Y, Shi Y, Zhang Y, Gao GF, Qiu XB, Liu CH
EMBO reports 2021 Jun 4;22(6):e52175
EMBO reports 2021 Jun 4;22(6):e52175
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Cao W, Guo Y, Cheng Z, Xu G, Zuo Q, Nie L, Huang Y, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Role of IL-6-IL-27 Complex in Host Antiviral Immune Response.
Zuo Q, Cheng Z, Zhang G, Xia Y, Xu G, Cao W, Yang X, Fu Y, He R, Fang P, Guo Y, Nie L, Huang Y, Liu L, Zhan J, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
Journal of immunology (Baltimore, Md. : 1950) 2021 Jul 15;207(2):577-589
Resveratrol affects the expression of uric acid transporter by improving inflammation.
Zhang X, Nie Q, Zhang Z, Zhao J, Zhang F, Wang C, Wang X, Song G
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells.
Fan Y, Ma K, Jing J, Wang C, Hu Y, Shi Y, Li E, Geng Q
Journal of Cancer 2020;11(1):25-40
Journal of Cancer 2020;11(1):25-40
Inducible MicroRNA-217 Inhibits NF-κB- and IRF3-Driven Immune Responses in Lower Vertebrates through Targeting TAK1.
Zhang L, Chu Q, Chang R, Xu T
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 15;205(6):1620-1632
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 15;205(6):1620-1632
Protein phosphatase 6 is a key factor regulating spermatogenesis.
Lei WL, Han F, Hu MW, Liang QX, Meng TG, Zhou Q, Ouyang YC, Hou Y, Schatten H, Wang ZB, Sun QY
Cell death and differentiation 2020 Jun;27(6):1952-1964
Cell death and differentiation 2020 Jun;27(6):1952-1964
TRIM14 promotes endothelial activation via activating NF-κB signaling pathway.
Huang X, Li Y, Li X, Fan D, Xin HB, Fu M
Journal of molecular cell biology 2020 Apr 24;12(3):176-189
Journal of molecular cell biology 2020 Apr 24;12(3):176-189
Dual-target MDM2/MDMX inhibitor increases the sensitization of doxorubicin and inhibits migration and invasion abilities of triple-negative breast cancer cells through activation of TAB1/TAK1/p38 MAPK pathway.
Fan Y, Li M, Ma K, Hu Y, Jing J, Shi Y, Li E, Dong D
Cancer biology & therapy 2019;20(5):617-632
Cancer biology & therapy 2019;20(5):617-632
JAZF1 Suppresses Papillary Thyroid Carcinoma Cell Proliferation and Facilitates Apoptosis via Regulating TAK1/NF-κB Pathways.
Huang L, Cai Y, Luo Y, Xiong D, Hou Z, Lv J, Zeng F, Yang Y, Cheng X
OncoTargets and therapy 2019;12:10501-10514
OncoTargets and therapy 2019;12:10501-10514
Conjugated Linoleic Acid Ameliorates High Fructose-Induced Hyperuricemia and Renal Inflammation in Rats via NLRP3 Inflammasome and TLR4 Signaling Pathway.
Tan J, Wan L, Chen X, Li X, Hao X, Li X, Li J, Ding H
Molecular nutrition & food research 2019 Jun;63(12):e1801402
Molecular nutrition & food research 2019 Jun;63(12):e1801402
DHA-phospholipids (DHA-PL) and EPA-phospholipids (EPA-PL) prevent intestinal dysfunction induced by chronic stress.
Cao W, Wang C, Chin Y, Chen X, Gao Y, Yuan S, Xue C, Wang Y, Tang Q
Food & function 2019 Jan 22;10(1):277-288
Food & function 2019 Jan 22;10(1):277-288
Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex.
Xu G, Xia Z, Deng F, Liu L, Wang Q, Yu Y, Wang F, Zhu C, Liu W, Cheng Z, Zhu Y, Zhou L, Zhang Y, Lu M, Liu S
PLoS pathogens 2019 Aug;15(8):e1008002
PLoS pathogens 2019 Aug;15(8):e1008002
NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1.
Xia Z, Xu G, Nie L, Liu L, Peng N, He Q, Zuo Q, Zhou Y, Cao Z, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
Journal of immunology (Baltimore, Md. : 1950) 2019 Aug 15;203(4):1001-1011
Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, Hao H, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704
Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure.
Zhou H, Gao S, Duan X, Liang S, Scott DA, Lamont RJ, Wang H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Sep;29(9):3737-49
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Sep;29(9):3737-49
Quantitative proteomic dissection of a native 14-3-3ε interacting protein complex associated with hepatocellular carcinoma.
Bai C, Tang S, Bai C, Chen X
Amino acids 2014 Apr;46(4):841-52
Amino acids 2014 Apr;46(4):841-52
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- COLO 320 cells were subjected to SDS PAGE followed by western blot with 12330-2-AP(MAP3K7 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TAK1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TAK1. This antibody recognizes human, hamster, mouse antigen. The TAK1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
