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- Antibody Data
- Antigen structure
- References [22]
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- Product number
- 19886-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19886-1-AP, RRID:AB_10641986
- Product name
- PHD2/EGLN1 antibody
- Antibody type
- Polyclonal
- Description
- PHD2/EGLN1 antibody (Cat. #19886-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Proteomic profiling and molecular reclassification of high-grade serous ovarian cancer identifies prognostic subtypes and immunotherapy biomarkers.
Fucoidan from Fucus vesiculosus alleviates MetALD via promoting HIF-1α ubiquitination to suppress peripheral monocyte infiltration.
Cancer-associated fibroblast-induced lncRNA WARS2-IT1 confers radioresistance of colorectal cancer via enhancing HIF-1α stability.
Immunodynamic axis of fibroblast-driven neutrophil infiltration in acute pancreatitis: NF-κB-HIF-1α-CXCL1.
Constitutive HIF-1α Expression in the Epidermis Fuels Proliferation and Is Essential for Effective Barrier Formation.
Targeting P4HA1 promotes CD8(+) T cell progenitor expansion toward immune memory and systemic anti-tumor immunity.
Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia-Inducible Factor-1 Signaling Pathway.
Modified Zhenwu Tang delays chronic renal failure progression by modulating oxidative stress and hypoxic responses in renal proximal tubular epithelial cells.
Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter.
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.
HIF-1α/m(6)A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity.
FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation.
Silencing of OGDHL promotes liver cancer metastasis by enhancing hypoxia inducible factor 1 α protein stability.
Chronic constant light exposure aggravates high fat diet-induced renal injury in rats.
Cancer associated fibroblast-derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis.
A novel PHD2 inhibitor acteoside from Cistanche tubulosa induces skeletal muscle mitophagy to improve cancer-related fatigue.
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
Stabilization of hypoxia-inducible factor-1α alleviates osteoarthritis via interacting with Per2 and resetting the circadian clock.
The DpdtbA induced EMT inhibition in gastric cancer cell lines was through ferritinophagy-mediated activation of p53 and PHD2/hif-1α pathway.
Sustained Hypoxia Suppresses Joint Destruction in a Rat Model of Rheumatoid Arthritis via Negative Feedback of Hypoxia Inducible Factor-1α.
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein.
Tu M, Tang S, Zhang Q, Guo T, Cen Y, Xu X, Wu S, Chen X, Lu W, Ding C, Xu J
EBioMedicine 2026 May;127:106248
EBioMedicine 2026 May;127:106248
Fucoidan from Fucus vesiculosus alleviates MetALD via promoting HIF-1α ubiquitination to suppress peripheral monocyte infiltration.
Li L, Luo J, Wang D, Chang Y, Duan C, Zuo D
Frontiers in pharmacology 2025;16:1617175
Frontiers in pharmacology 2025;16:1617175
Cancer-associated fibroblast-induced lncRNA WARS2-IT1 confers radioresistance of colorectal cancer via enhancing HIF-1α stability.
Li Y, Dai W, Zheng X, Wang Q, Zhang J, Kong X, Jiang J, Zhou Y
Cell death & disease 2025 Nov 10;16(1):823
Cell death & disease 2025 Nov 10;16(1):823
Immunodynamic axis of fibroblast-driven neutrophil infiltration in acute pancreatitis: NF-κB-HIF-1α-CXCL1.
Wang Q, Zhang X, Han C, Lv Z, Zheng Y, Liu X, Du Z, Liu T, Xue D, Li T, Wang L
Cellular & molecular biology letters 2025 May 7;30(1):57
Cellular & molecular biology letters 2025 May 7;30(1):57
Constitutive HIF-1α Expression in the Epidermis Fuels Proliferation and Is Essential for Effective Barrier Formation.
Boix J, Knuever J, Niehoff N, Sen A, Pla-Martin D, Baris OR, Etich J, Brachvogel B, Kaul H, Isbrandt D, Soroka E, Bazzi H, Wenger RH, Giavalisco P, Wiesner RJ
The Journal of investigative dermatology 2025 Jul;145(7):1683-1692.e8
The Journal of investigative dermatology 2025 Jul;145(7):1683-1692.e8
Targeting P4HA1 promotes CD8(+) T cell progenitor expansion toward immune memory and systemic anti-tumor immunity.
Ma S, Ong LT, Jiang Z, Lee WC, Lee PL, Yusuf M, Ditzel HJ, Wang Y, Chen Q, Wang W, Wu X, Tan EY, Yu Q
Cancer cell 2025 Feb 10;43(2):213-231.e9
Cancer cell 2025 Feb 10;43(2):213-231.e9
Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia-Inducible Factor-1 Signaling Pathway.
Zhao LN, Wang RL, Liu RX, Zheng MR, Zhao L, Li BF, Li JL, Liu DS, He XX, Peng QB, Li K, Lin TX, Liu YY, He SP, Lu J, Zheng SY, Liu X, Huang FZ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e17128
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e17128
Modified Zhenwu Tang delays chronic renal failure progression by modulating oxidative stress and hypoxic responses in renal proximal tubular epithelial cells.
Zhang YY, Jin PP, Guo DZ, Bian D
Heliyon 2024 May 30;10(10):e31265
Heliyon 2024 May 30;10(10):e31265
Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter.
Feng S, Ding B, Dai Z, Yin H, Ding Y, Liu S, Zhang K, Lin H, Xiao Z, Shen Y
Journal of translational medicine 2024 Mar 15;22(1):280
Journal of translational medicine 2024 Mar 15;22(1):280
Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.
Mao Y, Zhang J, Zhou Q, He X, Zheng Z, Wei Y, Zhou K, Lin Y, Yu H, Zhang H, Zhou Y, Lin P, Wu B, Yuan Y, Zhao J, Xu W, Zhao S
Cell research 2024 Jan;34(1):13-30
Cell research 2024 Jan;34(1):13-30
HIF-1α/m(6)A/NF-κB/CCL3 axis-mediated immunosurveillance participates in low level benzene-related erythrohematopoietic development toxicity.
Cong X, Li X, Xu K, Yin L, Liang G, Sun R, Pu Y, Zhang J
Environment international 2024 Feb;184:108493
Environment international 2024 Feb;184:108493
FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation.
Zhang T, Zhao C, Li Y, Wu J, Wang F, Yu J, Wang Z, Gao Y, Zhao L, Liu Y, Yan Y, Li X, Gao H, Hu Z, Cui B, Li K
Developmental cell 2024 Aug 19;59(16):2085-2100.e9
Developmental cell 2024 Aug 19;59(16):2085-2100.e9
Silencing of OGDHL promotes liver cancer metastasis by enhancing hypoxia inducible factor 1 α protein stability.
Dai W, Li Y, Sun W, Ji M, Bao R, Chen J, Xu S, Dai Y, Chen Y, Liu W, Ge C, Sun W, Mo W, Guo C, Xu X
Cancer science 2023 Apr;114(4):1309-1323
Cancer science 2023 Apr;114(4):1309-1323
Chronic constant light exposure aggravates high fat diet-induced renal injury in rats.
Xing L, Wu S, Shi Y, Yue F, Wei L, Russell R, Zhang D
Frontiers in endocrinology 2022;13:900392
Frontiers in endocrinology 2022;13:900392
Cancer associated fibroblast-derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis.
Xu H, Zhao J, Li J, Zhu Z, Cui Z, Liu R, Lu R, Yao Z, Xu Q
Cell death & disease 2022 May 20;13(5):478
Cell death & disease 2022 May 20;13(5):478
A novel PHD2 inhibitor acteoside from Cistanche tubulosa induces skeletal muscle mitophagy to improve cancer-related fatigue.
Zhang S, Gong F, Liu J, Liu T, Yang J, Hu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:113004
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:113004
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
Song CC, Pantopoulos K, Chen GH, Zhong CC, Zhao T, Zhang DG, Luo Z
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
Stabilization of hypoxia-inducible factor-1α alleviates osteoarthritis via interacting with Per2 and resetting the circadian clock.
Wang C, Zhang Y, Wang Z, Yu W, Tong M, Yan Z
Tissue & cell 2022 Dec;79:101942
Tissue & cell 2022 Dec;79:101942
The DpdtbA induced EMT inhibition in gastric cancer cell lines was through ferritinophagy-mediated activation of p53 and PHD2/hif-1α pathway.
Guan D, Li C, Li Y, Li Y, Wang G, Gao F, Li C
Journal of inorganic biochemistry 2021 May;218:111413
Journal of inorganic biochemistry 2021 May;218:111413
Sustained Hypoxia Suppresses Joint Destruction in a Rat Model of Rheumatoid Arthritis via Negative Feedback of Hypoxia Inducible Factor-1α.
Kaihara K, Nakagawa S, Arai Y, Inoue H, Tsuchida S, Fujii Y, Kamada Y, Kishida T, Mazda O, Takahashi K
International journal of molecular sciences 2021 Apr 9;22(8)
International journal of molecular sciences 2021 Apr 9;22(8)
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Wang X, Lin Y, Zheng Y
Molecular medicine reports 2020 Sep;22(3):2318-2328
Molecular medicine reports 2020 Sep;22(3):2318-2328
Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein.
Cilenti L, Di Gregorio J, Ambivero CT, Andl T, Liao R, Zervos AS
Scientific reports 2020 Jan 31;10(1):1609
Scientific reports 2020 Jan 31;10(1):1609
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PHD2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PHD2. This antibody recognizes human,mouse,rat antigen. The PHD2 antibody has been validated for the following applications: ELISA, WB analysis.
